ライフサイエンスコーパス: readily accessible

1 ry electron-poor products, making these more readily accessible.

2 iopsy (TJLB), a procedure that is not always readily accessible.

3 basis and disease-relevant tissue (skin) is readily accessible.

4 atives of lysine, arginine and glutamine are readily accessible.

5 to signaling network responses has not been readily accessible.

6 of individual rRNA genes in a genome is not readily accessible.

7 g the diversity of target molecules that are readily accessible.

8 ut functionally relevant) side chains is not readily accessible.

9 major objective where antenatal care is not readily accessible.

10 d (FFPE) tissues with clinical diagnosis are readily accessible.

11 s about their use of animals in research are readily accessible.

12 shell tetrapod ZnS@CdS heterostructures were readily accessible.

13 le one-pot synthesis of protoberberines from readily accessible 1,2,3,4-tetrahydroisoquinoline-1-carb

14 formation of the adamantanone core from the readily accessible 1,5-dimethyl-3,7-dimethylenebicyclo[3

15 ization of oxetane alcohol 17, prepared from readily accessible 2-methyleneoxetane 12, yielded epoxyt

16 Readily accessible 3-(2-aminophenyl)-5-hexenyn-3-ols und

17 addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines.

18 d whole blood aggregometry assay, based on a readily accessible 96-well plate format coupled with qua

19 Here, we describe a readily accessible AAAA-DDDD quadruple hydrogen-bonding

20 This site is located where it is readily accessible above the VSG layer.

21 mine antioxidants enables the preparation of readily accessible, air-stable analogues, several of whi

22 that allow for additions of alkenyl units to readily accessible allylic electrophiles is disclosed.

23 of a catalyst that is derived in situ from a readily accessible aminophenol compound at ambient tempe

24 A membrane based on 30 m(2) of graphene, a readily accessible amount, could provide a heavy-water o

25 2.1.1.67) as model enzymes, this robust and readily accessible analogue displays kinetic parameters

26 eb site to make these global expression data readily accessible and amenable to complex search strate

27 ally active carboxylic acid derivatives from readily accessible and commercially available starting m

28 d for anticancer lead discovery that is both readily accessible and easily diversified.

29 Readily accessible and easy-to-handle Ru complexes capab

30 This readily accessible and inexpensive "real-time" profiling

31 The "ate" complex (L(Li))ScR(3) is readily accessible and is best described as a Li carbene

32 of cyclopropanes and epoxides by combining a readily accessible and isolable N,N'-diamidocarbene with

33 ction, it was often used because it was more readily accessible and much less expensive than prescrip

34 Fully loaded: Readily accessible and shelf-stable 1-bismuth(III) acety

35 perimental protocols, our assembly method is readily accessible and will facilitate the construction

36 Three new, readily accessible, and previously unexplored auxiliarie

37 As a mobile app, it is intuitive to use, readily accessible, and sensitive to the severity of mac

38 Potent and readily accessible APC are critical for development of i

39 can be synthesized from copolymerization of readily accessible aryl dibromides and norbornadiene or

40 (CCRs) of aryl and heteroaryl chlorides with readily accessible aryl lithium reagents.

41 The means to utilize readily accessible aryl or vinyl ethers as counterparts

42 he presence of an air-stable Ni(II) complex, readily accessible aryl pivalates participate in the Suz

43 d circulating plasma exosomal miR-125a-3p is readily accessible as diagnosis biomarker for early-stag

44 We now describe an unbiased, sensitive, and readily accessible assay, referred to as high-throughput

45 calculated free energy surface, and both are readily accessible at 300 K.

46 The reaction is readily accessible at room temperature, and a computed a

47 de)-N-acetylglucosamine (lipid II), which is readily accessible at the outside of the cell and which

48 dels of autoimmunity against sequestered and readily accessible autoantigens, we studied experimental

49 imitless numbers of neural precursors from a readily accessible autologous adult human source provide

50 veloped and validated a model that uses five readily accessible "bedside" variables to accurately pre

51 At room temperature a readily accessible bench-stable Ni(II) precatalyst is hi

52 emonstrate that synthetically unexplored but readily accessible benzothiophene S-oxides serve as nove

53 +/-)-xylopinine from two closely related and readily accessible bicyclic alpha-aminonitriles.

