ライフサイエンスコーパス: rate-limiting enzyme

1 phyrin IX suggests that the chelatase is the rate-limiting enzyme.

2 l synthesis as measured via SQLE, its second rate-limiting enzyme.

3 ndent transcription of genes coding for key, rate-limiting enzymes.

4 mRNA levels of the cholesterol biosynthesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-coenzyme

5 This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an at

6 late in the cell cycle including Acc1p, the rate-limiting enzyme acetyl-CoA carboxylase.

7 Rate-limiting enzyme activities of PC synthesis, PEMT an

8 vator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control point in glyc

9 Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation,

10 Tissue factor (TF), a rate-limiting enzyme cofactor in activating coagulation,

11 Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of end

12 esis by repressing hepatic expression of the rate-limiting enzyme CYP7A1.

13 affinity small-molecule inhibitor of the NSP rate-limiting enzyme dC kinase (dCK).

14 press argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sens

15 beta-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for beta-amyloid (Abeta) production

16 The rate-limiting enzyme for BH(4) production is guanosine t

17 overexpression of GTP cyclohydrolase 1 (the rate-limiting enzyme for BH4 biosynthesis) in ECs by gen

18 pression of GTP cyclohydrolase I (GCH1), the rate-limiting enzyme for BH4 synthesis, restored cellula

19 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme for biosynthesis of tetrahydrobiopt

20 , via immunofluorescent visualization of the rate-limiting enzyme for CA synthesis, tyrosine hydroxyl

21 etermined by a high protein abundance of the rate-limiting enzyme for carotenoid biosynthesis, phytoe

22 show that, like other YUCs, CKRC2/YUC8 is a rate-limiting enzyme for catalyzing the conversion of in

23 horylated tyrosine hydroxylase (pTH-ir), the rate-limiting enzyme for catecholamine synthesis, in bra

24 oxylase (CYP46A1), the neuronal-specific and rate-limiting enzyme for cholesterol conversion to 24S-h

25 hylglutaryl coenzyme A reductase, which is a rate-limiting enzyme for cholesterol synthesis.

26 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for de novo BH4 synthesis.

27 a C57 background in which expression of the rate-limiting enzyme for dopamine synthesis, tyrosine hy

28 essed by SA cells, which also co-express the rate-limiting enzyme for dopamine synthesis, tyrosine hy

29 amide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for endogenous production of NAD(+)

30 Recently, elevated levels of aromatase, the rate-limiting enzyme for estrogen biosynthesis, were fou

31 ing the expression of aromatase, the key and rate-limiting enzyme for estrogen synthesis.

32 ported by lower gene expression of FAR1, the rate-limiting enzyme for ether-lipid synthesis in VAT.

33 sm, PPARG and PPARGC1A, as well as SCD1, the rate-limiting enzyme for fatty acid metabolism.

34 se (GAD), GAD65 (GAD2) and GAD67 (GAD1), the rate-limiting enzyme for GABA synthesis, exhibits altere

35 Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for gamma-aminobutyric acid (GABA)

36 expressed inducible isoform of the first and rate-limiting enzyme for heme degradation.

37 Gamma glutamyl cysteine ligase (GCL) is the rate-limiting enzyme for intracellular glutathione (GSH)

38 ies of adenylate cyclase and tyrosinase, the rate-limiting enzyme for melanogenesis.

39 ylalkylamine N-acetyltransferase (AANAT; the rate-limiting enzyme for melatonin synthesis from seroto

40 succinyl-CoA:3-oxoacid-CoA transferase, the rate-limiting enzyme for myocardial oxidation of beta-hy

41 ng nicotinamide phosphoribosyltransferase, a rate-limiting enzyme for NAD synthesis, specifically in

42 st central complex with TBH likely being the rate-limiting enzyme for octopamine synthesis in a small

43 ry cells, strongly suggesting that Far1 is a rate-limiting enzyme for plasmalogen synthesis.

44 , ornithine decarboxylase appeared to be the rate-limiting enzyme for polyamine production.

