ライフサイエンスコーパス: reactive site

1 ting chiral centres that are proximal to the reactive site.

2 hains of fibrin predominantly via its Gln103 reactive site.

3 gesting interactions between subsites in the reactive site.

4 aused by peptide backbone cleavage at its P1 reactive site.

5 H-terminal 39-46 residues, which include the reactive site.

6 g subsequent functionalization at the second reactive site.

7 roup 14 species with at least one additional reactive site.

8 es transforms directly into the [Cu(2)O](2+) reactive site.

9 ion of subsurface Ti interstitials to create reactive sites.

10 MOF, which allows "solution-like" access to reactive sites.

11 of bipyridine and methanol molecules at the reactive sites.

12 stidine residue separated the most and least reactive sites.

13 are cleaved by cognate proteinases at their reactive sites.

14 n map of solvent accessibility at individual reactive sites.

15 may thus alter metal uptake by blocking key reactive sites.

16 uggested that BP180 may harbor additional CP-reactive sites.

17 t of the clay mineral layer structure to the reactive sites.

18 y or bulky substituents to sterically shield reactive sites.

19 including structures with amine moieties as reactive sites.

20 enzymes based on the amino acids in cleaved reactive sites.

21 ultiple heterocycles, functional groups, and reactive sites.

22 s fluorine mineralization through functional reactive sites.

23 lative levels of steric hindrance at the two reactive sites.

24 esence of a pocket surrounding the metal ion reactive sites.

25 based approach considering hydrogen atoms at reactive sites.

26 mineral substrates possessing only external reactive sites.

27 aterials which will strongly differ in their reactive sites.

28 sual connectivity that may juxtapose the two reactive sites.

29 gate two different concentrations of surface reactive sites.

30 on based on a symmetric scaffold with two NO-reactive sites.

31 orinating species, shielding other potential reactive sites.

32 henomenon of induced heterogeneity of carbon reactive sites.

33 the cage at genetically introduced cysteine reactive sites.

34 eved to be a fibrin-cross-linking (or FXIIIa-reactive) site.

35 The additional reactive site accounts for a large portion of the discre

36 Modifications of the reactive sites afford multifunctional polymers with tuna

37 luded the distance and angle between the two reactive sites (aldehyde or amine functional groups) and

38 d mutagenesis of the predicted P1 inhibitory reactive site amino acid confirmed the role of Met(26) i

39 racil show that the mispair is both a highly reactive site and a barrier to radical cation hopping.

40 e away from the cleavage point, exposing the reactive site and buckling the DNAzyme catalytic core.

41 full nanometer, and the distance between the reactive site and the pro-stereogenic element is nearly

42 range 100ng to 1microg due to the increased reactive sites and distance.

43 rk allows for the spatial control of pendant reactive sites and dramatically increases the stability

44 n of SO2 at the water surface can affect the reactive sites and electrophilicity of SO2.

45 Fukui function analysis identified reactive sites and evaluated the chemical reactivity of

46 omponents of COFs including building blocks, reactive sites and functional groups with the aim of fin

47 The prediction of T-cell receptor-reactive sites and major histocompatibility complex clas

48 Identifying reactive sites and measuring their activities is crucial

49 erstand the role of the local arrangement of reactive sites and surface topography in the surface evo

50 le sizes will impact the number of available reactive sites and the reactivity of newly formed partic

51 ve the acid gas distributions away from more reactive sites and thus allow enhanced kinetic stability

52 significance of nonthermal processes at the reactive site, and the efficient photo-induced electron

53 st that an increase of the number of surface reactive sites, and possibly higher ozone uptake coeffic

54 hat altering the heterocycle or blocking the reactive site are two of the more effective strategies f

55 Furthermore, multiple reactive sites are activated in a sequential manner at t

56 tant form, which had Ala substituted for the reactive-site Arg364.

57 m Manduca sexta, whereas Egf1.0(R51A), whose reactive-site arginine was replaced with an alanine, had

58 aved human PCI and mouse PCI (mPCI) at their reactive sites as well as at sites close to their N term

59 This glycoprotein with a predicted reactive site at Lys(367)-His(368) is not able to inhibi

60 groups and the kinetic blocking of the most reactive sites at the bay region.

