ライフサイエンスコーパス: reactive site

1 hains of fibrin predominantly via its Gln103 reactive site.

2 gesting interactions between subsites in the reactive site.

3 aused by peptide backbone cleavage at its P1 reactive site.

4 roup 14 species with at least one additional reactive site.

5 H-terminal 39-46 residues, which include the reactive site.

6 es transforms directly into the [Cu(2)O](2+) reactive site.

7 ting chiral centres that are proximal to the reactive site.

8 may thus alter metal uptake by blocking key reactive sites.

9 stidine residue separated the most and least reactive sites.

10 are cleaved by cognate proteinases at their reactive sites.

11 n map of solvent accessibility at individual reactive sites.

12 uggested that BP180 may harbor additional CP-reactive sites.

13 esence of a pocket surrounding the metal ion reactive sites.

14 based approach considering hydrogen atoms at reactive sites.

15 mineral substrates possessing only external reactive sites.

16 aterials which will strongly differ in their reactive sites.

17 sual connectivity that may juxtapose the two reactive sites.

18 gate two different concentrations of surface reactive sites.

19 on based on a symmetric scaffold with two NO-reactive sites.

20 orinating species, shielding other potential reactive sites.

21 henomenon of induced heterogeneity of carbon reactive sites.

22 the cage at genetically introduced cysteine reactive sites.

23 enzymes based on the amino acids in cleaved reactive sites.

24 ion of subsurface Ti interstitials to create reactive sites.

25 MOF, which allows "solution-like" access to reactive sites.

26 of bipyridine and methanol molecules at the reactive sites.

27 eved to be a fibrin-cross-linking (or FXIIIa-reactive) site.

28 The additional reactive site accounts for a large portion of the discre

29 Modifications of the reactive sites afford multifunctional polymers with tuna

30 luded the distance and angle between the two reactive sites (aldehyde or amine functional groups) and

31 d mutagenesis of the predicted P1 inhibitory reactive site amino acid confirmed the role of Met(26) i

32 racil show that the mispair is both a highly reactive site and a barrier to radical cation hopping.

33 e away from the cleavage point, exposing the reactive site and buckling the DNAzyme catalytic core.

34 full nanometer, and the distance between the reactive site and the pro-stereogenic element is nearly

35 range 100ng to 1microg due to the increased reactive sites and distance.

36 rk allows for the spatial control of pendant reactive sites and dramatically increases the stability

37 n of SO2 at the water surface can affect the reactive sites and electrophilicity of SO2.

38 The prediction of T-cell receptor-reactive sites and major histocompatibility complex clas

39 erstand the role of the local arrangement of reactive sites and surface topography in the surface evo

40 le sizes will impact the number of available reactive sites and the reactivity of newly formed partic

41 significance of nonthermal processes at the reactive site, and the efficient photo-induced electron

42 st that an increase of the number of surface reactive sites, and possibly higher ozone uptake coeffic

43 hat altering the heterocycle or blocking the reactive site are two of the more effective strategies f

44 tant form, which had Ala substituted for the reactive-site Arg364.

45 m Manduca sexta, whereas Egf1.0(R51A), whose reactive-site arginine was replaced with an alanine, had

46 aved human PCI and mouse PCI (mPCI) at their reactive sites as well as at sites close to their N term

47 This glycoprotein with a predicted reactive site at Lys(367)-His(368) is not able to inhibi

48 groups and the kinetic blocking of the most reactive sites at the bay region.

49 the protonated cap at the small rim and the reactive sites at the large rim.

50 levels of nanosecond-scale motions in CI2's reactive site binding loop as the L68 side chain was pro

51 8) bond exhibits properties analogous to the reactive site bond of canonical trypsin inhibitors and s

52 n cleaves selectively at the Arg(15)-Ala(16) reactive site bond, with kinetic constants approaching t

53 ate-like fashion and are cleaved at a single reactive site bond.

54 lylic oxidations of substrates with the same reactive site but different molecular size (cyclohexene

55 diphenylcarbene carbenes and substitution of reactive sites by bulky protective groups serves to stab

56 Our studies show that the two reactive sites can communicate with each other on the su

57 of each protein that becomes disordered upon reactive site cleavage (to OMIPF3* and OMTKY3*).

