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1 (in the amygdala) and 5-HT1A binding (in the raphe).
2 respiratory centres, including the medullary raphe.
3 in the habenula, which project to the median raphe.
4 in the amygdala, medial septum, and inferior raphe.
5 transsynaptic viral tracer injected into the raphe.
6 ontine tegmentum, locus ceruleus, and dorsal raphe.
7 bed subjectively: clustering at the temporal raphe.
8 n raphe, whereas 237 (11.2%) had BAV without raphe.
9 ific cell death of 5HT neurons in the dorsal raphe.
11 d 110 [9.5%] at 5 years) vs patients without raphe (2 [1.8%] at 1 year, 3 [3.0%] at 2 years, and 5 [4
12 ns: the NTS (14% of CTB-ir neurons), midline raphe (26%), LHA (22%), zona incerta (ZI, 15%), CeA (5%)
13 447 [24.4%] at 5 years) vs patients without raphe (30 [14.0%] at 1 year, 32 [15.0%] at 2 years, and
14 ficantly higher among patients with BAV with raphe (364 [19.9%] at 1 year, 393 [21.4%] at 2 years, an
15 caudal ventrolateral medulla (17%), midline raphe (40%), ventrolateral periaqueductal gray (VLPAG, 1
16 stration, we found that inhibition of dorsal raphe 5-HT1A autoreceptors attenuates cocaine self-admin
17 ion to rodents desensitizes or downregulates raphe 5-hydroxytryptamine 1A (5-HT1A) autoreceptors.
18 ficantly higher among patients with BAV with raphe (77 [5.1%] at 1 year, 87 [6.2%] at 2 years, and 11
19 selective death of 5HT neurons in the dorsal raphe, a defined neuroanatomical pathway, and a behavior
21 le mitral cells at rest were also excited by raphe activation, their odor responses were bidirectiona
25 ciation between the presence and location of raphe and the risk of significant (moderate and severe)
26 ntral amygdala, mediodorsal thalamus, dorsal raphe, and deep mesencephalic nuclei, and sparse project
28 bed nucleus of the stria terminalis, dorsal raphe, and lateral hypothalamus, which regulate primitiv
29 to the RMTg, the median raphe, caudal dorsal raphe, and pontine central gray are major recipients of
30 pothalamus, VTA, median raphe, caudal dorsal raphe, and pontine central gray reside in characteristic
32 refrontal cortex (PFC), amygdala, and dorsal raphe are known to be involved in anxiety disorders.
33 de that dysfunction of even a portion of the raphe, as observed in many SIDS cases, can impair abilit
34 aled that specific optogenetic activation of raphe axons affected bulbar neurons through dual release
36 ure of the raphe system, which consists of a raphe canal raised on a keel (wing), supported by rib li
37 how that in addition to the RMTg, the median raphe, caudal dorsal raphe, and pontine central gray are
38 projecting to the hypothalamus, VTA, median raphe, caudal dorsal raphe, and pontine central gray res
39 imulation of serotonin neurons in the dorsal raphe causes mice to move more slowly without causing an
40 HT1A autoreceptor expression in serotonergic raphe cells while enhancing postsynaptic 5-HT1A heterore
42 long with some Pet1(+),Tph2(low or negative) raphe cells; in the other, approximately three-fourths o
48 and serotonin transporter mRNA in the dorsal raphe dorsalis and ventralis, and increases in glucocort
49 of orexin receptor expression in the dorsal raphe (DR) and in the locus coeruleus (LC) of mice lacki
56 in cell bodies originating within the dorsal raphe (DR) play a major role in the regulation of behavi
57 ine neurons in the ventral PAG (vPAG)/dorsal raphe (DR) region are a potentially critical site for th
58 pite the recognized importance of the dorsal raphe (DR) serotonergic (5-HT) nuclei in the pathophysio
60 ked in part through regulation of the dorsal raphe (DR)-serotonin (5-HT) system by the stress-related
62 in the interfascicular nucleus of the dorsal raphe (DRif), resulting in decreased 5HTergic innervatio
63 lts suggest that serotonergic afferents from raphe dynamically modulate olfactory processing through
65 inating from a small group of neurons in the raphe form an extensive plexus on most of the ventricula
68 to hypercapnia in BN rats is due to altered raphe gene expression and the consequent deficiencies in
