ライフサイエンスコーパス: reactivation

1 a more active configuration, leading to KSHV reactivation.

2 her investigation because of the risk of HBV reactivation.

3 s, prevention, and management of hepatitis B reactivation.

4 sistance to BRAFi is mediated by ERK pathway reactivation.

5 nd no retransplantation or deaths due to HBV reactivation.

6 st are predicted to be capable of full viral reactivation.

7 protects peripheral nerve systems during HSV reactivation.

8 of the integrated viral genome resulting in reactivation.

9 reaction steps to go to completion prior to reactivation.

10 donor serology, were not associated with HBV reactivation.

11 ntifying participants at risk of further CMV reactivation.

12 nscription activator (RTA) can promote lytic reactivation.

13 cineurin inhibitor, robustly inhibited HIV-1 reactivation.

14 us-specific or domain-specific human Xi gene reactivation.

15 BI) are at significant risk for tuberculosis reactivation.

16 on by small molecules is promising for their reactivation.

17 ay revealed differences in the extent of HIV reactivation.

18 pendent memory consolidation and hippocampal reactivation.

19 it plays any role in regulating viral lytic reactivation.

20 ological malignancies remain at risk for HBV reactivation.

21 ductive infection, latency, and intermittent reactivation.

22 tiation and positively regulates lytic viral reactivation.

23 ption activator (RTA) and during spontaneous reactivation.

24 tation, without any mortality related to HBV reactivation.

25 cells play a critical role in preventing its reactivation.

26 d in increased cell death independent of HIV reactivation.

27 while receiving regimens associated with HCV reactivation.

28 onal effects of HER2 and HER3 inhibition and reactivation.

29 -orientated state may be most permissible to reactivation.

30 nal kinase (JNK), in VZV lytic infection and reactivation.

31 current ocular herpes following UV-B-induced reactivation.

32 Of the 23 patients with reactivation, 10 (43%) had hepatitis flare.

33 Following UV-B-induced HSV-1 reactivation, a significant increase in both the number

34 ib use increased the risk of cytomegalovirus reactivation (adjusted hazard ratio, 7.65; 95% confidenc

35 oter in colon carcinoma HCT116 cells and its reactivation after 7 days of treatment.

36 HBc-positive patients had a high rate of HBV reactivation after allogeneic HSCT, with determinants of

37 We report on a case of late HBV reactivation after DAA-based treatment of recurrent hepa

38 yrylcholinesterase mutants that undergo self-reactivation after inhibition by the organophosphorus ag

39 imethyl fumarate (DMF) in preventing disease reactivation after NTZ discontinuation.

40 ting HIV-1-infected individuals with latency reactivation agents to reduce their latent HIV-1 reservo

41 The extent of reactivation along the inactive X chromosome (Xi) and th

42 luation was to identify and characterize HBV reactivation among veterans treated with oral DAA therap

43 Although reactivation and accumulation of autoreactive CD4(+) T c

44 d pluripotent reprograming to study human Xi reactivation and allele-specific single nucleotide polym

45 ke and sleep SWRs are associated with memory reactivation and are important for learning, but their s

46 same trigeminal ganglion (TG) neuron during reactivation and cooperatively stimulated productive inf

47 imental regimen significantly altered immune reactivation and DNA repair pathways.

48 y, MDSC restoration relied upon MAPK pathway reactivation and downstream production of the myeloid at

49 obulin is highly effective in preventing HBV reactivation and graft loss from recurrent hepatitis B a

50 re of recently learned cues, seeks to induce reactivation and has been shown to benefit later memory

51 To assess for HBV reactivation and hepatitis we identified all hepatitis B

52 to explore associations between polyomavirus reactivation and immune responses to the self-antigens f

53 d similar histology associated with beta-HPV reactivation and nuclear p63 expression within the HF in

54 may underlie their inability to contain VZV reactivation and prevent the development of HZ.

55 pha promoter thereby contributing to ERalpha reactivation and re-sensitized chemotherapeutic efficacy

56 has been done to elucidate the mechanisms of reactivation and stop reactivation in its tracks.