58 the "intact" (uncleaved, I) and "modified" (reactive site cleaved, I*) forms of the inhibitor.

59 dy demonstrates that MNEI has two functional reactive sites corresponding to the predicted P(1) and P

60 would be expanded by orders of magnitude if reactive sites could be probed with fragments rather tha

61 To eliminate a chemically reactive site, Cys58 was replaced by a seryl residue wit

62 tering materials as a function of controlled reactive site densities.

63 step densities, treated as equivalent to the reactive site density, as a function of aqueous calcium-

64 a key parameter for macroscopic models, the reactive site density, is poorly constrained.

65 vity associated with lengthening the Glu-342-reactive site distance by a single residue and the enhan

66 ts that optimize juxtaposition of the proper reactive sites during splicing.

67 result in completely opposite photogenerated reactive sites (e(-) and h(+)) and divergent energy flow

68 analysis of reaction products identified two reactive sites, each with a different specificity.

69 The T98L mutation, peripheral to the NTIMP1 reactive site, enhances binding by increasing DeltaSsolv

70 or was not affected, suggests that a similar reactive site exists in the ligand-binding domains of th

71 We show that binding of CH3Hg to such reactive sites facilitates the formation of (CH3)2Hg by

72 rdinated surface sites (Q(1)) as the primary reactive site for hydrolysis and precipitation.

73 es that the spiro-ketal group of IPAs is the reactive site for the acid-catalyzed hydrolytic transfor

74 sed to introduce single cysteine residues as reactive sites for adduct formation within each of the t

75 iol, or alkyne) onto the sn-2 chain provides reactive sites for bio-orthogonal conjugation of cargo w

76 surficial Sb-SnO2 islands also serve as the reactive sites for free radical generation.

77 e isophthalate pillars of the prisms provide reactive sites for post-self-asssembly modifications.

78 hat this inhibitor may have evolved separate reactive sites for the specific regulation of different

79 slow Co oxidation by interlayer Mn(III) and reactive sites formed upon removal of interlayer Mn(III)

80 d active rat SLPI, which shares the protease-reactive site found in human SLPI.

81 e metal-carbon pi bond provides a chemically reactive site from which a conjugated molecular wire can

82 ecular reactions in the presence of multiple reactive sites has been a long-standing challenge in the

83 complex formed between the two fragments of reactive-site-hydrolyzed chymotrypsin inhibitor-2 from b

84 The reactive site identified by these studies is a structura

85 ubstitution for each residue within these RF-reactive sites identified R48, W51, E55, Y107, R108, W14

86 icating that acivicin binds in the glutamine reactive site in a specific conformation.

87 The most reactive site in subunit B14 was Tyr122, while the most

88 he covalent reaction at a surface-accessible reactive site in which the required surrounding microenv

89 ted force is used to control the exposure of reactive sites in a single polyprotein substrate compose

90 ver, it has proven difficult to identify the reactive sites in natural HA substrates.

91 ration of multiple (2-4) chemically distinct reactive sites in the polymer chain.

92 Direct observation of multiple reactive sites in the zeolite HZSM-5, a member of the MF

93 red platinum binding sites compete with less reactive sites in these oligonucleotides.

94 To identify transglutaminase-reactive sites in WT-alpha(2)AP or Q2A-alpha(2)AP, each

95 Reactive sites, in contrast, are generally situated such

96 One feature of many exposed reactive sites is a wide DNA minor groove, which allows

97 The increasing number of reactive sites is probably related to the fact that orga

98 s the effect on inhibition of relocating the reactive site (Leu-358) of the serpin alpha(1)-antichymo

99 e protease: (i) a unique sequence within the reactive site loop (P(1))Asp(48)-(P(1'))Pro(49) in Ad5-1

100 on by P35 is correlated with cleavage of its reactive site loop (RSL) and formation of a stable P35.c

101 Reactive site loop (RSL) cleavage analysis showed that S

102 Homology of the reactive site loop (RSL) domain of endopin 2, notably at

103 ism of inhibition by SCCA1 revealed that the reactive site loop (RSL) is important for cysteine prote

104 n/ovalbumin chimeric proteins and the maspin reactive site loop (RSL) peptide to characterize the rol

105 sequence of the serpin endopin 2 predicts a reactive site loop (RSL) region that possesses high homo

106 The large size of the serpin reactive site loop (RSL) suggests that the role of the R

107 serine proteinase inhibitors have a flexible reactive site loop (RSL) that can convert from the activ

108 Although serpins employ a mobile reactive site loop (RSL) to bait and trap their target s

109 ubstitution of maspin p1' site Arg340 in the reactive site loop (RSL) with alanine not only abolished

110 ognition sequence within a highly protruding reactive site loop (RSL), which gets cleaved by a target

111 cated within the serpin scaffold but not the reactive site loop (RSL).

