ライフサイエンスコーパス: rationally

1 t how they are silenced, and how they may be rationally activated are areas of ongoing investigation.

2 Furthermore, binding to rationally and computationally designed site II helix-lo

3 Our ability to play rationally appears more likely when the outcome is posit

4 , this study presents a framework for how to rationally apply isosteric replacements of the carboxyli

5 ere formulated around a polymeric shell in a rationally arranged fashion with a surface glycoprotein

6 mensional arrangements of optical scatterers rationally arranged to control optical wavefronts.

7 In the search for rationally assembled functional materials, superatomic c

8 hose active electrode materials can be tuned rationally, at the molecular level.

9 ses lacking NSs is an attractive strategy to rationally attenuate bunyaviruses.

10 ng activity may serve as a novel approach to rationally attenuate hMPV and perhaps other pneumoviruse

11 yltransferase (MTase) is a novel approach to rationally attenuate the virus for vaccine purpose.

12 very useful in order to exploit and utilize rationally chan 11S globulin in food systems.

13 g technologies are now making it possible to rationally change the genetic code, offering resistance

14 Methods were rationally chosen and optimized to address the different

15 We find that two rationally chosen point mutations (His447Gln and His447A

16 Two rationally chosen point mutations cause a notable increa

17 To achieve DNA detection, a rationally chosen star-shaped nanoparticle (NP), namely

18 ithin a specific expression context could be rationally combined together in silico to create promote

19 Herein, we show how by rationally combining robust site-specific phosphine bioc

20 bust predictor of DLBCL outcome, and discuss rationally conceived experimental approaches to treat th

21 block these pathways, it may be possible to rationally construct drug combinations that yield more p

22 hat our work could provide a general way for rationally constructing metal and metal clusters codecor

23 e nature of DNA makes it an ideal system for rationally constructing self-assembled crystals and immo

24 uning the lipid structure, it is possible to rationally control the interaction force.

25 domains to DNA nanostructures can be used to rationally control the interface between synthetic nanos

26 Developing rationally controlled bottom-up device fabrication proce

27 cholera vaccines could, and should, be most rationally deployed.

28 We aimed to define whether FMT using a rationally derived stool donor is safe in recurrent HE c

29 Here, we rationally design a charging cycle to maximize energy-st

30 , metabolomics and pharmacological assays to rationally design a new inhibitor selective for the CSE

31 This knowledge was subsequently applied to rationally design a second-generation inhibitor scaffold

32 onses and this knowledge can be leveraged to rationally design and develop next generation vaccines a

33 Here we present a method to rationally design antibodies to enable them to bind virt

34 distribution, hereby providing a strategy to rationally design carbon-supported catalysts.Control ove

35 Our findings outline a possible strategy to rationally design channel specificity by modification of

36 To rationally design COF-based electrocatalysts for oxygen

37 tural information about this minimal Cas9 to rationally design compact transcriptional activators and

38 of conductive pores with active material to rationally design composites based on local charge densi

39 Here, we introduce a strain-driven scheme to rationally design defect spins in functional ionic cryst

40 , researchers have been looking for a way to rationally design dendritic amphiphiles for the last few

41 was investigated to better understand how to rationally design enhanced processivity in a Y-family po

42 owards CHO cell glycosylation can be used to rationally design feeding strategies that ensure optimal

43 ideline for further biomimetic strategies to rationally design hard-soft interfaces.

44 These results demonstrate the capability to rationally design increases in pol processivity and cata

45 f water transport in GOAL and can be used to rationally design more effective and efficient GO membra

46 and Titin, and applied the resulting data to rationally design mutants with improved antigen discrimi

47 responses frequently hampers our ability to rationally design nanomaterials with sharp responses.

48 facet/morphology-property relationships and rationally design nanostructures with desired properties

49 rgy, and to use the mechanistic knowledge to rationally design new combinations that bypass drug resi

50 d natural proteins' properties as well as to rationally design novel biomaterials of required mechani

51 Recent findings suggest means to rationally design novel recognition capabilities to coun

52 With such knowledge, we could rationally design peptides with desired residues to mani

53 subsequently used as a starting structure to rationally design peptidic inhibitors.