45 nvolves feed forward regulation of Raldh2, a rate-limiting enzyme for RA biosynthesis, and requires M

46 hyde dehydrogenase family 1, subfamily A2, a rate-limiting enzyme for RA synthesis in DCs.

47 hospholipase A(2)alpha (cPLA(2)alpha) is the rate-limiting enzyme for release of arachidonic acid, wh

48 By assaying activity and kinetics of the rate-limiting enzyme for serotonin biosynthesis, tryptop

49 an hydroxylase gene tph-1, which encodes the rate-limiting enzyme for serotonin biosynthesis.

50 nt mice have reduced expression of Tph1, the rate-limiting enzyme for serotonin biosynthesis.

51 Cyclooxygenase (COX)-2 is the rate-limiting enzyme for synthesis of PGE(2) from arachi

52 cholesterol 7alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme for the conversion of cholesterol t

53 osine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme for the de novo synthesis of guanin

54 beta-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer

55 disease, and lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides

56 Tyrosinase is the rate-limiting enzyme for the production of melanin pigme

57 against the glutamic acid decarboxylase, the rate-limiting enzyme for the production of the inhibitor

58 Comparative analysis revealed raldh2, a rate-limiting enzyme for the synthesis of retinoic acid,

59 YME A REDUCTASE1 (HMGR1) and MAKIBISHI1, the rate-limiting enzyme for triterpene biosynthesis and an

60 , brain cholesterol, its precursors, and the rate-limiting enzymes for cholesterol synthesis, HMG CoA

61 hythmic expression of the genes encoding the rate-limiting enzymes for glycogenolysis and gluconeogen

62 mus, significantly reduced the expression of rate-limiting enzymes for lipid synthesis and the expres

63 ough activity-regulated transcription of the rate-limiting enzyme GAD67.

64 ate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase.

65 biosynthesis depends on the activity of the rate-limiting enzyme glutamate-cysteine ligase (GCL), co

66 ression of glutathione (GSH) and its de novo rate-limiting enzyme glutamate-cysteine ligase (GCL), wh

67 gosterol biosynthetic pathway, including the rate-limiting enzyme HMG-CoA reductase.

68 xpression of GTP cyclohydrolase 1 (GCH), the rate limiting enzyme in BH4 synthesis, increased levels

69 ic activity of phosphofructokinase (PFK; the rate limiting enzyme in glycolysis) is positively affect

70 sion and activity of tyrosine hydroxylase, a rate limiting enzyme in the synthesis of dopamine and ot

71 cis-epoxycarotenoid dioxygenase 6 (NCED6), a rate-limiting enzyme in abscisic acid (ABA) biosynthesis

72 (25-50 mg/kg, IP), an inhibitor of the main rate-limiting enzyme in allopregnanolone synthesis.

73 rostate cancer cells do not express ASS, the rate-limiting enzyme in arginine synthesis, and are susc

74 H4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 biosynthesis which catalyses

75 nockdown" GTP cyclohydrolase-1 (GTPCH1), the rate-limiting enzyme in BH4 biosynthesis, and dihydrofol

76 opterins, GTP-cyclohydrolase 1 (GTPCH-1, the rate-limiting enzyme in BH4 synthesis), and NOS activity

77 xpression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 synthesis, to determine the

78 cellular cholesterol levels, and CYP7A1, the rate-limiting enzyme in bile acid biosynthesis (p<0.05).

79 CH1 gene, encoding GTP-cyclohydrolase I, the rate-limiting enzyme in biopterin biosynthesis, was asso

80 Argininosuccinate synthase (ASS) is the rate-limiting enzyme in both the urea and the L-citrulli

81 (Bsl1) locus in S. viridis, which encodes a rate-limiting enzyme in BR biosynthesis.

82 c deletion of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, prot

83 rter [VAChT]), tyrosine hydroxylase (TH; the rate-limiting enzyme in catecholamine synthesis), and se

84 tion sites in tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, are spe

85 Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is know

86 expression of tyrosine hydroxylase mRNA, the rate-limiting enzyme in catecholamine synthesis, was inc

87 e activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis.