112 nalyze the conformational changes of the P35 reactive site loop after caspase cleavage.

113 vage between the Gly and Ser residues of the reactive site loop and detection of a stable SCCA1-cathe

114 otion of a highly mobile and flexible serpin reactive site loop and suggesting that this inhibitor ma

115 ain Asp at the P1 position within the serpin reactive site loop and yet are only 35% identical overal

116 Distortion or destabilization of this reactive site loop by site-directed mutagenesis converte

117 ns two adjacent methionine residues near the reactive site loop cleaved by thrombin (Met314 and Met31

118 Native antithrombin (AT) has an inactive reactive site loop conformation unless it is activated b

119 s and/or the backbone carbonyls of the PAI-1 reactive site loop could restrict the reaction.

120 The determined reactive site loop domain of hippocampus ACT will allow

121 evealed the selectivity of the alpha1-PDX/hf reactive site loop for furin (Ki, 600 pM) but not for ot

122 d eglin c, Arg-42-Arg-45-eglin, in which the reactive site loop had been optimized for subtilisin-rel

123 These results suggest that a longer reactive site loop in AT is responsible for its inactive

124 oded "R(1)-eglin", having Arg at P(1) in the reactive site loop in place of Leu(45).

125 tor of furin identified that is not a serpin reactive site loop mutant, either naturally occurring or

126 al peptide library based on the anti-tryptic reactive site loop of a Bowman-Birk inhibitor (BBI).

127 ion sequences within the P6-P1 region of the reactive site loop of alpha(1)-antitrypsin were construc

128 Relative to alpha(1)-antitrypsin, the reactive site loop of AT has three additional residues,

129 To determine whether a longer reactive site loop of AT is responsible for loop preinse

130 heparin-induced conformational change in the reactive site loop of AT, the template effect of heparin

131 rt protein beta-sheet segment that forms the reactive site loop of Bowman-Birk inhibitors.

132 ture of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical

133 e nearly identical in primary structure, the reactive site loop of each inhibitor suggests that they

134 ar linkages result from the insertion of the reactive site loop of one serpin molecule into the middl

135 tations are predicted to lead to loss of the reactive site loop of SERPINB8, which is crucial for for

136 einsertion of two N-terminal residues of the reactive site loop of the serpin into the A-beta-sheet o

137 n which the P2 or the P3-P3' residues of the reactive site loop of the serpin were replaced with the

138 e cleavage by Arg-specific gingipains to the reactive site loop of the SPINK6 inhibitor.

139 consistent with a new model wherein the P35 reactive site loop participates in a unique multi-step m

140 ctPA) specifically interacts with the maspin reactive site loop peptide and forms a stable complex wi

141 Mutations in the alpha-helix of the reactive site loop preceding the cleavage site abrogate

142 us to determine whether cleavage within the reactive site loop region (RSL) of alpha1-proteinase inh

143 unique, because it involves an unusual HCII-reactive site loop sequence of Leu444-Ser445, requires t

144 eversed by a polyclonal antibody against the reactive site loop sequence of maspin.