54 esults suggest that it should be possible to rationally design ST toxoids that elicit neutralizing im

55 better understand their growth mechanism and rationally design superior catalysts and adsorbents.

56 To rationally design supramolecular polymers capable of sel

57 We then rationally design two mutants, one in the protein and an

58 the structure of protein excited states and rationally design validating experiments.

59 ghts from kinetic and spectroscopic tests to rationally design water treatment catalysts for enhanced

60 used to predict the properties of, and thus rationally design, new diareno-fused antiaromatic molecu

61 omputational and spectroscopic approaches to rationally design, synthesize, and test a series of subs

62 and the SARS-CoV fusion peptide sequence, we rationally designed a novel immunomodulatory peptide tha

63 To this end, we rationally designed a ribosomal RNA that covalently link

64 To target DDX3, we rationally designed a small molecule, RK-33, which docks

65 Here, we show that intravitreally injected, rationally designed AAV2(quadY-F+T-V) containing a novel

66 d the possibility for the development of new rationally designed alphavirus vaccine candidates that c

67 an atoxic derivative (ad) of BoNT/C1 through rationally designed amino acid substitutions in the meta

68 ere we focused on the study of Pa-MAP 1.9, a rationally designed AMP derived from the polar fish Pleu

69 th ferroelectric polymers by capitalizing on rationally designed amphiphilic star-like diblock copoly

70 controls to determine the mechanisms of four rationally designed AMPs with similar secondary structur

71 P5P) modulates the self-assembly of ASC, we rationally designed an N-terminal capped nonapeptide (Na

72 The rationally designed analogue, PYY-AP3H, has potential as

73 is advanced to facilitate the development of rationally designed and age-appropriate psychiatric trea

74 mposition (MAPb0.5 Sn0.5 (I0.8 Br0.2 )3 ) is rationally designed and developed, which possesses lower

75 in proteins have resulted in the creation of rationally designed and functional peptidic structures,

76 series of 1,4-dioxanes (4-11 and 12-19) were rationally designed and prepared to interact either with

77 1,2-phenylenebis(oxamidate) ligand) has been rationally designed and prepared to support a more exten

78 the molecular basis of TAAR1 activation, we rationally designed and synthesized a small family of th

79 ar-like amphiphilic triblock copolymers were rationally designed and synthesized by combining two seq

80 Light-switchable azoimidazoles were rationally designed and synthesized, and their performan

81 constitution of P1'-extended structures was rationally designed and the lead, phosphinic dipeptide h

82 The rationally designed AP probes exhibited excellent DNA bi

83 Soft structures with rationally designed architectures capable of large, nonl

84 within a flexible polymer binder matrix, the rationally designed artificial SEI not only mechanically

85 Rationally designed AuNPs could greatly benefit their an

86 thesis of novel PI4KB inhibitors, which were rationally designed based on two distinct structural typ

87 Rationally designed biosensing system supports multiplex

88 -coated SnO2 were crafted by capitalizing on rationally designed bottlebrush-like hydroxypropyl cellu

89 A series of rationally designed butterfly-like phosphorescent binucl

90 degradable nanogels for iron chelation were rationally designed by simultaneously polymerizing oxida

91 In this report, a new, rationally designed catalyst, Pd-PEPPSI-IHept(Cl), is de

92 The rationally designed catalysts promote effective turnover

93 e insights could be useful in developing new rationally designed combination therapies with sorafenib

94 single agent; therefore, there is a need for rationally designed combination therapies.

95 This platform technology can lead to a rationally designed combination therapy.

96 Rationally designed combinations of targeted therapies f

97 raphene-based functional nanocomposites with rationally designed compositions and architectures for p

98 st attempt to test this model using a set of rationally designed compounds.

