ライフサイエンスコーパス: reader

1 tified using a fluorescence multi-well plate reader.

2 correctly recognized by the original Glycan Reader.

3 for these functions and serves to orient the reader.

4 trauma CT studies were evaluated by a second reader.

5 ive factors, mammogram view, image type, and reader.

6 CNs was measured with a portable fluorescent reader.

7 est of Editor following concerns raised by a reader.

8 ull-size PerkinElmer laboratory luminescence reader.

9 structures was monitored with an inexpensive reader.

10 osolic delivery of model proteins on a plate reader.

11 itor-in-Chief following concerns raised by a reader.

12 n ileocolonoscopy scored by a masked central reader.

13 ly with the optical transducer of microplate reader.

14 ification by at least one A Reader and one B Reader.

15 cooperative and individual activities of the readers.

16 The authors apologize to the readers.

17 or in less than 15% of cases for one or more readers.

18 agnostic performance for lesion detection by readers.

19 value of 0.61 for either pairs or groups of readers.

20 ts (94%) with acceptable variability between readers.

21 bedside EEG interpretation of unexperienced readers.

22 hromatin mark and its epigenetic writers and readers.

23 Imaging was analyzed by two readers.

24 me- and/or histone-binding activities of the readers.

25 Images were assessed by two readers.

26 ty improved with the addition of DBT for all readers.

27 RADS categories), were randomly allocated to readers.

28 gher small opacity profusion compared with B Readers.

29 -5V) were 69.0% and 90.5%, respectively, for reader 1 (R1) and 88.3% and 95.5%, respectively, for rea

30 omatic patients (59% [10 of 17 patients] for reader 1 and 47% [eight of 17 patients] for reader 2), b

31 omatic patients (77% [13 of 17 patients] for reader 1 and 53% [nine of 17 patients] for reader 2) tha

32 mptomatic patients (seven of 17 patients) by reader 1 and in 53% of asymptomatic and symptomatic pati

33 ed in at least one anatomic location in 94% (reader 1, 32 of 34 patients) and 100% (reader 2, 34 of 3

34 h BRCA wild-type HGSOC (univariate analysis: reader 1, HR = 2.42, P < .001; reader 2, HR = 2.61; P <

35 n the study group than in the control group (reader 1: -2.1% vs -0.1%, respectively, P = .003; reader

36 Sensitivity was highest for readers 1 and 2 (68.5% and 63.9%, respectively) whereas

37 earance of PFP was independently analyzed by readers 1 and 2, and interobserver agreement (weighted k

38 cts on spine CT scans by three radiologists (readers 1, 2, and 3) working in consensus.

39 cium images (median score: 10, 9, and 10 for readers 1, 2, and 3, respectively) compared with bone re

40 uality (P = .016, P = .016, and P = .013 for readers 1, 2, and 3, respectively), with significantly b

41 , and 83.3% in the extraprostatic region for readers 1, 2, and 3, respectively.

42 After obtaining informed consent from the readers, 12 CT colonography fly-through examinations tha

43 Readers (19 radiologists, three advanced practitioner ra

44 (R1) and 88.3% and 95.5%, respectively, for reader 2 (R2).

45 r reader 1 and 53% [nine of 17 patients] for reader 2) than in symptomatic patients (59% [10 of 17 pa

46 reader 1 and 47% [eight of 17 patients] for reader 2), but without significant differences (P = .33)

47 94% (reader 1, 32 of 34 patients) and 100% (reader 2, 34 of 34 patients) of patients (P = .99).

48 ate analysis: reader 1, HR = 2.42, P < .001; reader 2, HR = 2.61; P < .001).

49 ients (nine of 17 patients in each group) by reader 2, without significant differences between the gr

50 r 1: -2.1% vs -0.1%, respectively, P = .003; reader 2: -2.0% vs -0.3%, P < .0001).

51 spine trauma following high-velocity trauma, readers 2 and 3 reviewed in consensus the cervical spine

52 ctively) whereas specificity was highest for reader 3 (83.6%).

