ライフサイエンスコーパス: raphe nuclei

1 pramammillary nucleus, lateral habenula, and raphe nuclei).

2 rgic genes that are known to be expressed in raphe nuclei.

3 by serotonin axons originating in the median raphe nuclei.

4 labeled neurons within the dorsal and median raphe nuclei.

5 itary tract (NTS), and the dorsal and median raphe nuclei.

6 ) receptor-immunoreactive cell bodies in the raphe nuclei.

7 ce of serotonergic innervation, the midbrain raphe nuclei.

8 , the periaqueductal gray, and/or the dorsal raphe nuclei.

9 ocaudal extent of rat serotonergic hindbrain raphe nuclei.

10 g the central gray and the dorsal and median raphe nuclei.

11 ing the neural circuitry between the LHb and raphe nuclei.

12 poglossal nucleus originates from the caudal raphe nuclei.

13 cleus, the ventral subiculum, and the median raphe nuclei.

14 L), receive serotonergic input from midbrain raphe nuclei.

15 in, thalamus, epithalamus, hypothalamus, and raphe nuclei.

16 present and arises from cells in the caudal raphe nuclei.

17 he periaqueductal gray and dorsal and median raphe nuclei.

18 subpopulation of SERT-containing synapses in raphe nuclei.

19 tic acid (5-HIAA), and norepinephrine in the raphe nuclei.

20 roughout both cortical brain regions and the raphe nuclei.

21 mical modulation via the locus coeruleus and raphe nuclei.

22 ls suggested this effect was mediated in the raphe nuclei.

23 ronal sections were cut through the midbrain raphe nuclei.

24 g in known SERT-rich structures, such as the raphe nuclei.

25 aflet of the thalamus, and dorsal and median raphe nuclei.

26 ive strong serotonergic projections from the raphe nuclei.

27 erences were found in cell counts within the raphe nuclei.

28 d on the ventrolateral medulla and medullary raphe nuclei.

29 de that (1) RTN receives input from multiple raphe nuclei, (2) serotonin, substance P, and TRH activa

30 ffected axon terminal field from the rostral raphe nuclei, (2) the degree of initial 5-HT axonal inju

31 d may antagonize self-inhibition of midbrain raphe nuclei 5-HT neurons.

32 In the raphe nuclei, 5-HT-immunoreactivity and 5-HT(5A)-immunor

33 ffinity dihydroergotamine receptors, and the raphe nuclei, a postulated brainstem site of action duri

34 Non-serotonergic neurons in the caudal raphe nuclei also project to the hypoglossal nucleus.

35 N include a serotonergic projection from the raphe nuclei and a neuropeptide Y (NPY) input from the i

36 within the dorsal, median, and caudal linear raphe nuclei and are suspected to inhibit AVP-facilitate

37 on after DD, including NA-LC, serotoninergic-raphe nuclei and dopaminergic-ventral tegmental area neu

38 es a dense serotonergic innervation from the raphe nuclei and expresses several serotonin (5-hydroxyt

39 ing was evident in the pontine and medullary raphe nuclei and in sensory and spinal trigeminal nuclei

40 lar granule neurons, the locus ceruleus, and raphe nuclei and in various nuclei of the hypothalamus.

41 anscripts expressed in neurons of the dorsal raphe nuclei and lateral hypothalamus that project to th

42 , locus coeruleus, pontine and caudal dorsal raphe nuclei and periaqueductal gray.

43 e (5-HT, serotonin), synthesized in midbrain raphe nuclei and released in various hypothalamic sites,

44 reas of the brainstem, the dorsal and median raphe nuclei and the locus coeruleus, were also investig

45 %) labeled for TPH2 in each of the medullary raphe nuclei and the medullary ventrolateral column were

46 te in the adult Pet-1(-/-) dorsal and median raphe nuclei and thus provided additional insight into F

47 mine was injected into the dorsal and median raphe nuclei and was visualized with Texas Red, while se

48 ontent, including the ventrolateral medulla, raphe nuclei, and area postrema, but were absent from al

49 ngulate cortex, nucleus accumbens, thalamus, raphe nuclei, and bed nucleus of the stria terminals.

50 lateral habenular nucleus, locus coeruleus, raphe nuclei, and cerebellar granule cells, intermediate

51 is bilaterally connected with serotoninergic raphe nuclei, and expresses high density of serotonin re

52 tegmental nucleus, in the linear and dorsal raphe nuclei, and in the substantia nigra.

53 the anterior nuclear group of the thalamus, raphe nuclei, and locus ceruleus.

54 thalamus, hypothalamus, periaqueductal gray, raphe nuclei, and locus coeruleus.