88 ribonucleotide reductase subunit-2 (RRM2), a rate-limiting enzyme in cell replication, were investiga

89 Squalene monooxygenase (SM) is the second rate-limiting enzyme in cholesterol biosynthesis and is

90 tion in Sqle, encoding squalene epoxidase, a rate-limiting enzyme in cholesterol biosynthesis, underl

91 polymorphisms in the gene encoding HMGCR, a rate-limiting enzyme in cholesterol synthesis and the di

92 sing upregulation of HMG Co-A reductase, the rate-limiting enzyme in cholesterol synthesis.

93 y-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis.

94 e amidinotransferase (GATM) that encodes the rate-limiting enzyme in creatine synthesis.

95 loroplast serine acetyltransferase (SAT1), a rate-limiting enzyme in cysteine biosynthesis, was ident

96 on and lead to significant inhibition of the rate-limiting enzyme in DA synthesis, tyrosine hydroxyla

97 ore, expression of GTP cyclohydrolase I (the rate-limiting enzyme in de novo BH4 synthesis) under dox

98 tidine triphosphate synthetase (CTPS) is the rate-limiting enzyme in de novo CTP synthesis and is req

99 all subunit of ribonucleotide reductase, the rate-limiting enzyme in de novo deoxyribonucleoside trip

100 hosphate (IMP) dehydrogenase 2 (IMPDH2) is a rate-limiting enzyme in de novo guanine nucleotide biosy

101 osine Monophosphate Dehydrogenase (IMPDH), a rate-limiting enzyme in de novo guanine nucleotide biosy

102 modulation of serine palmitoyltransferase, a rate-limiting enzyme in de novo sphingolipid synthesis.

103 te (IRES) that regulates SHMT1 expression, a rate-limiting enzyme in de novo thymidylate biosynthesis

104 Deoxycytidine kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a m

105 orresponding deoxyribonucleotides and is the rate-limiting enzyme in DNA synthesis.

106 modulator of tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis, and hence MT

107 tion is the enzyme tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, which is act

108 eactivity for tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis.

109 h as tyrosine hydroxylase (TH), which is the rate-limiting enzyme in dopamine synthesis.

110 oxylase 1 (Tph1) messenger RNA, encoding the rate-limiting enzyme in enterochromaffin cell serotonin

111 ed immunoblots to measure GAD(65) protein (a rate-limiting enzyme in GABA synthesis) and microdialysi

112 Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis and is frequentl

113 f Molecular Cell, Jiang et al. show that the rate-limiting enzyme in gluconeogenesis, phosphoenolpyru

114 n the yeast homotetrameric FBP1 complex, the rate-limiting enzyme in gluconeogenesis.

115 vity of glutamate cysteine ligase (GCL), the rate-limiting enzyme in glutathione biosynthesis.

116 Furthermore, the expression of PFKM, a rate-limiting enzyme in glycolysis, was nominally associ

117 tion of glutamate cysteine ligase (GCL), the rate-limiting enzyme in GSH biosynthesis).

118 cysteine ligase catalytic subunit (GCLC), a rate-limiting enzyme in GSH biosynthesis.

119 the loss of glutamate cysteine ligase (GCL, rate-limiting enzyme in GSH synthesis) in liver.

120 nit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have increased de

121 elta aminolevulinate synthase 1 (ALAS1), the rate-limiting enzyme in heme biosynthesis.

122 xygenase mRNA (HMOX1; 68-fold increase), the rate-limiting enzyme in heme catabolism.

123 The rate-limiting enzyme in heme synthesis, delta-aminolevul

124 ment of mice or cultured cells to bypass the rate-limiting enzyme in hepatic heme synthesis, ALA synt

125 gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis.

126 ypothesis that delta-6 desaturase (D6D), the rate-limiting enzyme in long-chain polyunsaturated fatty

127 amide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in mammalian NAD(+) biosynthesis, d

128 Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine d

129 Tyrosinase is the central and rate-limiting enzyme in melanin biosynthesis.

130 or the enzymatic activity of tyrosinase, the rate-limiting enzyme in melanin production.

