ライフサイエンスコーパス: random sequence

1 ich involved looking through the images in a random sequence.

2 d 10 mL was given rectally to 10 subjects in random sequence.

3 oligoribonucleotide of the same length and a random sequence.

4 mg twice daily or placebo for 1 week each in random sequence.

5 sing phage display of heptameric peptides of random sequence.

6 ughout and while asleep from 0000 to 0200 in random sequence.

7 ith the TFIID complex has been replaced by a random sequence.

8 construct that contains 26 nucleotides in a random sequence.

9 g(2+)-dependent self-cleaving ribozymes from random sequence.

10 ry 3 min) and post-TME (Bruce protocol) in a random sequence.

11 to dry cord care using a computer-generated random sequence.

12 ibutes more to the binding energetics than a random sequence.

13 rms similar complexes with DNA substrates of random sequence.

14 f faces and houses were displayed rapidly in random sequence.

15 a wide range of odor gradients, presented in random sequence.

16 was achieved by using the computer-generated random sequence.

17 ) on the expected density of minimizers in a random sequence.

18 red orange juice/d and 500 mL placebo/d in a random sequence.

19 se of a simple two-layer model to tones in a random sequence.

20 uscarinic cholinergic antagonist atropine in random sequence.

21 rokaryotes, 16 unicellular eukaryotes, and 2 random sequences.

22 initiate R-loops much more efficiently than random sequences.

23 populations or even in unselected samples of random sequences.

24 antly (p < 0.05) greater palindromicity than random sequences.

25 sis' conclusion that coding DNA behaves like random sequences.

26 s is added to differentiate coding exons and random sequences.

27 on CTS-containing DNA substrates compared to random sequences.

28 dary structures no more stable than those of random sequences.

29 00-fold decrease in abundance in a sample of random sequences.

30 oles (<1 attomole) of predominantly inactive random sequences.

31 ion from RNA libraries containing completely random sequences.

32 c (first-order) structure and the entropy of random sequences.

33 e effective at relieving PLN inhibition than random sequences.

34 ven folded, proteins occur in collections of random sequences.

35 g mRNA, to sample a large number of distinct random sequences.

36 f-the-pairs scoring system, which will align random sequences.

37 ribozymes (RNA enzymes) from large pools of random sequences.

38 ins have been evolved in vitro starting from random sequences.

39 l gene is then compared to a distribution of random sequences.

40 strong deviation of the yeast sequences from random sequences.

41 of an oligonucleotide library consisting of random sequences.

42 cted for the first time from a large pool of random sequences.

43 ns can be achieved with improved modeling of random sequences.

44 t not about objects or temporal positions in random sequences.

45 ng of approximately 10 copies each of 10(15) random sequences.

46 d performance for distinguishing ncRNAs from random sequences.

47 dehydrogenase was identified by large-scale random sequencing.

48 rease in gene discovery rates as compared to random sequencing.

49 strand conformation polymorphism (SSCP), and random sequencing.

50 ur women) were studied on three occasions in random sequence: 1) cycle exercise ( approximately 70% p

51 cise tolerance testing under 2 conditions in random sequence: (1) after a 27-hour washout period (Off

52 e almost 10-fold higher than HU binding to a random sequence 20 bp duplex (6.1 vs 0.68 microM(-1)).

53 nstants observed for counterion binding to a random-sequence 26-base pair (bp) oligomer ranged from 7

54 e TG dinucleotide tract in the minigene with random sequence abolished splicing of exon 9.

55 Randomisation was by a computer-generated random sequence, accessed via an interactive telephone a

56 ids by inserting 90-base oligonucleotides of random sequence ahead of DNA coding for the AraC DNA bin

57 The random sequences also showed over an order of magnitude

58 Recently Jordan et al. reported that the 'random' sequences amplified by degenerate oligonucleotid

59 pendent of their developmental expression, a random sequence analysis of the 10.4-megabase genome of

60 using nucleosomes reconstituted onto 167-bp random sequence and 208-bp (5 S rRNA gene) DNA fragments

61 Biphasic kinetics were observed for both random sequence and CTS-containing DNA complexes, reveal

62 sms of the lower burst amplitudes using both random sequence and CTS-containing DNA substrates.