55 nuclei, hippocampus, medial thalamic groups, raphe nuclei, and many hypothalamic nuclei including the

56 ubstantia nigra, serotonergic input from the raphe nuclei, and noradrenergic input from the nucleus l

57 amygdala, ventral hippocampus, mesencephalic raphe nuclei, and novel localizations in the nucleus of

58 medullary reticular formation, the medullary raphe nuclei, and nucleus retroambiguus (the expiration

59 ular nuclei, the ventral medial medulla, the raphe nuclei, and parapyramidal areas.

60 in the the serotoninergic dorsal and median raphe nuclei, and the core of the noradrenergic locus co

61 rea, the rhabdoid nucleus, the mesencephalic raphe nuclei, and the dorsal tegmental nucleus.

62 and lateral pontine reticular formation, the raphe nuclei, and the locus coeruleus.

63 gic neurons in the tuberomammillary nucleus, raphe nuclei, and ventrolateral medulla, as well as a fe

64 zoid nucleus (RTN), in the medullary midline raphe nuclei, and, more dorsally in the medulla, in the

65 circadian timekeeping system, and within the raphe nuclei, appear to be present on serotonin neurons.

66 We conclude that the raphe nuclei are affected in a subgroup of early drug-na

67 Serotonergic (5-HT) axons from the raphe nuclei are among the earliest afferents to innerva

68 The serotonergic raphe nuclei are involved in regulating brain states ove

69 Serotonergic neurons in the raphe nuclei associated with stress and fear project to

70 Pet-1 and 5-HTT mRNA levels in the midbrain raphe nuclei at a time when the anorexigenic effect of e

71 h tryptophan hydroxylase-positive neurons in raphe nuclei but not with their nonserotonergic neuron o

72 eriaqueductal grey and the dorsal and linear raphe nuclei, but no double labeled cells were seen in t

73 mpus, subiculum, locus coeruleus, and dorsal raphe nuclei, but not inferotemporal cortex or cerebellu

74 te that action potentials conducted from the raphe nuclei can release 5-HT throughout the NAc, wherea

75 in transporter availability in the brainstem raphe nuclei compared to controls (P < 0.01) and subject

76 rved at any level of the locus coeruleus, or raphe nuclei, comparing subjects with major depression t

77 The medullary raphe nuclei contain putative central respiratory chemor

78 .62 +/- 0.07; ADs 1.18 +/- 0.26) and also in raphe nuclei (controls 0.63 +/- 0.09; ADs 0.37 +/- 0.20)

79 Serotonergic neurons in the brainstem raphe nuclei densely innervate the olfactory bulb (OB),

80 Serotonin neurons in the dorsal and median raphe nuclei (DR and MR) are clustered into heterogeneou

81 to the serotonergic median (MnR) and dorsal raphe nuclei (DR).

82 quantified throughout the dorsal and median raphe nuclei (DRN and MRN) by conducting in situ hybridi

83 ectrical stimulation of the dorsal or median raphe nuclei (DRN and MRN, respectively) induced 5-HT re

84 found that neurotoxic lesions of the dorsal raphe nuclei (DRN) significantly decreased HAL-induced V

85 used to elevate RGS4 mRNA in the rat dorsal raphe nuclei (DRN) while extracellular levels of 5-HT in

86 a) in serotonin (5-HT) neurons in the dorsal raphe nuclei (DRN).

87 fatin-1 immunoreactivity was detected in the raphe nuclei, Edinger-Westphal nucleus, locus coeruleus

88 T), either systemically or into the midbrain raphe nuclei, elicit food intake in otherwise satiated r

89 vivo, stimulation of brainstem serotonergic raphe nuclei evokes whisker movements.

90 C regions (F1,88 = 5.19; P = .03) and in the raphe nuclei (F1,87 = 7.38; P = .008; R2 = 0.12).

91 FC regions (F1,88 = 0.03; P = .87) or in the raphe nuclei (F1,88 = 0.29; P = .59).

92 positive neurons were present in the midline raphe nuclei, formed a column in the ventrolateral medul

93 lore the role of GABAergic modulation in the raphe nuclei, from which most 5-HT in the forebrain orig

94 ut, the serotonin (5-HT) projection from the raphe nuclei, has been extensively investigated in rats

95 (5-HTP) in tissue from the dorsal and median raphe nuclei, hippocampus, cortex, caudate nucleus, and

96 onergic neurons would be found in the dorsal raphe nuclei in depressed elderly subjects, compared wit

97 the level of involvement of the serotonergic raphe nuclei in early Parkinson's disease is still debat

98 etermine: (i) the integrity of the brainstem raphe nuclei in early Parkinson's disease; and (ii) whet

99 urons or of neuritic pathology in the dorsal raphe nuclei in older people with depression, with or wi

100 TPH-IR) in the dorsal (DRN) and median (MRN) raphe nuclei in suicides and controls.

101 However, the role of these three raphe nuclei in the acupuncture responses is unknown.

102 In mammals, 5-HT release from the raphe nuclei in the brainstem can modulate the functiona

103 ey role for microRNA-135a [corrected] in the raphe nuclei in the molecular mechanisms underlying the

104 eniculate leaflet, and the median and dorsal raphe nuclei), in the Syrian hamster.