131 Methyl-coenzyme M reductase, the rate-limiting enzyme in methanogenesis and anaerobic met

132 namide mononucleotide adenylyltransferase, a rate-limiting enzyme in nicotinamide adenine dinucleotid

133 ide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in nicotinamide adenine dinucleotid

134 liance induces transcription of aromatase, a rate-limiting enzyme in oestrogen biosynthesis.

135 ene encodes GDP-L-galactose phosphorylase, a rate-limiting enzyme in plant vitamin C biosynthesis.

136 sion of ornithine decarboxylase (ODC), a key rate-limiting enzyme in polyamine biosynthesis, on cell

137 bition of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, phenocop

138 t lacking ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, was prof

139 s lacking ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, were cre

140 YCN amplification also overexpress ODC1, the rate-limiting enzyme in polyamine biosynthesis, when com

141 carboxylase (ODC) is the first and generally rate-limiting enzyme in polyamine biosynthesis.

142 SAT1 is a rate-limiting enzyme in polyamine catabolism critically

143 nd spermine to form acetyl derivatives, is a rate-limiting enzyme in polyamine catabolism.

144 Ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine metabolism, has been w

145 on of cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin biosynthesis from

146 he expression of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in prostaglandin biosynthesis, whic

147 sine triphosphate cyclohydrolase (GCH1), the rate-limiting enzyme in pterin synthesis, thereby elevat

148 amide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in regenerating nicotinamide adenin

149 As the rate-limiting enzyme in serotonin synthesis, tryptophan

150 Brain TPH2 mRNA, encoding the rate-limiting enzyme in serotonin synthesis, was induced

151 resulted in ORMDL-mediated inhibition of the rate-limiting enzyme in sphingolipid biosynthesis, serin

152 h serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production.

153 serine palmitoyl-CoA transferase (SPT), the rate-limiting enzyme in sphingomyelin synthesis.

154 ccordingly, induction of NCED3, encoding the rate-limiting enzyme in stress-induced ABA biosynthesis,

155 oxy-3-methylglutaryl coenzyme A reductase, a rate-limiting enzyme in synthesis of cholesterol and non

156 in D signaling via suppression of CYP24A1, a rate-limiting enzyme in the 1alpha,25-dihydroxyvitamin D

157 olesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathw

158 s to localize tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamin

159 of tyrosine hydroxylase (TH) expression, the rate-limiting enzyme in the biosynthesis of dopamine, no

160 Glycogen synthase is a rate-limiting enzyme in the biosynthesis of glycogen and

161 SCD1 is the rate-limiting enzyme in the biosynthesis of monounsatura

162 hydroxylase 1 (Tph1(-/-) mice), which is the rate-limiting enzyme in the biosynthesis of mucosal but

163 hisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pa

164 eral mechanisms for feedback control of this rate-limiting enzyme in the branched pathway that produc

165 sphorylation of tyrosine hydroxylase (TH), a rate-limiting enzyme in the CA synthetic pathway.

166 Phytoene synthase (PSY), the rate-limiting enzyme in the carotenoid biosynthetic path

167 (gene HMOX1; protein HO-1) is the inducible, rate-limiting enzyme in the catabolism of heme and might

168 As the rate-limiting enzyme in the CDP-choline pathway for PC s

169 ryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting enzyme in the cholesterol biosynthesis pat

170 Expression of Odc1, the rate-limiting enzyme in the conversion of ornithine into

171 ntributed by 5alpha-reductase (5alphaR), the rate-limiting enzyme in the conversion of progesterone i

172 Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleosid

173 rine palmitoyltransferase (SPT) is the first rate-limiting enzyme in the de novo ceramide synthesis.