145 ese data suggest that, contingent upon their reactive site loop sequences, mammalian serpins, in gene

146 his inhibitor, M. sexta serpin-3, contains a reactive site loop strikingly similar to the proteolytic

147 an arginine at the P1 position of trespin's reactive site loop suggests that trespin inhibits trypsi

148 propose a structural model of the alpha1-PDX-reactive site loop that explains the high degree of enzy

149 icate that the hippocampus ACT possesses the reactive site loop that is characteristic of serpins, wi

150 ovement in the carboxyl-terminal side of the reactive site loop that swings down and forms a new beta

151 Endopin 1 contains a unique reactive site loop with Arg as the predicted P1 residue,

152 on signal, a target sequence for SPCs in the reactive site loop, and the in vitro inhibitory activity

153 teractions can alter the conformation of the reactive site loop, converting a permanent inhibitor int

154 mal sequence for recognition by furin in its reactive site loop, was tested for its ability to inhibi

155 nds of contacts exist in such complexes: (i) reactive site loop-active site contacts and (ii) interac

156 es a protein-protein interaction besides the reactive site loop-active site interaction characteristi

157 rences were found to be in the region of the reactive site loop.

158 replacement of specific residues within the reactive site loop.

159 is stabilized following cleavage within its reactive site loop.

160 -terminal 39-46 residues, which includes the reactive site loop.

161 cies arise by cleavage of CAP at or near the reactive site loop.

162 , which occurred through cleavage within the reactive site loop.

163 pin28 encode a variable region including the reactive site loop.

164 SPI-1 reactive-site loop (RSL) mutations of the critical P1 an

165 Arg50 to the conformational stability of the reactive-site loop in CMTI-V.

166 ascade, the sequence of the protease-binding reactive-site loop of antithrombin has evolved such that

167 We substituted residues of the reactive-site loop of antithrombin into alpha(1)-antitry

168 was constructed based on the sequence of the reactive-site loop of Bowman-Birk inhibitor, a proteinas

169 Cooperative effects among residues of the reactive-site loop thus emerged as critical for restrict

170 interactions between the alpha-helix and the reactive-site loop, and leads to more open spacing betwe

171 conformation via hydrogen bonding within the reactive-site loop.

172 ition that require caspase cleavage of their reactive site loops (RSL) and chemical contributions of

173 eins are 92% identical, differences in their reactive site loops suggest that they inhibit different

174 wever, Spn4.1 and neuroserpin have divergent reactive site loops, with Spn4.1 showing a generic recog

175 ar to encode full-length serpins with intact reactive site loops.

176 Maspin derivatives mutated in the serpin reactive site lost their ability to inhibit the migratio

177 tem with tunable thermal response, end-group reactive sites, low toxicity, and controlled main-chain

178 ution structure and internal dynamics of the reactive-site (Lys44-Asp45 peptide bond) hydrolyzed form

179 protease attack at many sites, including the reactive-site (Lys44-Asp45 peptide bond), with the R50 m

180 e cleaved by subtilisin primarily at the CI2 reactive-site Met-59-Glu-60 bond, revealing that the seq

181 anges in the vicinity of site 1583, that the reactive site most likely faces away from the pore, and

182 ion of complexes containing thrombin and the reactive site mutant HCII(L444R) to yield active thrombi

183 sidues are the reactive centers of three NEM-reactive sites (NRS1-3).

184 The orientation of the electric field at the reactive site of [B12 Cl11 ](-) results in an energy bar

185 The reactive site of B-alkyl-substituted NHC-boranes switche

186 Determination of the reactive site of MNEI by N-terminal sequencing and mass

187 These results suggest that the reactive site of the platelet receptor for type I collag

188 e functional group localization found in the reactive sites of enzymes.

189 the antibody epitope(s) but lacks the T-cell reactive sites of full-length Abeta1-42.

190 inding of AIIt to the membrane protected the reactive sites of GSNO on AIIt.

191 The reactive sites of the nucleophiles or the nature of the

192 togenerated, valence band holes on different reactive sites of the oxide surface.

193 nd whereby the proximal distance between the reactive sites of the thioester intermediate (the N-term

194 ystem, we have titrated the transglutaminase-reactive sites of vimentin and, by sequencing the dansyl

195 high levels of IgG Abs against the major IgE-reactive site on Bet v 1 and related allergens.

196 region, however, there is a remarkably hyper-reactive site on each strand.

197 cell viability by obstructing monochloramine reactive sites on bacterial cells, protein EPS hindered

198 BCD has 21 reactive sites on each of its molecules.

199 nts; it reports the solvent accessibility of reactive sites on macromolecules with as fine as a singl

200 tions that broadly neutralizing epitopes and reactive sites on other structural elements are more exp

201 model, in which the proportion of accessible reactive sites on primary particles as well as the aggre

202 nt, can be a useful approach to the study of reactive sites on proteins.

