ライフサイエンスコーパス: rate-limiting

1 Rab7, suggesting that its amount is normally rate limiting.

2 llular system where MgNTP hydrolysis becomes rate limiting.

3 taching species, not the mineral surface, is rate limiting.

4 s, for which product dissociation may become rate limiting.

5 of substrate binding nor product release was rate-limiting.

6 during LipA catalysis in a step that is not rate-limiting.

7 e case of Rh, the Rh-imido formation step is rate-limiting.

8 ation of the initial Ir(III)-complex becomes rate-limiting.

9 r (i.e., transfer of the chemical proton) is rate-limiting.

10 y ensures that recruitment of protons is not rate-limiting.

11 e actin-activated ADP release rate to become rate-limiting.

12 existing Bronsted acidity could catalyze the rate-limiting acetone-to-isobutene reaction, the presenc

13 LL CYCLE SWITCH52 (CCS52) proteins represent rate-limiting activator subunits of the APC/C.

14 found that the directionality is due to the rate-limiting ADP release step rather than the potential

15 o GluTR accumulation levels, and thereby the rate-limiting ALA synthesis.

16 er at the cytochrome bc1 complex (cytbc1) as rate limiting and assuming that the quinone/quinol pool

17 pository for deciphering various structural, rate limiting and regulatory genes of CPT biosynthetic p

18 he C horizontal lineC bond, which is usually rate limiting and results in an intermediate carbonyl ca

19 tabolic pathways, in which the first step is rate-limiting and metabolic intermediates are short-live

20 coordination of nitrogen to Pd(II), which is rate limiting, and directly delivers the intermediate fo

21 change whether unfolding or translocation is rate limiting, and establish that one or a few power str

22 a pentavalent peroxide ate complex, prior to rate-limiting aryl migration, has evolved.

23 activation rather than spin-state change is rate-limiting at low reaction energy, where the main pro

24 itude faster than the latter, and involves a rate-limiting attack by a hydroxide at a MIDA carbonyl c

25 ons on a very coarse landscape with a single rate-limiting barrier and reproduced the stall force and

26 Besides identifying the 10-ms step as the rate-limiting bottleneck towards opening specific DNA si

27 Rate-limiting C-O bond cleavage occurs to generate a thr

28 showed that the base is not involved in the rate-limiting C-O bond cleavage.

29 ete early complement components, such as the rate-limiting C4, following CRP interaction and thereby

30 These data illustrate the importance of the rate-limiting C4/C2 stage of complement activation and r

31 or a new regulatory control mechanism of the rate limiting catalytic protein component of telomerase

32 ater, whereas the activation entropy for the rate-limiting catalytic step in the enzyme is close to z

33 veal that CD79B and surface IgM constitute a rate-limiting checkpoint against B cell dysregulation by

34 ty and affiliated tractable rates, reveals a rate-limiting complexation via a transition structure wi

35 istent with the observation that ATP5G1 is a rate-limiting component for ATP synthase activity, knock

36 lipid deposition in ccRCC by identifying the rate-limiting component of mitochondrial fatty acid tran

37 is is Rubisco, which is a critical but often rate-limiting component.

38 tivation energy barrier, likely related to a rate-limiting conformational change leading to the pre-c

39 rence in cleavage rates results from a slow, rate-limiting conformational change prior to HJ cleavage

40 ly unwinding RNA duplexes without undergoing rate-limiting conformational changes that precede activa

41 H3 acetylation in the coding region provides rate-limiting control during the transition from initiat

42 y diversification, but its significance as a rate-limiting control on phylogenetic speciation dynamic

43 The reaction is initiated by a rate-limiting deprotonation.

44 s the peroxidatic cysteine, and finally, the rate-limiting disulfide bond is formed.

45 arget membranes, which enabled bypass of the rate-limiting docking step of fusion reactions and allow

46 than the chemistry step, which appears to be rate-limiting during processive synthesis.

47 en alphaTM2, 4, 6, and 9 and accelerates the rate-limiting E1P-E2P conformational transition (site B)

48 and activity is up-regulated to catalyze the rate-limiting enzymatic step of heme degradation into ca

49 ion of adipose triglyceride lipase (ATGL), a rate limiting enzyme of TAG hydrolysis.

50 This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an at

51 late in the cell cycle including Acc1p, the rate-limiting enzyme acetyl-CoA carboxylase.

