ライフサイエンスコーパス: randomized trial

1 mally invasive esophagectomy, a multicenter, randomized trial).

2 onary Syndrome Quality Improvement in Kerala randomized trial.

3 with myelodysplastic syndrome (MDS) within a randomized trial.

4 ss the question of first-line treatment in a randomized trial.

5 ion (nAMD) who participated in a large-scale randomized trial.

6 he baseline assessment of an ongoing cluster-randomized trial.

7 lacebo in a double-blind, placebo-controlled randomized trial.

8 herapy use and IOP in the context of a large randomized trial.

9 We did a non-randomized trial.

10 5 emergency departments within a multicenter randomized trial.

11 h neurocognitive effects in a recent phase 3 randomized trial.

12 Stepped-wedge, cluster randomized trial.

13 ties in the SEARCH Study, an ongoing cluster randomized trial.

14 n uncertain because of lack of evidence from randomized trials.

15 in the observational studies but not in the randomized trials.

16 vational results be addressed in prospective randomized trials.

17 onvenience cohort, nested within two ongoing randomized trials.

18 left untreated, thus confirming results from randomized trials.

19 t been compared with PCI in such patients in randomized trials.

20 to-moderate risk kidney transplantation in 3 randomized trials.

21 icted mean survival times (RMST) in oncology randomized trials.

22 g, complementing and extending evidence from randomized trials.

23 o subsequent clinical development, including randomized trials.

24 D need improvement, including development of randomized trials.

25 patients with pneumonia could enrich future randomized trials.

26 pilepsy, but additional data are needed from randomized trials.

27 ntially more efficient than standard two-arm randomized trials.

28 METHODS AND In this cluster-randomized trial, 10 primary health facilities in the ci

29 In the absence of randomized trials, 2 possible approaches are the paramet

30 nction in elderly men.In this parallel-group randomized trial, 29 men aged >70 y [mean +/- SD body ma

31 One randomized trial, 3 quasi-experimental studies, and 40 o

32 In the ABSORB II randomized trial, 383 lesions (n = 359) were investigate

33 =0.75 g/dl over any 4-week period during the randomized trial; 57 [48.7%] versus 17 [14.8%] with plac

34 entified 425 eligible articles, including 31 randomized trials (7%), 116 cross-sectional studies (27%

35 Eleven randomized trials (8 peer-reviewed publications, 3 abstr

36 abilities of clinical outcomes from a recent randomized trial and hospital costs (2013 US$) from a un

37 Survival estimates were derived from a randomized trial and scaled relative to published US sur

38 These included 9 randomized trials and 1 observational study.

39 Sixty-seven studies (11 randomized trials and 56 observational studies) examinin

40 Two randomized trials and 6 other studies examining outcomes

41 the era of drug-eluting stents, large-scale randomized trials and all-comer registries have shown ex

42 estimating population-level impact, cluster-randomized trials and mechanistic models play particular

43 (through October 7, 2015) were searched for randomized trials and observational studies examining pa

44 PCNSL is an uncommon tumor, and only four randomized trials and one phase III trial have been comp

45 Randomized trials and systematic reviews of trials that

46 of clinical guidelines, systematic reviews, randomized trials, and intervention studies on hepatitis

47 from broad patient populations, contemporary randomized trials, and multiple recent studies with phar

48 ocardial infarction has been demonstrated in randomized trials, and the radial approach has become th

49 Double-blind, placebo-controlled randomized trial (April 2013-February 2015; 28-day follo

50 Seven ongoing randomized trials are evaluating the influence of weight

51 herapy has not been conclusively proven, and randomized trials are lacking.

52 Multicenter, randomized trials are needed to ascertain the optimal pr

53 Randomized trials are needed to determine optimal screen

54 Given the limitations of observational data, randomized trials are needed to determine the role of MV

55 More convincing data from randomized trials are required to inform the management

56 he efficacy of KNO3 and suggests that larger randomized trials are warranted.