71 or a P2-receptor blocker into the medullary raphe had no effect on cardiorespiratory activity or the
73 activation of 5-HT neurons within the dorsal raphe in females and activation of hypothalamic AVP neur
74 Omnipause neurons (OPNs) within the nucleus raphe interpositus (RIP) help gate the transition betwee
75 n that knockout of 5-HT1A selectively in the raphe leads to higher levels of anxiety during adulthood
76 lei included: cuneiform/subcuneiform, dorsal raphe, locus coeruleus, median raphe, parabrachial compl
77 fferent inputs from the dorsal raphe, median raphe, locus coeruleus, ventral tegmentum and nucleus ba
78 n rats, electrical stimulation of the dorsal raphe lowered movement thresholds and this effect could
81 he amygdala, afferent inputs from the dorsal raphe, median raphe, locus coeruleus, ventral tegmentum
84 blocked by pharmacological inhibition or by raphe neuron ablation, commissural pathfinding is disrup
86 the light chain from tetanus toxin (tox) in raphe neurons expressing serotonergic bacterial artifici
88 ively suppress 5-HT1A levels in serotonergic raphe neurons from post-natal days (P) 14 to P30, with a
89 alterations in the serotonergic phenotype of raphe neurons have dramatic effects on affective behavio
90 eted different fractions of serotonergic and raphe neurons in mice for tetanus toxin light chain expr
91 that knock-down of htr2a or ablation of the raphe neurons increases ephrinB2a protein levels in comm
92 at regulation of serotonin expression in the raphe neurons is modulated in response to the developmen
93 monstrate that serotonergic projections from raphe neurons regulate pathfinding of crossing axons.
94 of the acetylation-mimic mutant of Hsp90 in raphe neurons reproduced the behavioral effect of ACY-73
95 ants of human SERT in dissociated rat dorsal raphe neurons to examine the role of SEC24C-dependent ER
98 n expanded peripheral division of the dorsal raphe nuclear complex appears likely to play a role in t
99 n enlarged peripheral division of the dorsal raphe nuclear complex of the minke whale, all indicate t
100 Serotonin neurons in the dorsal and median raphe nuclei (DR and MR) are clustered into heterogeneou
101 found that neurotoxic lesions of the dorsal raphe nuclei (DRN) significantly decreased HAL-induced V
105 ncluding basal ganglia, locus coeruleus, and raphe nuclei (phase II), followed by primary motor corte
106 higher serotonin1A binding potential in the raphe nuclei (RN) is associated with greater lethality o
107 anscripts expressed in neurons of the dorsal raphe nuclei and lateral hypothalamus that project to th
110 in transporter availability in the brainstem raphe nuclei compared to controls (P < 0.01) and subject
112 the level of involvement of the serotonergic raphe nuclei in early Parkinson's disease is still debat
113 etermine: (i) the integrity of the brainstem raphe nuclei in early Parkinson's disease; and (ii) whet
114 ey role for microRNA-135a [corrected] in the raphe nuclei in the molecular mechanisms underlying the
115 formation as well as the spinally projecting raphe nuclei increased their projections to the cortical
119 Serotonin (5-HT) neurons located in the raphe nuclei modulate a wide range of behaviors by means
126 n the striatum, its binding in the brainstem raphe nuclei reflects serotonin transporter availability
127 TP influx rate was observed in the amygdala, raphe nuclei region, caudate nucleus, putamen, hippocamp
128 elevated [11C]DASB binding potential in the raphe nuclei region, caudate nucleus, putamen, thalamus,
132 l molecular and neurochemical changes in the raphe nuclei that dysregulate 5-HT neuronal activity and
133 ulate 5-HT neuronal activity in the midbrain raphe nuclei through alpha-amino-3-hydroxy-5-methyl-4-is
134 Serotonin (5-HT) neurons project from the raphe nuclei throughout the brain where they act to main
136 find that serotonergic projections from the raphe nuclei to the olfactory bulb dramatically enhance
137 ffinity dihydroergotamine receptors, and the raphe nuclei, a postulated brainstem site of action duri
138 ngulate cortex, nucleus accumbens, thalamus, raphe nuclei, and bed nucleus of the stria terminals.