52 Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation,

53 pression of GTP cyclohydrolase I (GCH1), the rate-limiting enzyme for BH4 synthesis, restored cellula

54 hylglutaryl coenzyme A reductase, which is a rate-limiting enzyme for cholesterol synthesis.

55 Recently, elevated levels of aromatase, the rate-limiting enzyme for estrogen biosynthesis, were fou

56 Gamma glutamyl cysteine ligase (GCL) is the rate-limiting enzyme for intracellular glutathione (GSH)

57 succinyl-CoA:3-oxoacid-CoA transferase, the rate-limiting enzyme for myocardial oxidation of beta-hy

58 ng nicotinamide phosphoribosyltransferase, a rate-limiting enzyme for NAD synthesis, specifically in

59 , ornithine decarboxylase appeared to be the rate-limiting enzyme for polyamine production.

60 nt mice have reduced expression of Tph1, the rate-limiting enzyme for serotonin biosynthesis.

61 YME A REDUCTASE1 (HMGR1) and MAKIBISHI1, the rate-limiting enzyme for triterpene biosynthesis and an

62 ate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase.

63 (25-50 mg/kg, IP), an inhibitor of the main rate-limiting enzyme in allopregnanolone synthesis.

64 H4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses

65 (Bsl1) locus in S. viridis, which encodes a rate-limiting enzyme in BR biosynthesis.

66 Squalene monooxygenase (SM) is the second rate-limiting enzyme in cholesterol biosynthesis and is

67 sing upregulation of HMG Co-A reductase, the rate-limiting enzyme in cholesterol synthesis.

68 Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis and is frequentl

69 n the yeast homotetrameric FBP1 complex, the rate-limiting enzyme in gluconeogenesis.

70 tion of glutamate cysteine ligase (GCL), the rate-limiting enzyme in GSH biosynthesis).

71 Methyl-coenzyme M reductase, the rate-limiting enzyme in methanogenesis and anaerobic met

72 SAT1 is a rate-limiting enzyme in polyamine catabolism critically

73 Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been w

74 eral mechanisms for feedback control of this rate-limiting enzyme in the branched pathway that produc

75 ntributed by 5alpha-reductase (5alphaR), the rate-limiting enzyme in the conversion of progesterone i

76 alpha-ketoglutarate dehydrogenase (OGDH), a rate-limiting enzyme in the Krebs cycle.

77 amine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of trypto

78 smic reticulum-associated degradation of the rate-limiting enzyme in the pathway, HMG-CoA reductase (

79 ice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine

80 ursor protein-cleaving enzyme (BACE1) is the rate-limiting enzyme in the production of amyloid-beta,

81 ere we describe p53-dependent control of the rate-limiting enzyme in the pyrimidine catabolic pathway

82 Overexpression of the rate-limiting enzyme in this pathway, nicotinamide phosp

83 Isyna1 (designated mIno1), which encodes the rate-limiting enzyme inositol-3-phosphate synthase.

84 e cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosph

85 f the dNTPs are synthesized "on the go." The rate-limiting enzyme of dNTP synthesis, ribonucleotide r

86 l for metastasis, and we determined that the rate-limiting enzyme of glutathione synthesis, GCLC, bec

87 T1A_i2 proteins in human tissues-namely, the rate-limiting enzyme of glycolysis pyruvate kinase (PKM)

88 s along with hematopoietic PGD synthase, the rate-limiting enzyme of PGD2 synthesis.

89 es tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catecholamine synthesis, del

90 -6-phosphate amidotransferase 1 (GFAT1), the rate-limiting enzyme of the HBP.

91 esterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme of the metabolic pathway that produ

92 Based on our results, the rate-limiting enzyme PEPCK1 is the primary target of sir

93 ase/fructose-2,6-biphosphatase 3 (PFKFB3), a rate-limiting enzyme that promotes glycolysis.

94 l synthesis as measured via SQLE, its second rate-limiting enzyme.

95 hythmic expression of the genes encoding the rate-limiting enzymes for glycogenolysis and gluconeogen

96 at these PFKL clusters colocalize with other rate-limiting enzymes in both glycolysis and gluconeogen

97 Although genes encoding the rate-limiting enzymes in Norway spruce stilbene and flav

98 aded nanoparticles induced the expression of rate-limiting enzymes in polyamine catabolism (SMOX, SSA

99 at members of the proprotein convertase were rate-limiting enzymes in the truncation of TSLP between

100 regulating the activity of their respective rate-limiting enzymes, ribonucleotide reductase (RNR) an

101 I from a proximal promoter paused state is a rate-limiting event in human gene control.

102 oduct of multiple somatic mutations or other rate-limiting events.