57 The randomized trial, assessed as having high risk of bias,

58 icle) study is a prospective multicenter non-randomized trial assessing the safety and performance of

59 Randomized trials assessing the efficacy of this strateg

60 After adjustment for age, sex, and randomized trial assignment, the hazard ratio for 60-day

61 We conducted a multicenter, randomized trial at 14 CF centers with subjects at least

62 We conducted a randomized trial at five U.S. emergency departments to d

63 We conducted a randomized trial at two hospitals.

64 h the use of data from 2 placebo-controlled, randomized trials at 2 academic medical centers in the U

65 A total of 12,233 patients enrolled to the randomized trials C-07, C-08, N0147, MOSAIC (Adjuvant Tr

66 The results of a recent large randomized trial (Cancer and Leukemia Group B/Alliance f

67 In a prospective, randomized trial cohort of 13,164 patients with stable C

68 DS Clinical Trials Group Longitudinal Linked Randomized Trials cohort participants not receiving a st

69 Program (RAISE-ETP) study, a 34-site cluster-randomized trial, compared NAVIGATE, a coordinated speci

70 In a recently published randomized trial, compared with intensified treatment of

71 pose To report on the long-term results of a randomized trial comparing a standard dose (400 mg/d) ve

72 the final results on treatment outcomes of a randomized trial comparing conventional and hypofraction

73 The original study was a double-blind, randomized trial comparing IIV-HD to IIV-SD in adults ag

74 st this hypothesis, we performed a phase III randomized trial comparing MAC with RIC in patients with

75 ith severe, symptomatic aortic stenosis in a randomized trial comparing TAVR (performed with the use

76 r interim results of the 5-year prospective, randomized trial comparing the 2 procedures (Swiss Multi

77 lar testing, but there are limited data from randomized trials comparing anatomic with functional tes

78 earched MEDLINE, Scopus, and web sources for randomized trials comparing BVS and EES.

79 METHODS AND Patient-level data from 5 randomized trials comparing CRT with no CRT were used to

80 ials, two reviewers independently identified randomized trials comparing HFOV with conventional venti

81 f individual participant data from completed randomized trials comparing PFO closure versus medical t

82 the second-line setting, three of which were randomized trials comparing programmed cell death protei

83 In two randomized trials comparing the PCSK9 inhibitor bococizu

84 Multicenter, randomized trial conducted at 120 intensive care units (

85 The Danish Calmette Study is a multicenter randomized trial conducted from 2012-2015 at 3 Danish ho

86 Randomized trial data support the superiority of coronar

87 Given the lack of randomized trial data to guide management strategies, we

88 Randomized-trial data on the risks and benefits of antir

89 Conclusion This randomized trial demonstrated efficacy of ConquerFear co

90 ectal cancer (CRC) screening is supported by randomized trials demonstrating effectiveness in cancer

91 Anti-Restenosis Treatment) was a multicenter randomized trial designed to estimate the effect of DA b

92 Within a randomized trial designed to examine nonspecific effects

93 Randomized trials designed to assess the impact of baria

94 From December 2012 to March 2014, three randomized trials, each implementing a unique interventi

95 In a randomized trial, effect size is often summarized using

96 SUMMARY BACKGROUND DATA: No randomized trial evaluating alginate staple-line reinfor

97 Results from ongoing randomized trials evaluating biomarkers and other checkp

98 men for entry at the time of PSA nadir onto randomized trials evaluating the impact on survival of s

99 Randomized trials evaluating treatment levels significan

100 s-even in most emergencies; for individually randomized trials-even in many emergencies; and for six

101 encies, we highlight three needs: for formal randomized trials-even in most emergencies; for individu

102 However, there is a lack of randomized trial evidence supporting these recommendatio

103 Few randomized trials exist with an observation time greater

104 matic review of the literature that included randomized trials, exploratory comparative studies, and

105 Given that randomized trials exploring adjuvant chemotherapy for bl

106 cal outcomes of patients included in a large randomized trial for 10 years to enable detection of lat

107 emohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cance

108 monly prescribed by primary care physicians, randomized trials for effectiveness, and trials and obse

109 This prospective, randomized trial found that treat and extend dosing of r

110 In a cluster-randomized trial from 22 March to 15 April 2012, we rand

111 s, based primarily on the results of 3 large randomized trials (grade D recommendation).

112 To our knowledge, no randomized trial has been conducted for recurrent/refrac

113 No randomized trial has demonstrated superiority of chemoem

114 Although risk reductions observed in randomized trials have been relatively consistent across

115 Few randomized trials have compared disease-free survival ou

116 Randomized trials have demonstrated increased morbidity

117 Randomized trials have demonstrated the efficacy of tran

118 Randomized trials have found that therapy including tamo

119 d cells can be stored for up to 6 weeks, but randomized trials have not assessed the effects of this

120 Randomized trials have studied bisphosphonates in the ad

121 We performed a multicenter, randomized trial in 27 hospitals in the Netherlands in w

122 y was a prospective 2 x 2 factorial, cluster-randomized trial in 467 FT-LBW infants during 2 periods:

123 We conducted a randomized trial in patients with nonbulky limited-stage

124 12249 Treatment as Prevention (TasP) cluster-randomized trial in rural KwaZulu-Natal, South Africa.