54 e increasingly recognized as noninvasive and readily accessible biomarker for risk stratification, di

55 ets, which has led to its extensive use as a readily accessible biomarker, under the assumption that

56 d, potentially, functional complexity within readily accessible biomimetic materials.

57 In this study, we demonstrate that the readily accessible (biphenyl-4-yl)methylammonium chlorid

58 ur results establish circulating miRNAs as a readily accessible blood biomarker to monitor disease in

59 mance of the Xpert assay as applied to other readily accessible body fluids such as exhaled breath co

60 concise and stereocontrolled manner from the readily accessible building blocks 4-6.

61 he Ugi multicomponent reaction in which four readily accessible building blocks are mixed together to

62 hosphorylated lipid A molecules that are not readily accessible by chemical methods.

63 y linked into complex molecules that are not readily accessible by classical synthetic methods.

64 ]pyridines, compounds that are currently not readily accessible by existing synthetic methods.

65 structurally simpler analogues that are not readily accessible by isolation.

66 opsin II intermediate (>1 ms) is beyond that readily accessible by molecular dynamics, we use NMR dis

67 irways and alveoli is highly complex; it not readily accessible by non-mathematicians.

68 ric and polymeric architectures that are not readily accessible by standard olefin polymerization.

69 Compounds 1a-c are readily accessible by synthesis and thus provide a novel

70 -hydroxy/aryl)imino-beta-oxodithioesters are readily accessible by the reaction of beta-oxodithioeste

71 e a route to complex phenotypes that are not readily accessible by traditional methods.

72 omoted in the presence of 2.5-7.5 mol % of a readily accessible C(1)-symmetric chiral imidazolinium s

73 The readily accessible carboxylate groups on the material su

74 The method employs a readily accessible catalyst (NiBr(2).diglyme/4,4'-di-ter

75 S in S. aureus known, and constitute new and readily accessible chemical tools for the study of the A

76 rformed in the presence of 1.0-5.0 mol% of a readily accessible chiral accessible N-heterocyclic carb

77 A new class of readily accessible chiral amino-phosphine precatalysts d

78 Thus, the readily accessible chiral dihydropyrrole 58 was first co

79 The use of readily accessible chiral starting materials and lactone

80 have been prepared by the direct addition of readily accessible chlorotetrafluorosulfanyl arenes to p

81 machinery, have been hampered by the lack of readily accessible chromosomal deletions of the correspo

82 ferrocenylsilanes (PFS), a well-established, readily accessible class of main chain organosilicon met

83 thogonal chemistries in that it makes use of readily accessible, commercially available reagents and

84 Sugar-expressed cell-surface thiols are readily accessible compared to their protein counterpart

85 It appears that D-Man, a safe and readily accessible compound, offers remarkable features

86 Administration of these readily accessible compounds nearly completely inhibits

87 MetaCyc serves as a readily accessible comprehensive resource on microbial a

88 MetaCyc also serves as a readily accessible comprehensive resource on microbial a

89 used to illustrate statistical methods with readily accessible computer software.

90 nation environment with two or three open or readily accessible coordination sites to promote direct

91 phosphino)ferrocene) catalyst system and the readily accessible coupling reagent (Me4N)SCF3.

92 This readily accessible cryptand is one of the most powerful

93 Overall, this paper reports readily accessible, cyanine-based through-bond ET casset

94 abeled) side chains to be added to a common, readily accessible dehydroalanine precursor in a range o

95 ta reveal that B cells represent a novel and readily accessible delivery system that can effectively

96 The skin contains readily accessible dendritic cells (DCs) with potent ant

97 se spatial arrangements and patterns using a readily accessible design strategy.

98 incubation at 37 degrees C, suggesting that readily accessible divalent cation binding sites in the

99 n donor solvents, or with substrates bearing readily accessible donor sites.

