ライフサイエンスコーパス: rearrangement

1 cyclization (vinylcyclopropane-cyclopentene rearrangement).

2 ed in 63 patients (50.8% of those with CRLF2 rearrangement).

3 nal and the other predicting a nonfunctional rearrangement).

4 imodal transition state, and a retro-Claisen rearrangement.

5 mammals can use an inverted order of Ig loci rearrangement.

6 becomes more polarized and undergoes radial rearrangement.

7 f a B-cell clonal lineage, the initial V(D)J rearrangement.

8 e during the course of a Pd-induced metalate rearrangement.

9 a genes, it is rapidly replaced by IgLlambda rearrangement.

10 sily adapted to generate any cancer-relevant rearrangement.

11 brane binding rather than to trigger bilayer rearrangement.

12 ased deletions/reduced insertions during VDJ rearrangement.

13 ck of reactivity in the studied BF3-promoted rearrangement.

14 S events were involved in this complex ERCC8 rearrangement.

15 egulating Arp2/3-mediated actin cytoskeletal rearrangement.

16 [1,5]-H shift in Z-pentadiene, and the Cope rearrangement.

17 hances the rate of the methylenecyclopropane rearrangement.

18 ur-electron electrocyclization followed by a rearrangement.

19 f an allyl diazene, i.e., an allylic diazene rearrangement.

20 cal interpretation of non-coding chromosomal rearrangements.

21 chine learning to be maximally predictive of rearrangements.

22 n situ hybridization for MYC, BCL2, and BCL6 rearrangements.

23 nses to shear, motor motilities, and network rearrangements.

24 three known and identified one novel genome rearrangements.

25 tatively different deformations and internal rearrangements.

26 a general solution to catalytic onium ylide rearrangements.

27 SR pipeline to analyze SHM and/or CSR in BCR rearrangements.

28 ncrease the individual risk for transmitting rearrangements.

29 propanation-Cope and translactonization-Cope rearrangements.

30 x genome, and (2) the elucidation of complex rearrangements.

31 ogenesis as loss of N-cadherin disrupts cell rearrangements.

32 finger-encoding genes associated with KMT2A rearrangements.

33 satDNA arrays that suggest recent structural rearrangements.

34 risk of ectopic recombination and chromosome rearrangements.

35 er form that adopts carboxyl-terminal domain rearrangements.

36 of the Ae. markgrafii genome involved in the rearrangements.

37 vity was critical for ICAM-1-induced F-actin rearrangements.

38 bosomal proteins and numerous RNA structural rearrangements.

39 roducts that frequently underwent subsequent rearrangements.

40 51%), ABL class fusions (9.8%), JAK2 or EPOR rearrangements (12.4%), other JAK-STAT sequence mutation

41 ed enantioselective tandem [3,3]-sigmatropic rearrangement-[2+2]-cyclization.

42 f patients with Ph-like ALL, including CRLF2 rearrangements (51%), ABL class fusions (9.8%), JAK2 or

43 merase 3 (PARP3) as promoters of chromosomal rearrangements across human cell types.

44 llar hypoplasia, whereas a case with genomic rearrangements affecting the ATAD3C/ATAD3B genes on one

45 olving cell division, growth, migration, and rearrangement, all of which occur within physically cons

46 of six ancestral chromosomes, with extensive rearrangement among neighboring regions.

47 nd to form a captodative radical followed by rearrangement and decarboxylation to form an aryl radica

48 ms to provide a comprehensive survey of this rearrangement and its application in the synthesis of na

49 underlying mechanism of this conformational rearrangement and its implications for heme transfer via

50 break (DSB) repair, is implicated in genomic rearrangement and oncogenic transformation; however, its

51 human RBCs resulted in abnormal cytoskeletal rearrangement and release of intracellular molecules ass

52 ation that extends existing models of genome rearrangement and used this to study the role of templat

53 nct subsets according to the presence of ALK-rearrangement and/or ALK-CNG signals.

54 gh-throughput sequencing of antigen-receptor rearrangements and blind multicenter reanalysis of flow

55 ong the orthogonal axis is cancelled by cell rearrangements and cell shape changes.