139 is bilaterally connected with serotoninergic raphe nuclei, and expresses high density of serotonin re
140 ubstantia nigra, serotonergic input from the raphe nuclei, and noradrenergic input from the nucleus l
153 e level of three glutamate afferents: dorsal raphe nucleus (DR), pedunculopontine nucleus (PPN), and
154 tingly, the RMTg also projects to the dorsal raphe nucleus (DR), which also receives direct LHb proje
155 serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GA
156 including the median (MnR) and caudal dorsal raphe nucleus (DRC), may contribute to the behavioral ef
158 that stimulation of the serotonergic dorsal raphe nucleus (DRN) afferents to the nucleus accumbens (
161 edial prefrontal cortex (mPFC) in the dorsal raphe nucleus (DRN) are of particular interest, in part,
162 ion in 5-HT1A receptor domains in the dorsal raphe nucleus (DRN) in brain slices and in vivo, which i
166 hesized that GABAergic neurons in the dorsal raphe nucleus (DRN) may participate in socioaffective re
167 , we discovered that the serotonergic dorsal raphe nucleus (DRN) mediates short-term locomotor learni
168 on activation of serotonergic (5-HT) dorsal raphe nucleus (DRN) neurons that project to the basolate
170 ) in the locus coeruleus (LC) and the dorsal raphe nucleus (DRN) regions of postmortem human brains.
171 ow short- and long-term activation of dorsal raphe nucleus (DRN) serotonergic neurons induces robust
172 -command Mauthner cells also activate dorsal raphe nucleus (DRN) serotonergic neurons, which project
173 s that median raphe nucleus (MRN) and dorsal raphe nucleus (DRN) serotonergic projections differentia
174 (alpha1-ARs) control the activity of dorsal raphe nucleus (DRn) serotonin (5-HT) neurons and play cr
175 ions and is extensively innervated by dorsal raphe nucleus (DRN) serotonin (5-hydroxytryptamine [5-HT
176 The serotonin (5-HT) pathway from the dorsal raphe nucleus (DRN) to the medial prefrontal cortex (mPF
177 ically identified 5-HT cells from the dorsal raphe nucleus (DRN) were examined with whole-cell record
178 TrkB are both highly expressed in the dorsal raphe nucleus (DRN), a brain region that has been sugges
180 functional role for DA neurons in the dorsal raphe nucleus (DRN), in which we observe synaptic change
181 nfralimbic prefrontal cortex (PFC) or dorsal raphe nucleus (DRN), prevented disruption of DRL perform
182 eable binding potential (BPND) in the dorsal raphe nucleus (DRN), the core area of 5-HT synthesis, an
186 including 5-HT2c-Rs, are found in the dorsal raphe nucleus (DRN); however, the function of 5-HT2c-Rs
188 he dorsal raphe nucleus (DRN) and the median raphe nucleus (MRN) are known to densely innervate the O
190 uit from the lateral hypothalamus and dorsal raphe nucleus and defined a discrete subset of transcrip
192 xytryptamine (5,7-DHT) lesions of the dorsal raphe nucleus and median raphe nucleus prevents LiCl-ind
197 nography, we observed time-delineated dorsal raphe nucleus dopaminergic (DRN(DA)) activity upon expos
198 lls or selectively in the area of the dorsal raphe nucleus failed to form an aversion to formalin-ind
199 evoked serotonin transmission in the dorsal raphe nucleus mediated by metabotropic 5-HT1A autorecept
200 Deakin and Graeff argued that the median raphe nucleus normally acts to inhibit consolidation of
203 ced GR translocation were observed in dorsal raphe nucleus of vulnerable mice after chronic social de
204 sions of the dorsal raphe nucleus and median raphe nucleus prevents LiCl-induced conditioned disgust
205 development of ruminations, while the dorsal raphe nucleus system is engaged by distal cues predictiv
206 inobutyric acidergic pathway from the dorsal raphe nucleus to the NAcSh to influence behavioral respo
209 rder is associated with an overactive dorsal raphe nucleus with overactive projections to the amygdal
210 grey and striatum, and an underactive median raphe nucleus with underactive projections to the hippoc
211 the nucleus accumbens (NAC) shell and dorsal raphe nucleus, and found that disruption of NF-kappaB-ex
212 mentation in serotonin neurons of the dorsal raphe nucleus, and long-term Ovx monkeys had fewer serot
213 e amygdala, brainstem in the vicinity of the raphe nucleus, and reticular formation, hypothalamus, an
214 Here, we show that neurons in the dorsal raphe nucleus, expressing vesicular transporters for GAB
215 periaqueductal gray, area postrema, pontine raphe nucleus, gracile nucleus, spinal trigeminal nucleu
