ライフサイエンスコーパス: reactivate

1 plicate, establish and maintain latency, and reactivate.

2 nt infections in neurons and to occasionally reactivate.

3 s for their ability to establish latency and reactivate.

4 The Xi is selectively reactivated.

5 ected cells are established, maintained, and reactivated.

6 me, after which the Ras/MAPK pathway becomes reactivated.

7 m regions enriched for SINEs are prone to be reactivated.

8 d, how they are maintained, and how they are reactivated.

9 The purified Mtb ClpB/DnaK system reactivated a heat-denatured model substrate, but the Dn

10 h loss of the Hippo tumor suppressor pathway reactivates a primary piRNA pathway in Drosophila somati

11 4 (Tbeta4) and myocardial infarction (MI) by reactivating a fetal gene programme to promote neovascul

12 ishment of aggressive, metastatic disease by reactivating a latent embryonic programme: epithelial-to

13 Reactivating a previously encoded memory is believed to

14 certain embryonic developmental programs are reactivated aberrantly in adult organs to drive repair a

15 hese compounds showed a promising ability to reactivate AChE inhibited by various types of CWA in vit

16 ce of an embryonic signaling pathway that is reactivated after AKI and involved in reducing injury an

17 latently infected CD4(+) T cells that become reactivated after discontinuation of antiretroviral ther

18 Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (

19 ng the development of antivirals and latency reactivating agents.

20 We show that a conformation-specific Fab can reactivate an IDH1 mutant associated with brain tumors.

21 ary infection (varicella), and the virus can reactivate and cause zoster after primary infection.

22 nt reservoirs of integrated HIV-1, which can reactivate and contribute to viral rebound following tre

23 to establish latency in ganglia and then to reactivate and move back to peripheral tissues for sprea

24 engue virus-specific immune memory cells are reactivated and large amounts of antibodies are produced

25 d memories return to their labile state when reactivated and need to be restabilized through reconsol

26 corresponding to one or more SePh groups are reactivated and sequenced by CID.

27 mphocytes is predisposed to become partially reactivated and to overexpress immunity-related genes, p

28 ppocampus can assist memory consolidation by reactivating and broadcasting experience-specific "index

29 Cysts will occasionally reactivate, and - depending on the host's immune status

30 rupt immunosuppression within the tumor, and reactivate antitumor immunity, but they have yet to live

31 C/C inhibition by MCC components, but cannot reactivate APC/C already bound to MCC.

32 ic transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve plurip

33 n inherited from Pleistocene fluvial systems reactivated as tidal channels during the post- Last Glac

34 controlled by HIF-1alpha and Arg starvation-reactivated ASS1 is associated with HIF-1alpha downregul

35 ence), we show here that different genes are reactivated at different stages, with more slowly reacti

36 We used isolated and reactivated axonemes [4] to investigate the relation bet

37 ely, novel dietary interventions designed to reactivate BAT could be possible.

38 ed formation of the BCL6 repression complex, reactivated BCL6 target genes, and mimicked the phenotyp

39 Sucrose supplementation reactivates both cell division and elongation in primary

40 In immunocompromised host, the virus can reactivate but rarely compromises kidney function except

41 at a down-regulated myostatin pathway can be reactivated by correcting the underlying gene defect.

42 These findings strongly suggest that GAD1 is reactivated by DNA methylation, which provided a model f

43 replication forks in Pten-null cells can be reactivated by ectopic Rad51 or PTEN, the latter facilit

44 operties of the adult mammalian heart can be reactivated by exposure to gradual systemic hypoxaemia,

45 The electrodes could, however, be reactivated by immobilizing Pt dendrimer-encapsulated na

46 periods, perpetuate disease and are rapidly reactivated by islet transplantation.

47 Unstable p53 was reactivated by PK11007 in some cancer cell lines, leadin

48 vation in NOK-Akata cells, cells that can be reactivated by R, but not Z.

49 During subsequent SWS, one sequence was reactivated by replaying the associated tones.

50 ection of macaque lungs by DeltasigH was not reactivated by simian immunodeficiency virus, despite hi

51 the surface of lithium, which is constantly reactivated by the catalyst, an unconventional catalyst

52 have an impaired immune system that could be reactivated by the immunomodulatory effects of lenalidom

53 of recovery, parts of the hand region become reactivated by touch on the hand or face.

