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1 slation pathway, which would result in their rapid degradation.
2 tranded DNA-sensing pathway, followed by its rapid degradation.
3 the majority of PER proteins are tagged for rapid degradation.
4 d protein synthesis but was a consequence of rapid degradation.
5 mbers under normoxic conditions, causing its rapid degradation.
6 high nuclear levels by protecting them from rapid degradation.
7 n vivo either by assembly in a complex or by rapid degradation.
8 are targeted for translational silencing and rapid degradation.
9 bility complex class I heavy chains (HC) for rapid degradation.
10 o the cytoplasm, and is sufficient to impose rapid degradation.
11 e, generating a complex that is targeted for rapid degradation.
12 y complex (MHC) products, resulting in their rapid degradation.
13 were targeted to the proteasomal pathway for rapid degradation.
14 s in Cln2 that result in binding to Grr1 and rapid degradation.
15 or metabolites may have been present despite rapid degradation.
16 rgoing premature translation termination for rapid degradation.
17 reas the others were poorly expressed due to rapid degradation.
18 ar targeting of antigen to lysosomes and its rapid degradation.
19 quent, and released tssRNAs are targeted for rapid degradation.
20 endent protein kinase (AMPK), leading to its rapid degradation.
21 rylated 5'-terminus, yet it manages to avoid rapid degradation.
24 as 5 nucleotides was sufficient to stimulate rapid degradation, although an in vivo tail length of 20
25 nucleotides in biologic media is hampered by rapid degradation and low final concentrations that are
27 ytosolic peptides, thus protecting them from rapid degradation and securing the peptide pool for furt
28 ntibody recycling mechanism, thus leading to rapid degradation and shortened half-life in vivo Here w
29 PTEN to the plasma membrane is coupled with rapid degradation and that the phosphatase domain and th
31 in strong IkappaBalpha phosphorylation, its rapid degradation, and enhanced nuclear translocation of
32 ds to a loss of REDD1 protein because of its rapid degradation, and in part reduced REDD1 expression
33 ascent class I molecules, resulting in their rapid degradation, and this process was found to be depe
34 Acetylated starches films exhibited more rapid degradation as compared with the native starches f
35 an targeting the antisense bound message for rapid degradation, as occurs in most other antisense RNA
39 green fluorescent protein (GFP) promoted its rapid degradation by ClpXP, attachment of 5-27 C-termina
40 vivo half-life of GLP-1 is short because of rapid degradation by dipeptidyl peptidase-IV (DPP-IV) an
41 e in vivo half-life of GLP-1 is short due to rapid degradation by dipeptidyl peptidase-IV (DPP-IV) an
45 protect these promising drug candidates from rapid degradation by plasma and intracellular nucleases.
52 compatibility complex (MHC) heavy chains for rapid degradation by the proteasome through a process te
53 continuous synthesis of IkappaBalpha and its rapid degradation by the proteasome through a ubiquitin-
54 PINK1-53) is often overlooked because of its rapid degradation by the proteasome upon its production.
55 ving both to target hundreds of proteins for rapid degradation by the proteasome, and as a dynamic si
58 18-30) as the signal for ER localization and rapid degradation by the ubiquitin (Ub)/proteasome pathw
59 e results indicate that Nrf2 is targeted for rapid degradation by the ubiquitin-proteasome pathway an
60 Ralpha) in the nuclear matrix accompanied by rapid degradation by the ubiquitin-proteasome pathway.
61 that marks dimerization-defective Elk-1 for rapid degradation by the ubiquitin-proteasome system.
62 he loss of REST in the nucleus is due to its rapid degradation by the ubiquitin-proteasome system.
63 oloenzyme incorporation protects Bgamma from rapid degradation by the ubiquitin/proteasome pathway.