99 Rationally designed conjugates of chrysin, indole, and b

100 A rationally designed crystalline Ti(3+) core/amorphous Ti

101 fficacy of the D-enantiomeric peptide RD2, a rationally designed derivative of the previously describ

102 Biochemical circuits made of rationally designed DNA molecules are proofs of concept

103 Rationally designed DNA nanoparticles (DNPs) have emerge

104 :Yb/Er UCNPs are first crafted by employing rationally designed double hydrophilic star-like poly(ac

105 se vaccinology in the HIV vaccine field with rationally designed epitope scaffold immunogens inducing

106 ASFV-G-Delta9GL/DeltaUK is the first rationally designed experimental ASFV vaccine that prote

107 f a novel 2,1,3-benzothiadiazole (BTD)-based rationally designed fluorophore.

108 ntained variable linker length while one was rationally designed for optimizing protein-protein inter

109 molecule as a Raman internal standard, were rationally designed for quantitative SERS analysis.

110 HA polymers are rationally designed from relatively low-molecular-weight

111 Three rationally designed glucose-platinum conjugates (Glc-Pts

112 gioselective and direct functionalization of rationally designed imidazole derivatives through electr

113 thod described here could form the basis for rationally designed immunotherapy strategies to combat A

114 This common mechanism open avenues for rationally designed inhibitors of all MbetaLs, notwithst

115 The X-ray structures of CYP3A4 bound to the rationally designed inhibitors provide deeper insights i

116 L6-dependent disease that can be targeted by rationally designed inhibitors that exceed the binding a

117 bi-cistronic and tri-cistronic operons with rationally designed intergenic regions and systematicall

118 tal synthesis and biological evaluation of a rationally designed library of simplified analogs that u

119 The rationally designed ligands exhibit a high photochemical

120 nce is presented that the performance of the rationally designed MALDI matrix 4-chloro-alpha-cyanocin

121 Yet rationally designed materials that exploit specific, dir

122 A new class of rationally designed mechanophores is developed for highl

123 h yield ( 75%) via efficient ring closing of rationally designed metallosupramolecular polymers.

124 The rationally designed MgB2/SN2 cooling system was first co

125 vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations

126 bling preorganized individual molecules into rationally designed molecular architectures via the bott

127 erization, and photophysical properties of a rationally designed multichromophoric tetracationic cycl

128 The rationally designed multifunctional soft electronic mate

129 which we then validate by a second round of rationally designed mutagenesis.

130 on activity; in each case, a small number of rationally designed mutations were sufficient to cause t

131 Rationally designed N, S co-doped graphitic sheets with

132 We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1

133 st-effective scalable manufacturing of those rationally designed nanophotonic structures remains a cr

134 manipulations, stress-tolerance assays, and rationally designed neuropeptide analogs, we demonstrate

135 Here, we report a rationally designed novel HIV-1 fusion inhibitor derived

136 The self-assembly of rationally designed NPCs into nanohelices is a promising

137 docrine signaling and illustrates the use of rationally designed peptide analogs as agents for disrup

138 In the present study, we develop a panel of rationally designed PPARdelta agonists.

139 his class of bnAbs is a favorable target for rationally designed preventative vaccine efforts.

140 ddress this challenge, we demonstrate that a rationally designed protein-DNA binding complex can be u

141 Rationally designed proteins and peptides could also be

142 Three rationally designed pyrrolobenzodiazepine (PBD) drug-lin

143 alkyl carboxylic acids respectively with two rationally designed reaction pathways.

144 bosome drafting by characterizing mRNAs with rationally designed ribosome binding rates, folding kine

145 conventional single-layer configuration, the rationally designed sandwich-structured polymer nanocomp

146 colorless and colored forms, observed for a rationally designed set of silyloxy-substituted diarylpy

147 In this study, we rationally designed several vaccine immunogens based on

148 Using rationally designed short peptide sequences, we determin

149 Here, we have rationally designed single-crystal core-shell-structured

150 f second- or third-generation inhibitors and rationally designed small molecule combinations are pote

151 We report rationally designed small molecules that target the DM1

152 Using this method, we synthesized rationally designed stereopure components of mipomersen,

153 Control is achieved via a rationally designed strand displacement circuit that res

154 ile potency gains were found with small, but rationally designed structural changes to P4.