57 es based on these parameters may prevent HBV reactivation and subsequent complications.

58 and the accuracy of detecting the timing of reactivation and the corresponding amount of infectious

59 o drive drug-seeking behavior after just one reactivation and treatment session.

60 Keratinocytes produced IL-17c during HSV-2 reactivation, and IL-17RE, an IL-17c-specific receptor,

61 In contrast, ATM facilitates replication, reactivation, and latency establishment of several gamma

62 method does not detect the initial timing of reactivation, and results obtained using this method are

63 monstrate a flow battery system based on the reactivation approach.

64 ytomegalovirus (HCMV) infection and periodic reactivation are generally well controlled by the HCMV-s

65 milarly, molecular switches which respond to reactivation are important.

66 tween viral and host functions that regulate reactivation are still incompletely understood.

67 e a valuable tool to study viral latency and reactivation as well as evaluate HCMV vaccines and immun

68 ce-based multiplex flow cytometric host cell reactivation assay that provides simultaneous readout of

69 Hepatitis B reactivation associated with immune-suppressive and biol

70 Here, we show that reactivation-based consolidation processes during sleep

71 We found coordinated reactivations between the hippocampus and the BLA during

72 The effect of polyomavirus reactivation (BK viremia or JC viruria) on antibodies to

73 sites in the HSV-1 genome during latency and reactivation, but its function has not been defined.

74 needed, particularly those aimed at reducing reactivation by enhancing immune responses.

75 Cs and that quiescent HSPCs are resistant to reactivation by histone deacetylase inhibitors or P-TEFb

76 or P-TEFb activation but are susceptible to reactivation by protein kinase C (PKC) agonists.

77 Following lytic reactivation by sodium butyrate, the levels of the appro

78 ation) at E1 by four PDC kinases (PDKs), and reactivation by two PDC phosphatases.

79 Reactivation can be induced by depletion of nerve growth

80 f the conditions under which targeted memory reactivation can benefit memory, and in doing so, suppor

81 ency in host sensory ganglia with occasional reactivation causing recurrent lytic infections.

82 Participants experiencing CMV reactivation compared with patients without CMV reactiva

83 Concurrent reactivations could be independently associated with mor

84 thway is regulated during the BoHV-1 latency-reactivation cycle (Y.

85 o mediate important steps during the latency-reactivation cycle because a mutant virus containing sto

86 Hepatitis B virus reactivation, defined as an abrupt increase in HBV repli

87 The primary endpoint was HBV reactivation, defined as detectable HBV DNA (>/=10 IU/mL

88 ersus-host disease, whereas CMV and BK virus reactivation did not predict clinical outcomes.

89 profound differences in hippocampal-cortical reactivation during awake and sleep SWRs, with key impli

90 ry, and in doing so, support the notion that reactivation during awake time periods improves memory s

91 predictors, and clinical significance of HCV reactivation during cancer treatment.

92 e retinotopic zones) and if these areas show reactivation during delayed actions in the dark toward h

93 neal B cells is required to facilitate viral reactivation during long-term infection.

94 ever, despite recent evidence for endogenous reactivation during post-encoding awake periods, less wo

95 and men the prediction that selective memory reactivation during sleep entails the reactivation of as

96 e results provide first evidence that memory reactivation during sleep might contribute to the negati

97 us-dependent memories is causally related to reactivation during sleep of previously encoded represen

98 onstrated that experimentally induced memory reactivation during sleep renders long-term memories of

99 id-specific ATM expression facilitates MHV68 reactivation during the establishment of viral latency.

100 Thus, hippocampal reactivations dynamically and abruptly switch between op

101 research in the field has sought to focus on reactivation, employing system-wide approaches and anima

102 ding on the host's immune status and site of reactivation - encephalitis or myositis can develop.

103 infectious virus produced in the ganglia per reactivation event.