103 enuated diffusion the substrate flux becomes rate-limiting, explaining why reaction rates in vivo can

104 ptimal, was linked to ribosome biogenesis, a rate-limiting factor in both cell growth and proliferati

105 mal protease cathepsin B in macrophages as a rate-limiting factor in degrading asparaginase both in v

106 We conclude that Aurora A and Plk4 are rate-limiting factors contributing to microtubule growth

107 es of miRNA target proteins are the dominant rate-limiting factors for miRNA-mediated gene silencing.

108 g regulation by identifying Fkh1 and Fkh2 as rate-limiting factors for origin firing that determine t

109 define a developmental program that appears rate limiting for cellular growth.

110 mini, suggesting that switching MT tracks is rate limiting for efficient transport.

111 quent rearrangement of the carbene ligand is rate limiting for electron poor and sterically large ket

112 under conditions where structure-opening is rate limiting for most backbone amide sites.

113 Interestingly, CBP activity is rate limiting for Pol II recruitment to these highly pau

114 AAVR binds directly to AAV2 particles and is rate limiting for viral transduction.

115 ng and unfolding of the first G3T monomer is rate-limiting for both annealing and melting processes.

116 This switch is rate-limiting for deubiquitination and strongly accelera

117 nstrate that double-strand breaks (DSBs) are rate-limiting for germination.

118 onal regulator MINIYO (IYO) is essential and rate-limiting for initiating cell differentiation in Ara

119 n pancreatic beta cells, and its activity is rate-limiting for insulin secretion.

120 arbonate ion to a growth site is found to be rate-limiting for kink nucleation, with this process hav

121 the transcription of "switch" genes that are rate-limiting for metabolic activity and lineage commitm

122 Cholesterol is rate-limiting for myelin biogenesis in the developing CN

123 cate that WRN helicase activity alone is not rate-limiting for the development of clinical WS.

124 de riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous NR and NMN for NA

125 conformational change of the light chain is rate-limiting for these proteins.

126 ext, Mal/serum response factor activation is rate-limiting for tumour dissemination.

127 -fold, suggesting that telestem formation is rate-limiting for U4/U6 pairing.

128 istent with the reaction mechanism involving rate-limiting formation of a transient oxirane intermedi

129 interfering RNA knockdown of the respective rate-limiting Gln-consuming enzymes CAD and PPAT.

130 s in the solid state were characterized by a rate limiting hydrogen transfer reaction from the triple

131 e kinetic isotope effect associated with the rate-limiting hydrogen-transfer step that releases OH ra

132 itylation of defective ribosomal products is rate limiting in generating class I peptide complexes.

133 lishment of a functional vascular network is rate-limiting in embryonic development, tissue repair an

134 mutation, indicating that ubiquitination is rate-limiting in this process.

135 n and the mRNA codon dramatically delay this rate-limiting, intramolecular process.

136 gration; 3) the AHR controls expression of a rate-limiting kynurenine pathway enzyme(s) in a closed a

137 ssing of the excessive autophagosomes by the rate-limiting lysosomal activity.

138 We found that rate-limiting mitochondrial enzymes that process lipids

139 increase in the expression of perforin, the rate-limiting molecule for cytotoxic CD8(+) T cell activ

140 The second step of the reaction is the rate-limiting one in which the formation of 1,2,4-oxadia

141 The second step is the rate-limiting one, and the whole process resembles the c

142 omised production is rarely elucidated since rate-limiting or inactive domain(s) remain unidentified.