56 n is particularly susceptible to chromosomal rearrangements and contains many genes crucial for neuro

57 , our data provide new insights into the RNP rearrangements and extensive exchange of proteins that o

58 ons predispose chromosome 22q11.2 to meiotic rearrangements and increase the individual risk for tran

59 thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.

60 Specifically targeting genomic rearrangements and mutations in tumor cells remains an e

61 family kinase cascade to drive cytoskeletal rearrangements and target engulfment through Rac1.

62 d both morphological assessments of cellular rearrangements and time-lapse imaging to visualize cochl

63 ng formation of an ate complex, 1,2-metalate rearrangement, and beta-elimination.

64 cesses such as genome expansion, chromosomal rearrangement, and chromosomal translocation.

65 lead to DNA double-strand breaks, chromosome rearrangements, and hypermutation, which are all sources

66 luding RBM15-MKL1, CBFA2T3-GLIS2, KMT2A gene rearrangements, and NUP98-KDM5A.

67 erase chain reaction analysis of Ig/TCR gene rearrangements, and patients were assigned to a genetic

68 Cys34 oxidation products, mixed disulfides, rearrangements, and truncations.

69 endent behavior within anionic phospho-Fries rearrangements (apFr) of P(O)(OFc)n(EAr)3-n (Fc = Fe(eta

70 B cell development and Ig rearrangement are governed by cell type- and development

71 Chromosome rearrangements are a common feature of human malignancie

72 Although these rearrangements are ascertained by junction PCR, we descr

73 .2 220 kb BP2-BP3 interval showed that these rearrangements are associated with autism spectrum disor

74 Although some gene rearrangements are diagnostic of particular sarcoma type

75 Chromosomal rearrangements are essential events in the pathogenesis

76 Chromosome rearrangements are important drivers in genome and gene

77 Chromosomal rearrangements are increasingly recognized to underlie n

78 affected by CNV has been difficult, as these rearrangements are often contained in large chromosomal

79 and sugar utilization in winemaking, whereas rearrangements are strongly associated with reproductive

80 we discovered that the distribution of human rearrangements arising in the mouse was generally compar

81 hat may point to the presence of chromosomal rearrangements as the primary disease cause.

82 tion, sulfur ylide formation/2,3-sigmatropic rearrangement, as well as nitrogen ylide formation follo

83 the reduced EcPlt exhibits large structural rearrangements associated with its activation.

84 of HA that inhibits the large conformational rearrangements associated with membrane fusion in the lo

85 and block the low pH-induced conformational rearrangements associated with membrane fusion.

86 Rearrangement at this position indicates that the DNA ha

87 Increase in P trafficking displayed a rearrangement between compartments by supplying P to the

88 costs that may be associated with structural rearrangements between the oligomer and fiber states.

89 Subsequently, GCK promoted cytoskeletal rearrangements by associating with actin.

90 report for the first time that the Winstein rearrangement can be enlisted as the racemization pathwa

91 e that endogenous Rspo2 and Rspo3 chromosome rearrangements can initiate and maintain tumour developm

92 metal-free C-H sulfenylation/intramolecular rearrangement cascade reaction employing an internally o

93 , [DippN=Si(OSiMe3 )Ni(Cl)(NHC)2 ] (3), in a rearrangement cascade.

94 cedented enzyme-promoted alpha-hydroxyketone rearrangement catalysed by vanadium-dependent haloperoxi

95 t in situ enantioselective [2,3]-sigmatropic rearrangement catalyzed by the isothiourea benzotetramis

96 imately 50% of prostate cancers, chromosomal rearrangements cause the fusion of the promoter and 5'-U

97 reak (DSB) repair results in complex genomic rearrangements (CGRs) in many cancers and various congen

98 Directed epitope rearrangements combined with a knowledge-based structura

99 ge-scale secondary, tertiary, and quaternary rearrangements compared with the prefusion trimer and ra

100 morphisms largely resulting from chromosomal rearrangements (CRs) are widely documented in fungal gen

101 ails a highly diastereoselective aldol/Brook rearrangement/cyclization cascade.