61 the protonated cap at the small rim and the reactive sites at the large rim.

62 levels of nanosecond-scale motions in CI2's reactive site binding loop as the L68 side chain was pro

63 8) bond exhibits properties analogous to the reactive site bond of canonical trypsin inhibitors and s

64 by cleavage of the Lys(368)-Thr(369) (P2-P1) reactive site bond with a stoichiometry of inhibition of

65 n cleaves selectively at the Arg(15)-Ala(16) reactive site bond, with kinetic constants approaching t

66 ate-like fashion and are cleaved at a single reactive site bond.

67 lylic oxidations of substrates with the same reactive site but different molecular size (cyclohexene

68 diphenylcarbene carbenes and substitution of reactive sites by bulky protective groups serves to stab

69 Our studies show that the two reactive sites can communicate with each other on the su

70 of each protein that becomes disordered upon reactive site cleavage (to OMIPF3* and OMTKY3*).

71 the "intact" (uncleaved, I) and "modified" (reactive site cleaved, I*) forms of the inhibitor.

72 c probes but cannot discern which chemically reactive sites contribute to protein function and should

73 dy demonstrates that MNEI has two functional reactive sites corresponding to the predicted P(1) and P

74 would be expanded by orders of magnitude if reactive sites could be probed with fragments rather tha

75 To eliminate a chemically reactive site, Cys58 was replaced by a seryl residue wit

76 tering materials as a function of controlled reactive site densities.

77 step densities, treated as equivalent to the reactive site density, as a function of aqueous calcium-

78 a key parameter for macroscopic models, the reactive site density, is poorly constrained.

79 vity associated with lengthening the Glu-342-reactive site distance by a single residue and the enhan

80 dence on particle size, particle type (i.e., reactive sites distributed within the particle body or c

81 ts that optimize juxtaposition of the proper reactive sites during splicing.

82 result in completely opposite photogenerated reactive sites (e(-) and h(+)) and divergent energy flow

83 analysis of reaction products identified two reactive sites, each with a different specificity.

84 The T98L mutation, peripheral to the NTIMP1 reactive site, enhances binding by increasing DeltaSsolv

85 or was not affected, suggests that a similar reactive site exists in the ligand-binding domains of th

86 We show that binding of CH3Hg to such reactive sites facilitates the formation of (CH3)2Hg by

87 riptors are amenable for delineating salient reactive site features to predict reactivity in other ch

88 rdinated surface sites (Q(1)) as the primary reactive site for hydrolysis and precipitation.

89 es that the spiro-ketal group of IPAs is the reactive site for the acid-catalyzed hydrolytic transfor

90 sed to introduce single cysteine residues as reactive sites for adduct formation within each of the t

91 iol, or alkyne) onto the sn-2 chain provides reactive sites for bio-orthogonal conjugation of cargo w

92 mportant insights into the radiation-induced reactive sites for corrosion and catalysis.

93 surficial Sb-SnO2 islands also serve as the reactive sites for free radical generation.

94 e isophthalate pillars of the prisms provide reactive sites for post-self-asssembly modifications.

95 ribenzimidazole (HATBim), respectively, with reactive sites for postfunctionalization.

96 Iron-sulfur clusters are emerging as reactive sites for the reduction of small-molecule subst

97 hat this inhibitor may have evolved separate reactive sites for the specific regulation of different

98 slow Co oxidation by interlayer Mn(III) and reactive sites formed upon removal of interlayer Mn(III)

99 d active rat SLPI, which shares the protease-reactive site found in human SLPI.

100 e metal-carbon pi bond provides a chemically reactive site from which a conjugated molecular wire can

101 ecular reactions in the presence of multiple reactive sites has been a long-standing challenge in the

102 complex formed between the two fragments of reactive-site-hydrolyzed chymotrypsin inhibitor-2 from b

103 The reactive site identified by these studies is a structura

104 ubstitution for each residue within these RF-reactive sites identified R48, W51, E55, Y107, R108, W14

105 e bifunctional analog, CDDO-Im, has a second reactive site (imidazolide) and can covalently bind to a

106 icating that acivicin binds in the glutamine reactive site in a specific conformation.