53 view a major emphasis is placed on informing readers about some of the most important practical aspec

54 Readers achieved 84.0% consensus and 85.8% reproducibili

55 ns, the linker position was in flux, and the reader adopted both extended and compact states.

56 ric contrast-enhanced MR imaging and between-reader agreement for interpretation of biparametric MR i

57 Between-reader agreement of biparametric MR imaging interpretati

58 To investigate between-reader agreement, biparametric MR images of 100 patients

59 immobilization of NHC compounds, giving the reader an overview on synthetic techniques and strategie

60 This review is intended to provide readers an overview of the use of the QCM for examinatio

61 cost-effective smartphone-based fluorescence reader, an important requirement toward a nucleic-acid-b

62 mages were read remotely by a trained retina reader and a glaucoma specialist.

63 rotein complex binding to the Pygo chromatin reader and acting through TCF/LEF-responsive enhancers.

64 objectives included comparison to the expert reader and assessment of intrareader reproducibility.

65 ss this need we present BiliSpec, a low-cost reader and disposable lateral flow card designed to meas

66 aphs with a classification by at least one A Reader and one B Reader.

67 as 84% (kappa = 0.61); agreement for primary readers and arbitrators across 5 conclusion categories w

68 the biological functions of DNA methylation readers and effectors.

69 n is mainly based on large equipment such as readers and imaging systems, which require intensive and

70 ths, and limitations of the database by both readers and investigators is of critical importance.

71 seful for carrying out meta-analyses and for readers and journal editors, who must interpret the find

72 The ICCs between the readers and OCT ranged between 0.50 and 0.63.

73 Patients underwent MR elastography with two readers and VCTE with three observers to acquire liver s

74 Sensitivity was improved for 19 of 24 (79%) readers and was significantly higher for those with less

75 estis-specific BRDT members, are epigenetic "readers" and play a key role in the regulation of gene t

76 patient level, between 12 (most experienced reader) and 17 (least experienced reader) MR examination

77 and extraterminal (BET) family of epigenetic readers, and of Bromodomain-containing protein 2 (BRD2)

78 ading and confirmation by an experienced ECG reader are essential and are repeatedly recommended in p

79 es (writers) and chromatin-binding proteins (readers) are flooded into the system.

80 Central reader area under the receiver operating characteristic

81 e proteomics reveals an interactome of known readers as well as protein complexes that were not known

82 and the onsite reader exceeded 75% for each reader at the lesion, region, and subject levels.

83 or Evaluation of Chest Pain (PROMISE) trial, readers at 193 North American sites interpreted coronary

84 Conclusion Compared with interpretation by readers at 193 North American sites, standardized core l

85 Readers at a central core laboratory also interpreted CT

86 ting probability maps was very high for both readers, AUC = 0.99 (SD = 0.05).

87 Reader-average sensitivities, specificities, and areas u

88 The goal of this series is to help readers better understand how to apply the results of ke

89 hanism by which these linked but independent readers bind to the intact nucleosome core particle (NCP

90 Two readers blinded to pathology findings and clinical follo

91 Two central readers, blinded to site read and reference standard, re

92 Here we report that the epigenetic reader BRD4 and the methyltransferase G9a repress a TFEB

93 The epigenomic reader Brd4 is an important drug target for cancers.

94 The epigenetic reader BRD4 plays a vital role in transcriptional regula

95 tributes to overexpression of the epigenetic reader bromodomain-containing protein 4 (BRD4).