100 for highly stereoselective syntheses of non-readily accessible E isomers, which normally require the

101 eural stem cells is needed; a source that is readily accessible, easily expanded, and reliably induce

102 resented here makes salient features of DSSR readily accessible, either via the Java-based Jmol appli

103 ixed PCE-vegetable oil NAPL which provided a readily accessible electron donor, resulting in rapid PC

104 dy's glycogen stores and a similar amount of readily accessible energy as intramyocellular triglyceri

105 A base-mediated 6-endo-trig cyclization of readily accessible enone-derived alpha-amino acids has b

106 The readily accessible enones 8, 17, and 18 undergo 2-fold r

107 t by controlled reductive elimination from a readily accessible Fe precatalyst.

108 lex materials from commercially available or readily accessible feedstocks.

109 forward semantics and clean syntax make it a readily accessible first language; (ii) it is expressive

110 Compatible with readily accessible fluorescence microscopes, these easy-

111 surface-exposed residues of VP2:428-446 are readily accessible for antibody binding.

112 precursor cells as a source of NSCs are not readily accessible for clinical application.

113 ed from the peptide-Fc fusion proteins, were readily accessible for complete separation by RP-HPLC an

114 ilon are not conformationally restricted and readily accessible for DAG binding unlike those of PKCde

115 The cornea is readily accessible for gene therapy in the laboratory an

116 tightly associated cell wall enzyme that is readily accessible for interactions with host immune cel

117 Because extravascular fragments are not readily accessible for removal, many patients are not re

118 s are kinetically and thermodynamically more readily accessible for the Gly41Ser variant than for the

119 which are only partially understood and not readily accessible for use in engineered systems.

120 cumulating information on RNA helicases in a readily accessible format.

121 rsons, ongoing vision-screening programs and readily accessible free eye clinics may help address thi

122 3-Aminovinylquinoxalines are readily accessible from (hetero)aryl glyoxylic acids or

123 e projects with curated annotation, which is readily accessible from a web based resource.

124 tion for therapeutic development that is not readily accessible from currently available technology.

125 new class of chiral 1,2-amino ether ligands, readily accessible from naturally occurring alpha-amino-

126 d compounds, and that the range of scaffolds readily accessible from nature is limited.

127 are invaginations of the plasma membrane and readily accessible from the extracellular space.

128 iciently synthesized from ketone 9 (which is readily accessible from the Inhoffen-Lythgoe diol) with

129 Access to more readily accessible functional mimics would be highly des

130 ave been limited to the highly sensitive and readily accessible hematopoietic tumors.

131 Readily accessible histidine-containing peptides mediate

132 of developing a procedure for reprogramming readily accessible human adult cells for cell replacemen

133 oup at C3 in glucose, circumventing the more readily accessible hydroxyl at C6 and the more reactive

134 ted system that makes phylogenetic knowledge readily accessible in computable form.

135 obile camera phone--devices that have become readily accessible in developing countries--into a highl

136 ccess elusive phase transitions that are not readily accessible in equilibrium.

137 the binding constant of soluble proteins is readily accessible in experiments, our results provide a

138 Partially protected sphinganines 11 are also readily accessible in five steps from 4.

139 e level of disorder, a parameter that is not readily accessible in mesoscopic systems.

140 These complexes are readily accessible in one step from commercially availab

141 From clinical factors readily accessible in primary care, our risk score could

142 enewable and sustainable wastewater which is readily accessible in the local environment.

143 prolonged exposure of epitopes that are not readily accessible in the native Env trimer.

144 sampling of multiple anatomical locations is readily accessible in the SIV-infected macaque models of

145 ene) have been prepared; these complexes are readily accessible in two steps from commercially availa

146 t that is derived from a simple, robust, and readily accessible (in multigram quantities) chiral amin

147 Thus, EPCs could become readily accessible informers of vascular status and enab

148 For biological fluids, the most readily accessible is blood, and metabolomic analyses ca

149 rationally simple approach that makes use of readily accessible isoxazolinones.

150 pared in a one step, gram-scale fashion from readily accessible KATs.

151 ing only picomole quantities of material and readily accessible laboratory equipment.

152 e starting alkene configurations, and uses a readily accessible ligand.