104 shed by the same subjects following repeated reactivation events, suggesting strong selective pressur

105 culture and enabled detection of KLKI MHV68 reactivation ex vivo These data demonstrate that kLANA a

106 ies obtained during asymptomatic human HSV-2 reactivation exhibit a higher density of nerve fibers re

107 No patient with reactivation experienced liver failure or liver-related

108 ped fluorescence-based multiplexed host cell reactivation (FM-HCR) assays to measure DRC in multiple

109 We provide direct evidence for transient reactivation followed by downscaling of functional conne

110 Certain genes show more rapid reactivation for several generations following repressio

111 e infection, mouse mortality, or the rate of reactivation from explanted latently infected ganglia.

112 (ADCC) to eliminate infected cells following reactivation from HIV-1 latency.

113 s of SEC-P-TEFb also potently stimulated HSV reactivation from latency both in a sensory ganglia mode

114 Reactivation from latency is initiated by the synthetic

115 cent HSPCs are more resistant to spontaneous reactivation from latency than more differentiated HSPCs

116 s (KLF), including KLF15, are induced during reactivation from latency, and they stimulate certain vi

117 originating from either external exposure or reactivation from latency.

118 y escape from host defence mechanisms during reactivation from latency.

119 hed the virus in their body fluids following reactivation from latently infected sensory ganglia, the

120 TM expression was necessary to support viral reactivation from peritoneal cells during long-term infe

121 lls play a critical role in preventing HSV-1 reactivation from TG and subsequent virus shedding in te

122 drugs on steps of the HIV life cycle, or its reactivation from the latent state, thus facilitating th

123 genome to maintain sequence fidelity during reactivations from its latent state within an individual

124 fidelity of the viral genome during repeated reactivations from its latent state.

125 ctivation compared with patients without CMV reactivation had a reduced proportion of polyfunctional

126 emains to be explored whether and how memory reactivation has an impact on overlapping memories acqui

127 Hepatitis B virus (HBV) reactivation has been reported in HBV-HCV-coinfected pat

128 ublished recently on hepatitis B virus (HBV) reactivation (HBV-R) in patients with HBV-HCV co-infecti

129 ivity is associated with a decreased risk of reactivation; HBV screening in this patient population s

130 in the dark after a delay, these areas show "reactivation." Here, we show that these areas are also a

131 s, and tuning viral control of migration and reactivation improves strategies to eliminate latent HIV

132 Various assays are used for measuring reactivation in animal models, but there have been limit

133 Naf1 knockdown significantly enhanced viral reactivation in both latently HIV-1-infected Jurkat T ce

134 Recombinant IL-32gamma blocked HIV reactivation in CD4+ T-cells and was associated with an

135 monstrate that LMP1 promotes efficient lytic reactivation in EBV-infected epithelial cells by enhanci

136 and its potential roles in regulating lytic reactivation in epithelial cells are as yet unexplored.

137 ion factors KLF4 and BLIMP1 induce lytic EBV reactivation in epithelial cells by synergistically acti

138 Hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg)-nega

139 date the mechanisms of reactivation and stop reactivation in its tracks.

140 as ineffective in reducing the rate of HSV-1 reactivation in latently HSV-1-infected IFN-gamma-KO mic

141 ementation with oral glutamine reduced virus reactivation in latently HSV-1-infected mice and HSV-2-i

142 curately measure the frequency and timing of reactivation in latently infected neurons.

143 The role of cytomegalovirus (CMV) reactivation in mediating adverse clinical outcomes in n

144 ns toward more active forms and induced KSHV reactivation in naturally infected cells.

145 Hepatitis C virus (HCV) reactivation in patients receiving cancer treatment has

146 , in Medline and other sources that examined reactivation in patients with resolved HBV infection rec

147 surface antigen (anti-HBs) protects against reactivation in patients with resolved infection (hepati

148 Among secondary outcomes, CMV reactivation in plasma was significantly lower in the ga

149 Secondary outcomes were incidence of CMV reactivation in plasma, mechanical ventilation days, inc

150 rge reservoir of individuals at risk for HBV reactivation in the general population.

151 e significant differences in awake and sleep reactivation in the hippocampal-prefrontal network.

