ライフサイエンスコーパス: reaction intermediate

1 es through differential stabilization of the reaction intermediate.

2 nts that it is not an energetically feasible reaction intermediate.

3 lpha position followed by isomerization of a reaction intermediate.

4 ered nicks invariably at 6-bp spacing as the reaction intermediate.

5 ed tetraiodide radical anion (I4(*)(-)) as a reaction intermediate.

6 vironment of the [2Fe-2S](+) cluster in this reaction intermediate.

7 tance of protonated carbonic acid (PCA) as a reaction intermediate.

8 6-TG, suggesting that G(SO3) is an important reaction intermediate.

9 lly assigned the hyperfine interactions in a reaction intermediate.

10 site hydrogen bonds donated to the dienolate reaction intermediate.

11 eals the structure of the proposed thioester reaction intermediate.

12 ect scattering dynamics through a long-lived reaction intermediate.

13 similar to the measured pK(a) (10.0) of the reaction intermediate.

14 of a dizinc metallo-beta-lactamase (MbetaL) reaction intermediate.

15 he formation of the same, or a very similar, reaction intermediate.

16 d alpha-biliverdin, confirming its role as a reaction intermediate.

17 for stabilization of the nitrocefin-derived reaction intermediate.

18 negatively charged pentacoordinate phosphate reaction intermediate.

19 and catalysis and into the chirality of the reaction intermediate.

20 inetic method was applied in identifying the reaction intermediate.

21 forms a covalent protein-DNA linkage in the reaction intermediate.

22 lly provides the first view of an asymmetric reaction intermediate.

23 tion and without the formation of a covalent reaction intermediate.

24 n the active site, thus mimicking an achiral reaction intermediate.

25 2.1.0(2,4)]oct-8-ylidene is a foiled carbene reaction intermediate.

26 gh the identification of ketene (CH2CO) as a reaction intermediate.

27 appearing as a band shoulder) arising from a reaction intermediate.

28 e level, which revealed a long-lived (4.5-s) reaction intermediate.

29 e, generating a vinyl radical as a potential reaction intermediate.

30 (II)alamin rather than cob(I)alamin is a key reaction intermediate.

31 6F5 groups reduces the binding energy of all reaction intermediates.

32 information is not available for any of the reaction intermediates.

33 g carbannulation of in situ generated Blaise reaction intermediates.

34 with formation of squaramates as detectable reaction intermediates.

35 ves organogold complexes as precatalysts and reaction intermediates.

36 saturated 16- and 17-electron organometallic reaction intermediates.

37 into its reactions with commonly encountered reaction intermediates.

38 h Lewis acid catalyzed benzene alkylation by reaction intermediates.

39 or to elucidate the structures of the labile reaction intermediates.

40 powerful tool for the investigation of ionic reaction intermediates.

41 between D309 and the substrate to stabilize reaction intermediates.

42 fects on the cluster properties and possible reaction intermediates.

43 d and that gold carbenes are not involved as reaction intermediates.

44 tathione sulphinic acid, and GSSG are rather reaction intermediates.

45 ginine and NOHA oxidation reactions and trap reaction intermediates.

46 ce that uses positively charged reagents and reaction intermediates.

47 N-DBPs formation mechanisms and to identify reaction intermediates.

48 lectron density and frontier orbitals of key reaction intermediates.

49 hey meet minimal kinetic criteria to be true reaction intermediates.

50 n structure in controlling the reactivity of reaction intermediates.

51 C assay to identify and characterize sortase reaction intermediates.

52 m, which entails the characterization of the reaction intermediates.

53 characterized, isolated, or hypothesized as reaction intermediates.

54 active iron-nitrosyl adduct, a surrogate for reaction intermediates.

55 conversion of amino acids includes numerous reaction intermediates.

56 e O2 bond and then will proceed to over-bind reaction intermediates.

57 the dNTP, suggesting its role in stabilizing reaction intermediates.

58 nd formation among weakly adsorbed water and reaction intermediates.

59 ms that derives from characterization of key reaction intermediates.

60 due to difficulties in identifying distinct reaction intermediates.

61 rves as a template for identification of the reaction intermediates.

62 reactions in real time and identify unstable reaction intermediates.

