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1 non-equilibrium processes by which the atoms rearrange.
2 urements over times long enough for cells to rearrange.
3 Approximately 21% of the blocks were rearranged.
4 with alpha2, alpha3, and alpha4 helices was rearranged.
5 de chains become disordered and which become rearranged.
6 ts, the 'hydrophobic plug' loop in crenactin rearranges.
7 cipal discriminating feature: it drastically rearranges a network of proximal hydrogen bonds, modifyi
8 advanced our assay to investigate effects of rearranging actin filaments on the lateral membrane orga
14 eleted Cdc42 or Rac1 in a mouse model of ALK-rearranged ALCL to show that either Cdc42 or Rac1 deleti
15 e and crizotinib-resistant patients with ALK-rearranged (ALK-positive) non-small-cell lung cancer (NS
18 e acetyltransferases EP300 and CREBBP ZNF384-rearranged ALL showed significant up-regulation of CLCF1
19 pediatric mixed-lineage leukemia gene (MLL)-rearranged ALL were established in NOD.Cg-Prkdc(scid) Il
21 dels in vitro, as well as in the in vivo MLL-rearranged AML BMT model coupled with treatment of "5 +
22 as further confirmed in human and murine MLL-rearranged AML cell models in vitro, as well as in the i
23 lates leukemogenesis in murine and human MLL-rearranged AML cells, demonstrating a crucial role for t
24 o potentially overcome the resistance of MLL-rearranged AML to conventional chemotherapies and prompt
25 at ALOX5 is especially down-regulated in MLL-rearranged AML, via transcription repression mediated by
29 Here we report DNA-coated colloids that can rearrange and anneal, thus enabling the growth of large
30 D bioprinting, contract immediately as cells rearrange and compact the spheroid in relation to viabil
31 ynthetic pathway, an isomerocyclase that can rearrange and cyclize geranylated indolenine (2) to a pr
32 D4-bound state, in which the V1V2 loops must rearrange and separate to allow access to the coreceptor
34 the transcription factor ERG is recurrently rearranged and plays a critical role in prostate oncogen
36 linearity, whereas the remaining were highly rearranged as a result of inversions and inter- and intr
37 class of systems that the time delays can be rearranged as long as the total time delay over the cons
38 the less thermodynamically stable isotopomer rearranges at cryogenic temperatures in the dark to the
39 ent a critical pathogenetic mechanism in MLL-rearranged B-ALL and support IGF2BP3 and its cognate RNA
41 ed in mixed lineage leukemia-rearranged (MLL-rearranged) B-acute lymphoblastic leukemia (B-ALL), whic
43 ent option for infants and children with MLL-rearranged BCP-ALL who have a poor outcome when treated
44 Schizosaccharomyces pombe cells drastically rearrange both their actin and microtubule (MT) cytoskel
45 we discuss potential pathways to target ALK-rearranged brain metastases, including next generation A
48 annealing reveal that on Ag(111), structures rearrange by rotation and elongation of bonds in order t
49 rmalized eg-orbital bands are systematically rearranged by misfit strain to change its fermiology.
51 dditional fusion partner, FOXJ2; thus, MEF2D-rearranged cases comprise 5.3% of cases lacking recurrin
55 proximately 4% of the samples have massively rearranged chromosomes, many of which are associated wit
58 f ATP hydrolysis and conformational flipping rearranges client-binding sites, providing a paradigm of
61 utations impaired GABAA receptor function by rearranging conserved structural domains, supporting the
62 ide decent selectivity for the expected (non-rearranged) cross-coupled product with aryl or heteroary
63 hich structures and molecules are assembled, rearranged, disassembled, packaged, sorted, and transpor
64 Our results suggest that REMs during sleep rearrange discrete epochs of visual-like processing as d
65 al work reveals that TFIID's conversion to a rearranged DNA binding conformation is enhanced in the p
68 naptic connections in the nervous system are rearranged during development and in adulthood as a feat
69 rine tumor mainly caused by mutations in the rearranged during transfection (RET) proto-oncogene.