152 Memory reactivation in the model occurs in discrete oscillatory

153 Only 3 of the 9 patients identified with HBV reactivation in this cohort exhibited peak alanine amino

154 cute replication, latency establishment, and reactivation in vivo Despite structural similarities in

155 The population at risk for HBV reactivation includes those who either currently are inf

156 er allogeneic HSCT, with determinants of HBV reactivation including age >/=50 years and chronic graft

157 However, the reconsolidation view on a reactivation-induced plasticity is not supported.

158 Notch reactivation induces electrical changes, resulting in si

159 in the adult ventricle, injury-induced Notch reactivation initiates global transcriptional and epigen

160 Moreover, even upon effective post-reactivation interference, hindered performance may rapi

161 Awake reactivation is a higher-fidelity representation of beha

162 CMV reactivation is a major complication after allogeneic st

163 Hepatitis B virus reactivation is a newly identified safety concern in pat

164 theta- and gamma-oscillation coupling during reactivation is an electrophysiological signature of thi

165 Transposon reactivation is an inherent danger in cells that lose ep

166 nd memory-guided behavior, whereas sleep SWR reactivation is better suited to support integration of

167 Our findings suggest that awake reactivation is ideally suited to support initial memory

168 ation, retrieval and planning, whereas sleep reactivation may play a broader role in integrating memo

169 To determine whether Notch reactivation may stably alter atrial ion channel gene ex

170 was stronger during awake SWRs, and spatial reactivation, measured using both pairwise and ensemble

171 ly explored objects (and if so, whether this reactivation might be due to imagery).

172 has addressed whether awake targeted memory reactivation modulates memory.

173 eloped CMV disease (n = 8) compared with CMV reactivation (n = 26) or spontaneous viral control (n =

174 Reactivation occurred in 23 (23%) patients, including 18

175 HCV reactivation occurred in 23% of HCV-infected patients re

176 tients treated with DAAs had evidence of HBV reactivation occurring while on DAA treatment.

177 ow through direct tissue homogenization that reactivation occurs much earlier than can be detected by

178 In each mutant cell line, gene reactivation occurs to 6% genes along Xi(Xist) in a rec

179 sized that severe infections might be due to reactivation of a persistent infection, but this hypothe

180 e after primary EBV infection, or because of reactivation of a prior infection, and represents a lead

181 Delayed CD4 reconstitution predicted reactivation of adenovirus (hazard ratio [HR], 0.995; P

182 GLI1 nuclear translocation and promotes the reactivation of AKT post-inhibition of mTOR in PDAC cell

183 stress in prostate cancer (PCa), leading to reactivation of androgen receptor (AR) signaling in a ho

184 escape available hormonal treatments due to reactivation of androgen receptor (AR) signaling.

185 These results demonstrate the importance of reactivation of AR-regulated lipid biosynthetic pathways

186 to Arg starvation is often developed through reactivation of ASS1 expression.

187 memory reactivation during sleep entails the reactivation of associated events and that this may lead

188 y, thought to be mediated by the coordinated reactivation of behavioral experiences in hippocampal-co

189 ies production and oxidative DNA damage, and reactivation of cardiomyocyte mitosis.

190 o the central nervous system, and decreasing reactivation of chronic infection in severely immunocomp

191 omes in glomerular disease by repressing the reactivation of developmental pathways.

192 healed from L. guyanensis infection induced reactivation of disease pathology, overriding the protec

193 efore distinct from the previously described reactivation of end-point oxidized PTP1B, which requires

194 nduces compensatory mechanisms involving the reactivation of endocrine developmental processes that r

195 ifen (TAM), via at least in part, epigenetic reactivation of ERalpha expression in ERalpha-negative b

196 st cancer due at least in part to epigenetic reactivation of ERalpha, which in turn increases TAM-dep

197 rosine kinase-driven cancers associated with reactivation of ERK signaling in response to targeted in

198 Here, we identified reactivation of ERK signaling within hours following tre

199 Mechanistically, reactivation of functional hNIS expression could be attr

200 ry single-nucleotide variants and found that reactivation of gene expression on the X chromosome depe

201 Reactivation of hepatitis B virus (HBV) has been reporte

202 Reactivation of hippocampal place cell sequences during

203 the potential application of exosome in the reactivation of HIV latency, in combination its use as f

204 Reactivation of human cytomegalovirus (HCMV) in transpla

205 retinoblastomas reemerged, typically without reactivation of human MYCN or amplification of murine My

206 Finally, we observed increased lytic reactivation of KSHV from latently infected cells upon S

207 ing both the initiation of HSV infection and reactivation of latent genomes.