63 rized as a result of this study, including a reaction intermediate, 2 Schiff bases, and 28 bis- or tr

64 ructure of CYP11A1 in complex with the first reaction intermediate, 22HC.

65 the substrate and is transformed to a second reaction intermediate, a C(4a)-FMN-hydroxy species.

66 proposed that these enzymes utilize a common reaction intermediate, a ferric hydroperoxide species, t

67 s been proposed to proceed through two novel reaction intermediates, a sulfinic phosphoryl ester and

68 Here, we report the structures of reaction intermediates accumulated at the reaction stead

69 the oxidation rate is enhanced and a unique reaction intermediate accumulates.

70 ructures of the reaction product and several reaction intermediates agree well with the relevant crys

71 The observation of individual reaction intermediates allows the measurement of an isot

72 For R = MeSO2 and CF3SO2, the corresponding reaction intermediates, amidoaryl Pd(IV) complexes were

73 nsity at the active site appropriate for the reaction intermediate aminoacrylate, which is consistent

74 RNA synthetase is through the aminoacylation reaction intermediate aminoacyl-AMP, thus making Ap4A sy

75 xamined the spectra in the presence of (a) a reaction intermediate analog known to affect the mobilit

76 acetyl-lysine 16 histone H4 substrate and a reaction intermediate analog, ADP-HPD.

77 oth apo PGG/GGG and in the form bound to the reaction-intermediate analog, 2-phosphoglycolate (2-PGA)

78 netic mechanism and substrate specificity, a reaction intermediate analogue of OSB-AMP, 5'-O-{N-[2-(t

79 ra of three metabolically stable phosphonate reaction intermediate analogues complexed to Saccharomyc

80 as been shown to stabilize a glycosyl cation reaction intermediate and a related tight binding inhibi

81 Although the first reaction intermediate and its decay are not affected by

82 the closure of the lid domain stabilizes the reaction intermediate and protects the reactive intermed

83 nserved cysteine residue of the protein to a reaction intermediate and the demonstration that THI4p i

84 ing to the unambiguous identification of one reaction intermediate and two reaction products.

85 vide structural evidence of several proposed reaction intermediates and allow for a more complete und

86 hanistic investigations provide insight into reaction intermediates and allow the development of a mi

87 -coupling reactions involving organometallic reaction intermediates and catalysis by Lewis acid sites

88 ontrol the timing of interaction between the reaction intermediates and catalytically essential amino

89 (HAMs) and haloacetic acids (HAAs) as major reaction intermediates and end products.

90 nic acid complexes represent a "snapshot" of reaction intermediates and implicate the cysteine-sulfen

91 xtract rate constants for the degradation of reaction intermediates and investigate the effects of va

92 s, as established by preparation of putative reaction intermediates and mass spectrometric analysis.

93 Insight into the nature of transient reaction intermediates and mechanistic pathways involved

94 Computational chemistry research into reaction intermediates and pathways may further aid in u

95 t via a hydrogen network that stabilizes the reaction intermediates and possibly shuttles protons.

96 , which reveal remarkable differences in the reaction intermediates and products expected in sea spra

97 Reaction intermediates and products were subsequently an

98 ted trends in activity and the nature of the reaction intermediates and products.

99 its suitable adsorption energies to some key reaction intermediates and reaction kinetics in the HER

100 tification of influential parameters and key reaction intermediates and reactions.

101 istry and biology, and immobilisation of the reaction intermediates and substrates, for example on mi

102 uted to both the stabilization of protonated reaction intermediates and the effect of constrictive bi

103 trosynthesis reaction in order to reveal the reaction intermediates and to shed light into the reacti

104 Furthermore, hypothetical reaction intermediates and transition structures were an

105 hese mechanisms requires characterization of reaction intermediates and, in particular, snapshots of

106 bon-halogen bond cleavage, identification of reaction intermediates, and elucidation of mechanisms).

107 The reaction mechanism, reaction intermediates, and final degradation products w

108 of benzynes and nonclassical carbocations as reaction intermediates, and he was instrumental in estab

109 Reagents, catalysts, reaction intermediates, and products involved in the oxy

110 uperoxo and ferric hydroperoxide species are reaction intermediates, and the lysine 48 plays a key ro

111 mplex of eIF2B with its substrate, eIF2-GDP, reaction intermediates, apo-eIF2 and eIF2-GTP, and produ

112 arge stabilization of the nitroxyl disulfide reaction intermediate are discussed.