54 etains the capacity to establish latency and reactivate, causing zoster.

55 ual KSHV episomes to stimuli within a single reactivating cell; those episomes that did respond to st

56 could provide a means by which to eliminate reactivated cells in the latent HIV reservoir.

57 nfected cells and subsequently eliminate the reactivated cells through immune-mediated killing.

58 nfected cells and subsequently eliminate the reactivated cells through immune-mediated killing.

59 +) individuals can efficiently eliminate the reactivated cells.

60 ular or pharmacologic inhibition of FLT3-ITD reactivated ceramide synthesis, selectively inducing mit

61 Antagomir inhibition of miR-223 reactivated CLDN8 and improved a number of signs associa

62 We developed a transplantation method to reactivate critical period plasticity in the adult visua

63 isual deprivation through dark exposure (DE) reactivates critical period plasticity in adults.

64 (CS)) only interferes with the memory of the reactivated CS while leaving other drug-paired CSs intac

65 s with human herpesvirus 6 reactivation also reactivated cytomegalovirus (70%).

66 his problem, herein we propose a strategy to reactivate dead sulfide species by reacting them with su

67 r-PBTC), which both increases activation and reactivates desensitized nAChRs.

68 place cells representing the shock zone were reactivated, despite the fact that the animals did not e

69 ain lesions, such as traumatic brain injury, reactivate developmental-like programs and increase p75

70 and directions for the treatment of cancers, reactivating developmental pathways for tissue regenerat

71 nd determine the extent that CDK activity is reactivated during acquired resistance are lacking.

72 tion that affect-related neural patterns are reactivated during later experience.

73 "engram") are recruited during learning and reactivated during memory retrieval.

74 of high-reward contexts were preferentially reactivated during post-learning rest, and the number of

75 yonic prostate developmental program that is reactivated during prostate cancer metastasis and is the

76 mparison with the social bias not externally reactivated during sleep.

77 d lipid biosynthesis is highly conserved and reactivated during the progression to CRPC, and increase

78 (namely, CT-ncRNAs) may be two mechanisms to reactivate EECTG gene expression.

79 splenocytes and peritoneal cells but did not reactivate efficiently ex vivo kLANA repressed the MHV68

80 roylanilide hydroxamine to neuroLSD1(KO)mice reactivates egr1 and c-fos transcription and restores th

81 ethylase gene that promotes reprogramming by reactivating endogenous pluripotency genes.

82 Our strategy of reactivating endogenous PP2A may be applicable to the tr

83 nt cells, PAKs phosphorylate CRAF and MEK to reactivate ERK.

84 Furthermore, they rationalize strategies to reactivate ERRgamma signaling as a generalized therapeut

85 ve impairment in Alzheimer's disease (AD) by reactivating expression of the developmental synapse rep

86 is necessary and sufficient to maintain the reactivated fear extinction engram.

87 findings of the current study indicate that reactivating features idiosyncratic to a particular expe

88 e molecular mechanisms by which pomalidomide reactivates fetal hemoglobin, reinforcing its potential

89 rategies for sickle cell anemia are aimed at reactivating fetal hemoglobin.

90 However, most reactivate following anti-TNFalpha discontinuation.

91 er was an indicator of how rapidly the virus reactivated following explant TG-induced reactivation.

92 (huNSG) results in viral latency that can be reactivated following G-CSF treatment.

93 that the mitotic recombination machinery is reactivated following prophase I exit to repair any pers

94 We demonstrate that CRISPR2 can be reactivated for genome defense in MDR strains.

95 show that these areas are also activated and reactivated for haptic object exploration and haptically

96 simplex virus (HSV) establishes latency and reactivates frequently, and breakthrough reactivation ca

97 Migrating infected cells reactivate from dormancy more than non-migrating cells a

98 achomatis strains for mutants that failed to reactivate from IFN-gamma-induced persistence.

99 Although the ability of gammaHV to reactivate from latency and re-enter the lytic phase is

100 Lifelong latency and the ability to reactivate from latency are crucial for virus transmissi

101 Latently infected calves consistently reactivate from latency following a single intravenous i

102 may be critical for the ability of BoHV-1 to reactivate from latency following stressful stimuli.