96 ly bound by RNA-binding proteins (the m(6)A 'readers'), but also removed by demethylases (the m(6)A '

97 , we find that in congenitally blind Braille readers, but not sighted readers of print, the VWFA regi

98 ing mammography improved specificity for all readers, but the gain in sensitivity was greater for rea

99 The aim is that the reader can use this information while assigning vibratio

100 ffer significantly from measurements in good readers-can help parents and educators select the best r

101 ts m(6)A 'writer' complex, validate its YTH 'readers' CG6422 and YT521-B, and generate mutants in fiv

102 The analysis included 79 185 matched A and B Reader chest radiograph classifications.

103 A Readers classified more images as "good" quality (preval

104 Conclusion A Readers classified substantially more radiographs with e

105 alent contacts of histone-binding domains or readers commonly mediate localization and activities of

106 Readers completed a demographic survey, assigned LI-RADS

107 formance and the overall interpretation (2/3 reader concordance) compared with standard-of-truth data

108 Mean reader confidence in the interpretation of images showed

109 , we investigated the impact on accuracy and reader confidence offered by the addition of image quant

110 reading analysis and offered an increase in reader confidence.

111 kappa-agreement analyses were used to assess reader consistency and agreement of scoring of FA.

112 routine GES with moderate agreement and high reader consistency.

113 Two readers correlated mapped lesions with reports of prospe

114 that inhibitors of broadly active chromatin-readers could have utility in nuanced clinical contexts

115 cytosine modifications, their modifiers and readers cross-regulate themselves.

116 major feature characterization, with minimal reader demographic effect.

117 ce (MR) imaging, and the potential effect of reader demographics on agreement with a preselected nonc

118 ed using a commercially available microplate reader, demonstrate its suitability to high-content micr

119 used to describe differences between A and B Reader determinations of image technical quality, small

120 mary objectives were to establish individual readers' diagnostic performance and the overall interpre

121 Notably, an intact YEATS chromatin-reader domain was essential for ENL-dependent leukaemic

122 e recognized by and interact with designated reader domains in histone-binding proteins.

123 Results A total of 113 readers evaluated 380 image sets.

124 Readers evaluated baseline and follow-up morphology on d

125 Concordance between the BIE and the onsite reader exceeded 75% for each reader at the lesion, regio

126 e driving force for binding may differ; some readers exhibit evidence for cation-pi interactions wher

127 erformance likely achievable with a range of reader expertise.

128 xon techniques is highly reproducible across readers, field strengths, and imaging platforms.

129 a high throughput Fluorometric Imaging Plate Reader (FLIPR) assay to monitor agonist-evoked Ca(2+) si

130 sion There was substantial agreement between readers for BPE detected on CE spectral mammographic and

131 tching force and the binding affinity of the readers for chromatin, the fibre undergoes a sharp trans

132 nce for the primary outcome, or distract the reader from statistically nonsignificant results) in pub

133 Three expert readers from different institutions assessed the likelih

134 with small molecules to modulate its histone reader function for therapeutic or experimental purposes

135 Two trained non-physician readers graded each eye independently for ROP features i

136 point is surpassed), e-ROP IMAGING (trained reader grading of type 1 or 2 ROP initiates diagnostic e

137 A and B Readers had minimal agreement on technical image quality

138 Glycan Reader has been improved and now identifies most sugar t

139 r private practice readers than for academic readers (ICC difference, 0.009; 95% CI: 0.000, 0.021).

140 Individual reader ICCs for hepatic PDFF measurements across all thr

141 iography caused by stable chest pain, expert readers identified 30 patients with NRS plaques and matc

142 Results Readers identified polyps correctly in 56 of 77 (72.7%)

143 epatic magnetic resonance (MR) imaging among readers, imager manufacturers, and field strengths.

144 Overall reader impression yielded the highest accuracy for diagn

145 Overall reader impression yielded the highest sensitivity and sp

146 hest radiographic classifications of A and B Readers in a national surveillance program offered to U.

147 col than with the standard protocol for both readers in a per-patient analysis (sensitivity, 97.9%-98

148 coneogenesis and into the roles of chromatin readers in metabolic homeostasis.

149 the nucleosomal DNA, and the linker between readers in modulating nucleosome- and/or histone-binding

150 ns of interest were drawn by two independent readers in peripheral zone lesions and normal-appearing

151 curacy equivalent to that of the experienced readers in the initial studies.