105 Therefore, the raphe nuclei, in addition to their role in neuromodulati

106 formation as well as the spinally projecting raphe nuclei increased their projections to the cortical

107 ed in Pet-1(+/-) and Pet-1(-/-) adult dorsal raphe nuclei, indicating that the majority of mutant ser

108 sent study evaluated c-Fos activation in the raphe nuclei induced by EA and examined its relationship

109 retrorubral field, rostral and caudal linear raphe nuclei, interfascicular nucleus, and supramammilla

110 mosensory behaviours driven by the brainstem raphe nuclei into these parallel systems.

111 Elevated 5-HT1A binding in raphe nuclei is associated with subsequent remission wit

112 system, which originates from the brainstem raphe nuclei, is disrupted in Parkinson's disease.

113 n the hippocampus and cortex, but not in the raphe nuclei, is sufficient to rescue the behavioural ph

114 NTS, area postrema, VRC, dorsolateral pons, raphe nuclei, lateral hypothalamus, central amygdala, an

115 zona incerta, thalamus, periaqueductal gray, raphe nuclei, lateral parabrachial nucleus, locus coerul

116 following brainstem/forebrain sites: caudal raphe nuclei, laterodorsal tegmental nucleus, dorsal rap

117 Brief stimulation of the raphe nuclei led to excitation of tufted cells at rest a

118 aused neuronal loss in the substantia nigra, raphe nuclei, locus coeruleus, nucleus basalis of Meyner

119 significant effect of MAO-A genotype in the raphe nuclei, medial and inferior temporal cortex, insul

120 Serotonin (5-HT) neurons located in the raphe nuclei modulate a wide range of behaviors by means

121 sms through which 5-HT neurons in the dorsal raphe nuclei modulate amygdala circuits.

122 CRFR2 in the midbrain raphe nuclei modulate serotonergic activity of this key

123 The dorsal (DRN) and median raphe nuclei (MRN) are two major sources of serotonergic

124 vely few PVH-projecting neurons in ascending raphe nuclei, nucleus of the solitary tract, or ventrola

125 aining the opioid and 5-HT were found in the raphe nuclei of all animals following application of col

126 hology in serotonergic neurons in the dorsal raphe nuclei of elderly subjects with primary major depr

127 Serotonin(1A )BPF in the raphe nuclei of suicide attempters was positively correl

128 lei, nucleus incertus, and dorsal and median raphe nuclei of the brainstem.

129 malian spinal cord, originates mainly in the raphe nuclei of the brainstem.

130 e of dopamine (DA) in the frontal cortex and raphe nuclei of the freely moving rat was measured using

131 the locus coeruleus as well as in the dorsal raphe nuclei of the human.

132 The serotonergic raphe nuclei of the midbrain are principal centers from

133 tor heterocomplexes in the dorsal and median raphe nuclei of the Sprague Dawley rat as well as in the

134 PHA-L was also placed into the dorsal raphe nuclei or nucleus of Darkschewitsch and interstiti

135 prelimbic PFC that may arise from different raphe nuclei or that represent varicose and intervaricos

136 tal gray matter, dorsal and central superior raphe nuclei, parabrachial nucleus, pre-locus coeruleus

137 ular nuclei; substantia nigra, central gray; raphe nuclei; parabrachial nuclei; locus ceruleus, nucle

138 tic labeling was identified in the medullary raphe nuclei, parapyramidal region, A5, Barrington's nuc

139 These results suggest that the medullary raphe nuclei, particularly the NRP, process somatic sign

140 ic nuclei, the reticular formation, midbrain raphe nuclei, periaqueductal gray and parabrachial nucle

141 ental area, oculomotor nucleus, red nucleus, raphe nuclei, periaqueductal gray, locus coeruleus, trig

142 ncluding basal ganglia, locus coeruleus, and raphe nuclei (phase II), followed by primary motor corte

143 Midbrain raphe nuclei provide a diffuse projection to all regions

144 The raphe nuclei provide serotonergic innervation widely in

145 The dorsal raphe nuclei receive light input from the circadian visu

146 n the striatum, its binding in the brainstem raphe nuclei reflects serotonin transporter availability

147 e of PR-ir cells colocalizing TPH-ir in both raphe nuclei, regardless of sex and genotype.