155 These data may inform further refinement of rationally designed surveillance schedules.

156 ate the safety and efficiency of Anc80L65, a rationally designed synthetic vector, for transgene deli

157 With rationally designed telodendrimer architectures, we then

158 erogeneity in patient outcome and a need for rationally designed therapeutic strategies that target d

159 nscriptomics-based selection of patients for rationally designed therapy with immune checkpoint inhib

160 e a class of synthetic molecules that can be rationally designed to "read" specific DNA sequences.

161 ese results demonstrate that 5'pppRNA can be rationally designed to achieve a maximal RIG-I-mediated

162 ature, artificial composite materials can be rationally designed to achieve this anisotropic behavior

163 3, and dihydro-4-thiopyranone 13, which were rationally designed to boost the rate of enzyme inactiva

164 ery diverse smart fluorescent architectures, rationally designed to elicit a fluorescent signal only

165 nly as highly reactive intermediates, can be rationally designed to have adequate stability for organ

166 Variants of BChE were rationally designed to increase the enzyme's ability to

167 , GdDOTA-diBPEN, new structural targets were rationally designed to increase the rate of water exchan

168 Bumps that are rationally designed to integrate these mechanisms are ab

169 y for the examination of synthetic analogues rationally designed to not only overcome vancomycin resi

170 through the introduction of point mutations, rationally designed to optimize the shape and hydrophobi

171 Collections of DNA sequences can be rationally designed to self-assemble into predictable th

172 Inhibitor of Phosphatase (PIP) peptides were rationally designed to stimulate phosphorylation of intr

173 The nanosensors are rationally designed to target different areas of this re

174 High-quality SiNW arrays have been rationally designed toward their implementation as molec

175 Using this strategy, we rationally designed two thermosensor internal ribosome e

176 ries of stable metal-organic frameworks with rationally designed ultra-large mesoporous cages as sing

177 Here we show that they can be rationally designed using familiar cis-3WJ examples as a

178 mmunogenicity study using epitope-targeting, rationally designed vaccine constructs that induced an F

179 ssion luminogen (AIEgen), namely DPA-SCP, is rationally designed with alpha-cyanostilbene as a simple

180 ion dependence of the ligand response of the rationally designed, artificial theophylline riboswitch

181 The resulting rationally designed, conformationally stable template en

182 The conjugates were rationally designed, looking at drug loading and drug re

183 We report rationally designed, multi-target agents for myotonic dy

184 Here, we describe DPLG3, a rationally designed, noncovalent inhibitor of the immuno

185 atural materials, is an attractive route for rationally designed, sustainable manufacturing.

186 chemically active; if selected correctly and rationally designed, these organic molecules offer a pro

187 ge, with the hope that better devices can be rationally designed.

188 ors of the urotensin II receptor (UT) can be rationally designed.

189 ymmetric Diels-Alder (DA) reactions has been rationally designed.

190 estigates the antimicrobial activity of new, rationally-designed derivatives of a short alpha-helical

191 Ultimately, this rationally-designed fluorescent ligand can facilitate th

192 A rationally-designed library of ternary siRNA polyplexes

193 Here, we explored this relationship by rationally designing a variant form of Abeta1-42 (vAbeta

194 upport for this 'double-anchor' mechanism by rationally designing and experimentally testing a furthe

195 ug-crystal interactions and open avenues for rationally designing antimalarial compounds.

196 Thus, rationally designing arbitrary materials requires comple

197 re of the intermediate was then validated by rationally designing four mutational variants predicted

198 ential for elucidating animal behaviours and rationally designing gecko-inspired devices.

199 esults that shed light on new approaches for rationally designing ideal combination cancer therapies

200 scern fundamental molecular requirements for rationally designing porous molecular solids.