152 eir accuracy was close to that of the expert readers in the original studies (range, 83.3%-87.2%).

153 Seven readers, including five neuroradiologists and two interv

154 Two readers independently analyzed all MR arthrographic imag

155 Three readers independently rated BPE on CE spectral mammograp

156 racked by using an infrared eye tracker, and readers indicated that they saw a polyp by clicking a mo

157 ieve a consensus interpretation of GES FA, 4 readers interpreted FA in 148 GES studies from normal vo

158 Experienced readers interpreted the images, and the detection rate (

159 CHARMM-GUI Glycan Reader is updated to generate the simulation system and

160 -binding domain 1 (MBD1), a DNA methylation "reader," is important for maintaining the integrity of N

161 yl-CpG-binding proteins that are epigenetic "readers" linking DNA methylation to transcriptional regu

162 The reader may view this article as a work in progress, beca

163 cus on the interplay of the 5-methylcytosine reader Mbd1 and modifier Tet1 by analyzing their dynamic

164 Two masked readers measured CDR and noted possible evidence of glau

165 Fluorometric imaging plate reader membrane potential dye (FMP-Red-Dye) is a proprie

166 r domain-plant homeodomain (TTD-PHD) histone reader module, including its 20-residue interdomain link

167 n and plant homeodomain mutants reveals that reader modules of BAZ1A and BAZ1B, even when non-standar

168 ne-binding protein that contains two histone reader modules, a plant homeodomain (PHD) and a bromodom

169 xperienced reader) and 17 (least experienced reader) MR examinations could have been avoided.

170 In this secure web-based, multiple-reader-multiple-case study, 45 board-certified dermatolo

171 to demonstrate that, after limited training, readers naive to (18)F-fluciclovine could interpret (18)

172 goals of this study were to evaluate trained readers' (nuclear medicine and radiology physicians) vis

173 e by Zhao et al. (2017) finds that YTHDF2, a reader of N(6)- methylation, facilitates maternal mRNA d

174 domain (BET) proteins, which are epigenetic readers of acetylated histone lysine tail residues.

175 Thus, bromodomain readers of histone acetylation have emerged as attractiv

176 Bromodomains (BD) are readers of lysine acetylation marks present in numerous

177 tally blind Braille readers, but not sighted readers of print, the VWFA region is active during gramm

178 on this matter and apologies are offered to readers of the journal that this was not detected during

179 on this matter and apologies are offered to readers of the journal that this was not detected during

180 This narrative review aims to inform readers of the most relevant up-to-date evidence on the

181 arger than or equal to 0.5 mL for any of the readers of the short MR imaging protocol, with areas und

182 nfidence interval [CI]: 0.64, 0.89), and for readers of the standard MR imaging protocol, areas under

183 ropose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentrati

184 tion, modulated by 'writers', 'erasers' and 'readers' of this mark.

185 ricle were drawn by two blinded, independent readers on cine images in end systole by using a freely

186 i-natural experimental set-up and placed tag-readers on the side of bowers to determine which fish he

187 re were no differences between the groups or readers (P = .99).

188 Reader pairwise weighted kappa-values for the visual ass

189 For each radiation exposure level, readers' perception of image quality and lesion conspicu

190 Purpose To assess whether individual reader performance with digital breast tomosynthesis (DB

191 33) and to compare central and institutional reader performance.

192 s used as the cutoff point for comparison of reader performance.