153 TCs), which are prevalent in SCLC, present a readily accessible 'liquid biopsy'.

154 cally labile protecting groups or for use in readily accessible materials that respond to mechanical

155 rotein conformational changes, and provide a readily accessible means of studying protein structure i

156 en]) through postsynthetic modification of a readily accessible meso-(2-aminophenyl) tris-substituted

157 ities should emphasize the identification of readily accessible metabolic biomarkers of responsivenes

158 These findings offer a powerful, readily accessible method for the rational design of can

159 that CEST provides an accurate, precise, and readily accessible method to noninvasively measure liver

160 Since the system is so easily assembled from readily accessible modules, various functional groups ca

161 ed, size-tunable nucleic acid particles from readily accessible molecular building blocks.

162 mmercially available and inexpensive CuCl, a readily accessible monodentate imidazolinium salt, and c

163 ally being sought which can be produced from readily accessible monomers, which can be tuned for drug

164 In this study, we use the readily accessible mouse superior cervical ganglion (SCG

165 wealth of mammalian gene expression data is readily accessible, much of which is based on expressed

166 , N, O, and S nucleophiles, which provides a readily accessible multifunctionalized pyrimidine templa

167 nthase CrtM, this method was used to exclude readily accessible mutations at position F26, which conf

168 docyclopropenes by combining an isolable and readily accessible N,N'-diamidocarbene (DAC) with a rang

169 ives containing two stereogenic centers from readily accessible N,N-disubstituted glycine aryl esters

170 ant of the Smiles rearrangement that employs readily accessible N-aryl anthranilamides as precursors

171 Herein, we report a readily accessible N-mercaptoethoxyglycinamide (MEGA) so

172 A readily accessible new class of near infrared (NIR) mole

173 We demonstrate hydrazonyl chlorides serve as readily accessible nitrileimine precursors, whose reacti

174 xperimental quantity the rest potential is a readily accessible, nonperturbing metric of the equilibr

175 Here a readily accessible, novel method for quantitatively mapp

176 able information from biomedical research is readily accessible on the Internet, providing a powerful

177 The formation of boron enolates from readily accessible ortho-alkynylbenzeneboronic acids pro

178 ular information (delta and J), which is not readily accessible otherwise.

179 Conversion of readily accessible oxazole-5-trifluoroacetamides into th

180 This paper presents a readily accessible patterning platform--based upon geome

181 ndings represent a potentially effective and readily accessible pharmacologic approach to fertility p

182 nstrated through the Swern-type oxidation of readily accessible phenethanol analogues.

183 Suzuki-Miyaura coupling reactions involving readily accessible phenolic derivatives such as aryl sul

184 Such reactions will be readily accessible photochemically and thermally, e.g.,

185 (DABCO) derivatives are synthesized from the readily accessible piperazines in 50-64% yield by cycliz

186 atic molecular cage COP-5 in one step from a readily accessible porphyrin-based precursor.

187 pyran is easily prepared in three steps from readily accessible precursors and is amenable to structu

188 esence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with amm

189 PCDCs can be easily prepared from readily accessible precursors by a variety of different

190 an be achieved by ring closing metathesis of readily accessible precursors.

191 er natural product griffipavixanthone from a readily accessible prenylated xanthone monomer.

192 e most promising scaffold identified was the readily accessible proline derivative (e.g., 79).

193 The reaction between readily accessible propargyl acetates and sulfonyl azide

194 The reaction between readily accessible pyrazole and propargyl acetates in th

195 Thus, we establish ced as a readily accessible, quantitative descriptor of solvophob

196 oxide (TATP) can be easily manufactured from readily accessible reagents and is extremely difficult t

197 The respiratory system, although readily accessible, remains a challenging target, as eff

198 est that even highly homologous LHEs offer a readily accessible resource of related scaffolds that di

199 available Z-butene together with robust and readily accessible Ru-based dithiolate catalysts develop

200 ort a facile in situ synthesis that utilizes readily accessible SiCl4 cross-linking chemistry to crea

201 developing a polymeric ectopic scaffold in a readily accessible site under the skin.