113 n the human E1b heterotetramer harboring the reaction intermediate are identical.

114 alysts through direct observation of surface reaction intermediates are discussed.

115 enzymatic nucleophile and that the proposed reaction intermediates are not covalently bound to the e

116 The unusual spiroepoxide and vinylether reaction intermediates are precursors to the final bicyc

117 studies showed that K(+)- and Rb(+)-occluded reaction intermediates are similar.

118 ron biosynthetic reaction is determined, and reaction intermediates are structurally characterized.

119 action is also explored; E/Z geometry of the reaction intermediate as well as the presence of catalyt

120 Exhaustive structure characterization of all reaction intermediates as well as the precision polymers

121 By solving structures of reaction intermediates at near-atomic resolution, we hav

122 ethyl glutathione, an analogue of a proposed reaction intermediate, at a resolution of 1.3 A.

123 time that at certain concentrations of DBU, reaction intermediates become stabilized, an effect that

124 teract functionally, perhaps by shuttling of reaction intermediates between subunits.

125 onodisperse Au NPs to optimize the available reaction intermediate binding sites for efficient and se

126 ent structures of OOR in which two different reaction intermediate bound states have been trapped: th

127 ant (10(5 +/- 2.5) M(-1) s(-1)), forming the reaction intermediate (BrNO)(SO2)N(CH3)2(-).

128 ly a minor role in the formation of the enol reaction intermediate but a critical role in the protona

129 ulse-chase experiments to differentiate each reaction intermediate by a distinct kinetic fingerprint

130 al kinetic experiments to differentiate each reaction intermediate by a distinct time sequence of FRE

131 rmed from ionic Cu in solution via catalytic reaction intermediated by reduced Cu(I) species.

132 mited spectrophotometric characterization of reaction intermediates by masking the absorption of the

133 different conditions and identifying several reaction intermediates by NMR spectroscopy, mass spectro

134 However, not every reaction intermediate can be identified via a distinct F

135 ation of the way in which destabilization of reaction intermediates can lead to changes in substrate

136 les as the reactions proceed with changes in reaction intermediates, catalyst composition, and oxidat

137 (T)/6-31+G(d) level should be used for these reaction intermediates; CCSD(T)/6-31+G(d) and CCSD(T)/6-

138 the outcome of remodeling by influencing how reaction intermediates collapse into a particular set of

139 es is transiently dephosphorylated while the reaction intermediate completes a 180 degrees reorientat

140 es reported by Rebek et al. in which elusive reaction intermediates could be detected in the inner ca

141 ibility facilitates the reorientation of the reaction intermediate, coupling changes in structural dy

142 e) pathway is shut down, so that instead the reaction intermediate diverts through the alternative (h

143 tography have been used to study the surface reaction intermediates during the hydrogenation of three

144 Ethoxy and acetate are identified as two key reaction intermediates during the oxidation of ethanol.

145 n of the DNA can be used to reveal transient reaction intermediates during transcription initiation b

146 an important reagent ion as well as the key reaction intermediate for the formation of other reagent

147 within MoFeP and the population of discrete reaction intermediates for structural investigations.

148 SAXS measurements show that the reaction intermediate formed at 100 degrees C presents a

149 efin and that there are large amounts of the reaction intermediate formed during the reaction.

150 of the adjacent framework, and the specific reaction intermediate formed is very sensitive to this f

151 ce stopped-flow spectroscopy to characterize reaction intermediates formed under catalytic turnover c

152 MBPP to an (unreactive) E126A IspH mutant, a reaction intermediate forms that has a very similar EPR

153 e max) CAS and OASS form alpha-aminoacrylate reaction intermediates from Cys and O-acetylserine, resp

154 PS5, (2Z,6E)-FDP, an analogue of presumptive reaction intermediates from natural reaction cascade, wa

155 transition state is bimodal, leading to two reaction intermediates from one transition state, which

156 of local structure in homogeneous amorphous reaction intermediates from techniques such as PDF can b

157 A channel can allow for a reaction intermediate generated at one active site to be

158 voltammetry is proposed as a way to quantify reaction intermediates generated in the solution at smal

159 spectroscopy to detect and characterize HydG reaction intermediates generated with a set of (2)H, (13

160 d conformations of transition structures and reaction intermediates have been located.