107 The most reactive site in subunit B14 was Tyr122, while the most

108 he covalent reaction at a surface-accessible reactive site in which the required surrounding microenv

109 organic building blocks that offer multiple reactive sites in a polyhedral geometry.

110 ted force is used to control the exposure of reactive sites in a single polyprotein substrate compose

111 ased radicals at each of the three potential reactive sites in an allene substrate are described.

112 tered in the environment react directly with reactive sites in biological macromolecules.

113 ver, it has proven difficult to identify the reactive sites in natural HA substrates.

114 ration of multiple (2-4) chemically distinct reactive sites in the polymer chain.

115 Direct observation of multiple reactive sites in the zeolite HZSM-5, a member of the MF

116 red platinum binding sites compete with less reactive sites in these oligonucleotides.

117 To identify transglutaminase-reactive sites in WT-alpha(2)AP or Q2A-alpha(2)AP, each

118 Reactive sites, in contrast, are generally situated such

119 ely at the indole C3 position over the other reactive sites (indole N and C2 and pyrrole C2 positions

120 improvement of these processes over a single reactive site is challenging due to the linear scaling r

121 One feature of many exposed reactive sites is a wide DNA minor groove, which allows

122 The increasing number of reactive sites is probably related to the fact that orga

123 s the effect on inhibition of relocating the reactive site (Leu-358) of the serpin alpha(1)-antichymo

124 e protease: (i) a unique sequence within the reactive site loop (P(1))Asp(48)-(P(1'))Pro(49) in Ad5-1

125 on by P35 is correlated with cleavage of its reactive site loop (RSL) and formation of a stable P35.c

126 Reactive site loop (RSL) cleavage analysis showed that S

127 Homology of the reactive site loop (RSL) domain of endopin 2, notably at

128 ism of inhibition by SCCA1 revealed that the reactive site loop (RSL) is important for cysteine prote

129 n/ovalbumin chimeric proteins and the maspin reactive site loop (RSL) peptide to characterize the rol

130 sequence of the serpin endopin 2 predicts a reactive site loop (RSL) region that possesses high homo

131 The large size of the serpin reactive site loop (RSL) suggests that the role of the R

132 serine proteinase inhibitors have a flexible reactive site loop (RSL) that can convert from the activ

133 Although serpins employ a mobile reactive site loop (RSL) to bait and trap their target s

134 ubstitution of maspin p1' site Arg340 in the reactive site loop (RSL) with alanine not only abolished

135 ognition sequence within a highly protruding reactive site loop (RSL), which gets cleaved by a target

136 cated within the serpin scaffold but not the reactive site loop (RSL).

137 nalyze the conformational changes of the P35 reactive site loop after caspase cleavage.

138 vage between the Gly and Ser residues of the reactive site loop and detection of a stable SCCA1-cathe

139 otion of a highly mobile and flexible serpin reactive site loop and suggesting that this inhibitor ma

140 ain Asp at the P1 position within the serpin reactive site loop and yet are only 35% identical overal

141 Distortion or destabilization of this reactive site loop by site-directed mutagenesis converte

142 ns two adjacent methionine residues near the reactive site loop cleaved by thrombin (Met314 and Met31

143 Native antithrombin (AT) has an inactive reactive site loop conformation unless it is activated b

144 s and/or the backbone carbonyls of the PAI-1 reactive site loop could restrict the reaction.

145 The determined reactive site loop domain of hippocampus ACT will allow

146 evealed the selectivity of the alpha1-PDX/hf reactive site loop for furin (Ki, 600 pM) but not for ot

147 d eglin c, Arg-42-Arg-45-eglin, in which the reactive site loop had been optimized for subtilisin-rel

148 These results suggest that a longer reactive site loop in AT is responsible for its inactive

149 oded "R(1)-eglin", having Arg at P(1) in the reactive site loop in place of Leu(45).

150 tor of furin identified that is not a serpin reactive site loop mutant, either naturally occurring or

151 al peptide library based on the anti-tryptic reactive site loop of a Bowman-Birk inhibitor (BBI).