102 r "clefting." Cell migration, proliferation, rearrangement, deformation, and ECM dynamics have varied

103 everal other mechanisms, such as chromosomal rearrangements, deletion/insertion, transposon-mediated

104 ibrillar alphaS is taken up by pMac by actin-rearrangement-dependent pathways, and monomeric alphaS b

105 ch was associated with TERT point mutations, rearrangements, DNA amplifications and transcript fusion

106 ing provide evidence that protein structural rearrangements during aggregation impact the populations

107 ore an essential regulator of conformational rearrangements during ion channel opening and closing.

108 ide resolution insights into rRNA structural rearrangements during nucleolar 60S assembly.

109 ests substantial inter- and intra-chromosome rearrangements during the Caryophyllales genome evolutio

110 py to analyze nuclear morphology and F-actin rearrangements during the initiation, progression, and c

111 or successful, predictive models of particle rearrangement dynamics in bulk systems.

112 th styryl bromide via O-styrylation, Claisen rearrangement, ene reaction, and O-alkylation occurred i

113 which feedback repression of sequential DNA rearrangements ensures that only one autosome expresses

114 The assay of signal-joint/DbetaJbeta T-cell rearrangement excision circles (sj/beta-TREC ratio) over

115 ort that this strong binding enables a quark-rearrangement, exothermic reaction in which two heavy ba

116 lyzed hydrosilylation helped stymie unwanted rearrangements facilitated by vinyl group participation

117 ses revealed a two-step mechanism, a complex rearrangement followed by gene amplification, for the si

118 ative examples of geometry or conformational rearrangements for each selected class of the numerous p

119 he relative role of these EJ pathways during rearrangement formation has remained controversial.

120 A likely mechanism of chromosomal rearrangement formation involves joining the ends from t

121 HEJ factors are required for the increase in rearrangement frequency caused by inhibition of the ATM

122 In this article, we show that the rearrangement frequency distribution within the V region

123 e identified as products of intrachromosomal rearrangements fusing the 3' coding portion of the EGFR

124 These dramatic rearrangements generate new interesting phenotypes that

125 apillatum (Euglenozoa), mitochondrial genome rearrangements have resulted in nearly hundred chromosom

126 Alder reaction, and the Cope and the Claisen rearrangements) have been characterized.

127 terrogate the oncogenic potential of genomic rearrangements identified in human brain cancers.

128 sponds with fission being the rarest type of rearrangement in avian genome evolution.

129 We identify profound rearrangement in cellular proteostasis occurring very ea

130 in understanding the consequences of genetic rearrangement in evolution and disease, and in using vir

131 We demonstrate that the gephyrin rearrangement in nanodomains stabilizes the amplitude of

132 C expulsion was accompanied by a major actin rearrangement in neighboring cells that maintained epith

133 RK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer).

134 t synergistically to induce a conformational rearrangement in the C-terminal domain of ExoU.

135 maturation protein, we observed a structural rearrangement in the capsid coat proteins that is requir

136 anonical amino acid, we show that there is a rearrangement in the eag domain-CNBHD interaction with t

137 The fast adsorption and slow chain rearrangement in the first regime are found to be the ca

138 also facilitated the elucidation of complex rearrangements in a mutagenized strain.

139 Finally, we observe reciprocal rearrangements in actin and myosin accompanying the tran

140 e SF within a monolayer induces cytoskeletal rearrangements in cells long distances away.

141 Chromatin rearrangements in enhancer regions occurred before the s

142 certain significance, especially chromosomal rearrangements in non-coding regions of the human genome

143 of both balanced and unbalanced chromosomal rearrangements in primary human tumour samples, with the

144 sequencing techniques to examine chromosomal rearrangements in primary murine B cells and discovered

145 gly, an important mechanism affecting genome rearrangements in prokaryotes, the symmetrical inversion

146 NA repair result in elevated rates of genome rearrangements in radiation-resistant bacteria.

147 also sufficient to mediate PGBD5-induced DNA rearrangements in rhabdoid tumor cells.

148 The metabolic rearrangements in RNAi seeds resulted in an altered sulf

149 se and a cytochrome P450-produces unexpected rearrangements in strictosidine when assayed simultaneou

150 alysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-throughput way h

151 matic shifts have been associated with major rearrangements in the deep ocean circulation and stratif

152 barrier induces a distinct pattern of genome rearrangements in the newly replicated region behind the

153 of the s(2) modification also slows down the rearrangements in the ribosome-EF-Tu-GDP-Pi-Lys-tRNA(Lys

154 Notably, nonproductive human VH rearrangements in the transgenic mice expressed shorter

155 he membrane without causing major structural rearrangements in the transporter.