65 GAPDH, where it protected telomeres against rapid degradation, concomitant with increased resistance
66 ived beta-galactosidase causes it to undergo rapid degradation, demonstrating that this C-terminal do
69 zed through caveolin-1 lipid rafts undergoes rapid degradation, effectively decreasing TGF-beta signa
70 essing of the Hh precursor competes with its rapid degradation, explaining the impaired Hh signaling
71 ATF5 protein, which is otherwise subject to rapid degradation, facilitated by both proteasome-depend
72 that involves protecting nascent chains from rapid degradation followed by its folding function in as
74 NAs need to be actively translated for their rapid degradation following the inhibition of DNA synthe
76 25I-TGF-beta1 undergoes nystatin-inhibitable rapid degradation in CHO-K1 cells but not in CHO-677 cel
78 role in the protection of telomeres against rapid degradation in response to chemotherapeutic agents
81 Polyadenylation of synthetic RNAs stimulates rapid degradation in vitro by using either Chlamydomonas
82 these proteins need further verification for rapid degradation in vivo, they cluster in chlorophyll a
86 at IkappaBalpha is an unstable protein whose rapid degradation is slowed upon binding to NF-kappaB, b
87 rexpressed Cdc17 that is normally subject to rapid degradation is stabilized by Mcm10 co-overexpressi
88 e, or charge reversal mutations results in a rapid degradation (<30 min) of total protein, confirming
90 ng recovery from shock, contrasting with the rapid degradation observed for many exogenous thermolabi
92 It has previously been shown to cause the rapid degradation of a number of mRNAs that encode prote
93 report that IRE1 independently mediates the rapid degradation of a specific subset of mRNAs, based b
94 ntrol mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs.
95 ive selection pressure during evolution, via rapid degradation of aberrant transcripts that might yie
96 horylation of ACS2 and ACS6 by MPK6 prevents rapid degradation of ACS2/ACS6 by the 26S proteasome pat
97 mislocalized-mutant tafazzins to include the rapid degradation of aggregation-prone polypeptides that
101 ants had low Aer expression levels caused by rapid degradation of apparently nonnative subunits.
103 participate in inhibiting or promoting their rapid degradation of ARE mRNAs, and influence cytokine e
105 s, the potent transcriptional activities and rapid degradation of ATF6 and VP16 require the VN8 domai
106 s show that exon 7 blocks ubiquitination and rapid degradation of AUF1 proteins, whereas its deletion
108 2 to sublethal oxidative stress results in a rapid degradation of Bcl-2 and cellular inhibitor of apo
111 g of Reaper/Hid/Grim, selectively causes the rapid degradation of c-IAP1 and c-IAP2 but not XIAP and
112 egrasyn, a small synthetic molecule, induces rapid degradation of c-Myc protein in MM-1 multiple myel
113 slocated across the ER membrane, causing the rapid degradation of CB1 by proteasomes; this leads to a
115 man cytomegalovirus gene product US11 causes rapid degradation of class I major histocompatibility co
116 olic but not ER stresses slowed the normally rapid degradation of connexins, and led to a striking in
121 rictive to permissive temperature results in rapid degradation of CtrA, initiation of DNA replication
122 ults in the enhanced expression of E2F-1 and rapid degradation of cyclin B in the absence of the modu
123 se control of cytokine expression depends on rapid degradation of cytokine mRNAs, mediated by an AU-r
126 dent activity of EndA is responsible for the rapid degradation of DNA and NETs, and is required for t
128 activation of photoreceptor phyB results in rapid degradation of EIN3, the master transcription fact
129 danamycin-based HSP90 inhibitors resulted in rapid degradation of EML4-ALK in vitro and substantial,
130 elop novel therapies that limit the inherent rapid degradation of endogenous apelin peptides and prod
132 f MCL1 by siRNA-MCL1 was associated with the rapid degradation of fortilin protein, which was found q
134 ation of FRH results in hypophosphorylation, rapid degradation of FRQ, as well as low levels of WHITE
135 n of Chlamydomonas gamete membranes leads to rapid degradation of FUS1 and HAP2, proteins required fo
139 otein (pVHL) mediates the ubiquitination and rapid degradation of HIF-alpha (including HIF-1alpha and
141 We now report that HIV-1 Vif could induce rapid degradation of human APOBEC3G that was blocked by