202 hese initial steps of DNA binding occur at a readily accessible site, which is likely to be on the ou

203 cations as the detection of MSI in prevalent readily accessible skin lesions could form the basis of

204 -1H-1,2,3-triazol-4-yl)methyl)arylamide is a readily accessible small molecule scaffold for compounds

205 these findings support an important role for readily accessible small steps in protein evolution that

206 ydroboration of allenes 8 and 14a-d with the readily accessible Soderquist borane 7, which is generat

207 nversion devices due to their utilization of readily accessible solar energy; however, the output of

208 resources, providing a manually-curated and readily accessible source of age-related changes.

209 ost species, which by their abundance form a readily accessible source of blood.

210 oxol in 9 steps and 20% overall yield from a readily accessible starting material.

211 ters with improved properties, produced from readily accessible starting materials.

212 approach to this class of heterocycles from readily accessible starting materials.

213 r follicle represents a miniature organ with readily accessible stem cells, multiple cell lineages, a

214 Our findings reveal skin as a source of readily accessible stem cells, the nuclei of which can b

215 and interstitium making the immobilized Fg a readily accessible substrate for binding Abeta and cellu

216 d thiopyrano[3,4-c]pyridine derivatives from readily accessible substrates.

217 lasses for which reference standards are not readily accessible such as TPs of household chemicals.

218 ted at the base of a narrow cleft and is not readily accessible, suggesting a highly regulated cleava

219 We hypothesized that the most readily accessible target in the versican-TLR2/6 pathway

220 Such proteins constitute readily accessible targets of these relatively impermeab

221 Survival analysis is a readily accessible technique that can improve inferences

222 a coherent rotation of magnetization) at the readily accessible temperatures T > 2 K.

223 ers, compounds that previously have not been readily accessible, that can be further manipulated to c

224 Since a variety of 1,5-enynes are readily accessible, the cycloisomerization provides a ra

225 y acquired at three magnetic fields that are readily accessible, the IMPACT analysis gives a satisfac

226 sIgG1/sIgE balance might represent a readily accessible therapeutic target for asthma/rhiniti

227 d in good to excellent yields, starting from readily accessible thiosemicarbazides, bis-diarylthioure

228 etones to generate ethers are catalyzed by a readily accessible thiourea organocatalyst that operates

229 The oxalyl unit, readily accessible through commercially available starti

230 The requisite spirodienone substrates are readily accessible through the nitrenium ion cyclization

231 d pore surfaces have been demonstrated to be readily accessible, thus providing more opportunities fo

232 However, the ability to reprogram readily accessible tissue from patients into pluripotent

233 Furthermore, muscle may provide a readily accessible tissue in which to monitor therapeuti

234 olecular marker that is easily detectable in readily accessible tissues.

235 In addition, they are readily accessible to a novel thia zip cyclization proce

236 much of the RIF AngII is formed at sites not readily accessible to ACE inhibition or is formed via no

237 m the bulk aqueous environment as it remains readily accessible to acrylamide and water.

238 In contrast, the C terminus was readily accessible to antibodies at the cell surface and

239 In general, host apolipoproteins were more readily accessible to antibody labeling than HCV glycopr

240 , and partially disordered structure, is not readily accessible to any of the typical structure deter

241 e copper site of SOD5 is not recessed and is readily accessible to bulk solvent.

242 sness, learning seemed from the outset to be readily accessible to cellular and molecular analysis.

243 olecules at the surface of blood vessels are readily accessible to circulating compounds.

244 eaction mechanisms and pathways, but are not readily accessible to conventional optical spectroscopic

245 n a constitutively open conformation that is readily accessible to DNase I.

246 However, these approaches are not readily accessible to every researcher.

247 and management of cancer because the skin is readily accessible to examination and biopsy.

248 y wall of Drosophila melanogaster larvae are readily accessible to experimental manipulation.

249 his intriguing regime, however, has not been readily accessible to experimentalists because of the la

250 y to other exothermic reactions that are not readily accessible to investigation by more conventional

251 h the inner and outer membranes, where it is readily accessible to its periplasmic, PC-specific phosp

252 ber-rich foods, whereas the colonic lumen is readily accessible to lithium chloride.