152 ion sequences within the P6-P1 region of the reactive site loop of alpha(1)-antitrypsin were construc

153 Relative to alpha(1)-antitrypsin, the reactive site loop of AT has three additional residues,

154 To determine whether a longer reactive site loop of AT is responsible for loop preinse

155 heparin-induced conformational change in the reactive site loop of AT, the template effect of heparin

156 rt protein beta-sheet segment that forms the reactive site loop of Bowman-Birk inhibitors.

157 ture of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical

158 e nearly identical in primary structure, the reactive site loop of each inhibitor suggests that they

159 ar linkages result from the insertion of the reactive site loop of one serpin molecule into the middl

160 tations are predicted to lead to loss of the reactive site loop of SERPINB8, which is crucial for for

161 einsertion of two N-terminal residues of the reactive site loop of the serpin into the A-beta-sheet o

162 n which the P2 or the P3-P3' residues of the reactive site loop of the serpin were replaced with the

163 e cleavage by Arg-specific gingipains to the reactive site loop of the SPINK6 inhibitor.

164 ory properties are due to (a) Leu(15) in the reactive site loop P1 position that sits at the water-ex

165 consistent with a new model wherein the P35 reactive site loop participates in a unique multi-step m

166 ctPA) specifically interacts with the maspin reactive site loop peptide and forms a stable complex wi

167 Mutations in the alpha-helix of the reactive site loop preceding the cleavage site abrogate

168 us to determine whether cleavage within the reactive site loop region (RSL) of alpha1-proteinase inh

169 unique, because it involves an unusual HCII-reactive site loop sequence of Leu444-Ser445, requires t

170 eversed by a polyclonal antibody against the reactive site loop sequence of maspin.

171 ese data suggest that, contingent upon their reactive site loop sequences, mammalian serpins, in gene

172 his inhibitor, M. sexta serpin-3, contains a reactive site loop strikingly similar to the proteolytic

173 an arginine at the P1 position of trespin's reactive site loop suggests that trespin inhibits trypsi

174 propose a structural model of the alpha1-PDX-reactive site loop that explains the high degree of enzy

175 icate that the hippocampus ACT possesses the reactive site loop that is characteristic of serpins, wi

176 ovement in the carboxyl-terminal side of the reactive site loop that swings down and forms a new beta

177 Endopin 1 contains a unique reactive site loop with Arg as the predicted P1 residue,

178 on signal, a target sequence for SPCs in the reactive site loop, and the in vitro inhibitory activity

179 teractions can alter the conformation of the reactive site loop, converting a permanent inhibitor int

180 mal sequence for recognition by furin in its reactive site loop, was tested for its ability to inhibi

181 nds of contacts exist in such complexes: (i) reactive site loop-active site contacts and (ii) interac

182 es a protein-protein interaction besides the reactive site loop-active site interaction characteristi

183 rences were found to be in the region of the reactive site loop.

184 replacement of specific residues within the reactive site loop.

185 is stabilized following cleavage within its reactive site loop.

186 -terminal 39-46 residues, which includes the reactive site loop.

187 cies arise by cleavage of CAP at or near the reactive site loop.

188 , which occurred through cleavage within the reactive site loop.

189 pin28 encode a variable region including the reactive site loop.

190 SPI-1 reactive-site loop (RSL) mutations of the critical P1 an

191 Arg50 to the conformational stability of the reactive-site loop in CMTI-V.

192 ascade, the sequence of the protease-binding reactive-site loop of antithrombin has evolved such that

193 We substituted residues of the reactive-site loop of antithrombin into alpha(1)-antitry

194 was constructed based on the sequence of the reactive-site loop of Bowman-Birk inhibitor, a proteinas

195 Cooperative effects among residues of the reactive-site loop thus emerged as critical for restrict

196 interactions between the alpha-helix and the reactive-site loop, and leads to more open spacing betwe

197 conformation via hydrogen bonding within the reactive-site loop.

198 ition that require caspase cleavage of their reactive site loops (RSL) and chemical contributions of

199 eins are 92% identical, differences in their reactive site loops suggest that they inhibit different

200 wever, Spn4.1 and neuroserpin have divergent reactive site loops, with Spn4.1 showing a generic recog

201 ar to encode full-length serpins with intact reactive site loops.