142 ssive phosphorylation of Per, leading to the rapid degradation of hyperphosphorylated isoforms by the
143 ] in Drosophila) and ultimately leads to the rapid degradation of hyperphosphorylated isoforms via a
145 DINGS: TNF-alpha treated RASMCs demonstrated rapid degradation of IkappaBalpha (10-30 min), followed
150 ing wild-type NSP1 were characterized by the rapid degradation of IRF3 during the replication cycle,
153 ivo activities, allowing for recognition and rapid degradation of LIN-28 and thus facilitating a swit
154 3.5.1.4.) is the enzyme responsible for the rapid degradation of lipid-derived chemical messengers s
155 alovirus (HCMV1) US11 and US2 proteins cause rapid degradation of major histocompatibility complex (M
156 ARE) in the 3' noncoding region promotes the rapid degradation of mammalian cytokine and proto-oncoge
157 diator of PE-mediated apoptosis and that the rapid degradation of Mcl-1 unleashes Bak to activate apo
158 inhibition of translation thus involves the rapid degradation of Mcl-1, leading to activation of Bim
159 emarkably, common T-cell stimuli induced the rapid degradation of MCPIP1 in both T-cell lines and qui
162 We demonstrate the visible light-driven rapid degradation of microcystin-LR, one of the most tox
163 cal neurons and demonstrated that Tat causes rapid degradation of microtubule-associated protein 2 (M
165 disease phenotypes of ATD patients with more rapid degradation of misfolded ATZ and lack of globular
166 Disruption of these complexes results in rapid degradation of Monarch-1 via the proteasome and pr
167 rion host shutoff (vhs) protein mediates the rapid degradation of mRNA and the shutoff of host protei
168 bonuclease Xrn1 act in concert to elicit the rapid degradation of mRNA substrates observed in vivo, a
171 ) is an RNA-binding protein required for the rapid degradation of mRNAs containing AU-rich elements.
172 thiolutin in nup116-delta strains revealed a rapid degradation of mRNAs in the nucleus that was suppr
173 ed pathway that leads to the recognition and rapid degradation of mRNAs with premature termination co
174 ndria, recruitment of the 26S proteasome and rapid degradation of multiple outer membrane proteins.
176 embryonic fibroblasts substantially restored rapid degradation of mutant SP-C proprotein, whereas tra
177 ations (L22P, T101I, and L408P) by mediating rapid degradation of mutated RPE65s via a ubiquitination
179 therefore studied if p97 participates to the rapid degradation of myofibrillar proteins during muscle
180 ific case of mK3, it selectively targets the rapid degradation of nascent class I heavy chains in the
183 de (MDP) in the bacterial cell wall, induces rapid degradation of Nod2, which confers MDP tolerance i
185 me function, can markedly delay the normally rapid degradation of nontranslocated secretory and membr
187 to retrieve the CI-MPR, resulting in either rapid degradation of or mislocalization to the plasma me
191 ein hdm2 ubiquitinates p53, resulting in the rapid degradation of p53 through the ubiquitin (Ub)-prot
195 abundance and activity, which is caused by a rapid degradation of Peroxisome proliferator-activated r
198 phytochrome family of photoreceptors induce rapid degradation of PIFs to promote photomorphogenesis.
201 -delta trm4-delta double mutant demonstrates rapid degradation of preexisting tRNA(Val(AAC)) accompan
202 Nonsense-mediated mRNA decay (NMD) directs rapid degradation of premature termination codon (PTC)-c
204 igase, which mediates the ubiquitination and rapid degradation of proteins, and a recombinant, antibo
205 e CHO-K1 cells, exhibit nystatin-inhibitable rapid degradation of receptor-bound 125I-TGF-beta1), tre
206 es to ClpX for trans-targeting, Vir promoted rapid degradation of Rep by ClpX deleted for the tetheri
208 models however presents obstacles, including rapid degradation of RNA duplexes in plasma, insufficien
209 virulence-associated genes as well as in the rapid degradation of rnpB read-through transcripts.
210 s inhibit cellular transcription by inducing rapid degradation of Rpb1, a catalytic subunit of the RN
211 ar luminal ATP concentrations significantly; rapid degradation of secreted ATP by ecto- and soluble n
213 us mediates two functions, i.e., it mediates rapid degradation of some mRNAs exemplified by beta-acti
214 respectively, in 20S proteasomes and caused rapid degradation of some of the 26S proteasomal subunit
215 inus from Lon protease, since Lon's normally rapid degradation of SoxS is blocked in the chimera.