103 odons at the amino terminus of ORF2 does not reactivate from latency in calves.

104 odons at the amino terminus of ORF2 does not reactivate from latency or replicate efficiently in cert

105 ability to establish and, more specifically, reactivate from latency.

106 red for life, and the virus can periodically reactivate from latency.

107 ble to acutely replicate, enter latency, and reactivate from this latent state.

108 c antibodies can potentially eliminate cells reactivated from latency via Fc effector functions by re

109 epresentations of experience are transiently reactivated from memory, movement- and immobility-associ

110 matous aortitis, and it develops after virus reactivates from ganglia and spreads transaxonally to ar

111 To learn how virus maintains and reactivates from latency, studies are done in neurons ta

112 s (JC and BK viruses) become pathogenic when reactivating from latency.

113 On the other hand, expression of rapidly reactivated genes may be driven by transcription factors

114 ivated at different stages, with more slowly reactivated genes tending to be enriched in H3meK27.

115 ed to repeatedly and periodically deactivate/reactivate growing chains.

116 ations in cortex of area 3b representing the reactivated hand and normally activated face in adult sq

117 In addition, tracer injections in the reactivated hand region of area 3b labeled more neurons

118 harmless on SsoPox-W263I activity and could reactivate heat-inactivated enzyme.

119 ogenic potential of HHV-7 is unclear, it can reactivate HHV-6 from latency and thus contributes to se

120 representations related to the concurrently reactivated hippocampal representation, while inhibition

121 Finally, chronically reactivating hippocampal cells associated with a positiv

122 bitors (BETis), which act synergistically to reactivate HIV in latently infected cells.

123 elate, prostratin, bryostatin-1, and JQ1) to reactivate HIV latency in vitro, and examined their effe

124 nd activation, especially their potential to reactivate HIV latency.

125 "shock and kill" HIV-1 cure strategy aims to reactivate HIV-1 expression in latently infected cells a

126 e strategy, termed "shock and kill," aims to reactivate HIV-1 expression in latently infected cells a

127 stant isolates of Mycobacterium tuberculosis reactivate HIV-1 through modulation of intracellular E(G

128 vation, might be a candidate for effectively reactivating HIV latency as part of a therapeutic strate

129 ents were induced with alphaCD3/alphaCD28 to reactivate HIVex vivo Thus, priming CD4 T cells from ART

130 Neurons active during behavior reactivate in both structures during sleep, in conjuncti

131 ZV) establishes lifelong persistence and may reactivate in individuals with impaired immune function.

132 the level of latency in TG, and the time to reactivate in the mouse model.

133 pathogenesis is the ability to periodically reactivate in those neurons and be transported back to t

134 JC polyomavirus (JCPyV) is reactivated in approximately 20% of renal transplant rec

135 and laminar activation during behavior were reactivated in compressed form during post-experience sl

136 indefinitely in cell culture and can also be reactivated in differentiated cells via nuclear reprogra

137 to be completed soon after birth, and to be reactivated in later life only under pathological circum

138 In this way, apoptosis has been reactivated in malignant cells.

139 melanomas, suggesting these receptors are co-reactivated in melanoma to promote survival.

140 eport that TWIST1 and HOXA9 coexpression are reactivated in mouse and human primary prostate tumors a

141 active X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions.

142 ic differentiation during development and is reactivated in pancreatic cancer.

143 It is reactivated in response to injury and is reported to pla

144 escent at early larval stages, when they are reactivated in response to metabolic changes.

145 trinsic developmental growth programs can be reactivated in RGCs, neural activity can enhance RGC reg

146 or H3R26 methylation, HIV-1 transcription is reactivated in several HIV latency cell models, includin

147 ning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave

148 ced patterns of interareal coactivation were reactivated in the absence of stimulation for the visual

149 essed in adult life but has been shown to be reactivated in the context of proliferation and neoplasm

150 We discovered that, when reactivated in the presence of low ATP concentrations, a

151 mary restricted to germ cells and aberrantly reactivated in various cancers.