156 lification (MLPA) did not reveal any genomic rearrangements in TSC1 and TSC2 in the samples with no m

157 iated EIF3E-RSPO2 and PTPRK-RSPO3 chromosome rearrangements in vivo.

158 These rearrangements included a deletion of GCH1, which likely

159 A structural rearrangement includes the F23G24A25I26L27 region of hIA

160 ditions manifested by submicroscopic genomic rearrangements including copy number variants (CNVs).

161 ows that the ion undergoes several different rearrangements, including a rearrangement to the energet

162 finity, binding kinetics, and conformational rearrangements induced by VX-787.

163 s through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides

164 malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two

165 -cell lymphomas, detection of characteristic rearrangements involving MYC in Burkitt lymphoma, BCL2 i

166 Chromosome rearrangements involving the mixed-lineage leukemia gene

167 thway to the formation of a 0.4-Mbp deletion rearrangement is enhanced in ATM-deficient cells.

168 Finally, this type of atom-economical rearrangement is envisioned to prompt the development of

169 A cationic mechanism for the rearrangement is implicated by the available data.

170 t leads to elimination of nitrogen and Wolff rearrangement is one of the highest singlet excited stat

171 we demonstrate that the alpha-hydroxyketone rearrangement is potentially a conserved biosynthetic re

172 (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function.

173 tions, inversions, translocations, and other rearrangements, is common in human and cancer genomes.

174 end joining (ALT-EJ)], which cause distinct rearrangement junction patterns.

175 creased de novo point mutations flanking the rearrangement junctions.

176 y multiple cases of catastrophic chromosomal rearrangements known as chromoanagenesis, including soma

177 k of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for

178 l PrfA activity) were missing due to genomic rearrangements likely caused by a transposable element.

179 talline solids flow plastically via particle rearrangements localized around structural defects.

180 evels, the number of large-scale chromosomal rearrangements (LST), and the status of several DNA repa

181 n indication of the immediate product of the rearrangement machinery without an impact of selection,

182 We describe a novel rearrangement mechanism in which translocation between i

183 tenuated matrix mineralization, cytoskeletal rearrangement, mitochondrial dysfunction, and reduced ty

184 simulation results reveals common structural rearrangements near the ligand binding site induced by t

185 the molecular details of this conformational rearrangement, NMR spectroscopy was used to discover tha

186 Chromosomal rearrangements occur constitutionally in the general pop

187 We show that chromothriptic rearrangements occurred before copy number amplification

188 ivergent outcome observed during the Hofmann rearrangement of 3 and 5 was investigated by DFT calcula

189 HKs result from the rearrangement of a di-endoperoxide intermediate formed i

190 ing, and support a structural model in which rearrangement of a flexible loop upon binding of the cor

191 le contacts to the signaling modules through rearrangement of a hydrogen bond network previously iden

192 addition is primarily generated through the rearrangement of a pool of undifferentiated cells, there

193 gating compliance is that the conformational rearrangement of a single channel directly shortens the

194 hiophene ring was forged through the Stevens rearrangement of a sulfonium ylide, generated in situ fr

195 isothiourea-catalyzed enantioselective [2,3]-rearrangement of allylic ammonium ylides is described.

196 The [2,3]-sigmatropic rearrangement of allylic sulfoxides to allylic sulfenate

197 d promotion of cell expansion and underlying rearrangement of cell wall components are poorly underst

198 ecurrent SCNAs exert their influence through rearrangement of cis-regulatory elements (CREs) remains

199 ing 284 patients (20.4%), overexpression and rearrangement of CRLF2 (IGH-CRLF2 or P2RY8-CRLF2) were i

200 Isotope scrambling shows that intramolecular rearrangement of cyclohexyl phenyl ether does not signif

201 The rearrangement of cyclopropylketone arylhydrazones genera

202 sult in cell death, accompanying significant rearrangement of cytoskeletal proteins and plasma membra

203 We further show that, surprisingly, loss and rearrangement of DNA in centromere 21 is associated with

204 ology and synthetic biology for assembly and rearrangement of DNA sequences.