161 It has been proposed to be a reaction intermediate in several chemical reactions and

162 tions of allene oxide synthesis and an ionic reaction intermediate in the AOS-catalyzed transformatio

163 it has been proposed that 5hmC may only be a reaction intermediate in the process of demethylation.

164 e consistent with a structural model for the reaction intermediate in which 9-mercaptodethiobiotin is

165 eeds with the participation of two different reaction intermediates in ActVA active site.

166 Here, we present evidence for sortase reaction intermediates in Corynebacterium diphtheriae.

167 the mass spectrometric detection of fleeting reaction intermediates in electrochemical reactions util

168 , we have characterized and assigned two key reaction intermediates in IspH catalysis.

169 nd mutagenesis are used to identify catalase reaction intermediates in M. tuberculosis KatG.

170 They have also been proposed as reaction intermediates in numerous catalytic processes (

171 ugh endoperoxides have been suggested as key reaction intermediates in several cases, the only well-c

172 e enzymatic reaction detected no accumulated reaction intermediates in solution, suggesting that rear

173 mutation facilitates the detection of closed reaction intermediates in the activation pathway of glyc

174 nal high-valent metal-oxygen species are key reaction intermediates in the catalytic cycle of both en

175 a result of prolonging the residence time of reaction intermediates in the hydrophilic microenvironme

176 onated and identified in vitro transcription reaction intermediates in the presence or absence of Rap

177 (2))(n)(-) ions are trapped entrance channel reaction intermediates in which the charge remains local

178 (DCMTases) catalyze cytosine methylation via reaction intermediates in which the DNA is drastically r

179 Rather, the enhanced presence of reaction intermediates in which Top2 is clamped around D

180 distribution of the free energy cost to form reaction intermediates, in analogy with metal-oxide cata

181 The detection by mass spectroscopy of the reaction intermediates, in conjunction with the results

182 too high, hence rendering the corresponding reaction intermediates inaccessible.

183 ave detected previously proposed short-lived reaction intermediates, including two nitrenoid complexe

184 Diffraction simulations indicate that the reaction intermediate involved on picosecond times may n

185 In an effort to generate more stable reaction intermediates involved in substrate oxidation b

186 oncognate DNA, we have characterized several reaction intermediates involving the WT enzyme.

187 electron source for the reaction and that a reaction intermediate is bound directly to the cluster.

188 The chemically modified reaction intermediate is consistent with currently propo

189 The cleavage reaction intermediate is exploited by cytotoxic agents,

190 echanism as Zn(II)-containing L1, in which a reaction intermediate is formed when using nitrocefin as

191 e lid, the enzyme's ability to stabilize the reaction intermediate is weakened, resulting in catalyti

192 ow procedure involving minimal processing of reaction intermediates is also reported.

193 d hydrogen peroxide without stabilization of reaction intermediates is consistent with the data prese

194 A reaction intermediate, Knoevenagel adduct 7, plays the m

195 ted to enhancement of the formation of a key reaction intermediate known as DNA networks.

196 he sulfide source, we were able to observe a reaction intermediate (lambda(max) = 473 nm), which we a

197 The formation of oxetane, the reaction intermediate leading to (6-4) adducts, occurs v

198 f a fluorescent analog (coumarin 183) of the reaction intermediate mimics the change in charge distri

199 odulating catalysis and implicates three new reaction intermediates; Nia-I, Nia-D, and Nia-SR(-).

200 tional findings suggest the existence of new reaction intermediates not covalently bound to TSase, wh

201 In addition, we proposed that the first reaction intermediate observed by pulse radiolysis is a

202 The two paramagnetic reaction intermediates observed correspond to the two in

203 rystallographic structures of a serine-bound reaction intermediate of 2 with SHV-1 (class A) and GC1

204 An EPR-silent di-heme reaction intermediate of MauG was trapped.

205 Furthermore, we provide evidence for the reaction intermediate of PopP2-mediated acetylation, an

206 an be attributed to the formation of the E.S reaction intermediate of the ATPase reaction.