71 endothelial growth factor receptors and RET (rearranged during transfection) have been used when a sy
73 crosslinking assays revealed that DHX29 may rearrange eIF1A and eIF2alpha in key nucleotide context
75 e., the variety of ways the analyte ions can rearrange following electrospray into kinetically stable
76 ndomness of the order and orientation of the rearranged fragments, are all consistent with a chromoth
78 igen receptor gene loci spatially juxtaposes rearranging gene segments in the appropriate cell lineag
79 Igs ABCs express, we sequenced VH and Vkappa rearranged genes from unimmunized 22-mo-old C57BL/6 mice
85 ecific complete sequences for mRNAs encoding rearranged heavy and light chain immunoglobulins in B ce
87 inbred species, the assembly of noninbred or rearranged heterozygous genomes remains a major challeng
88 odent cardiac phospholipidome is extensively rearranged; however, whether specific acyl chains impair
89 Z868 potently suppressed the growth of CRLF2-rearranged human B-ALL cells, abrogated JAK2 signaling,
91 ) technology, involving inserting functional rearranged human variable exons into the mouse IgH and I
93 rules for Watson-Crick base pairing but have rearranged hydrogen bonding donor and acceptor groups.
99 We performed a deep sequencing analysis of rearranged immunoglobulin (Ig) heavy chain genes from bi
100 polymerase chain reaction (PCR) analysis of rearranged immunoglobulin and T-cell receptor genes (all
102 of particles are thermodynamically driven to rearrange in regions of low density and bond orientation
104 RNA/ssDNA binding protein that is frequently rearranged in a number of different cancers by chromosom
105 astic lymphoma kinase (ALK) is chromosomally rearranged in a subset of certain cancers, including 2%
107 o APC3, show how APC3's C-terminal domain is rearranged in the full APC/C assembly, and visualize res
108 n at 10 K, the triplet nitrene spontaneously rearranges in the dark to singlet 6-imino-2,4-cyclohexad
109 notable exception is mixed lineage leukemia-rearranged infant ALL, where venetoclax largely recapitu
111 to overcome a barrier of 9.1 kcal mol(-1) to rearrange into cyclohexyne (with DeltaE for ring expansi
112 to surmount a barrier of 1.6 kcal mol(-1) to rearrange into cyclopentyne (with DeltaE for ring expans
113 Astonishingly, MTs are also stabilized and rearranged into a novel antiparallel bundle associated w
115 g metamorphosis, the epithelium of the PC is rearranged into the adult "air nose," whereas a new olfa
116 tream scissile peptide bond is consecutively rearranged into two thioester or oxoester intermediates
120 ichloromethane for one month, the PCO-isomer rearranges into the thermodynamically more stable POC-is
122 plasticity of the remaining community, which rearranged itself through rewiring, while maintaining it
125 lence subbands of the AlN/GaN DA is properly rearranged leading to the heavy-hole (HH) miniband being
128 mary human HSPCs faithfully models acute MLL-rearranged leukemia and provides an experimental platfor
129 he relevance of MLL2 as a drug target in MLL-rearranged leukemia and suggest its broader significance
130 o observe an unexpected role for MLL2 in MLL-rearranged leukemia cells and identify potential therape
143 nation of the unique features of the sirtuin rearranging ligands (SirReals) as highly potent and isot
145 atients were aged 18 years or older with ALK-rearranged locally advanced or metastatic cancer that ha
147 12, and April 30, 2016, 26 patients with RET-rearranged lung adenocarcinomas were enrolled and given
149 metastatic anaplastic lymphoma kinase (ALK)-rearranged lung cancer, resistance to crizotinib develop
150 ctivity of cabozantinib in patients with RET-rearranged lung cancers defines RET rearrangements as ac
151 ctivity of cabozantinib in patients with RET-rearranged lung cancers, we did a prospective phase 2 tr
152 g P2Y receptors) in crizotinib-resistant ALK-rearranged lung tumors compared to treatment-naive contr
153 1 have nonredundant roles in controlling ALK-rearranged lymphoma survival and morphology but are redu
154 Our results indicate that the capacity to rearrange meaningless sounds in order to create new sign
156 thylation in the egg cell depends on DOMAINS REARRANGED METHYLASE 2 (DRM2) and RNA polymerase V (Pol
157 including RNA POLYMERASE V (POL V), DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) and SAWADEE HOMEOD
158 clude the de novo methyltransferase, DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2), which methylates
159 hylation is largely dependent on the DOMAINS REARRANGED METHYLTRANSFERASES 1/2 (DRM1/DRM2) RdDM pathw
160 e and intermediate antibodies, IGHV1-2( *)02-rearranging mice, which also express a VRC01-antibody pr
162 a birth and death event, the cells are being rearranged minimizing the overall energy expenditure.