152 tion sequence-related dopamine signaling was reactivated in well-trained rats if they became disengag

153 BK polyomavirus (BKPyV) frequently reactivates in kidney transplant recipients during immun

154 ratively disaggregate protein aggregates and reactivate inactive proteins.

155 IL-1alpha enemas reactivated inflammation after DSS colitis recovery, ind

156 establishes and maintains latency and how it reactivates is poorly understood, largely due to the lac

157 it is now clear that every time a memory is reactivated it becomes momentarily labile-with implicati

158 omains shows that when an existing memory is reactivated, it becomes susceptible to modifications.

159 lts from simultaneously remethylated DNA and reactivated kinase cascades.

160 ronger tumorigenicity that was caused by the reactivated KIT kinase signaling and further CDH1 silenc

161 ion of PRDM1 was necessary and sufficient to reactivate KSHV by activating its RTA promoter.

162 Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinicall

163 ency and potential therapeutic approaches to reactivate latent infections in quiescent cells.

164 To reactivate latent virus and boost cell-mediated immune r

165 Small-molecule approaches to reactivate latent wild-type UCH activity of these mutant

166 e as an immunotherapeutic agent to eliminate reactivated latent cells and deplete the HIV-1 reservoir

167 e as an immunotherapeutic agent to eliminate reactivated latent cells and deplete the HIV-1 reservoir

168 reservoirs, new approaches for killing these reactivated latent HIV reservoir cells are urgently need

169 edge, this represents the first detection of reactivated latent HIV reservoirs from patients without

170 n of SMYD2 or its pharmacological inhibition reactivated latent HIV-1 in T cell lines and in primary

171 nt cellular cytotoxicity (ADCC) to eliminate reactivated latent HIV-1-infected cells is a strategy wh

172 zation of ADCC may facilitate elimination of reactivated latent HIV-1-infected cells to deplete the H

173 re insufficient to effectively eliminate the reactivated latent HIV-1-infected T cells.

174 l phenotyping of viral reservoirs, including reactivated latent reservoirs in clinical samples.

175 t inhibiting their recruitment paradoxically reactivates latent HIV-1 transcription.

176 tion into the potential of ADCC to eliminate reactivated latently infected cells is warranted.

177 (ART) and may not be sufficient to eliminate reactivated latently infected cells.

178 ishes latency in the sensory ganglia and can reactivate later in life to cause herpes zoster.

179 remain dormant in the nervous system and may reactivate later in life, leading to shingles or inflamm

180 orted LATS1 inactivation, and its inhibition reactivated LATS1, down-regulated Yap, suppressed prolif

181 nucleotide polymorphisms (SNPs) to identify reactivated loci.

182 alpha4 subunits were required for Br-BPTC to reactivate long term desensitized nAChRs.

183 ion of reconsolidation, the process by which reactivated memories become susceptible to modifications

184 Our data show that new/reactivated memories can be formed without protein synth

185 Reactivated memories can be modified during reconsolidat

186 Reinforcing reactivated memories did not strengthen the memory, but

187 that the effects of garcinol are specific to reactivated memories only, temporally constrained, cue-s

188 plasticity would therefore impair specific, reactivated memories.

189 Active (new and reactivated) memories are considered to be labile and se

190 hypothesis states that active (i.e., new and reactivated) memories are similarly labile and (re)estab

191 perience can be separated into independently reactivated memory representations.

192 ntly infected B cells that are stimulated to reactivate MHV68, RTA bound specifically to endogenous p

193 ults indicated that even when only partially reactivated, most of the expected connections of area 3b

194 e protein synthesis, suppress ER stress, and reactivate mTOR signaling.

195 elators called zinc metallochaperones (ZMCs) reactivate mutant p53 by restoring zinc binding to zinc-

196 xpectedly, depletion of KDM3A was capable of reactivating mutated p53 to induce the expression of pro

197 with AIDS is often presumed to be caused by reactivated Mycobacterium tuberculosis.

198 K/ERK activation neither impaired myelin nor reactivated myelination.

199 lable: during prospective evaluation, offers reactivate neural responses to outcomes that are unique

200 helial 3D sprouting assays can be rescued by reactivating Notch signaling by recombinant Jagged ligan

201 echinoid in the niche only is sufficient to reactivate NSCs.