148 TP influx rate was observed in the amygdala, raphe nuclei region, caudate nucleus, putamen, hippocamp

149 elevated [11C]DASB binding potential in the raphe nuclei region, caudate nucleus, putamen, thalamus,

150 ervation from the dorsal and median midbrain raphe nuclei, respectively.

151 er the hippocampal formation or the midbrain raphe nuclei resulted in retrograde labeling of many cel

152 , various tegmental nuclei, locus coeruleus, raphe nuclei, reticular nuclei, and the nuclei of the tr

153 higher serotonin1A binding potential in the raphe nuclei (RN) is associated with greater lethality o

154 At day 31, their raphe nuclei (RN), amygdala (AMY), frontal cortex (FC),

155 Raphe nuclei serotonin(1A) BPF was 45.1% greater in high

156 urons), rostral ventromedial medulla, caudal raphe nuclei (serotonin neurons in the raphe pallidus an

157 vision are known to be the dorsal and median raphe nuclei, sources of serotonin located within other

158 ptor sub-type at different locations (brain, raphe nuclei, spinal cord and autonomic ganglia) may mod

159 Consistent SERT pathology in raphe nuclei, striatum, thalamus, and hypothalamus and a

160 (5-HT)-immunoreactive neurons of the caudal raphe nuclei, substance P (SP)-immunoreactive neurons of

161 serotonergic projections from the medullary raphe nuclei, suggesting that 5-HT modulates vagal activ

162 eral nuclei, but not with locus coeruleus or raphe nuclei support the view that these peptides origin

163 dbrain but higher uptake in the thalamus and raphe nuclei than control patients.

164 ad 33% higher baseline 5-HT1A binding in the raphe nuclei than nonremitters (p = .047).

165 l molecular and neurochemical changes in the raphe nuclei that dysregulate 5-HT neuronal activity and

166 enkephalin-containing neurons in the caudal raphe nuclei that projected to the hypoglossal nucleus a

167 samples that contained the dorsal and median raphe nuclei (the location of serotonin cell bodies that

168 ental area, the interpeduncular nucleus, the raphe nuclei, the dorsal tegmental nucleus, and the nucl

169 , the medial reticular formation nuclei, the raphe nuclei, the glossopharyngeal nuclei, and the Purki

170 the central gray, the substantia nigra, the raphe nuclei, the parabrachial area, the medullary retic

171 c periaqueductal grey, the dorsal and linear raphe nuclei, the parabrachial nucleus, and the dorsal v

172 binding for each marker was observed in the raphe nuclei, the site of the highest density of 5-HT ce

173 the inferior olivary nucleus, the medullary raphe nuclei, the spinal and principal trigeminal nuclei

174 ulate 5-HT neuronal activity in the midbrain raphe nuclei through alpha-amino-3-hydroxy-5-methyl-4-is

175 Serotonin (5-HT) neurons project from the raphe nuclei throughout the brain where they act to main

176 The two raphe nuclei thus give dual innervation within the OB, w

177 pallidus, and the rostral and caudal linear raphe nuclei to subsets of midline and intralaminar thal

178 find that serotonergic projections from the raphe nuclei to the olfactory bulb dramatically enhance

179 and several brainstem cell groups: medullary raphe nuclei, ventromedial medulla (VMM), rostral ventro

180 oss of 5-HT nerve cell bodies in the rostral raphe nuclei was found, indicating that abnormal innerva

181 Innervation of raphe nuclei was most dense at the level of RVLM, but ro

182 and the serotonergic cell groups, the dorsal raphe nuclei, was measured autoradiographically in postm

183 s in the SLN, PMRF, dorsal raphe, and median raphe nuclei were 4,571, 1,948, 15,191, and 4,114, respe

184 Many non-serotoninergic neurons in the raphe nuclei were also infected with rabies virus, indic

185 Tryptophan hydroxylase protein levels in the raphe nuclei were not significantly different between co

186 inding densities of [3H]nisoxetine in dorsal raphe nuclei were similar to that in the locus coeruleus

187 repositus hypoglossi, vestibular nuclei, and raphe nuclei, were infected by transynaptic passage of P

188 ibers originating from the dorsal and median raphe nuclei while fluorescence immunohistochemistry was

189 f 5-HTT mRNA were detected in all brain stem raphe nuclei, with variations in labeling among the vari

190 tegy to manipulate 5-HT(1A) autoreceptors in raphe nuclei without affecting 5-HT(1A) heteroreceptors,