174 , we identified HO-1 (heme oxygenase-1), the rate-limiting enzyme in the degradation of heme to biliv

175 cells requires deoxycytidine kinase (dCK), a rate-limiting enzyme in the deoxyribonucleoside salvage

176 zyme 1), a membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer

177 sphate amidotransferase (GFAT), which is the rate-limiting enzyme in the HBP pathway.

178 -6-phosphate transaminase 1 (GFPT1) is a key rate-limiting enzyme in the hexosamine biosynthetic path

179 Up-regulation of a gene encoding the rate-limiting enzyme in the hexosamine pathway suggests

180 dehydrogenase multienzyme complex (OGDHc), a rate-limiting enzyme in the Krebs (citric acid) cycle.

181 alpha-ketoglutarate dehydrogenase (OGDH), a rate-limiting enzyme in the Krebs cycle.

182 amine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of trypto

183 otein indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the L-tryptophan-kynurenine meta

184 gene (TKTL1), which encodes an essential and rate-limiting enzyme in the nonoxidative part of the pen

185 smic reticulum-associated degradation of the rate-limiting enzyme in the pathway, HMG-CoA reductase (

186 Choline cytidylyltransferase (CCT) is the rate-limiting enzyme in the phosphatidylcholine biosynth

187 infection upregulated the expression of the rate-limiting enzyme in the polyamine biosynthetic pathw

188 decarboxylase (ODC) is the first and usually rate-limiting enzyme in the polyamine biosynthetic pathw

189 permidine/spermine N1-acetyltransferase, the rate-limiting enzyme in the polyamine oxidation pathway.

190 ice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine

191 Renin is the rate-limiting enzyme in the production of all angiotensi

192 ursor protein-cleaving enzyme (BACE1) is the rate-limiting enzyme in the production of amyloid-beta,

193 enzymes such as ornithine decarboxylase, the rate-limiting enzyme in the production of polyamines, im

194 ere we describe p53-dependent control of the rate-limiting enzyme in the pyrimidine catabolic pathway

195 reported that mast cells express renin, the rate-limiting enzyme in the renin-angiotensin cascade.

196 ribosyltransferase (Nampt) gene encoding the rate-limiting enzyme in the salvage pathway of NAD(+) bi

197 amide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the salvage pathway of nicotinam

198 nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in the salvage pathway that convert

199 amide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the salvage pathway.

200 , a cytochrome P450 enzyme, is the first and rate-limiting enzyme in the steroidogenic pathway, conve

201 ning is the most robust were stained for the rate-limiting enzyme in the synthesis of 5-HT, tryptopha

202 methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme in the synthesis of cholesterol via

203 Glutamic acid decarboxylase is the rate-limiting enzyme in the synthesis of gamma-aminobuty

204 nd phosphate activated glutaminase (PAG; the rate-limiting enzyme in the synthesis of glutamate) immu

205 A rate-limiting enzyme in the synthesis of glycogen is gly

206 ALAS-1 is a PGC-1alpha target gene and the rate-limiting enzyme in the synthesis of heme, a ligand

207 Ai) of tryptophan hydroxylase-2 (Tph-2), the rate-limiting enzyme in the synthesis of neuronal 5-HT.

208 The rate-limiting enzyme in the synthesis of peripheral sero

209 hionine beta-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway, wh

210 S1) is a liver-specific, intramitochondrial, rate-limiting enzyme in the urea cycle.

211 Overexpression of the rate-limiting enzyme in this pathway, nicotinamide phosp

212 e cytidylyltransferase 1 alpha (PCYT1A), the rate-limiting enzyme in this pathway.

213 ity of nitrate reductase (NR), the first and rate-limiting enzyme in this pathway.

214 y of adipose triglyceride lipase (ATGL), the rate-limiting enzyme in triacylglycerol hydrolysis.