253 a in Mouse Genome Informatics (MGI) and made readily accessible to many types of database searches.

254 requirements, including large surface areas readily accessible to molecules, may now be assembled on

255 are predominantly intracellular and thus not readily accessible to monoclonal antibodies.

256 ose multiple broadly cross-reactive epitopes readily accessible to NAbs.

257 on is ligand-dependent, the P2204L mutant is readily accessible to PKA, promoting ligand-independent

258 pB expressed by the de-energized mutants was readily accessible to protease, similar to TbpB expresse

259 section of the topological space that is not readily accessible to proteins on either thermodynamic o

260 undant, not considered high quality, and not readily accessible to researchers in a systematic fashio

261 their enzymatic functions and are therefore readily accessible to small molecule inhibition at their

262 oss, indicating that the prosthetic group is readily accessible to solvent.

263 even with highly abundant cytosolic proteins readily accessible to the bud neck (including molecular

264 Institute (EBI) is committed to making data readily accessible to the community in ways that meet ex

265 d to the ER membrane with their protein bulk readily accessible to the cytosolic proteasome.

266 Two amino acids, Phe(66) and Leu(67), were readily accessible to the non-polar relaxation agent oxy

267 bled the development of a web server that is readily accessible to the practising biologist while pro

268 Published time estimates are now readily accessible to the scientific community, K-12 and

269 atiotemporal expression patterns in a format readily accessible to the scientific community.

270 e insert size of approximately 115 kb and is readily accessible to the scientific community.

271 ine, 7-deazaguanine, and cytosine bases, was readily accessible to tiled 8-mer LNA and 15-mer DNA pro

272 response to exogenous stimuli and makes them readily accessible to topical drugs.

273 search findings need to be compiled and made readily accessible to users for policy making, programmi

274 ostsynaptic somatodendritic domains that are readily accessible to whole-cell patch electrodes.

275 These probes therefore represent a readily accessible toolkit to monitor cellular signaling

276 eneous cell populations creates the need for readily accessible tools for the analysis of single-cell

277 s 14a and 14b is described starting from the readily accessible trans-1 bis-Diels-Alder adduct 12.

278 ic cages via one-step alkyne metathesis from readily accessible triyne precursors is presented.

279 nd aromatic N-heterocycles, were found to be readily accessible under notably mild conditions.

280 Readily accessible unsaturated organoboron compounds ser

281 hard to synthesize or require multisteps are readily accessible using a common set of reaction condit

282 micromolar concentration range, which is not readily accessible using other techniques.

283 Previously, these were not readily accessible using palladium catalysis.

284 ron-based catalyst, generated in situ from a readily accessible valine-derived aminophenol and a Z- o

285 As the eye is a readily accessible VEGF laboratory, features expressed t

286 selected as starting compound because it is readily accessible via acid-mediated Grob fragmentation-

287 detection and comparative analysis tools are readily accessible via SecReT6, which may aid identifica

288 pothesized that the imidazo[1,2-a]pyrazines, readily accessible via the Groebke-Blackburn-Bienayme mu

289 ntaining dual sp(3)-hybridized C centers are readily accessible via this platform, and the herein dem

290 f the Fermi velocity in Dirac materials in a readily accessible way for experiments.

291 e potential of iPSCs is the establishment of readily accessible well-characterized panels of lines fo

292 utomated external defibrillators deployed in readily accessible, well-marked public areas in Chicago

293 strands, and chain-end biotin groups become readily accessible, while at lower temperatures these ac

294 des, dinitriles, etc., many of which are not readily accessible with alternative methods.

295 ulation information about face viewpoint was readily accessible with fMRI MVPA from all face patches,

296 structures to engage biological pathways not readily accessible with linear oligonucleotides.

297 n information for defined lipids that is not readily accessible with nonmass spectrometric methods.

298 um for photocatalysis of water splitting, is readily accessible with these systems.

299 te that human ability to keep information in readily accessible working memory is limited to four ite

300 ynthesis of highly substituted oxazoles from readily accessible ynamides in the presence of ytterbium