202 ction in sensory or autonomic ganglia and to reactivate on physical, hormonal, or emotional stress.

203 electrocatalytic properties of the PtNPs are reactivated only if miRNA complementary to ssDNA is pres

204 y (2 cases); and (3) previously diagnosed OI reactivated or exacerbated by pregnancy (3 cases).

205 enes, such as tumor suppressor genes, and by reactivating other regions, such as repeated elements, i

206 The H80R mutation reactivates P187S by enhancing FAD binding affinity thro

207 e oncogene product MDMX therefore might help reactivate p53 and enhance the efficacy of DNA-damaging

208 suggest that inhibiting p53 aggregation can reactivate p53 pro-apoptotic function.

209 n vitro and in cells and ultimately does not reactivate p53.

210 reduction of the cognate methyltransferases reactivates p53 and promotes differentiation of the NTer

211 hydrophilic loop were found in 24.1% of HBV-reactivated patients (vs. 0% of chronic patients; P<0.00

212 Of HBV-reactivated patients, 51.7% were treated with rituximab,

213 ity due to CMV-specific clonal expansions in reactivating patients.

214 e as well as for detection of spatiotemporal reactivated patterns in SWS or quiet wakefulness.

215 to episodic memory by creating, storing, and reactivating patterns that are unique to each experience

216 strate how herbivores combine stabilized and reactivated plant toxins to defend themselves against a

217 ent systems by stabilizing, sequestering and reactivating plant toxins.

218 ficantly suppressed H3K27Me3 and effectively reactivated polycomb repressor complex 2 (PRC2)-silenced

219 enomes lacked the rearrangements typical for reactivating polyomaviruses.

220 sleep, the most recent rate distribution was reactivated preferentially.

221 Reactivating primitive reparative ability in the mature

222 via ICP4) for the transition from latency to reactivated productive infection.

223 GrpE, although they retained some ability to reactivate proteins with DnaJ and GrpE in the absence of

224 liminate these reservoirs are thus needed to reactivate proviral gene expression in latently infected

225 associated HIV-1 DNA levels, suggesting that reactivated proviruses proliferate.

226 Reactivating quiescent cells to proliferate is critical

227 o stasis, with limited species turnover, and reactivate rapidly and relatively uniformly when water b

228 Nf1 ablation in Fgfr1-deficient chondrocytes reactivated Ras-ERK1/2 signaling in hypertrophic chondro

229 iescent viral genomes retain the capacity to reactivate, resulting in viral DNA replication and relea

230 The virus frequently reactivates, resulting in virus shedding in the genital

231 -associated activity patterns are most often reactivated separately.

232 Angiogenesis in pathophysiological settings reactivates signaling pathways involved in developmental

233 d kill" strategy, where HIV transcription is reactivated so that antiretroviral therapy and the immun

234 mino acids as nutrients that synergistically reactivate somatic progenitor cells and upregulate expre

235 r function in spinal cord injury patients by reactivating spinal central pattern generators (CPGs) re

236 al components of hippocampal cell firing are reactivated spontaneously during sleep, supporting the c

237 re, we studied whether the rate component is reactivated spontaneously during sleep.

238 complex with ATPase RapA that is involved in reactivating stalled RNAPs.

239 nt embryos, these genes are even more slowly reactivated, suggesting that these genes carry an epigen

240 after transplant and can be physiologically reactivated, sustaining a stable hematopoietic output.

241 The RNA polymerase I promoters of reactivated T. porrifolius-origin rRNA genes showed redu

242 i-CTLA4 immunotherapy is highly effective at reactivating T-cell responses against melanoma, which is

243 Constitutively active MYC and reactivated telomerase often coexist in cancers.

244 T cells, suggesting that RLI was not able to reactivate terminally exhausted CD8(+) T cells.

245 Reactivating TERT and hence reconstituting telomerase is

246 blocking CD8 antibody and CD8(+) T cells in reactivated TG explants from mice latently infected with

247 Strategies to reactivate TGFbeta signaling in colorectal tumors might

248 latency in the TG, and took a longer time to reactivate than virulent strains of HSV-1.

249 ontribution to reprogramming in systems that reactivate the expression of pluripotency genes in the a

250 y of epigenetic changes that are required to reactivate the genes on the human Xi chromosome.