143 ed nickelacycle intermediate, which upon the rate-limiting oxidative insertion to aryl iodide forms a

144 RNA increases kcat and rate-limiting Pi release 20-fold, although Pi release co

145 nsity exercise performance because it is the rate-limiting precursor of the dipeptide carnosine (beta

146 aMP-s have a common kinetic mechanism with a rate-limiting process in the interaction of the RS20 pep

147 e number of receptors increases, a competing rate-limiting process takes over: the center of mass of

148 ulting energetics-function model reveals the rate-limiting process to be the transition from the elec

149 Over the course of hours and in a rate-limiting process, a majority of these aggregation i

150 key drug release mechanisms and uncover the rate limiting processes; allow for the estimation of val

151 Hemiacetal intermediates for the rate-limiting proton transfer step were also intercepted

152 of acetyl-CoA to malonyl-CoA, the first and rate-limiting reaction in de novo synthesis of fatty aci

153 evealed that one slow and seven equally fast rate-limiting reactions best explain the overall pore fo

154 restores HIF-1alpha stability, indicating a rate-limiting role for FAD in LSD1-mediated HIF-1alpha r

155 We identify rate-limiting SHM positions for VRC-PG04 maturation, as

156 suggesting that CGA hydrolysis could be the rate limiting step for CO2 formation from CGA.

157 neO intermediate (O-O bond formation) is the rate limiting step for OER catalysis at low pH.

158 the voltage sensor in the first domain is a rate limiting step for release of the inactivation domai

159 action, catalyst resting state, and turnover-rate limiting step has been examined.

160 inhibition of acetyl CoA carboxylase 1, the rate limiting step of FAS, inhibit generation of early m

161 ed in the presence of the secretome, and the rate limiting step of the reaction was the oxidation of

162 n of the catalyst resting state and turnover-rate limiting step.

163 P14 is formed in the rate-limiting step along the conformational selection pa

164 nformational selection pathway but after the rate-limiting step along the induced-fit pathway.

165 d, it acts as a viable proton donor past the rate-limiting step and a sluggish buffer that maintains

166 tional strategies agree on the nature of the rate-limiting step and provided close results for the re

167 oplet reactions and it is concluded that the rate-limiting step at steady state is reagent transport

168 strate that Jak3 autophosphorylation was the rate-limiting step during Jak3 trans-phosphorylation of

169 somerization of proline peptide bonds is the rate-limiting step during triple-helix formation.

170 We found that the overall rate-limiting step for aldol cleavage shifted from C-C b

171 nts that suggest the isomerization to be the rate-limiting step for bispropargyl ethers, while cycliz

172 ate of hydration of [Formula: see text] is a rate-limiting step for calcite dissolution in seawater.

173 es and high-energy states can constitute the rate-limiting step for catalytic turnover.

174 In samples containing excess albumin the rate-limiting step for the chronopotentiometry readout a

175 most likely arising from differences in the rate-limiting step for the two activities.

176 flavodoxin reported a major revision of the rate-limiting step from MoFe protein and Fe protein diss

177 It can also be a rate-limiting step if high false positive or negative ra

178 n of CYP27A1, the enzyme responsible for the rate-limiting step in 27-hydroxycholesterol biosynthesis

179 ing have made computational analysis a major rate-limiting step in adaptive laboratory evolution and

180 E-1 (beta-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-beta (Abeta) production an

181 on of metastasis suppressor genes is a major rate-limiting step in breast cancer progression that pre

182 ncentrations above approximately 100 nm, the rate-limiting step in detergent- or membrane- induced po

183 onstrate that the search for homology is the rate-limiting step in DSB repair and suggest that cells

184 The rate-limiting step in each mechanism is **COOH formation

185 ic acid (ACC) synthases (ACS), generally the rate-limiting step in ethylene biosynthesis, which is re

186 se (ACC), the enzyme that controls the first rate-limiting step in fatty acid biosynthesis.

187 called poly(A) tail shortening, is the first rate-limiting step in general cytoplasmic mRNA degradati

188 n, and that proteolysis is the regulated and rate-limiting step in generating soluble EGF bioactivity

189 Pyruvate kinase catalyzes the last and rate-limiting step in glycolysis and theMtbgenome harbor

190 using by RNA polymerase II (Pol II) is a key rate-limiting step in HIV-1 transcription and latency re

191 iption of Atgl, the enzyme that mediates the rate-limiting step in lipolysis, is a key point of this

192 amide phosphoribosyltransferase (NAMPT), the rate-limiting step in NAD(+) synthesis, is highly expres

193 cellular carboxylesterases is considered the rate-limiting step in polyester biodegradation.

194 that MOR conformational changes are not the rate-limiting step in receptor activation.