201 on the role of surface ligands in tuning and rationally designing properties of functional nanomateri

202 By rationally designing single-stranded DNA (ssDNA) donors

203 This work envisions a strategy for rationally designing stable cathodes for lithium-ion bat

204 ine (Poly A)-assisted fabrication method for rationally designing surface-enhanced resonance Raman sc

205 upercapacitors based on graphene and MnO2 by rationally designing the electrode microstructure and co

206 nsport in superlattices and the prospects of rationally designing thermal systems with tailored phono

207 We validate this structure by rationally designing two mutations, the first engineered

208 inetics/pharmacodynamics (PK/PD) analysis to rationally develop an anti-Wolbachia chemotherapy by lin

209 ears has provided the platform from which to rationally develop molecular targeted therapies for both

210 that an era of treatment approaches based on rationally developed drugs or therapeutic strategies has

211 The effective deployment of rationally developed therapies for diffuse large B cell

212 nt gaps in knowledge need to be addressed to rationally devise new therapies.

213 tion and treatment of obesity should be more rationally directed to the complex and often redundant m

214 These findings demonstrate the first rationally discovered molecule targeting specific neural

215 ence variation, which complicates efforts to rationally discriminate individual isolates.

216 In this study, a rationally driven strategy was implemented and applied t

217 rise in the application of this knowledge to rationally elicit desired T cell responses through vacci

218 ically improve the success with which we can rationally engineer central metabolism in plants.

219 sary to benchmark the algorithms required to rationally engineer highly efficient enzymes.

220 latory mechanism and offering the ability to rationally engineer operons with desired behaviors.

221 central metabolism is extremely difficult to rationally engineer.

222 thogens modulate their hosts is critical for rationally engineered disease resistance in agricultural

223 inning and self-healing properties employing rationally engineered polymer-nanoparticle (NP) interact

224 To test this possibility, we rationally engineered QUAD opsin by tryptophan substitut

225 second-generation recombinant vaccine can be rationally engineered to maximize levels of immunogenici

226 The recombinant GFP probe was rationally engineered to possess a His-tag and a substra

227 n of self-assembled moldable hydrogels using rationally engineered, biomimetic polymer-nanoparticle i

228 zymes has limited the repertoire that can be rationally engineered.

229 us to suggest an activity-based strategy for rationally engineering catalyst-improved photoelectrodes

230 hogenesis, but also provide a foundation for rationally engineering minimized dystrophins for DMD gen

231 To make this process more efficient, we rationally evolved tRNA(Pyl) to create tRNA(Pyl-opt) wit

232 ed the tools needed to target the microbiome rationally for the prevention and treatment of critical

233 ample, we establish that twin defects can be rationally generated by equilibrating nanoparticles of d

234 s with varying chemical contrast are used to rationally guide the assembly of block copolymers.

235 etinopathy that will further guide us toward rationally-guided new therapies: synergistic combination

236 he design of new materials and structures by rationally harnessing surface instabilities.

237 We exploited these epigenetic states to rationally identify two small molecules that effectively

238 ical functionalities have been carefully and rationally implanted into the coordination nanospace of

239 This study defines a strategy to rationally improve the immunogenicity of peptides and wi

240 xylates, the first reported RGGT inhibitors, rationally improve understanding of their structure-acti

241 ese studies are expected to pave the way for rationally improving the versatility of this flavoenzyme

242 medicinal compounds, however, our ability to rationally incorporate this functional group in modified

243 barriers, innovative design features can be rationally incorporated that will create a new generatio

244 the output of an object-tracking system that rationally infers different generative causes of motion

245 t requiring detailed structural knowledge to rationally introduce this potentially useful property in

246 t of applying the curved surface approach to rationally investigate the chemical activity of surfaces

247 the extent to which non-human animals behave rationally is unclear.

248 prostate cancer, the way is open to explore rationally its application as a biomarker to detect F77-

249 The ability to rationally manipulate the transcriptional states of cell

250 ecently developed, we report the rescue of a rationally modified recombinant MACV containing a single

251 he binding reaction coordinate are needed to rationally modulate the lifetime of the drug-target comp

252 By rationally modulating the ratio of NoDGAT2A:2C:2D transc

253 f 7.1 H2 wt % can be quickly achieved over a rationally optimized platinum catalyst with high electro

254 and kinetics were fully understood and then rationally optimized.