193 Materials and Methods Two independent readers performed a systematic review of the literature

194 In 2 readings at least 1 mo apart, readers performed either a visual interpretation alone o

195 Central reader PET/CT interpretation demonstrated sensitivity, s

196 In contrast, knockdown of the H3K4me2 reader PHF8 decreases the H3K4me2 level at the LSD1-E2F1

197 Five readers placed one large region of interest, inclusive o

198 Implemented on a microplate reader platform, the FDL-based approach enabled sensitiv

199 The readers' positive predictive value and negative predicti

200 leven-nineteen leukemia (ENL) is a chromatin reader present in complexes stimulating transcriptional

201 We identified the histone reader protein DPF3 as a brown fat-selective component o

202 ecent studies have shown that the epigenetic reader protein EED, associated with Ezh2 in PRC2, has an

203 tor p75 splicing variant (LEDGF), which is a reader protein of H3K36me3, and the KAT5 (TIP60) histone

204 ethal 3 malignant brain tumor 1 (L3MBTL1), a reader protein with chromatin-compacting properties that

205 main containing 1 (YTHDC1), an m(6)A nuclear reader protein, in conjunction with serine/arginine-rich

206 trast, overexpression of the cellular m(6)A "reader" protein YTHDF2 increases IAV gene expression and

207 fication states are recognized by epigenetic reader proteins and how this is linked to their biologic

208 Bromodomain-containing reader proteins are part of multiprotein complexes that

209 Trimethyllysine (Kme3) reader proteins are targets for inhibition due to their

210 Although all such reader proteins bind Kme3 in an aromatic cage, the drivi

211 Specific m6A writer, eraser, and reader proteins have been identified.

212 odifications, bromodomain and extra-terminal reader proteins regulate joint-specific HOX gene express

213 The two H3K9me states recruit reader proteins with different efficiencies, explaining

214 Recognition of modified histones by "reader" proteins constitutes a key mechanism regulating

215 ription-associated proteins that are termed "reader" proteins.

216 Recognition of modified histones by 'reader' proteins constitutes a key mechanism underlying

217 orms within smartphone-integrated electronic readers provides accurate on-site and on-time diagnostic

218 on-HCC malignancies than among HCCs for both readers (R1: 24 of 36 [66.7%] vs 13 of 124, [10.5%], P <

219 n exposure by using SAFIRE-3 yielded similar reader rankings of image quality and lesion conspicuity

220 Two independent readers rated venous contamination as absent, mild, or m

221 Seven independent blinded readers reviewed diagnostic CT and PET/CT results in dif

222 Independent readers reviewed US images obtained with the OA/US devic

223 sliding to NM duplexes, consistent with its reader role.

224 ereas hedonistic reward is contingent on the reader's needs, in the moment, for pleasure or distracti

225 graphy and DARC MR lymphangiography for each reader separately.

226 Masked image evaluations by trained readers showed good inter-eye agreement in ROP character

227 oice perception experiment was performed (16 readers [six radiologists, 10 medical physicists]).

228 minal examination were used for this central reader study.

229 ed CT colonography data for this prospective reader study.

230 focused on Brd4, a BET protein and chromatin reader targeted by FMRP.

231 C was borderline higher for private practice readers than for academic readers (ICC difference, 0.009

232 upporting a number sense nor to convince the reader that a magnitude sense provides a better explanat

233 tform incorporates a fluorescence microplate reader that allows xyz-dimensional detection and fine-tu

234 YTH domain-containing 2 (YTHDC2) is an m(6)A reader that is essential for male and female fertility i

235 ings identify Brd4 as an enhancer epigenomic reader that links active enhancers with cell identity ge

236 study identifies YEATS2 as a histone H3K27ac reader that regulates a transcriptional program essentia

237 r data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs

238 (KLF4), as sequence-specific DNA methylation readers that preferentially recognize methylated CpG (mC

239 We remind readers that what happens during a fixation depends on m

240 This review aims at giving the readers the basic concepts needed to understand two-dime

241 lls and in vivo, and hopes to communicate to readers the diversity of applications within which these

242 A pair of readers, the PHD fingers of the protein CHD4, has been s

243 For central readers, the specificity and PPV of PET/CT detection of

244 The same independent readers then reviewed OA/US images, scored OA features,

245 oach to this triad of symptoms and guide the reader to discover the patient's ultimate genetic diagno

246 tional spectra of ionic liquids, helping the reader to distinguish the scope of application of differ

247 This review will introduce the reader to pathogen vs sterile inflammation, inflammatory

248 guide, Darmaillacq and Osorio introduce the reader to the fascinating biology of the cuttlefish.