163 aused them to expand their apical cytoplasm, rearrange mitochondrial/lysosome trafficking, and genera
164 omplete mitochondrial genomes, including two rearranged mitochondrial genomes within Haemosporidia.
167 dhood B-ALL, the outcome of infants with MLL-rearranged (MLL-r) B-ALL remains dismal, with overall su
168 ally overexpressed in mixed lineage leukemia-rearranged (MLL-rearranged) B-acute lymphoblastic leukem
172 ith PML had a single neurotropic strain with rearranged NCCR, and 1 patient had a single strain with
173 The natural history of PDGFRA- and PDGFRB-rearranged neoplasms has been dramatically altered by im
174 eukoencephalopathy of the brain is caused by rearranged neurotropic JCPyV, little is known about vira
175 f clinical response are unpredictable in ALK-rearranged non-small cell lung cancer (NSCLC) patients t
176 ddress this, we evolved resistance in an ALK rearranged non-small cell lung cancer line (H3122) to a
177 and determine outcomes for patients with ALK-rearranged non-small-cell lung cancer (NSCLC) and brain
178 K)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non-small-cell lung cancer (NSCLC) are sensit
179 h untreated anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC) is not kno
181 t chemotherapy in patients with advanced ALK-rearranged non-small-cell lung cancer who had previously
183 in untreated patients with stage IIIB/IV ALK-rearranged non-squamous NSCLC was done in 134 centres ac
184 2 into five cohorts: ALK inhibitor-naive ALK-rearranged NSCLC (cohort 1), crizotinib-treated ALK-rear
185 ged NSCLC (cohort 1), crizotinib-treated ALK-rearranged NSCLC (cohort 2), EGFR(T790M)-positive NSCLC
186 sess ceritinib activity in patients with ALK-rearranged NSCLC and brain or leptomeningeal metastases.
188 ated analysis includes all patients with ALK-rearranged NSCLC given oral ceritinib at the recommended
189 All eight crizotinib-naive patients with ALK-rearranged NSCLC had a confirmed objective response (100
190 ors have shown systemic efficacy against ALK-rearranged NSCLC in many clinical trials, but the effect
191 al in patients with crizotinib-resistant ALK-rearranged NSCLC is prospectively assessing the safety a
193 of crizotinib observed in both ROS1- and ALK-rearranged NSCLC patients, resistance due to acquisition
195 Patients with brain metastases from ALK-rearranged NSCLC treated with radiotherapy (SRS and/or W
196 f 90 patients with brain metastases from ALK-rearranged NSCLC were identified from six institutions;
197 reatment with ceritinib in patients with ALK-rearranged NSCLC who have received crizotinib, or as an
198 d crizotinib-naive or crizotinib-treated ALK-rearranged NSCLC with active, measurable, intracranial C
199 51 (72% [60-82]) of 71 patients with ALK-rearranged NSCLC with previous crizotinib treatment had
201 and had advanced malignancies, including ALK-rearranged NSCLC, and disease that was refractory to ava
209 o elevated gammadeltaT17 differentiation and rearranging of fetal specific TCRVgamma/delta in adultho
210 recede those in IgL loci, 2) IgLlambda genes rearrange only when IgLkappa genes are consumed, and 3)
211 layers that nevertheless are mobile and can rearrange or be displaced by other molecules to strongly
213 tients with anaplastic lymphoma kinase (ALK)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non
215 ted a poor outcome, compared with RBM15/MKL1-rearranged patients and those with AMKL not carrying the
220 routing, endothelial cells (ECs) dynamically rearrange positions in the sprout to compete for the tip
221 attach to crystal surfaces and structurally rearrange (postattachment) to incorporate into the under
224 by beta-hydride elimination, and as a result rearranged products are not observed with secondary alky
225 ld and with only minor contaminations of the rearranged products that are frequently observed if the
226 ide chains of residues coordinating the zinc rearrange quickly to promote the nucleophilic attack of
227 rees of freedom: the tethers can diffuse and rearrange, radically changing the physics of the interac
228 mmune system relies on germline-encoded, non-rearranging receptors expressed by innate immune cells r
230 g of the ArfA N-terminus in the second state rearranges RF2 into an extended conformation that docks
235 ed below their melting temperature, but also rearrange so that aggregated particles can anneal into t
236 solution of 3a or 3b at reflux afforded the rearranged species ArSn(3-tricyclo[2.2.1.0(2,6)]heptane)
237 ted patients aged at least 18 years with ALK-rearranged stage IIIB or IV non-small-cell lung cancer (
238 ce were crossed with mice expressing a fully rearranged T cell receptor alphabeta transgene, normal l
239 rophic receptors and did not proliferate but rearranged Tcra prematurely and differentiated rapidly.