207 otide-binding domains (NBDs) is an important reaction intermediate of the transport cycle.

208 we determined the crystal structures of two reaction intermediates of a marine bacterial Tmm (RnTmm)

209 anic-coated mercury sulfide nanoparticles as reaction intermediates of heterogeneous mineral precipit

210 s for the sequestration of potentially toxic reaction intermediates of melanin synthesis and depositi

211 Observation and structural studies of reaction intermediates of proteins are challenging becau

212 t any damage at room temperature, and of the reaction intermediates of PS II during O-O bond formatio

213 15)N HMBC NMR spectroscopy to resolve scarce reaction intermediates of the non-enzymatic discoipyrrol

214 try observed is due to the topologies of the reaction intermediates of the proposed two-step mechanis

215 synthesis and characterization of potential reaction intermediates offered a glimpse of the elementa

216 idene is most likely generated as one of the reaction intermediates on the basis of both mechanistic

217 cause it has not been possible to detect the reaction intermediates on the electrode surface experime

218 7-cyclooctatetraenyl radical accesses exotic reaction intermediates on the triplet surface, which can

219 eveloped methodology for studying metastable reaction intermediates prepared with a high-energy molec

220 osqualene synthase (CrtM) complexed with its reaction intermediate, presqualene diphosphate (PSPP), t

221 tivity is also promoted by the fact that the reaction intermediates produced from methanol decomposit

222 EPR/HYSCORE spectra of reaction intermediate, product, and inhibitor ligands bo

223 trate and covalent pre- and post-dehydration reaction intermediates provide snapshots of successive s

224 hrough (18)O labeling and the synthesis of a reaction intermediate provides evidence for an unusual u

225 ron-carbodicarbene complex was isolated as a reaction intermediate, providing mechanistic insight int

226 duct is proposed to correspond to a derailed reaction intermediate, providing unique evidence for the

227 The latter observation suggests that a reaction intermediate reacts with oxygen to initiate the

228 Abeta self-assembly, which involves multiple reaction intermediates related by nonlinear and intercon

229 protection rate can be optimized so that all reaction intermediates remain soluble, allowing cyclodeh

230 arbon and binder with discharge products and reaction intermediates, respectively.

231 Addition of p-anisidine to the reaction intermediate resulted in the formation of the c

232 Mutation of residues capable of stabilizing reaction intermediates resulted in large decreases in th

233 The reaction intermediates [Ru(DuPHOS)(2)] and [Ru(BPE)(2)]

234 er generated by C-O bond rupture) or both as reaction intermediate(s).

235 It is possible to trap the reaction intermediate selenenic acid when the resolving

236 However, the instability and reactivity of reaction intermediate, semiquinone, might require a cofa

237 st these mechanisms via chemical trapping of reaction intermediates, stopped-flow, and substrate hydr

238 natural substrate acetyl-CoA synthetase 2, a reaction intermediate structure trapped by a thioacetyl

239 besides the expected reaction products, the reaction intermediates such as the monopyrazolylborate i

240 ed geometric factors of the substrate-enzyme reaction intermediates, such that catalysis is limited b

241 The structures of reaction intermediates suggest a detailed mechanism of d

242 These results help clarify the nature of the reaction intermediate, supporting a direct interaction b

243 ton affinity between the active site and the reaction intermediate supports the possibility that a sh

244 till controversy surrounding the identity of reaction intermediate that catalyzes carbon-carbon sciss

245 nzyme did not stabilize a nitrocefin-derived reaction intermediate that had been previously detected.