215 rain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a k

216 at these PFKL clusters colocalize with other rate-limiting enzymes in both glycolysis and gluconeogen

217 l lipid synthesis and lipolysis, ablation of rate-limiting enzymes in hepatic PC biosynthetic pathway

218 and steaoryl-coenzyme A desaturase, the two rate-limiting enzymes in lipogenesis, were upregulated i

219 Although genes encoding the rate-limiting enzymes in Norway spruce stilbene and flav

220 aded nanoparticles induced the expression of rate-limiting enzymes in polyamine catabolism (SMOX, SSA

221 s-Epoxycarotenoid Dioxygenase3, which encode rate-limiting enzymes in proline and abscisic acid (ABA)

222 diet exhibited decreased mRNA expression of rate-limiting enzymes in several important glucose and l

223 oid (17-HAS) inhibitors of Cyp17, one of the rate-limiting enzymes in the biosynthesis of testosteron

224 Overexpression of rate-limiting enzymes in the endogenous heme biosyntheti

225 at members of the proprotein convertase were rate-limiting enzymes in the truncation of TSLP between

226 an is catabolized in the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO) e

227 Isyna1 (designated mIno1), which encodes the rate-limiting enzyme inositol-3-phosphate synthase.

228 ketone bodies and hepatic expression of the rate-limiting enzyme involved in ketone body production.

229 Here we investigated the biologic role of a rate-limiting enzyme involved in NAD(+) synthesis, Nampt

230 amide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme involved in the conversion of nicot

231 e cytidylyltransferase alpha (CCTalpha), the rate-limiting enzyme involved in the synthesis of phosph

232 enotypes, likely through MeCP2 regulation of rate-limiting enzymes involved in aminergic neurotransmi

233 tancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism acro

234 Surprisingly, PKM2, a rate limiting enzyme of glycolysis displayed a nuclear l

235 ion of adipose triglyceride lipase (ATGL), a rate limiting enzyme of TAG hydrolysis.

236 ssion of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme of cholesterol catabolism and bile

237 f the dNTPs are synthesized "on the go." The rate-limiting enzyme of dNTP synthesis, ribonucleotide r

238 down-regulation of tyrosine hydroxylase, the rate-limiting enzyme of dopamine (DA) biosynthesis, spec

239 expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine biosynthesis [5, 13].

240 acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme of FA de novo synthesis.

241 results indicate that HCMV targets ACC1, the rate-limiting enzyme of fatty acid biosynthesis, through

242 we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), caus

243 l for metastasis, and we determined that the rate-limiting enzyme of glutathione synthesis, GCLC, bec

244 T1A_i2 proteins in human tissues-namely, the rate-limiting enzyme of glycolysis pyruvate kinase (PKM)

245 t isoform of phosphofructokinase (PFKP), the rate-limiting enzyme of glycolysis that catalyzes the ir

246 uce transcription of INO1, which encodes the rate-limiting enzyme of inositol biosynthesis.

247 s along with hematopoietic PGD synthase, the rate-limiting enzyme of PGD2 synthesis.

248 ornithine decarboxylase (ODC), which is the rate-limiting enzyme of polyamine biosynthesis, decrease

249 Degradation of ornithine decarboxylase, the rate-limiting enzyme of polyamine biosynthesis, is promo

250 enesis is ornithine decarboxylase (Odc), the rate-limiting enzyme of polyamine biosynthesis.

251 n with ornithine decarboxylase 1 (ODC1), the rate-limiting enzyme of polyamine synthesis, was observe

252 n the allosteric site of GNE, coding for the rate-limiting enzyme of sialic acid biosynthesis, UDP-Gl

253 cting tyrosine hydroxylase (TH), the initial rate-limiting enzyme of the CA synthesis, to study: 1) t

254 es tyrosine hydroxylase (TH) expression, the rate-limiting enzyme of the catecholamine synthesis, del

255 palmitoyltransferase (SPT) is the first and rate-limiting enzyme of the de novo biosynthetic pathway

256 S subdomain) of IMP dehydrogenase (IMPDH), a rate-limiting enzyme of the de novo GMP biosynthesis, is

257 -B inhibits serine palmitoyltransferase, the rate-limiting enzyme of the de novo sphingolipid biosynt

258 -6-phosphate amidotransferase 1 (GFAT1), the rate-limiting enzyme of the HBP.