216 noradrenergic locus coeruleus and the dorsal raphe nucleus, in parallel with decreased DNA methylatio
218 hypothalamic area, trochlear nucleus, dorsal raphe nucleus, medial lemniscus, pontine nuclei, vagus n
220 nergic neurons in the locus ceruleus, dorsal raphe nucleus, substantia nigra, and ventral tegmental a
221 of these receptors specifically from dorsal raphe nucleus, which provides serotonergic (5-hydroxytry
222 -releasing factor (CRF) regulates the dorsal raphe nucleus-serotonin (DRN-5-HT) system during stress
234 V containing an anomalous cord attaching the raphe of the conjoined cusp near its free margin to the
236 muscarinic cholinergic inhibition of rostral raphe pallidus (rRPa) neurons influences thermogenesis o
237 cholinergic input to neurons in the rostral raphe pallidus (rRPa), the site of sympathetic premotor
238 hough the DMH neurons project to the rostral raphe pallidus (rRPa), these projections did not contain
239 eus [PaMP]) and autonomic (rostral medullary raphe pallidus [RPa]) responses were targeted with disti
240 gonist clonidine (1.2 nmol) into the rostral raphe pallidus area (rRPa) inhibited BAT sympathetic ner
241 the neuroaxis with highest densities in the raphe pallidus nucleus, nucleus of the solitary tract, p
242 iform, dorsal raphe, locus coeruleus, median raphe, parabrachial complex, pontine oralis, pedunculopo
243 in the interpeduncular nucleus (IP), median raphe/paramedian raphe (MnR/PMnR), and dorsal tegmental
244 dissection of inputs originating from dorsal raphe, pedunculopontine, and subthalamic nuclei were tes
246 d down 5-HT1A receptors in either the dorsal raphe (presynaptic autoreceptors) or the hippocampus (a
249 )-sensitive neurons in the NTS and medullary raphe respond to ATP, and whether purinergic signalling
253 ained [Ca(2+)]i may influence development of raphe serotonergic and ventral tegmental dopaminergic ne
254 ists induced tagged-5-HT(1A)R endocytosis in raphe serotonergic neurons and a portion of hippocampal
255 ers targeted different portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (Tph2)(+) n
257 in mice demonstrates that stimulating dorsal raphe serotonin boosts patient waiting but stimulation i
258 ings in mice to study a population of dorsal raphe serotonin neurons, whose activity we could link to
259 ent induces enduring changes in mouse dorsal raphe serotonin neurons-programming their firing rate, r
261 n's disease subgroup had significantly lower raphe serotonin transporter availability but less severe
262 arkinson's disease patients and that reduced raphe serotonin transporter availability is associated w
265 early Parkinson's disease; and (ii) whether raphe serotonin transporter levels correlate with severi
269 basal forebrain (acetylcholine; ACh), dorsal raphe (serotonin; 5HT), and singly labeled Fos(+) cells
270 T1A receptors in hippocampus, but not dorsal raphe, significantly decreased the antidepressant-like e
271 protein-coupled 5-HT receptors responding to raphe-spinal activity, although these signaling molecule
272 and found that prolonged stimulations of the raphe-spinal pathway increased the level of 5-HT to a co
273 , we found that prolonged stimulation of the raphe-spinal pathway--as during motor exercise--activate
274 ession of optical reporters to visualize how raphe stimulation alters sensory responses in two classe
276 rast, in MT cells imaged from the dorsal OB, raphe stimulation elicited a strong increase in resting
277 ation that reveals the true structure of the raphe system, which consists of a raphe canal raised on
279 erotonergic projection neurons in the dorsal raphe that project to the anterior hypothalamus and may
280 with prior studies of IP projections to the raphe, these results form an emerging map of the habenul
287 ssociation between BAV morphologic findings (raphe vs nonraphe) and the degree of valve dysfunction,
290 international BAV registry, the presence of raphe was associated with a higher prevalence of signifi
291 serotonin circuitry in the dorsal and median raphe was functionally mature during the first 3 postnat
292 tes than patients without, the presence of a raphe was not independently associated with increased al
293 , on multivariable analysis, the presence of raphe was not significantly associated with all-cause mo
300 the rhombomeric segments 2-3 of the rostral raphe, which participate in high-order brain functions.
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