255 E layers on flexible fiber glass fabrics, by rationally optimizing the printing inks consisting of TE

256 individual variants that are either designed rationally or discovered through selection or screening.

257 orced in the face of disturbances, through a rationally predefined strategy of microbial resource man

258 ls kinetically; however, it was difficult to rationally predict and design nanoparticle shapes.

259 ng optimized nanoscale electrocatalysts with rationally predicted properties.

260 trimers can be limited by the difficulty of rationally predicting beneficial mutations, here we used

261 We present a strategy to rationally prepare CF3(-) transfer reagents at ambient t

262 natural amino acid l-methionine (1) has been rationally prepared.

263 ra of advances have provided a framework for rationally purifying, describing, and manipulating macro

264 mains limited, thus hindering our efforts to rationally re-engineer PKSs.

265 ritical in order to stratify patients and to rationally select combinations in the context of an expa

266 quantitative phase diagram is constructed to rationally select parameters for the new strategy.

267 creening workflow, and lead compounds can be rationally selected based on biological and/or chemical

268 FMT from a rationally selected donor reduced hospitalizations, impr

269 he readthrough-inducing drug geneticin of 11 rationally selected factor IX (FIX) nonsense mutations,

270 and minimal long-term systemic toxicity, (2) rationally selected functional moieties that interact to

271 ulation with an oncolytic virus expressing a rationally selected ligand can be an effective strategy

272 Attaching two pdDronpa domains at rationally selected locations in the kinase domain, we c

273 eration of the indigenous microbiota with 17 rationally selected strains of high butyrate-producing C

274 le cyanobacterial Sfp-type PPTases that were rationally selected.

275 pies to those that are now more targeted and rationally selected.

276 ire synthesis and provide new guidelines for rationally selecting catalysts, forming heterostructures

277 The system is then rebuilt by rationally selecting parts that implement the optimal ex

278 s between doses were longer than 4 weeks and rationally synchronized with other chemotherapy drugs to

279 block-poly(3,4-ethylenedioxythiophene)] were rationally synthesized and exploited as nanoreactors for

280 We report a cholesterol imaging method using rationally synthesized phenyl-diyne cholesterol (PhDY-Ch

281 It is thus highly desirable to rationally tailor the reaction interface to boost the ne

282 tion solar cell operation is achieved in the rationally-tailored (FAPbI3 )0.7 (CsSnI3 )0.3 -compositi

283 on compartments is fundamental to developing rationally targeted repair strategies.

284 EC development and its potential control by rationally targeted therapies.

285 tudies have found specific pathways could be rationally targeted; it might also be possible to take a

286 ng their (patho)/physiological roles and for rationally targeting them therapeutically.

287 n that available resources must be allocated rationally to maximise their effect.

288 fect key driver pathways and to combine them rationally to optimize their benefit.

289 n active self-organization should generalize rationally to other active 2D and three-dimensional (3D)

290 We demonstrate the ability to rationally tune the fluorescence and physical properties

291 Alterations to the diacid structure could rationally tune the physicochemical properties of the po

292 of TAT/CGC triplets in the switches, we can rationally tune their pH dependence over more than 5 pH

293 the pressure needed to open the pores-can be rationally tuned over a wide pressure range.

294 properties of the carbazole unit can thus be rationally tuned to improve catalytic activity.

295 of coarse-grained simulations as a tool for rationally tuning and optimizing RNA folding and functio

296 inspired us to improve catalyst stability by rationally tuning Re ligand structure and adding a ClOx(

297 h tailored thermoelasticity and fragility by rationally tuning the chemical composition of the alloy

298 es the manipulation of furfural reduction by rationally tuning the electrode potential, electrolyte p

299 Biomaterials are now designed rationally with controlled structure and dynamic functio

300 ity to design peptide-based nanotubes (PNTs) rationally with defined and mutable internal channels wo