63 omisation was done with a computer-generated random sequence and stratified by renal impairment, HbA1

64 th potential binding affinity from a pool of random sequences and developed a protocol for RNA 3D str

65 were studied using high-throughput Illumina random sequences and full-length 16S rRNA genes extracte

66 ing cassettes, artificial aptamers, pools of random sequences and natural long noncoding RNAs.

67 For N6= M6= GGGGGG, N6= M6= a 'random' sequence and N6= GGGGGG and M6= a 'random' seque

68 the randomisation with a computer-generated random-sequence and interactive voice-response and web-r

69 -helical potential is a common occurrence in random sequences, and that the presence of amphiphilic a

70 This AP-1-targeting aptamer, as well as a random sequence aptamer with no target (5ECdsRan) as a c

71 Random sequences are accumulated, and the data are proce

72 for assessing whether a source produce truly random sequences are still missing.

73 Random EGSs that have 14-nt random sequences are used in the selection procedure for

74 s diverged from their D. yakuba orthologs as random sequences are.

75 short A/T tracts, dispersed within seemingly random sequences, are strong terminator elements, and bi

76 f testing was chosen by a computer-generated random sequence, assigned by independent members of the

77 the nucleotide content reveal striking, non-random, sequence-biases that are correlated with genome

78 sphorylthioate-modified oligoDNA (sODN) with random sequence (bio-sODN-Ran) were conjugated with Neut

79 fMRI analyses comparing repeating versus random sequence blocks demonstrated activation of fronta

80 An RNA library was generated by using random-sequence bridges to join a hammerhead self-cleavi

81 imordial proteins presumably originated from random sequences, but it is not known how frequently fun

82 th predicted stabilities resembling those of random sequences can enhance processing.

83 short oligonucleotides, of both specific and random sequence, can modulate ribozyme activity.

84 t sequencing (HT-SELEX), creates billions of random sequences capable of binding different epitopes o

85 Replacement of IAS2 and the ISAR core with random sequences capable of stem formation resulted in t

86 ligase, a ribozyme previously isolated from random sequence, catalyzes a reaction similar to RNA pol

87 t the degree to which pseudogenes approach a random sequence composition may be useful in dating diff

88 ment over the background rate of cleavage of random sequences containing a single embedded ribonucleo

89 Several virus-targeted P-PMO and a random-sequence control P-PMO showed low inhibitory acti

90 We show that in solutions of completely random sequences, corresponding to a remarkably large nu

91 l/l) twice weekly for 1 month, compared in a random-sequence crossover design with an otherwise ident

92 y to predict cattle chromosome location from random sequence data, demonstrating this tool to be valu

93 Ribozymes could be selected from a pool of random sequences depending on the length of their stems.

94 equences with known secondary structures and random sequences designed with similar melting temperatu

95 Mutagenesis with linkers of random sequence detected two subdomains separated by 21

96 double-stranded DNA (dsDNA) consisting of a random sequence did exhibit the expected single peak.

97 A pool of random sequence DNA molecules were immobilized via a cap

98 on the burst amplitude were determined using random sequence DNA substrates.

99 n more diverse pools of chemically synthetic random sequence DNA.

100 rence for binding DNA containing an RSS over random sequence DNA.

101 gment; replacing all five A- and T-tracts by random-sequence DNA causes the 199-bp mutant to adopt a

102 on mononucleosomes reconstituted from either random-sequence DNA derived from native nucleosomes or a

103 on constant for [Rh(phi)(2)(phen')](3+) with random-sequence DNA is 7.0 x 10(-7) M.

104 e been identified by in vitro selection from random-sequence DNA pools.

105 selection to isolate aptamers from a pool of random-sequence DNAs and subjected two distinct clones t

106 measure the binding of monovalent cations to random sequence, double-stranded (ds) DNA.