202 Maspin derivatives mutated in the serpin reactive site lost their ability to inhibit the migratio

203 tem with tunable thermal response, end-group reactive sites, low toxicity, and controlled main-chain

204 ution structure and internal dynamics of the reactive-site (Lys44-Asp45 peptide bond) hydrolyzed form

205 protease attack at many sites, including the reactive-site (Lys44-Asp45 peptide bond), with the R50 m

206 e cleaved by subtilisin primarily at the CI2 reactive-site Met-59-Glu-60 bond, revealing that the seq

207 anges in the vicinity of site 1583, that the reactive site most likely faces away from the pore, and

208 ion of complexes containing thrombin and the reactive site mutant HCII(L444R) to yield active thrombi

209 sidues are the reactive centers of three NEM-reactive sites (NRS1-3).

210 The orientation of the electric field at the reactive site of [B12 Cl11 ](-) results in an energy bar

211 a machine learning model able to predict the reactive site of an electrophilic aromatic substitution

212 The reactive site of B-alkyl-substituted NHC-boranes switche

213 Determination of the reactive site of MNEI by N-terminal sequencing and mass

214 ation of an unnatural coumarin-lysine at the reactive site of SpyCatcher003.

215 These results suggest that the reactive site of the platelet receptor for type I collag

216 (4)(2-)) complexed at different edge surface reactive sites of a cis-vacant montmorillonite layer usi

217 e functional group localization found in the reactive sites of enzymes.

218 the antibody epitope(s) but lacks the T-cell reactive sites of full-length Abeta1-42.

219 inding of AIIt to the membrane protected the reactive sites of GSNO on AIIt.

220 n the spacer part connecting recognition and reactive sites of the maleimide component was applied by

221 The reactive sites of the nucleophiles or the nature of the

222 togenerated, valence band holes on different reactive sites of the oxide surface.

223 nd whereby the proximal distance between the reactive sites of the thioester intermediate (the N-term

224 ystem, we have titrated the transglutaminase-reactive sites of vimentin and, by sequencing the dansyl

225 high levels of IgG Abs against the major IgE-reactive site on Bet v 1 and related allergens.

226 region, however, there is a remarkably hyper-reactive site on each strand.

227 cell viability by obstructing monochloramine reactive sites on bacterial cells, protein EPS hindered

228 BCD has 21 reactive sites on each of its molecules.

229 nts; it reports the solvent accessibility of reactive sites on macromolecules with as fine as a singl

230 tions that broadly neutralizing epitopes and reactive sites on other structural elements are more exp

231 al approaches for predicting the location of reactive sites on PAHs (i.e., the carbon where atmospher

232 model, in which the proportion of accessible reactive sites on primary particles as well as the aggre

233 nt, can be a useful approach to the study of reactive sites on proteins.

234 and photocatalytic properties of the surface reactive sites on single Au-CdS hybrid nanocatalysts.

235 that the rate of reaction of this fuel with reactive sites on the cyclic track is faster when the ma

236 Our data show that the reactive sites on the metal oxide surfaces were not pass

237 led knowledge of the spatial organization of reactive sites on the NC protein in its free and oligonu

238 Here, we show that the reactive sites on the surface of a tetrairidium cluster

239 displacement of the macrocycle away from the reactive sites on the track.

240 rials, such as large surface area, versatile reactive sites or functionalities, and scaffolding stabi

241 t has been reported to utilize Arg341 as the reactive site P1 residue to neutralize a broad variety o

242 is more complex than that of presenting the reactive site (P1 residue) to the protease.

243 data on trypsin-catalyzed hydrolysis of the reactive-site peptide bond (P(1)-P(1)') suggest that the

244 rare variants K41N and I42M that affect the reactive-site peptide bond of SPINK1 decrease inhibitor

245 function: mesotrypsin rapidly hydrolyzed the reactive-site peptide bond of the Kunitz-type trypsin in

246 primarily by disulfide bridges flanking the reactive-site peptide bond, eglin c possesses an enzyme-

247 ariant of SGPI-2, and it readily cleaved the reactive-site peptide bonds in eglin C and ecotin.

248 Asp-2 increases reactive site polarity, reducing DeltaCp, but increases

249 ounts of adsorbed water may hinder access to reactive sites, promote formation of unreactive NH4(+),

250 eaction extent was similar among the various reactive sites, ranging from approximately 1 to 12%, and

251 eered by incorporating factor Xa exosite and reactive site recognition determinants in a serpin.