240 -associated TCRbeta paired with endogenously rearranged TCRalpha endowed unprimed T cells with autoan
241 nd leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfull
246 double-positive (DP) thymocytes, which then rearrange the locus encoding the TCR alpha-chain (Tcra).
249 meable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding.
251 g by members of related paramyxovirus genera rearranges the head domains of the attachment proteins,
253 ents with distinct functions as follows: one rearranges the translocon, displacing Sec62 from Sec61.
255 d then resolves the structure by iteratively rearranging the local genome structure, in a randomized
256 La4Ni3O10-x by removing two oxygen atoms and rearranging the rock salt layers to fluorite-type layers
257 is believed to underlie adaptive behavior by rearranging the way neuronal circuits process informatio
258 es genomic integrity while cells somatically rearrange their antigen receptor genes [in a process cal
260 ted reporters driven by divergent promoters, rearranged their gene order, and probed their expression
262 Following this, the two bound ligands slowly rearrange, thereby leading to the minor population with
266 s show how ligands and surface-support sites rearrange to accommodate these changes, consistent with
267 s resulting from PFAA-enamine cycloadditions rearrange to amidines at room temperature, while (3 + 2)
268 e latent regime, the adsorbed polymer chains rearrange to anchor their ends onto the surface and cont
270 re precursors of imidoylnitrenes, which also rearrange to carbodiimides or add intramolecularly to ar
272 a single V segment to frequently contact and rearrange to D and J segments and dominate the adult TCR
276 ye development, interommatidial cells (IOCs) rearrange to generate the highly organized pupal lattice
277 ing group, such as C(4)-Cl or C(5)-NO2, they rearrange to products 4 in the presence of aqueous ammon
278 oup of the peroxyvinylsulfenic acid can also rearrange to the alpha position, and by reaction with th
279 methylazines and azinylcarbenes, which often rearrange to the energetically more stable arylnitrenes.
282 nt, while the tRNA cluster trnW-trnC-trnY is rearranged to trnY-trnW-trnC in J. hyalinus, the first r
283 ically activated bicyclo[3.2.0]hept-1(5)-ene rearranges to 1,2-dimethylenecyclopentane via electrocyc
285 under ambient conditions, and [Ter2 SnAs](-) rearranges to form [TerSnAsTer](-) , an unprecedented an
286 NA from precursor segments in the MIC genome rearranges to form transcriptionally active genes in the
287 a carbenium ion and dihydrocinnamic acid, or rearranges to generate protonated dihydrocinnamic acid a
293 ngton's disease model, that integration of a rearranged transgene with coincident deletion of 5,444 b
296 arate such local variation into colinear and rearranged variation, because they usually do not recove
297 ich an upstream VH element recombines with a rearranged VHDHJH joint to generate a new BCR specificit
298 ghly labile and by visible or IR irradiation rearranges via a 1,2-fluorine migration from boron to ca
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