125 n +/- SEM)] participated in a parallel-group randomized trial in which they adapted to either a LOW P

126 ta from eight induction and five maintenance randomized trials in 3,837 evaluable patients were analy

127 Randomized trials in breast cancer have demonstrated the

128 In 2 randomized trials in Guinea-Bissau of early BCG-Denmark

129 etocytes (targeting Pf3D7_1469900 mRNA) in 2 randomized trials in Kenya and Mali, comparing dihydroar

130 were combined for borderline personality and randomized trials in PubMed, PsycINFO, EMBASE, and the C

131 ata meta-analysis of three large prospective randomized trials in which sorafenib was the control arm

132 efore, we chose to conduct a multicenter non-randomized trial, in which all patients would receive fa

133 This was a multicenter prospective randomized trial including 143 patients with moderate-se

134 ce and mortality, and there are many ongoing randomized trials investigating the effects of metformin

135 This randomized trial involved 99 colorectal surgery patients

136 We conducted a multicenter randomized trial involving 446 patients who were assigne

137 INOVATE-HF was a multinational, randomized trial involving 85 centers including patients

138 We evaluated the two procedures in a randomized trial involving intermediate-risk patients.

139 Conclusions In a randomized trial involving patients who received either

140 In this open-label, randomized trial involving patients with locally advance

141 A large prospective cohort study or randomized trial is needed.

142 A randomized trial is needed.

143 A larger and longer randomized trial is warranted to assess the effectivenes

144 An adequately powered randomized trial is warranted.

145 Further information from randomized trials is critical to evaluate clinical outco

146 Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2

147 clusion Long-term follow-up data of the four randomized trials largely support the current risk-adapt

148 In this multicenter randomized trial, long-term endoscopic variceal ligation

149 at the benefits seen with empagliflozin in a randomized trial may be a class effect applicable to a b

150 d long-term survival by means of prospective randomized trials may offer more definitive conclusions

151 Twenty studies (17 observational and 3 randomized trials) met eligibility criteria.

152 One cluster randomized trial (n = 1737) demonstrated noninferiority

153 One randomized trial (n = 302) reported significantly reduce

154 dical Research Council UKALL2003 multicenter randomized trial (NCT00222612) between 2003 and 2011.

155 Despite many studies, including 4 randomized trials, no consensus exists.

156 nemic.In this 2 x 2 factorial, double-blind, randomized trial, nonpregnant women (aged 18-45 y) with

157 prevent recurrent cardiovascular events in a randomized trial of 10 065 post-myocardial infarction pa

158 We conducted a cluster randomized trial of 2 HIVST distribution mechanisms comp

159 The study was a randomized trial of a behavioral health home developed a

160 METHOD: The study was a randomized trial of a behavioral health home developed a

161 om 1,238 pregnant women during a 3-y cluster-randomized trial of a home visiting intervention in Cape

162 atients With Heart Failure) is a multicenter randomized trial of a patient-centered transitional care

163 We conducted a cluster-randomized trial of adults with cough who were HIV posit

164 We conducted the first randomized trial of behavioral weight loss for HIV-infec

165 A well-powered randomized trial of CABG versus PCI in the ACS populatio

166 d a cooperative group phase III prospective, randomized trial of conventional versus hypofractionated

167 We performed a prospective, cluster randomized trial of CPR education for family members of

168 ed 12 months after inclusion in the TEMPRANO randomized trial of early ART, we estimated the risk of

169 REDUCE-MRSA was a 3-arm, cluster-randomized trial of either screening and isolation witho

170 p to 18 hours after symptom onset supports a randomized trial of endovascular therapy in this patient

171 FOURIER was a randomized trial of evolocumab versus placebo in 27 564

172 Pragmatic noninferiority cluster-randomized trial of general surgery residency programs w

173 In a randomized trial of patients with chronic nausea and vom

174 In a phase 2B randomized trial of patients with moderate to severe DG,

175 In 7-year extended follow-up of a randomized trial of patients with severe intermediate, p

176 In a randomized trial of periodic presumptive treatment (PPT)

177 amin D Antenatal Asthma Reduction Trial is a randomized trial of pregnant women at risk of having chi

178 This was a placebo-controlled randomized trial of rituximab (2 biweekly infusions of 1

179 spectively collected data from a multicenter randomized trial of sedation (Randomized Evaluation of S

180 nical trial, a pediatric multicenter cluster randomized trial of sedation.