107 d every 30 min from -60 through 180 min with random-sequence, double-blind administration of diazoxid

108 A)/poly(T) is at least two-fold stiffer than random-sequence dsDNA in bending, stretching, and torsio

109 Monovalent cation binding to random-sequence dsDNA would be expected to occur in addi

110 Z-DNA to be at least three-fold stiffer than random-sequence dsDNA, with a near-zero link-extension c

111 ut a 2:1 stoichiometry to the T4A4 tract and random sequence duplex.

112 ls (allocation done on the basis of a pseudo-random sequence-eg, odd/even hospital number or date of

113 ing of nucleotide types in heterozygotes and random sequencing error.

114 in infection according to a simple model of random sequence evolution.

115 d in the classification of enhancers against random sequences, exhibiting advantages of deep learning

116 We use a large-scale random sequence experiment to show that while most align

117 a molecular "slithering" mechanism, whereas random sequences favor a restrictive pathway involving t

118 optimal gapped local alignment score of two random sequences follows a Gumbel distribution.

119 ro selection to search an unbiased sample of random sequences for comparably active self-cleaving mot

120 otein-protein or DNA-DNA local alignments of random sequences, for arbitrary substitution score matri

121 es with small divergence, and within 30% for random sequences, for which Affine-DO produced the worst

122 Duplex DNAs of random sequence from 20 to 500 bp were efficiently packa

123 uent double noise bursts were presented in a random sequence from these eight locations.

124 The earliest RNA molecules must have been random sequences, from which the first genomes that code

125 e methods for sample size calculation (45%), random sequence generation (43%), allocation concealment

126 Low rates of reports of random sequence generation, allocation concealment, and

127 ale, which assesses the adequacy of reported random sequence generation, allocation concealment, blin

128 ity of the trials, but the rates of reported random sequence generation, allocation concealment, powe

129 s lack of allocation concealment, inadequate random sequence generation, lack of reporting of power,

130 ls with inadequate or unclear (vs. adequate) random-sequence generation (ratio of odds ratios, 0.89 [

131 were randomly assigned (1:1) using an online random sequence generator to either a 4-h face-to-face R

132 esearch/compbio/sam.html and the open-source random sequence generator with varying compositional bia

133 of normal numbers, reasonable candidates for random sequences, given their limiting equidistribution

134 his study according to the heirarchy: ssDNA (random sequence) > epsilonDNA (random sequence) > poly(d

135 archy: ssDNA (random sequence) > epsilonDNA (random sequence) > poly(dA) > poly(depsilonA); (3) gp59

136 delineation of individual, infinite-length "random" sequences have been longstanding yet incompletel

137 d bimodal entropy, possibly corresponding to random sequences (high entropy) and sequences that posse

138 were offered for 4 consecutive days each in random sequence: high energy density, high viscosity (HD

139 cent of base pairs as the AQP1-siRNAs but in random sequence (i.e. scrambled siRNAs) had no effect.

140 tion of active mutants from 10(6) completely random sequences identified hairpin structures that func

141 retrospect, but so are some features of most random sequences--if the features are selected after loo

142 acteria form a sister group when rooted with random sequences; (iii) Planctomycetes, which possesses

143 viral DNA molecules with short stretches of random sequence in Psi and transfected each pool into av

144 extent F139/L, and mut13F139/L (F139/L with random sequence in the first 13 positions) but not Delta

145 nt in affinity for CRP compared to that of a random sequence in the presence and absence of the two h

146 replicons from plasmid libraries containing random sequences in the distal element.

147 , we analyzed the splicing of pre-mRNAs with random sequences in the exon bases at the splice junctio

148 or without atropine) were both performed, in random sequence, in each patient of a study group of 36

149 tinin 307-319 presented by HLA-DR4, but with random sequences inserted at CDR1alpha or CDR2alpha, wer

150 The random sequence inserts were sequenced for phage populat

151 gnment by a centralized, computer-generated, random-sequence interactive voice-response system to exe

152 reas CRISPR Cas1-Cas2 integrates essentially random sequences into a specific site in the CRISPR locu

153 how catalytic activity is distributed across random sequences is fundamental to estimating the probab

154 sought to extend this strategy for use with random sequence libraries by combining a quality-control

155 ed from the yeast genome and from completely random sequence libraries, and compare the results to re

156 s that can bind a specific ligand, from both random-sequence libraries and libraries based on a known

157 ency of occurrence of functional proteins in random-sequence libraries appears to be similar to that

158 he selection of bicyclic peptides from large random-sequence libraries.