251 tion of Stat3-inhibitory strategies that may reactivate the immunosurveillance program.

252 t-induced photochemical reaction was able to reactivate the intein and trigger protein splicing.

253 is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be elim

254 escribes current pharmacologic approaches to reactivate the latent reservoir so that infected cells c

255 Previous clinical attempts to reactivate the latent reservoirs in an individual so tha

256 In contrast, cardiomyocytes failed to reactivate the neonatal proliferative network following

257 show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing t

258 homolog TTG1, complement ph3 in petunia, and reactivate the PH3 target gene PH5.

259 Reverted ESCs reactivate the silenced X chromosome and contribute to e

260 ectrical stimulation and exogenous drugs can reactivate the spinal CPGs and improve the motor functio

261 fusion of hypothalamic-releasing factors can reactivate the thyroid axis in patients with NTIS, induc

262 nalogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and

263 To identify compounds that could reactivate the Xi, here we screened approximately 367,00

264 ter methylation, but 5-azacytidine treatment reactivated the expression.

265 As a result, compound 9: (i) reactivated the p53 functionality; (ii) inhibited the vi

266 toring paracrine TGF-beta-Slug-EMT signaling reactivated the transdifferentiation of keratinocytes, r

267 e accumulation of granulosa cell tumors that reactivates the epithelial program from their progenitor

268 r, the typical reconsolidation paradigm that reactivates the memory through the presentation of the c

269 -mutant; p53-deficient), a single melanocyte reactivates the NCP state, revealing a fate change at me

270 ppocampal cortex, reflected how strongly one reactivates the temporal context of a retrieved memory,

271 Reactivating the cytotoxicity of CD8(+) T cells is of gr

272 emerged as bona fide clinical candidates for reactivating the tumor suppression function of p53 in ca

273 indicate that SOX9 expression drives PCa by reactivating the WNT/beta-catenin signaling that mediate

274 of tumor suppressor gene (TSG) promoters and reactivate their expression, such as SLIT2, ZNF382 and H

275 nts itself as an intervention opportunity to reactivate this tumor suppressor mechanism.

276 itol-3 (PI3) kinase pathway genes and can be reactivated through pharmacologic inhibition of casein k

277 cella, establish latency, and in rare cases, reactivate to cause herpes zoster (HZ).

278 y in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the lif

279 elong latent infections from which virus can reactivate to cause recurrent disease.

280 , cranial nerve, and enteric ganglia and can reactivate to cause zoster.

281 neurons, the virus can establish latency and reactivate to produce infectious virus.

282 Importantly, fission is reactivated to drive adenoma growth.

283 of the trigeminal ganglion, could be stress reactivated to produce infectious virus, following expla

284 pport a model in which stalled ribosomes are reactivated to rapidly generate Arc protein.

285 They are then reactivated to remain in the tissue and exert their effe

286 (chickenpox), becomes latent in ganglia, and reactivates to produce zoster and multiple other serious

287 er virus (VZV), simian varicella virus (SVV) reactivates to produce zoster.

288 ic metabotropic glutamate receptors (mGluRs) reactivates translation of these particular mRNAs to pro

289 d destruction, and checkpoint inhibitors can reactivate tumor-related immune responses.

290 red tumours from autophagy-deficient animals reactivate tumorous growth when transplanted into autoph

291 On degassing, the locked dislocations can be reactivated under cyclic loading to move in a stick-slip

292 ixed together to form a product that links a reactivating unit and a potential peripheral site ligand

293 s suppressed in malignant cells, but becomes reactivated upon HDACi.

294 when entering the nervous tissue and become reactivated upon local encounter of their cognate CNS an

295 w that a subset of human Xi genes is rapidly reactivated upon re-expression of the pluripotency netwo

296 nfection, silence viral replication, and can reactivate viral production upon specific treatments.

297 +) T cell frequency, with rapid clearance of reactivated virus.

298 essed in cultured Kras(G12D) tumor cells but reactivated when transplanted in vivo.

299 The drug memory was later reactivated with either i.v. or i.p. cocaine presentatio

300 ize their autoantigen and become efficiently reactivated within the immune-deprived nervous tissue.