205 In addition, the rearrangement of free volumes depends strongly on consti

206 y annihilated after structural relaxation by rearrangement of free volumes.

207 acceptor reactions with free Glc and not by rearrangement of Glc in the active site.

208 nd p75(NTR) signaling fosters a long-lasting rearrangement of glutamatergic network that contributes

209 to maintain homeostasis leads to a dramatic rearrangement of intracellular membranes.

210 diastereoselective, and regioselective [2,3]-rearrangement of iodonium ylides has been developed as a

211 hene network, followed by a further flexible rearrangement of layers for a long-term stable cycling.

212 depends on large conformational changes, the rearrangement of local motifs, and the binding and hydro

213 This coincides with a large conformational rearrangement of miropin, which inserts the segment upst

214 so revealed a previously unseen drug-induced rearrangement of nucleotides U2506 and U2585 of the 23S

215 The mechanism of the rearrangement of oxiranyl N-methyliminodiacetyl (MIDA) b

216 with, or accompanied by, the production and rearrangement of progenitor cells.

217 The low activation barrier to the Cope rearrangement of semibullvalenes has been attributed to

218 ransition are interpreted by the topological rearrangement of solute-centered clusters in medium-rang

219 olocalize with incoming viral particles, and rearrangement of the actin cytoskeleton in infected cell

220 served changes in cBLI signal is mediated by rearrangement of the actin cytoskeleton, a process refer

221 o-domain dimerization, together with partial rearrangement of the active site upon activation, explai

222 A heme-dependent conformational rearrangement of the C-terminal domain of heme binding p

223 microscopy structure indicates that dramatic rearrangement of the C-terminal region of Nop15 in the p

224 capsid pores involve a global conformational rearrangement of the capsid and a complex alteration of

225 hannels involves a slow open-state dependent rearrangement of the direct interaction between the eag

226 gate the mechanisms leading to the polarized rearrangement of the IF network along the polarity axis.

227 rts to a conjugated polymer via an extensive rearrangement of the macromolecular structure in respons

228 Additional tricks are a rearrangement of the order, when iterating through the d

229 the [CYP121(cYY)CN] ternary complex showed a rearrangement of the substrate in the active-site, when

230 an A3B has a tightly closed active site, and rearrangement of the surrounding loops is required for b

231 tion was accompanied by a temperature-driven rearrangement of the water molecules inside the channel.

232 to host dietary calorie alterations through rearrangement of their transcriptome accompanied by subs

233 person from another, may manifest as diverse rearrangements of functional connectivity during heterog

234 ains into the bilayers, initiating the lipid rearrangements of fusion.

235 nisms (via diradical intermediates) of known rearrangements of linear [3]phenylene, benzo[b]biphenyle

236 interaction networks revealed that concerted rearrangements of local interacting modules at the inter

237 KI models expressing deduced precursor V(D)J rearrangements of mature bnAbs or unrearranged germline

238 sequencing of immunoglobulin heavy chain VDJ rearrangements of naive, mature CD5(+), IgM(+) memory, a

239 es Ckappa, carry predominantly nonproductive rearrangements of other L chain isotypes.

240 s because site diffusion requires only local rearrangements of polyelectrolyte repeat units, placing

241 itation causes dramatic but fully reversible rearrangements of the OCP structure, including carotenoi

242 ignature predominantly driven by chromosomal rearrangements of the ZNF384 gene with histone acetyltra

243 stinguish the two conformations and possible rearrangements of TMHs within them responsible for chann

244 In a previous study, we showed that genomic rearrangements of up to one million base pairs can be ge

245 ents associated with enthalpically favorable rearrangements of water are stronger than those associat

246 itutes an unprecedented application of Brook rearrangement, one which involves the intermediacy of ca

247 In cases with MYC rearrangement or copy gain, FISH for BCL2 and BCL6 was a

248 We identified 8 new rearrangement partners for 4 kinase genes previously rep

249 Examination of 73 chromosome 1q21 rearrangement patients reveals that HYDIN2 is deleted or

250 s particularly detrimental in oncology where rearrangements play diagnostic and prognostic roles.