159 s of displayed protein library: a completely random sequence library, a library of concatemerized oli

160 silico mutated native protein sequences into random sequence-like ensembles and monitored the change

161 sed in antisense-treated muscles compared to random sequence-loaded controls.

162 e in protein levels of CaP to 54% of that in random sequence-loaded muscles, but no change in the pro

163 Starting from random sequences, low free energy sequences were generat

164 ly bound to the polyguanosine tract than the random sequence, making it less available for crosslink

165 segment just 5' of the BPS with a series of random sequences markedly repressed splicing, whereas su

166 of structurally related pseudoknots with non-random sequence matches and reveals modular units in rRN

167 but could not be distinguished reliably from random sequence matches.

168 These probes include random-sequence MB, dye-labeled single-strand linear oli

169 repetitive patterns, for which weaknesses in random sequence models yield notably inaccurate statisti

170 roteins to the frequencies predicted by four random sequence models.

171 somes from a mixture of approximately 10(14) random sequence molecules contain sequence motifs shown

172 t-containing aptamer isolated from a pool of random sequence molecules has been shown previously to r

173 display a low affinity for a small dsDNA of random sequence, mthCdc6-1 binds tightly to a short dupl

174 We have used random sequence mutagenesis and complementation in a bac

175 We have used random sequence mutagenesis and functional complementati

176 We have used random sequence mutagenesis to gain structure-function i

177 We used random sequence mutagenesis to replace 13 codons within

178 olate biologically active mutants created by random sequence mutagenesis, synthesized the mutant prot

179 ed agents, with 2'-deoxyguanosine (dGuo) and random-sequence native DNA by in-line liquid chromatogra

180 5, 75, 65, 55, and 45 mg/dl steps) after, in random sequence, nocturnal (2330-0300) hypoglycemia (48

181 ability to isolate new functional RNAs from random sequences now ultimately makes the world of possi

182 bust interference effects when switched to a random sequence of cued responses (at 4-, 8-, and 12-seq

183 ed denaturation bubbles in a long, stretched random sequence of DNA.

184 A random sequence of equiprobable loud and soft speech sou

185 patial light modulator is used to generate a random sequence of phase-modulated wavefronts, and the r

186 Subjects viewed a pseudo-random sequence of smoking images, neutral nonsmoking im

187 or example, when measuring the response to a random sequence of tones, frequencies that appear rarely

188 coded information and became errors when the random sequence of trials conflicted with these constrai

189 Assignment to random sequences of 2- and 4-week rotations.

190 with two retroviral libraries that contained random sequences of 9 or 18 nt in the intercistronic reg

191 al isolation, traditional cloning methods or random sequences of complementary DNAs.

192 all sizes stacking-disordered, consisting of random sequences of cubic and hexagonal ice layers.

193 ss of biological information generation from random sequences of heteropolymers, where unfavorable Sh

194 Participants listened to random sequences of high or low tones.

195 We study the folding and binding of random sequences of hydrophobic ([Formula: see text]) an

196 known GPx is 6.3 SD higher than expected for random sequences of similar composition.

197 tabolism in A. nidulans is that expected for random sequences of the same composition.

198 In contrast, it predicts that random sequences of the same length and many partially r

199 e compound, (T,G)-A-L, was tipped with short random sequences of tyrosine and glutamic acid.

200 selected in vitro from libraries containing random sequences of up to a few hundred nucleotides.

201 uence tag (EST) sequences were obtained from random sequencing of 16,152 cDNA clones.