195 RP3) inflammasome activation often acts as a rate-limiting step in regulating critical cell-fate deci

196 so2-Sec9 'binary' t-SNARE complex, the early rate-limiting step in SNARE complex assembly, and stimul

197 nsferase, an enzyme catalyzing the first and rate-limiting step in sphingolipid biosynthesis: the con

198 nzyme A reductase (HMGCR), which catalyzes a rate-limiting step in synthesis of cholesterol.

199 We now conclude that the rate-limiting step in the base-catalyzed aldol condensat

200 butyrate dehydrogenase 2 (Bdh2), catalyzes a rate-limiting step in the biogenesis of the eukaryotic s

201 ive sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the catabolism of heme into the bi

202 d others demonstrated that the regulated and rate-limiting step in the choline pathway for PC biosynt

203 f goethite, suggesting Fe(II) release is the rate-limiting step in the conduction mechanism during re

204 osomal proteases functioning in a direct and rate-limiting step in the Ctr1 ectodomain cleavage.

205 Axin, a scaffolding protein that controls a rate-limiting step in the destruction of beta-catenin, t

206 Phospholipase A2s mediate the rate-limiting step in the formation of eicosanoids such

207 R by suppressing end resection, which is the rate-limiting step in the initiation of HDR.

208 l colonization of the secondary organ is the rate-limiting step in the metastatic process; thus, expe

209 and -2.8, respectively, indicating that the rate-limiting step in the oxidations involves hydride ab

210 tidic acid phosphatase (PAP) controlling the rate-limiting step in the phospholipid synthesis pathway

211 ot observed with 1b, which suggests that the rate-limiting step in the reaction is neither C-H activa

212 enhances product release, which also is the rate-limiting step in the steady-state.

213 sion of l-tyrosine into l-DOPA, which is the rate-limiting step in the synthesis of catecholamines, s

214 this case, a slow transient process was the rate-limiting step in the transitions.

215 Initiation is a highly regulated, rate-limiting step in transcription.

216 The overall nitrogenase rate-limiting step is associated with ATP-driven electro

217 he diffusion through the coating and (2) the rate-limiting step is the diffusion through the aqueous

218 s can be simplified into two models: (1) the rate-limiting step is the diffusion through the coating

219 according to the theoretical discussion, the rate-limiting step is the diffusion through the coating;

220 The rate-limiting step is the iodine abstraction from an alk

221 he self-immolative reaction reveals that the rate-limiting step is the release of the first fluoride

222 ting cytosines and causing U:G mismatches, a rate-limiting step of Ab gene diversification.

223 SS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis.

224 ASS1 catalyzes the rate-limiting step of arginine synthesis in urea cycle a

225 cine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: the transfe

226 se, the enzyme responsible for the first and rate-limiting step of de novo sphingolipid biosynthesis.

227 The rate-limiting step of eicosanoid generation is the liber

228 a general acid nor a reaction partner in the rate-limiting step of electrochemical CO2 reduction cata

229 EEDs address the critical rate-limiting step of endosomal escape in delivery of ma

230 sion that FOL2 was the key gene encoding the rate-limiting step of folate biosynthesis in wine yeast.

231 ctions in the viral envelope may control the rate-limiting step of fusion.

232 enzyme in glycogen metabolism, catalyzes the rate-limiting step of glycogen mobilization.

233 vealing that a single H/D is involved in the rate-limiting step of H2 formation.

234 Kinetic analysis revealed the rate-limiting step of inactivation of the PLP-dependent

235 The rate-limiting step of PAR signaling is determined by the

236 nt of viral hemagglutinin, which affects the rate-limiting step of pH-triggered fusion.

237 d suggest that PCSK9 self-proteolysis is the rate-limiting step of secretion.

238 Arguably, the first and rate-limiting step of SNARE assembly is the formation of

239 o 0.05 s(-1), making the hydrolysis step the rate-limiting step of the ATPase cycle in the presence a

240 In addition to decreasing the rate-limiting step of the cycle (phosphate release), mav

241 ansition state supports a model in which the rate-limiting step of the hybridization reaction is the

242 kov state model that allowed identifying the rate-limiting step of the ligand unbinding process.

243 he transition state, thereby determining the rate-limiting step of the phosphorylation reaction of ar

244 by the catalyst as well as to determine the rate-limiting step of the process, which consists in the

245 the other hand, for nonpolar compounds, the rate-limiting step of the uptake process is diffusion th

246 glycerol acyltransferases (DGATs) catalyze a rate-limiting step of triacylglycerol (TAG) biosynthesis

247 at dysregulation of cell fate may be a novel rate-limiting step of tumorigenesis.