252 or near the previously defined autoantibody-reactive site recognized by bullous pemphigoid and herpe

253 ridge, to act as a mimetic of the functional reactive site region of this protein.

254 The relative sequence positions of the reactive site residues determined for AcAP5 with the hom

255 In addition to the reactive site residues in the P(6)-P(5)' region of KD1,

256 Substitution of P35's reactive site residues with TETDG failed to increase its

257 te constants different proteases at distinct reactive site residues, strongly supporting the notion o

258 olymer and graphene forming 3D structures of reactive sites resulted in a N-MIP with excellent affini

259 uantum mechanics descriptors to identify its reactive site(s).

260 oups within substrates that contain a second reactive site, setting the stage for applications in div

261 s, residues P4-P2'(P3'), where P1-P1' is the reactive site, share a common main chain conformation th

262 Reactive sites, sometimes called mechanophores, have bee

263 " (SMART), which we have applied to quantify reactive site spatial constraints for an expansive libra

264 High concentration of reactive sites, strong bonding to the conductive substra

265 these chlorinating agents differed for each reactive site such that OCl(-) > HOCl for N-chlorination

266 th surface complexation reactions to surface reactive sites suggests that ~90% of the binding sites w

267 riggered or induced form after cleavage of a reactive-site target bond in an exposed reactive-center

268 s faster when the macrocycle is far from the reactive site than when it is near to it.

269 ed wheat germ CaM for the presence of highly reactive sites that correlate with the loss of function.

270 mely the substantial steric crowding at both reactive sites, the nucleophilic addition of C8' over N1

271 acids and acid chlorides, and possess three reactive sites, their application in organic synthesis h

272 ed nonorphan reaction, using their substrate reactive sites, their surrounding structures, and the st

273 or macromolecules with multiple inequivalent reactive sites, this is no longer sufficient, even in th

274 rtho-nitrobenzyl(oNB)-caged lysine into SC's reactive site to generate a photoactivatable SC (pSC).

275 ITLLSA was changed to ITLSSA to relocate the reactive site to P2 (Leu-357) and to ITITLS to relocate

276 itions a hydrogen-bond acceptor anion at the reactive site to promote functionalization.

277 the side chain and the accessibility of the reactive site to the radical.

278 , thereby decreasing the number of available reactive sites to complex Cu.

279 our connecting bonds around the atoms of the reactive sites to correctly annotate proteins for 93% of

280 sense preference of the helix enables remote reactive sites to fall under the influence of the termin

281 Bound internal rotors then enable the reactive sites to find each other and become chemically

282 owered surface passivation allowing for more reactive sites to participate in the reaction.

283 res capable of succinctly describing complex reactive site topologies in terms of numerical inputs fo

284 nding" of the impact of key substituents and reactive sites toward HO(*).

285 esidues and a well-conserved Leu(65)-Ser(66) reactive site, typical for chymotrypsin inhibitors.

286 encodes, through alternative exon usage, 12 reactive site variants.

287 omponents with complementary recognition and reactive sites via a slow bimolecular pathway and a fast

288 substituent placement largely affected which reactive site was kinetically favorable.

289 ntum-mechanical treatment for atoms near the reactive site, was utilized to simulate the minimum ener

290 By controlling the microenvironment of the reactive site, we can control selectivity towards the hy

291 When most reactive sites were consumed by chlorine, Cl-substituted

292 Further, two distinct CP-reactive sites were identified on the extracellular doma

293 In contrast, T-cell-reactive sites were not detected within the relatively c

294 Interestingly, the most stable and reactive sites were those that were partially buried, pr

295 echanisms: one involving blocking of surface reactive sites, which is equivalent to reducing the rate

296 less chain reactions are shown between these reactive sites, which provide thermally stable aromatic

297 t the formation of an O(2)-precursor of this reactive site with an associated absorption band at 29,0

298 ed hematite slab (corresponding to 1/3 ML of reactive sites) with an additional overlayer of water mo

299 Each of these tyrosines resides in a known reactive site within the protein, i.e., subdomains IIIA

300 ediated by cooperative chemistry between two reactive sites within a catalytic assembly, the most com