251 ous mutations and the maintenance of neutral rearrangement polymorphism due to balancing selection on

252 to DFT calculations (B3LYP/6-311+G(d,p)) the rearrangement proceeds via intermediate formation of a d

253 lation to produce acrylamide without Amadori rearrangement product and sugar fragmentation.

254 of higher molecular weight than the Amadori rearrangement product, contribute to a large extent to t

255 n-protein interaction induces conformational rearrangement, promoting a ligand switch from His-209 to

256 of relapse including histologic subtype, MYC rearrangement, protein expression, and extranodal involv

257 Two CuCN-mediated rearrangement reactions of allenylcyclopropanols to cycl

258 controlled cyanate-to-isocyanate sigmatropic rearrangement reactions of the corresponding allyl carba

259 transitions, which have only local particle rearrangement, require thermal activation.

260 such as those that impair the conformational rearrangement required for proteinase inactivation, incr

261 n-disulfide isomerase (PDI) direct disulfide rearrangements required for proper folding of nascent pr

262 that antagonist binding prevents structural rearrangements required for receptor activation and sign

263 We further show that this synaptic rearrangement requires the activity-dependent, non-apopt

264 as ATM, whereas the influence of ATM on this rearrangement seems independent of 53BP1.

265 r understanding of the cyclopropanation-Cope rearrangement sequence.

266 Here we define the mechanism underlying this rearrangement signature.

267 relations and strain response of softness to rearrangement size and yield strain, respectively.

268 Although rearrangement starts with IgLkappa genes, it is rapidly

269 In the rearrangement step for the reaction of 1, the MIDA-boryl

270 Detection of balanced rearrangements, such as reciprocal translocations and in

271 lso be used to delineate complex chromosomal rearrangements, such as those that occur in tumor cells,

272 e of Med14 facilitate a large-scale Mediator rearrangement that is essential for holoenzyme formation

273 through accumulation of several active site rearrangements that lead to a decreased nucleotide bindi

274 th the catalytic core, similar to structural rearrangements that occur in allosterically controlled e

275 wever, often they undergo complex structural rearrangements that preclude a precise description of th

276 known about ribosomal RNA (rRNA) structural rearrangements that take place during early 60S assembly

277 vage of the C-N multiple bond to give, after rearrangement, the carbene-ligated Al(III) amide, NacNac

278 everal different rearrangements, including a rearrangement to the energetically favorable para isomer

279 nonequilibrium tetramer system prior to its rearrangement to the lower energy cyclic species.

280 oundary allowed myosin driven actin filament rearrangements to actively move individual lipid domains

281 s particularly important in tumors with such rearrangements to establish the correct diagnosis, ackno

282 ng site but also induces some conformational rearrangements to form a network of inter- and intraprot

283 The most favored [3,3]-sigmatropic rearrangement transition state is bimodal, leading to tw

284 TSPyV genomes lacked the rearrangements typical for reactivating polyomaviruses.

285 ions for the formation of simple and complex rearrangements underlying human pathologies.

286 e P-B peptide did not display any structural rearrangement upon procyanidins binding.

287 no-1,5-diene precursor, (2) facilitating the rearrangement via a lithium enolate chelate, and (3) imp

288 Oxidative [1,2]-Brook rearrangements via hypervalent silicon intermediates ind

289 The key sulfur ylide intermediate for the rearrangement was formed by the S-arylation of allylthio

290 The mechanism of the discovered rearrangement was studied both using deuterium-labeled b

291 Genomic rearrangements were detected in approximately 7% of AC p

292 Eleven new kinase rearrangements were identified, including four involving

293 Neither the copy number differences nor the rearrangements were observed in a clinical sample with a

294 T-DNA inserts are stable; no transgene rearrangements were observed.

295 enation of an oxime, and a subsequent Lossen rearrangement which occurs through a unique reaction mec

296 The disfavored [3,3]-sigmatropic rearrangement, which would produce the unobserved indole

297 nation with a severe reduction in productive rearrangements, which directly corresponded to the loss

298 dinated iodonium ylides, which undergo [2,3]-rearrangements with high selectivities (up to >95:5 r.r.

299 The exact profile of rearrangement within the V region appears to be V gene s

300 ther TCRBV families also shows selection for rearrangement within the V region of a number of genes a