202 ins of this complex natural product pathway, random sequencing of a cDNA library derived from Taxus c

203 By random sequencing of a library prepared from developing

204 Random sequencing of a peppermint oil gland secretory ce

205 ell-wall-degrading enzymes were found during random sequencing of an opium poppy latex cDNA library.

206 Random sequencing of cDNA clones from a hepatopancreas c

207 Random sequencing of cDNA clones identified approximatel

208 es expressed wild-type K-ras mRNA based on a random sequencing of eight K-ras cDNA samples obtained b

209 This study suggests that the random sequencing of Mutator-tagged fragments is capable

210 Random sequencing of this material revealed 75 genes tha

211 d rats received an injection of antisense or random-sequence oligodeoxynucleotide for VIP in the SCN

212 A 26-basepair random-sequence oligomer was used as the reference; lith

213 free solution mobilities of the A-tract and random-sequence oligomers were identical in solutions co

214 resemble the Rep binding sites identified by random sequence oligonucleotide selection, and the trans

215 1 exon 18 was replaced with two libraries of random sequences, one seven nucleotides in length, the o

216 unlike intact controls that experienced the random sequences only.

217 rees (i) Archaea, Bacteria, Eukaryota, and a random sequence outgroup are clearly separated; (ii) Arc

218 nucleotides of the DEN-2 virus genome and a random-sequence P4-PMO showed relatively little suppress

219 cilitate the construction of high-complexity random sequence peptide libraries on MS2 VLPs and that a

220 on of antibody-specific peptide ligands from random sequence peptide library.

221 Random-sequence peptide libraries are a commonly used to

222 Experiments with random-sequence peptide libraries show the single-chain

223 The array consists of 10,000 random sequence peptides (20-mers) capable of detecting

224 incubated with a microarray of thousands of random sequence peptides.

225 on many-to-many binding of antibodies to the random sequence peptides.

226 mixtures of antibodies binding to arrays of random sequence peptides.

227 NA ligase ribozyme, isolated previously from random sequences, performs an efficient RNA ligation rea

228 ibution of optimal local alignment scores of random sequences plays a vital role in evaluating the st

229 binding and catalytic structures in pools of random sequence polynucleotides versus polypeptides.

230 we find that the hydrodynamic radius of this random sequence polypeptide also approaches that of the

231 ule-like compaction, we have characterized a random sequence polypeptide of identical amino acid comp

232 distribution of fitness and activity in the random sequence pool for the first time.

233 ot select for a specific DNA sequence from a random sequence pool.

234 sphorothioester linkage were selected from a random sequence pool.

235 de kinase-like activity were isolated from a random-sequence pool by using in vitro selection.

236 n were isolated by in vitro selection from a random-sequence pool of DNA.

237 monophosphate (cAMP; 1) were isolated from a random-sequence pool using in vitro selection.

238 ugh identification of active motifs in large random sequence pools is central to RNA in vitro selecti

239 ptamers) isolated by in vitro selection from random sequence pools provide convenient model systems f

240 re identified from each of N30, N40, and N50 random-sequence pools.

241 elected an allosteric ribozyme ligase from a random sequence population that is activated up to 10,00

242 that can be obtained from entirely unbiased (random) sequence populations.

243 ing RNAs isolated by in vitro selection from random-sequence populations can rival the catalytic effi

244 rapid presentation was evident even when the random sequence preceding a stimulus did not stimulate t

245 selected from a total of 10(8)-10(9) unique random sequences present in the library.

246 lves priming template polynucleotide(s) with random-sequence primers and extending to generate a pool

247 ne or that received a SPION conjugate with a random-sequence probe and amphetamine showed no retentio

248 pre-mRNAs generated by this method contained random sequences ranging from 0 to 18 nucleotides in len

249 proximately 25% of the sunflower genome from random sequence reads and assembled bacterial artificial

250 he BAC clones analyzed, a global analysis of random sequence reads indicates that the evolutionary pa

251 we can refine our estimates of the number of random sequences required for a 50% probability of findi

252 ated the synthesis of short- and medium-size random sequence RNA analogues and thereby provided a mic

253 CA to a greater extent than a similar length random sequence RNA mixture.

254 al 40mer library of approximately 6 x 10(14) random-sequence RNA molecules for their ability to bind

255 c acid enzymes starting from a population of random-sequence RNA or DNA molecules.