208 strategies for HIV-1 eradication require the reactivation of latent HIV-1 in resting CD4+ T cells (rC

209 rther support for the occurrence of repeated reactivation of latent HSV1 in the brain in AD pathogene

210 not determine whether TB disease was due to reactivation of latent infection or a result of recent t

211 er by transplantation-mediated transmission, reactivation of latent infections in an immunosuppressed

212 and provides a crucial role in the timing of reactivation of latent parasites towards proliferative s

213 iated immune response and reduce the rate of reactivation of latent virus infection.

214 by physiological stress is characteristic of reactivation of lifelong latent infections.

215 Studies have demonstrated that reactivation of MAPK signaling via CRAF overexpression a

216 Reactivation of mitochondrial bioenergetics is followed

217 However, reactivation of mitochondrial dynamics only occurs after

218 wn to maintain glutamatergic plasticity upon reactivation of modified circuits, and we therefore next

219 Thus, reactivation of mutant p53 using small molecules has bee

220 ter quiescence extrinsic factors control the reactivation of neuroblast proliferation in a fashion th

221 ed to as memory consolidation-depends on the reactivation of newly acquired memories during sleep.

222 The reactivation of plasticity by LRx is absent in Mmp9(-/-)

223 assay allows discrimination of drug-induced reactivation of productive HIV based on protein expressi

224 to RAF inhibitor monotherapy due to feedback reactivation of receptor tyrosine kinase signaling.

225 On reactivation of replication-competent provirus, HIV-1 en

226 Reactivation of representations corresponding to recent

227 timulated CD4+ T cells, effectively promoted reactivation of resting CD4+ T-cell, as indicated by an

228 Resurgence of the virus is due to the reactivation of T cells harboring latent integrated prov

229 of MDSCs promoted macrophage reprogramming, reactivation of T cells, apoptosis of Kras mutant neopla

230 lectron/ion transport and promote continuous reactivation of the active material during the charge/di

231 at was abrogated by phosphocreatine-mediated reactivation of the arginine-creatine pathway.

232 ross-frequency coupling in dorsal CA1 during reactivation of the avoidance response.

233 opose that prospective evaluation involves a reactivation of the neural response to the outcome.

234 llelic X-linked gene transcription indicates reactivation of the silenced X chromosome.

235 cacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired

236 aintained hypoglycemia at 1 h accompanied by reactivation of vagal tone.

237 s an ocular complication that can occur with reactivation of varicella-zoster virus (VZV).

238 HBV reactivation of varying severity, even in the setting of

239 ve to detect latent HIV reservoirs following reactivation of virus.

240 NK pathway resulted in a marked reduction in reactivation of VZV.

241 These results suggest that reactivation of Wnt/beta-catenin signaling in CNS vessel

242 Systemic reactivations of herpesviruses may occur in intensive ca

243 Concurrently, distinct hippocampal reactivations of movement- or immobility-associated repr

244 among the foreign-born - a declining rate of reactivation or a decrease in imported subclinical TB -

245 FR amplification, guided by adaptive pathway reactivation or by co-occurring genomic alterations, sho

246 lin G antibodies, raising 2 major questions: reactivation or reinfection?

247 endritic cell (DC) phenotypes promotes viral reactivation or renders them permissive for lytic infect

248 Targeted memory reactivation, or the re-exposure of recently learned cue

249 abolished this negative effect of adenovirus reactivation (OS, P = .67; NRM, P = .64).

250 onal variables with the potential to obscure reactivation outcomes.