259 We describe the rate-limiting enzyme of the ketogenic energy metabolism

260 esterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme of the metabolic pathway that produ

261 -hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme of the mevalonate pathway, by lipop

262 and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway.

263 n resulted in a decreased activity of COX, a rate-limiting enzyme of the mitochondrial electron trans

264 Statins block HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the MVA pathway.

265 NAMPT is the rate-limiting enzyme of the NAD(+) salvage pathway and e

266 lciparum (PfIspC, PfDxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of iso

267 cose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway an

268 Aldose reductase, the rate-limiting enzyme of the polyol pathway, plays a key

269 lucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, is dynamically modified

270 ne palmitoyltransferase (SPT), the first and rate-limiting enzyme of the sphingolipid biosynthetic pa

271 e dehydrogenase complex (KGDHC), an arguably rate-limiting enzyme of the TCA cycle, declines with AD,

272 Citrate synthase, the first and rate-limiting enzyme of the tricarboxylic acid branch of

273 idine dehydrogenase (DPD) is the initial and rate-limiting enzyme of the uracil catabolic pathway, be

274 leamine 2,3-dioxygenase (IDO), the first and rate-limiting enzyme of tryptophan catabolism in the kyn

275 by L. johnsonii, with specific focus on the rate-limiting enzyme of tryptophan catabolism, indoleami

276 thylglutaryl (HMG)-CoA reductase (HMGR), the rate-limiting enzymes of sterol synthesis, undergoes fee

277 xpression of hexokinase II (HK2), one of the rate-limiting enzymes of the glycolytic pathway.

278 have implicated polyamines, generated by the rate-limiting enzyme ornithine decarboxylase (ODC), in g

279 tabolism and excretion, is controlled by the rate-limiting enzymes ornithine decarboxylase (ODC) and

280 ells, as well as by the up-regulation of the rate-limiting enzymes PEPCK and G6Pc.

281 Based on our results, the rate-limiting enzyme PEPCK1 is the primary target of sir

282 We find that a single rate-limiting enzyme, phosphoribosyl-pyrophosphate synth

283 A1; median 12-fold induction; P<0.0001), the rate-limiting enzyme promoting the conversion of cholest

284 -617, a small molecule inhibitor of NAMPT, a rate-limiting enzyme required for NAD generation, to pro

285 ine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme required for the production of guan

286 of nicotinamide phosphoribosyltransferase, a rate-limiting enzyme required for the regeneration of NA

287 Since papillomaviruses lack most of the rate-limiting enzymes required for genome synthesis, the

288 regulating the activity of their respective rate-limiting enzymes, ribonucleotide reductase (RNR) an

289 t de novo synthesis of ceramide, through the rate-limiting enzyme serine palmitoyltransferase long ch

290 pane-1-carboxylic acid synthase (ACS) is the rate-limiting enzyme that catalyzes the committing step

291 BACE1 is the rate-limiting enzyme that cleaves amyloid precursor prot

292 al prostaglandin E synthase-1 (mPGES-1) is a rate-limiting enzyme that is coupled with cyclooxygenase

293 ase/fructose-2,6-biphosphatase 3 (PFKFB3), a rate-limiting enzyme that promotes glycolysis.

294 cose-6-phosphatase (G6Pase) is an essential, rate-limiting enzyme that serves as a terminal gatekeepe

295 , also known as aldehyde dehydrogenases, are rate-limiting enzymes that convert retinaldehyde (Rald)

296 First, the rate-limiting enzyme tyrosine hydroxylase (TH) converts

297 essary for neurotransmitter synthesis by the rate-limiting enzymes tyrosine and tryptophan hydroxylas

298 NE is synthesized from tyrosine by the rate-limiting enzyme, tyrosine hydroxylase (TH), and tyr

299 al delta-aminolevulinic acid synthase 2, the rate-limiting enzyme upstream of delta-aminolevulinic ac

300 CYP11A1 (rate-limiting enzyme) was expressed in cancerous and non