256 ificantly more ordered than conformations of random-sequence RNA, this analysis demonstrates that the

257 from a conformationally constrained pool of random sequence RNAs.

258 exhaustively within a starting population of random-sequence RNAs.

259 itro evolution starting from a population of random-sequence RNAs.

260 We test six coalescent priors and six random sequence samples of H3N2 influenza during the 201

261 nserved central Gly(6)-Gln(7) residues or by random sequence scrambling demonstrated a crucial role f

262 the study reported here, a restricted set of random sequences (semi-random) was introduced into the a

263 paring them to null models constructed using random sequence sets from the same genomes.

264 The control is a random-sequence sODN (Ran).

265 Nucleic acid polymers selected from random sequence space constitute an enormous array of ca

266 chips on which 130,000 peptides chosen from random sequence space have been synthesized.

267 'random' sequence and N6= GGGGGG and M6= a 'random' sequence, spermine concentrations of 20, 1 and 3

268 tin mRNA (SPION-beta-actin) and to sODN with random sequence (SPION-Ran).

269 ecific conditions, this ligase ligated 30-nt random sequence ssDNA (5'-N(30)-3') to a specified 20-nt

270 to other "primer-free" approaches where the random sequence ssDNA starting pool has no fixed sequenc

271 so occur on specific templates found within 'random' sequence substrates and on G-rich motifs proxima

272 We have solved these problems by including a random sequence tag in the initial primer such that each

273 mationally complex (i.e., rarer in a pool of random sequences) than aptamers selected to bind a large

274 he simplest way to obtain maximally unbiased random sequences that are subject to GC usage and primar

275 more matches between the two halves than do random sequences that can form the tRNA structure, but t

276 ch can easily be expanded to create unbiased random sequences that incorporate more complicated const

277 thod with RT-Ec86 and primer RNAs containing random sequences, the identical stem-loop structure (inc

278 t we have selected a dual-catalytic RNA from random sequences: the RNA promotes both cleavage at one

279 For random sequences this distance is approximately 12, cons

280 different from the predicted stability of a random sequence to be useful as a general genefinding ap

281 igher and lower energies were delivered in a random sequence to develop a distribution curve.

282 allocentric head direction in rats running a random sequence to light locations around a circular pla

283 mly assigned (1:1:1) by a computer-generated random sequence to receive a subcutaneous injection of 8

284 domly assigned (1:1) by a computer-generated random sequence to receive subcutaneous injections of pl

285 illing in gaps, blunting the ends, or adding random sequences to the 3' ends of DNA, producing 3' fla

286 plates for threading calculations and adding random sequences to the analysis.

287 To address this issue, we used random sequencing to survey the pheromone composition of

288 domly assigned (1:1:1) by computer-generated random sequence via an interactive voice or web response

289 The random sequence was fused to the CCR5 chemokine receptor

290 condition (implicit sequence learning versus random sequence) was observed across diagnostic groups i

291 Oligodeoxynucleotides that contained 16-bp random sequences were purified by vnd/NK-2 affinity colu

292 library and identifying those peptides with random sequence which can recognize mAb aggregates.

293 mly assigned (1:2:2:2) by computer-generated random sequence with an interactive voice response syste

294 n was done according to a computer-generated random sequence with an interactive voice response syste

295 andomly assigned (1:1) by computer-generated random sequence with an interactive voice-response syste

296 Studies were performed in random sequence with vitamin E 800 IU and vitamin C 1 g

297 cture decrease reaction rates; however, even random sequences with no known internal single-stranded

298 e developed a method that generates unbiased random sequences with pre-specified amino acid and GC co

299 in sequences have been minimized compared to random sequences with uniform and natural amino acid com

300 duced a population of HIV-2 DNA genomes with random sequences within the 5' side of pal and transfect