181 E) and postoperative complication rates in a randomized trial of short-course (SC) versus long-course

182 A prospective, multi-institutional randomized trial of SRS followed by EGFR-TKI versus EGFR

183 METHODS AND We conducted an unblinded, randomized trial of standard ART initiation versus same-

184 s of data from 8 observational cohorts and 1 randomized trial of statin therapy.

185 -recorded meetings from a larger, multisite, randomized trial of structured informational and support

186 We performed a randomized trial of the ability of the neurokinin-1 rece

187 Conclusion This prospective, randomized trial of the European Society of Blood and Ma

188 Randomized trials of 9 nonpharmacologic options versus s

189 es of TP53/KRAS and TP53/EGFR comutations in randomized trials of adjuvant chemotherapy versus observ

190 therapy, we conducted a systematic review of randomized trials of any intervention applied for the em

191 of studies of de-escalation of BMAs, and two randomized trials of BMAs in control of pain secondary t

192 The authors systematically searched for randomized trials of DOAC versus warfarin for prevention

193 Randomized trials of FIRM-guided ablation and mechanisti

194 Randomized trials of medications for alcohol dependence

195 Future placebo-controlled randomized trials of neonatal caffeine are unlikely.

196 fiber and whole-grain content, assessed in 3 randomized trials of overweight participants.After an 8-

197 ta-analysis was conducted of phase III or IV randomized trials of potent P2Y12 inhibitors, including

198 Randomized trials of rituximab in primary membranous nep

199 nd overall survival of 554 patients from two randomized trials of the German CLL Study Group (CLL8: f

200 ted search strategy, we searched MEDLINE for randomized trials of therapies for primary or secondary

201 Randomized trials of various statin types in hospitalize

202 The guidelines were based on randomized trials of vitamin D deficiency screening and

203 nce has led to the initiation of prospective randomized trials of vitamin D supplementation in indivi

204 In this randomized trial, off-pump CABG led to lower rates of 5-

205 We review data from randomized trials on relative and absolute CVD risk redu

206 Recent meta-analyses and randomized trials on secondary prevention of squamous ce

207 include in a sequential multiple-assignment randomized trial (or randomized controlled trial) may be

208 In a second randomized trial, PREVAIL (Evaluation of the WATCHMAN LA

209 Two recent randomized trials produced discordant results when testi

210 A recent series of successful randomized trials provides new systemic therapy options

211 Likewise, in the single randomized trial published to date, early-administered n

212 A multicenter randomized trial recruiting 321 patients 16 years or old

213 METHODS AND Randomized trials reporting clinical outcomes beyond 1 y

214 A randomized trial should be performed to test DAT and DAE

215 ans and policymakers interpreting results of randomized trials should recognize that the significance

216 Randomized trials show that unmonitored NOAC therapy is

217 eveloped in the 1980s, and recently, 5 major randomized trials showed an overwhelming superior benefi

218 Randomized trials showed significantly longer hospital s

219 2-group, parallel, randomized trial stratified by initial weight loss (<10

220 This randomized trial suggests that the use of a pelvic drain

221 Randomized trials support the use of transcatheter aorti

222 Randomized trials support use of procalcitonin (PCT)-bas

223 One randomized trial supports the use of objective clinical

224 The 3 eligible randomized trials (TAPAS [Thrombus Aspiration During Per

225 h were substantially less common among the 3 randomized trials than in contemporaneous cohort studies

226 ND DATA: We recently completed a prospective randomized trial that demonstrated an 11.7% absolute ris

227 ERA trial was an international, multicenter, randomized trial that included 5099 patients with early-

228 English-language cohort studies and randomized trials that compared different doses of nalox

229 METHODS AND We searched for randomized trials that compared longer than 1-year DAPT

230 Randomized trials that incorporate this regimen are need

231 f FCR for patients with CLL and identified 5 randomized trials that met our inclusion criteria.

232 It has been demonstrated in randomized trials that optimism can be learned.

233 Data from 2 large randomized trials that randomly allocated hypertensive p

234 Randomized trials that reported pain, function, or harms

235 ivity to standard therapies in two phase III randomized trials that represent the development of the

236 In this randomized trial, the routine use of pasireotide signifi

237 A recent randomized trial, the Survey of Inhibitors in Plasma-Pro

238 In randomized trials, the efficacy and safety of the potent

239 d overweight/obesity has been established in randomized trials, the feasibility and effect of a globa

240 Conclusion: Consistent with previous randomized trials, this study found no association betwe

241 Consistent with previous randomized trials, this study found no association betwe

242 enges of transporting a causal effect from a randomized trial to a specific target population.