249 8)F-fluciclovine PET/CT images enables naive readers to achieve acceptable diagnostic performance and

250 gories assigned by seven blinded independent readers to benign and malignant breast masses using OA/U

251 purpose of this Users' Guide is to introduce readers to fundamental concepts underlying adjustment as

252 This review introduces readers to the basic principles and fundamentals of flow

253 inuous analysis allows reviewers, editors or readers to verify reproducibility without manually downl

254 Nonphysician trained readers (TRs) evaluated all image sets from eyes that ev

255 Specificity was analyzed according to reader type and years and volume of experience, and then

256 als include wording modifications to improve readers' understanding and the addition of 3 new items.

257 Two readers used lumen boundary to determine scanner blur an

258 Reader variability was assessed with statistical estimat

259 laque tissue characteristics, as well as low reader variability.

260 d ex vivo histologic findings and (b) assess reader variability.

261 s is tedious and subject to inter- and intra-reader variability.

262 Two independent readers visually evaluated all vertebral bodies (n = 163

263 Two independent readers visually evaluated standard CT and color-coded V

264 Glycan Reader was originally developed to simplify the reading

265 or without other infiltrate) between primary readers was 78% (kappa = 0.50) and between arbitrators w

266 Excellent agreement between readers was found for time-signal intensity curve analys

267 pectral mammography and MR imaging and among readers was substantial (kappa = 0.66; 95% confidence in

268 pectral mammographic and MR images and among readers, weighted kappa coefficients with quadratic weig

269 Readers were asked to rate their confidence of image int

270 Readers were blinded to histopathology results during pr

271 Readers were blinded to their original scores, and then

272 Readers were masked to all eye examination results, prev

273 Three readers were trained using standardized interpretation m

274 s and all study staff, including the central readers, were masked to treatment assignment apart from

275 nstruction images alone for two of the three readers when both bone reconstruction and virtual noncal

276 apeptide repeats of the CTD engage specific "readers." Whereas phospho-Ser5 and phospho-Ser2 marks ar

277 (BET) domain-containing family of epigenetic readers which is under intensive investigation as a targ

278 he importance of multiple classifications by readers who have demonstrated ongoing competence in the

279 Readers who initially performed a combined analysis had

280 The same two readers, who were not blinded to histopathologic finding

281 g protein 2 (MeCP2) protein is an epigenetic reader whose binding to chromatin primarily depends on 5

282 Cbx3/HP1gamma is a histone reader whose function in the immune system is not comple

283 We think that the unbiased reader will follow our argumentation on astrocytic or mi

284 The goal is to provide the reader with (1) an appreciation for what QDs are capable

285 this classification scheme will provide the reader with a rapid way to identify systems of interest

286 This tutorial review aims to provide the reader with a set of tools to identify different types o

287 This perspective provides the reader with an update of an earlier article entitled "Ch

288 f this pictorial essay is to familiarize the reader with the various causes of toxic leukoencephalopa

289 his state of the art review familiarizes the reader with these categories of PE.

290 We provide the reader with tools to estimate the number of EC towers ne

291 This review will provide readers with an updated vision of current and foreseeabl

292 sk the rate of improvement was shallower for readers with dyslexia and the segment size where perform

293 Readers with dyslexia are purported to have a selective

294 is suggests that segmentation is impaired in readers with dyslexia but only on tasks containing motio

295 but the gain in sensitivity was greater for readers with less than 10 years of experience.

296 The addition of quantification allowed readers with limited experience in the interpretation of

297 tory mechanism for the association of paired readers with the nucleosome that provides an intricate b

298 re independently scored by three experienced readers without access to 2-second flow images.

299 al. (2017) report key functions of the m(6)A reader YTHDF2 in the regulation of mammalian development

300 In summary, the m(6)A-reader YTHDF2 is an intrinsic determinant of mammalian o