203 and photocatalytic properties of the surface reactive sites on single Au-CdS hybrid nanocatalysts.

204 that the rate of reaction of this fuel with reactive sites on the cyclic track is faster when the ma

205 Our data show that the reactive sites on the metal oxide surfaces were not pass

206 led knowledge of the spatial organization of reactive sites on the NC protein in its free and oligonu

207 Here, we show that the reactive sites on the surface of a tetrairidium cluster

208 displacement of the macrocycle away from the reactive sites on the track.

209 t has been reported to utilize Arg341 as the reactive site P1 residue to neutralize a broad variety o

210 is more complex than that of presenting the reactive site (P1 residue) to the protease.

211 data on trypsin-catalyzed hydrolysis of the reactive-site peptide bond (P(1)-P(1)') suggest that the

212 function: mesotrypsin rapidly hydrolyzed the reactive-site peptide bond of the Kunitz-type trypsin in

213 primarily by disulfide bridges flanking the reactive-site peptide bond, eglin c possesses an enzyme-

214 ariant of SGPI-2, and it readily cleaved the reactive-site peptide bonds in eglin C and ecotin.

215 Asp-2 increases reactive site polarity, reducing DeltaCp, but increases

216 ounts of adsorbed water may hinder access to reactive sites, promote formation of unreactive NH4(+),

217 eaction extent was similar among the various reactive sites, ranging from approximately 1 to 12%, and

218 eered by incorporating factor Xa exosite and reactive site recognition determinants in a serpin.

219 or near the previously defined autoantibody-reactive site recognized by bullous pemphigoid and herpe

220 ridge, to act as a mimetic of the functional reactive site region of this protein.

221 The relative sequence positions of the reactive site residues determined for AcAP5 with the hom

222 In addition to the reactive site residues in the P(6)-P(5)' region of KD1,

223 Substitution of P35's reactive site residues with TETDG failed to increase its

224 te constants different proteases at distinct reactive site residues, strongly supporting the notion o

225 olymer and graphene forming 3D structures of reactive sites resulted in a N-MIP with excellent affini

226 oups within substrates that contain a second reactive site, setting the stage for applications in div

227 s, residues P4-P2'(P3'), where P1-P1' is the reactive site, share a common main chain conformation th

228 Reactive sites, sometimes called mechanophores, have bee

229 riggered or induced form after cleavage of a reactive-site target bond in an exposed reactive-center

230 s faster when the macrocycle is far from the reactive site than when it is near to it.

231 ed wheat germ CaM for the presence of highly reactive sites that correlate with the loss of function.

232 mely the substantial steric crowding at both reactive sites, the nucleophilic addition of C8' over N1

233 acids and acid chlorides, and possess three reactive sites, their application in organic synthesis h

234 or macromolecules with multiple inequivalent reactive sites, this is no longer sufficient, even in th

235 ITLLSA was changed to ITLSSA to relocate the reactive site to P2 (Leu-357) and to ITITLS to relocate

236 the side chain and the accessibility of the reactive site to the radical.

237 , thereby decreasing the number of available reactive sites to complex Cu.

238 sense preference of the helix enables remote reactive sites to fall under the influence of the termin

239 owered surface passivation allowing for more reactive sites to participate in the reaction.

240 esidues and a well-conserved Leu(65)-Ser(66) reactive site, typical for chymotrypsin inhibitors.

241 encodes, through alternative exon usage, 12 reactive site variants.

242 ntum-mechanical treatment for atoms near the reactive site, was utilized to simulate the minimum ener

243 When most reactive sites were consumed by chlorine, Cl-substituted

244 Further, two distinct CP-reactive sites were identified on the extracellular doma

245 In contrast, T-cell-reactive sites were not detected within the relatively c

246 echanisms: one involving blocking of surface reactive sites, which is equivalent to reducing the rate

247 t the formation of an O(2)-precursor of this reactive site with an associated absorption band at 29,0

248 ed hematite slab (corresponding to 1/3 ML of reactive sites) with an additional overlayer of water mo

249 Each of these tyrosines resides in a known reactive site within the protein, i.e., subdomains IIIA