248 rone, indicating that C-H bond breaking is a rate-limiting step over a 10(4)-fold range of catalytic

249 e promoter-proximal pausing of RNAPII, a key rate-limiting step required for productive elongation.

250 phasizes that niclosamide degradation is the rate-limiting step to dehalogenation and mineralization

251 f.i-Bu3N bearing a hindered amine shifts the rate-limiting step to proton transfer.

252 nd use different substrates, reveal that the rate-limiting step under these conditions is the H2 form

253 present in both intermediate states, and the rate-limiting step which is likely to involve the thread

254 e-independent, relatively slow, and thus the rate-limiting step).

255 the proton transfer is occurring during the rate-limiting step, as in the distinction between genera

256 he first carbon-carbon bond formation is the rate-limiting step, followed by a rotation about the new

257 encing (WGS), genetic mapping has become the rate-limiting step, inhibiting unbiased forward genetics

258 To exert control over this rate-limiting step, we designed sequence-specific synthe

259 single proton is critical in the peroxidase rate-limiting step, which is very likely the proton-coup

260 t photo-oxidation of PhPyr by the QDs is the rate-limiting step.

261 nd demonstrate that product formation is the rate-limiting step.

262 and a simple classifier for determining the rate-limiting step.

263 ent, suggesting that ejection of the SM is a rate-limiting step.

264 tely 58 s(-1) so that PPi release became the rate-limiting step.

265 fect indicate that H-H bond formation is the rate-limiting step.

266 the requisite allosteric coupling, remains a rate-limiting step.

267 the product complex would correspond to the rate-limiting step.

268 emains linear, consistent with an unchanging rate-limiting step.

269 lified quantitative models based on a single rate-limiting step.

270 viously assumed and sorption serves as a key rate-limiting step.

271 rmediate to a small-molecule acceptor is the rate-limiting step.

272 minant parallel and consecutive pathways and rate limiting steps by estimating the reaction rate cons

273 pecific aspects include the time scales, the rate limiting steps in the degradation pathway, the effe

274 t tertiary mutations may be used to identify rate-limiting steps and dissect folding and assembly pat

275 this strange region of nonlimiting behavior, rate-limiting steps are often poorly defined, sometimes

276 These changes in dominant rate-limiting steps have a direct effect on the duty rat

277 t mechanism of adaptation was to relieve the rate-limiting steps in cofactor metabolism and substrate

278 e microtubule (MT; KT capture) is one of the rate-limiting steps in establishing proper KT-MT interac

279 ngs help reveal the nature and origin of the rate-limiting steps in substrate translocation on the ba

280 xygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic aci

281 entify the primary HS response genes and the rate-limiting steps in the transcription cycle that GAGA

282 lained by differences in the kinetics of the rate-limiting steps in transcription between promoters a

283 and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated

284 ng the mechanisms behind translation and its rate-limiting steps is crucial for both the development

285 l-tRNA reductase, which catalyzes one of the rate-limiting steps of chlorophyll biosynthesis.

286 l protein hubs and DNA processing during the rate-limiting steps of transcription.

287 ch dichotomous kinetics implicate additional rate-limiting steps that are essential for DNA-damage-in

288 ailoring elegantly precise inhibitors of the rate-limiting steps within the signaling pathways that c

289 in conditions routinely cause shifts in the rate-limiting steps, and autocatalysis is prevalent and

290 opic, kinetic and theoretical evidence for a rate limiting, surface active ozonide formed at the inte

291 ) catalyzes the highly regulated, frequently rate-limiting synthesis of the first biosynthetically fo

292 coli biotin and fatty acid synthesis that is rate limiting to cell growth.

293 nds, but subsequent target identification is rate-limiting to developing improved agents with higher

294 enesis.Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism.

295 enable the separation of Pi-release from the rate-limiting transition f into force states nor differe

296 reviously, we predicted the structure of the rate-limiting transition state that controlled the time-

297 igher iodine species are not involved in the rate-limiting transition state.

298 f hepatic glucose production by insulin; the rate-limiting transport of insulin across the adipose ti

299 uses of solid-state memory, the existence of rate-limiting volatility is a key feature for capturing

300 Mechanistic experiments indicate HAT is rate-limiting, whereas intramolecular amination is produ