218 mediated mRNA decay was generated to prevent rapid degradation of target mRNA containing premature st
219 lomeres and also show that mechanisms of the rapid degradation of telomeres in response to ceramide i
220 caveolae/lipid-raft-mediated endocytosis and rapid degradation of TGF-beta1, thus diminishing non-lip
221 from the nucleus to the cytoplasm, mediating rapid degradation of the 9-1-1 complex via the 26 S prot
224 nal mechanism, Notch signaling also leads to rapid degradation of the basic helix-loop-helix (bHLH) t
225 e, which stabilizes the macrocycle, and (ii) rapid degradation of the C-terminal proteolysis fragment
226 for rILYd4 in promoting internalization and rapid degradation of the complement inhibitor CD59, and
227 omoplasmic 1624C>T-cell lines is caused by a rapid degradation of the deacylated form of the abnormal
228 rine residue 301 promotes ubiquitination and rapid degradation of the E2 protein by the proteasome pa
230 RPE cells with IL-1beta or TNF-alpha caused rapid degradation of the endogenous, but not mutant, Ika
234 y proteasome inhibitors, suggesting that the rapid degradation of the F protein is mediated by the pr
239 hat luteolin triggers a superoxide-dependent rapid degradation of the JNK-inactivating phosphatase mi
241 on, it has been thought that the products of rapid degradation of the mistakes of protein synthesis (
242 ck of effect at a distant site is due to the rapid degradation of the molecule to inactive fragments.
248 greatly diminished levels of protein due to rapid degradation of the NQO1*2 protein by the ubiquitin
249 rylation events acts collectively to trigger rapid degradation of the PIF3 protein in response to ini
250 otoactivated phytochromes bind to and induce rapid degradation of the PIFs, indicating that the photo
255 n of such proteins, based on conditional and rapid degradation of the target protein in vivo, so that
257 lut4 prior to induction of sortilin leads to rapid degradation of the transporter, whereas overexpres
261 with an altered C-terminal sequence promote rapid degradation of the wild-type repressor by inducing
262 n premature termination codons (PTC) and the rapid degradation of their mRNAs by nonsense-mediated RN
264 bidopsis thaliana, we previously showed that rapid degradation of these proteins requires conserved A
265 deficient in both albumin and IgG because of rapid degradation of these proteins, suggesting a lack o
269 We recently reported that ischemia induced rapid degradation of tight junction protein occludin in
270 complex formation, dexrazoxane also induced rapid degradation of Top2beta, which paralleled the redu
275 d opening of the substrate-entry channel and rapid degradation of unfolded proteins without PAN; howe
277 many instances, small peptides are prone to rapid degradation or aggregation and may lack the confor
278 flammatory cell infiltration that led to its rapid degradation, promoting the infiltration of angioge
279 ion caused alpha1(AD) subunit misfolding and rapid degradation, reducing its total and surface expres
281 or fused to heterologous proteins, exhibited rapid degradation similar to wild-type GADD34, thereby i
282 rylation sites on SCG10 are required for its rapid degradation, suggesting that direct JNK phosphoryl
283 Although the mitofusins Mfn1 and Mfn2 are rapid degradation targets of Parkin, we find that degrad
284 tered holo-iso-1-cytochrome c are due to the rapid degradation that is carried out by a novel proteol
285 ence that Vif binds APOBEC3G and induces its rapid degradation, thus eliminating it from cells and pr
286 g of repeated canonical AUUUA motifs confers rapid degradation to many cytokine mRNAs when present in
287 report that nuclear FL SIRT3 is subjected to rapid degradation under conditions of cellular stress, i
288 the bulk of solid BBA particles but undergo rapid degradation upon deliquescence/liquefaction at hig
290 ion is essential for stabilizing FRQ against rapid degradation via a pathway distinct from its typica
291 proprotein in the endoplasmic reticulum, and rapid degradation via a proteasome-dependent pathway.
294 tly to DELLA proteins and targeting them for rapid degradation via the ubiquitin-proteasome pathway.
296 Perovskite films based on CH3NH3PbI3 undergo rapid degradation when exposed to oxygen and light.
297 f plant-based fibers to HCl vapor results in rapid degradation with simultaneous crystallization.
298 ly plasma membrane-impermeant and subject to rapid degradation within endosomes and lysosomes upon ce
299 ach to destabilize Asf1p that results in its rapid degradation within minutes of transcriptional repr
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