251 Our results demonstrate that a US-reactivation paradigm may be preferable to traditional C

252 we used a novel unconditioned-stimulus (US) reactivation paradigm to interfere with the ability of m

253 paradigm may be preferable to traditional CS-reactivation paradigms for treating disorders that invol

254 Despite frequent herpes simplex virus (HSV) reactivation, peripheral nerve destruction and sensory a

255 Consistent with this notion, post-reactivation pharmacological protein synthesis blockage

256 deling was used to understand differences in reactivation potential between these compounds.

257 Adenovirus reactivation predicted lower OS (HR, 2.17; P = .0039) an

258 Here, we show that sleep memory reactivation promotes strengthening and weakening of ove

259 a significantly lower 2-year cumulative HBV reactivation rate (5.6% versus 65.0%, P = 0.004).

260 The mechanisms underlying Xp reactivation remain enigmatic.

261 competing risks, only concurrent CMV and EBV reactivations remained independently associated with inc

262 B-cell reactivation requires allergen re-exposure and IL-4 prod

263 thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells

264 ing cells and exhibit differential migration-reactivation responses to drugs.

265 their precursors without increasing the CMV reactivation risk after allogeneic SCT.

266 nts not receiving antiviral prophylaxis, the reactivation risk was 14% (95% confidence interval [CI]

267 Anti-HBs reduced reactivation risk with a pooled OR of 0.21 (95% CI 0.14-

268 ew tools, such as tests that better indicate reactivation risk, and even shorter latent tuberculosis

269 nalysis to determine if anti-HBs reduces HBV reactivation risk.

270 P was infused into IL-mPFC after four 10-min reactivation sessions, which resulted in reduced lever p

271 Systemic injection of garcinol 30 min after reactivation significantly impaired the reconsolidation

272 Pol III inhibition affects gene reactivation status along Xi(Xist), alters chromatin con

273 of nerve growth factor; other commonly used reactivation stimuli have no significant effect.IMPORTAN

274 pisomes were uniformly transcribed following reactivation stimuli.

275 Here the authors show a reactivation strategy by a reaction with cheap sulfur po

276 urrently used to assess viral replication in reactivation studies.

277 Our reactivation theory parsimoniously explains these result

278 tivation were more likely than those without reactivation to have prolonged lymphopenia (median, 95 v

279 Blocking IL-32 may facilitate HIV reactivation to improve shock and kill strategies.

280 those of de novo infection and directly link reactivation to neuronal stress response pathways.

281 There JQ1 reduces BRD4 recruitment during reactivation to preclude replication initiation.

282 s expected for a latent infection, including reactivation to produce newly infectious virus.

283 unprecedented LRA combination induces HIV-1 reactivation to unparalleled levels and avoids global T-

284 dre of genes that only become susceptible to reactivation upon induction of pluripotency.

285 ERK reactivation was also observed following inhibition of o

286 HBV reactivation was defined as a >1000 IU/mL increase in HB

287 Memory reactivation was detected rapidly ( approximately 200-80

288 Finally, awake CA1-PFC reactivation was enhanced most prominently during initia

289 well-established murine model in which HSV-1 reactivation was induced from latently infected TG by UV

290 Stronger awake reactivation was observed despite the absence of coordin

291 Similar results were seen when lytic reactivation was stimulated by the KSHV protein replicat

292 Notably, reactivation was stronger for the hippocampus-BLA correl

293 ed human neuronal model of viral latency and reactivation, we found that inhibition of the JNK pathwa

294 In univariate analysis, patients with reactivation were more likely than those without reactiv

295 EBV and HHV6 reactivations were predictors for the occurrence of graf

296 Periodically, latent virus undergoes reactivation whereby lytic genes are activated and viral

297 onocytes was not sufficient to trigger viral reactivation which is likely linked with the failure of

298 HBV reactivation with its potential consequences is particul

299 The absolute risks and odds ratio (OR) of reactivation with versus without anti-HBs were estimated

300 ion of noradrenergic signaling during memory reactivation would reverse the cocaine-evoked plasticity