246 s at pH 7.0-8.5, and represents a metastable reaction intermediate that is converted into manganite a

247 nt kinetic stabilization of a reductive half-reaction intermediate that is detectable with the mutant

248 e binding of half-protonated semiquinone - a reaction intermediate that is potentially formed during

249 vage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by

250 a variety of small thiols to compete for the reaction intermediate that precedes the hydride transfer

251 ept-1-ylidene is a markedly strained carbene reaction intermediate that was generated by high-vacuum

252 wo most recently proposed mechanisms involve reaction intermediates that are unusual in pyrimidine bi

253 c C-N coupling reaction and giving access to reaction intermediates that reveal details about each st

254 reactions in crystals, we have trapped hExo1 reaction intermediates that reveal structures of these s

255 a covalent inhibitor that mimics one of the reaction intermediates, there is an overall decrease in

256 strength between the metal ion and adsorbed reaction intermediates thereby maximizing oxygen-reducti

257 om the branching of an enzyme-ethylnitronate reaction intermediate through oxidative and nonoxidative

258 valent resolvase-DNA linkages in the natural reaction intermediate thus perform an essential DNA-teth

259 osphonate-based analogues of the tetrahedral reaction intermediate (TI) in a parallel study utilizing

260 The peptide forms a gem-diol tetrahedral reaction intermediate (TI) in the crystal structures.

261 g the cyclization of the bis-quinone methide reaction intermediate to yield (+)- or (-)-pinoresinol.

262 e active site and react with a deacetylation reaction intermediate to yield an ADP-ribosylated peptid

263 n of Lys(286) had an increase in exposure of reaction intermediates to a dynamic quencher.

264 e allowed the determination of structures of reaction intermediates to a resolution of 1.6 angstroms.

265 ared photodissociation spectroscopy of model reaction intermediates to applications of infrared multi

266 nases can proceed through the same principal reaction intermediates to catalyze the O2-dependent clea

267 dependent structures, each associated with a reaction intermediate; to establish the pathways and rat

268 ed a protein-substrate complex and a protein-reaction intermediate (transition state) complex on the

269 We then followed the reaction intermediate transitions as Holliday junctions

270 The neutral reaction intermediates undergo pinacolic rearrangements

271 tructure energy calculations of the involved reaction intermediates using ab initio theoretical metho

272 Analysis of reaction intermediates using mass spectrometry provides

273 calculations were performed on the possible reaction intermediates using the Gaussian 03 program at

274 A catalyst functions by stabilizing reaction intermediates, usually through surface adsorpti

275 bitor, nicotinamide, that reacts with a Sir2 reaction intermediate via a base-exchange reaction to re

276 The main reaction intermediate was found to be CO2(delta-), with

277 uring the reaction with H(2)O(2), a discrete reaction intermediate was observed, which is likely the

278 ze the accumulation of potentially hazardous reaction intermediates, we have also developed a continu

279 Several possible reaction intermediates were investigated, and the quater

280 Reaction intermediates were isolated, and possible pathw

281 riginate from CS2 and H2O, respectively, and reaction intermediates were observed by gas-phase and el

282 Cationic reaction intermediates were studied by means of NMR and

283 The distributions of reaction intermediates were the same for mutant and wild

284 corresponding nitroso oxides, which are the reaction intermediates, were investigated by flash photo

285 n novel autoxidation products, including two reaction intermediates, were isolated and identified usi

286 finity and residue protonation show that, in reaction intermediates where an acid is ionized in BR, a

287 ism involving chloramines and chloramides as reaction intermediates, where the initial chlorination i

288 zed by Srx, with glutathionylated Srx as the reaction intermediate, whereas glutaredoxin I was more f

289 it resembles the conformation of the acyclic reaction intermediate, which is observed here for the fi

290 tic reaction proceeds via the formation of a reaction intermediate, which is subsequently hydrolyzed

291 a thionitrate adduct to Cys-302 as the first reaction intermediate, which was also found by mass spec

292 istic picture that involves Ni(I) as the key reaction intermediates, which are generated via compropo

293 Based on the reaction intermediates, which can be trapped at low temp

294 uncovered distinct catalytic activities and reaction intermediates, which plausibly rationalized the

295 This is the first crystal structure of a reaction intermediate with a purine substrate that is hy

296 competent time upon formation of a transient reaction intermediate with the substrate imipenem.

297 k-field imaging, we structurally examine the reaction intermediates with 1 nm resolution.

298 ped a protocol to observe normally invisible reaction intermediates with a surface enhanced spectrosc

299 Bursting disassembly generates unstable reaction intermediates with lowered affinity for CapZ at

300 sions was studied by independently preparing reaction intermediates within model NCPs.