243 A Phase III randomized trial to assess impact on neurologic outcome

244 We conducted a randomized trial to assess the incidence of factor VIII

245 We performed an investigator-initiated, randomized trial to compare an everolimus-eluting biores

246 We conducted a single-center randomized trial to compare the efficacy of 8 mm Fluency

247 To our knowledge, this was the first randomized trial to evaluate addition of an oncolytic vi

248 We conducted a randomized trial to evaluate cognitive outcomes after ET

249 Methods We performed a randomized trial to evaluate treatment adaptation on the

250 ARY BACKGROUND DATA: EVAR-2 remains the sole randomized trial to identify whether EVAR reduces mortal

251 I-SPY 2, a phase 2, multicenter, adaptively randomized trial to screen multiple experimental regimen

252 be applied to sequential multiple-assignment randomized trials to develop personalized adaptive treat

253 These findings support conducting randomized trials to explore risks and benefits of OAT r

254 rapy following BCS have been demonstrated in randomized trials to reduce the risk of both invasive an

255 We conducted the first randomized trial, to our knowledge, to evaluate ERCC1 pr

256 ter can only be verified through prospective randomized trials using hormonal replacement therapy.

257 This is the first randomized trial utilizing an accurate and validated bio

258 rticipants: In this pragmatic, double-blind, randomized trial, VLBW infants were recruited from 4 neo

259 line gastric cancer incidence, study design (randomized trial vs observational study), clinical scena

260 A cluster randomized trial was conducted in 18 centers for primary

261 A cluster-randomized trial was conducted in 75 villages in Kampong

262 A three-arm placebo-controlled randomized trial was conducted in homes with wood-burnin

263 A cluster randomized trial was conducted in Sudan with pyrethroid-

264 A multicenter randomized trial was conducted on patients undergoing el

265 A prospective, international 1:1 randomized trial was conducted to evaluate in a noninfer

266 This randomized trial was done to assess effectiveness of PRF

267 The primary objective of this randomized trial was to compare thoracic epidural analge

268 Patients and Methods In this phase III randomized trial, we assessed the noninferiority of cisp

269 In this multicenter randomized trial, we assigned patients with severe acute

270 In a 3-y cluster-randomized trial, we developed an OHP INT with Navajo in

271 In a prospective, open-label, multicenter, randomized trial, we enrolled patients presenting with s

272 Based on a large-scale, cluster-randomized trial, we find that increasing instruction ti

273 In a placebo-controlled, randomized trial, we found a prebiotic (OI) to selective

274 In a randomized trial, we found covered stents for TIPS to in

275 In light of evidence from recent randomized trials, we assessed whether percutaneous coro

276 fat composition and general overfeeding in a randomized trial.We studied the effects of 7 wk of exces

277 women from the Women's Health Initiative CaD randomized trial were included.

278 hest risk of bias were excluded or when only randomized trials were considered.

279 Funders and regulators (n = 39) of randomized trials were contacted and the literature was

280 tic reviews, 3 observational studies, and no randomized trials were found.

281 thods By June 2013, 102 completed or ongoing randomized trials were identified and individual patient

282 No relevant randomized trials were identified.

283 Seven RCTs and three quasi-randomized trials were included.

284 ous double-blind, placebo-controlled cluster-randomized trials were revisited at age 8 y between Febr

285 Ongoing larger randomized trials will clarify whether monitoring and su

286 This multicenter randomized trial with 2 parallel arms (drain vs no drain

287 Cluster randomized trial with assignment to patient, provider, a

288 A double-blind, placebo-controlled randomized trial with capsaicin nasal spray was performe

289 A randomized trial with long-term outcomes is needed to de

290 We performed a randomized trial with magnetic resonance imaging (MRI) a

291 knee replacements over 3 y.The design was a randomized trial with participants aged >50 y who had kn

292 collected during the course of a 3-y cluster-randomized trial with the aim of estimating the associat

293 Randomized trials with >/=50 patients, that had exclusiv

294 Our meta-analysis of randomized trials with a follow-up of >/=2 years demonst

295 ssions abstracts, and relevant Web sites for randomized trials with a follow-up of >/=2 years investi

296 (Danish Organization on Randomized Trials With Clinical Outcome II [SORT OUT II]

297 All were randomized trials with low or medium risk of bias.

298 sed measures should be routinely reported in randomized trials with time-to-event outcomes.

299 ulmonary Air Leakage study was a multicenter randomized trial, with blinded evaluation of endpoints.

300 oated balloon has differed greatly among the randomized trials, with better outcomes observed with hi