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1 lycine change at position 135 [liaS(R135G)]) recapitulated a carrier phenotype defined by an increase
4 atic tumors developed in both models closely recapitulated advanced human HCC and displayed a strikin
5 ag1(Ndr)) disrupts bile duct development and recapitulates Alagille syndrome phenotypes in heart, eye
6 ion of hydrogen sulfide gas to growing cells recapitulates all aspects of reversible MT depolymerizat
8 on of exogenous adipogenic genes, our method recapitulates an adipogenic developmental pathway throug
9 we demonstrated that amyloid-beta pathology recapitulates an Alzheimer-like profile of biomarker abn
10 V-1 infection, inspiring novel approaches to recapitulate and accelerate the events that give rise to
11 le of prophage WO from Wolbachia strain wMel recapitulate and enhance cytoplasmic incompatibility.
14 del systems and discusses how well they have recapitulated aspects of the human disease as well as hi
15 fragments of EWSR1 to FLI1 is sufficient to recapitulate BAF complex retargeting and EWS-FLI1 activi
17 we describe robust gene-interaction networks recapitulating both protein complexes and functional coo
18 the oscillatory diurnal transcriptome is not recapitulated by a high-fat diet in young adult mice, it
19 ilencing defect of disome X can be partially recapitulated by an extra copy of several genes on chrom
22 n Lhx1 but not Vip mice, which was partially recapitulated by heat application to cultured Lhx1-defic
23 potentiate cocaine-primed reinstatement was recapitulated by intra-PL injection of corticosterone, t
24 ured from genome-wide 3C studies are largely recapitulated by model polymer genomes subject to landma
26 c and interphase cells - effects that can be recapitulated by RNase treatment or RNA polymerase inhib
27 ween cell length and denticle spacing can be recapitulated by specific mathematical equations in embr
28 ous heat pain threshold and that this can be recapitulated by the selective NaV 1.7 antagonist PF-519
30 ly, the results of Shah et al. (2016) do not recapitulate canonical cellular hierarchies and improper
32 orbol-12-myristate-13-acetate and ionomycin, recapitulating CAVD microenvironment, resulted in IFN-ga
34 harmacological PI3K/AKT pathway manipulation recapitulated cellular phenotypes in control cells and a
36 mal models of human diseases that accurately recapitulate clinical pathology are indispensable for un
37 re combined immunodeficiency mice faithfully recapitulated clinical and pathological features of meni
38 ections in a preclinical model of ITX, which recapitulates clinical findings and highlights the impor
39 nhuman primate hepatic IR model that closely recapitulates clinical liver dysfunction following liver
40 gly impairs NDP/FZD4 signalling in vitro and recapitulates CNS angiogenesis and blood-CNS-barrier def
41 rmacological stimulation of mGluR5 in NAcore recapitulated cue-induced reinstatement in the absence o
42 ignaling through Gq in nNOS interneurons, we recapitulated cue-induced reinstatement in the absence o
44 nt, we defined a qualitative dynamical model recapitulating cytokine-induced differentiation of commo
45 ferentiation of human pluripotent stem cells recapitulates development of the neocortex, an area affe
46 anscriptional regulatory network models that recapitulated differentiation of HSCs into progenitor ce
47 and overexpression of small 22q11.2 segments recapitulates dimensional aspects of developmental neuro
48 human microcirculation with the potential to recapitulate discrete steps of early metastatic seeding,
49 CMs derived from iPSC and nt-ESCs could both recapitulate doxorubicin-induced cardiotoxicity and exhi
51 post-implantation amniotic sac embryoid, to recapitulate early embryogenic events of human amniotic
54 While self-organizing organoids excel at recapitulating early developmental events, bioengineered
55 n for studying JH receptor function, we have recapitulated endogenous JH receptor expression with sin
56 with fetal mouse lung mesenchyme, the cells recapitulated epithelial-mesenchymal developing lung int
58 ides in length yields structural models that recapitulate experimentally determined structures with a
62 was observed, demonstrating that human CCRCC recapitulates features and gene expression changes obser
63 ated that E2f3a overexpression substantially recapitulates genome-wide transcriptional profiles and a
64 proliferative, and diffusely spreading, thus recapitulating hallmark molecular and histopathological
65 ion that uses human organotypic systems that recapitulate hallmarks of aging in order to better under
66 ium was validated in Shh(-/-) mutants, which recapitulate heart shape changes expected from a persist
67 enous ASGR-expressing cells and were able to recapitulate hepatocyte ASO uptake and activity in cells
68 evelopmental stages are highly reproducible, recapitulate histone modification changes, and reveal ke
73 been characterized, model organisms may not recapitulate human or veterinary diseases, filling evolu
78 pes based on their epigenomic profiles, thus recapitulating important aspects of human hematopoiesis.
79 lasts from pre-symptomatic mutation carriers recapitulate in vitro features found in the brains of AD
83 ngly, some aspects of NPC function have been recapitulated in artificial nanochannel mimics, even tho
84 e expressivity of the human phenotype can be recapitulated in Cwc27 mutant mouse models, with signifi
85 quirement for THAP1 in the OL lineage and is recapitulated in developmental assays performed on OL pr
89 ese observations in vitro and cell lines are recapitulated in primary neurons and in vivo, as genetic
90 m the existing Golgi to the new Golgi can be recapitulated in semipermeabilized cells and is sensitiv
92 pact of ubiquitous mutant SOD1 expression is recapitulated in transgenic mouse models of the disease.
93 nvestigated whether this conversion could be recapitulated in vitro and whether such converted cells
94 in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells
96 e and Threonine (CAT) tail elongation-can be recapitulated in vitro with a yeast cell-free system.
100 nt as augmented mast cell responses could be recapitulated in wt mast cells differentiated in the abs
101 lmonella Typhi (the cause of typhoid fever), recapitulates in an animal model many symptoms of typhoi
104 Inpp5e ablation is embryonically lethal and recapitulates JBTS, including neural tube defects and po
105 vital factor for engineered human tissues to recapitulate key aspects of the tumour microenvironment.
106 dies as an integrated tissue system that can recapitulate key disease features, thereby providing an
107 mmunication are gaining interest as they can recapitulate key features regarding the intrinsic hetero
110 ve established a zebrafish model of ALD that recapitulates key features of human disease pathology an
111 cological insensitivity to pain that closely recapitulates key features of the Nav1.7-null phenotype
114 n in vitro model of bronchial dysplasia that recapitulates key molecular and phenotypic characteristi
115 devised and imaged primary co-culture model recapitulates key molecular mechanisms that underlie bac
116 usly reported that our 26-d protocol closely recapitulates key stages of biliary development, startin
117 dic epithelium by first identifying and then recapitulating key events in embryonic fundus developmen
121 idation confirmed that OncoLead analysis can recapitulate known inhibitors as well as prioritize nove
124 ns of drug-treated LRV1(+) and LRV1(-) lines recapitulated LRV1-dependent pathology and parasite repl
125 a humanized pathological context that would recapitulate major events in plaque formation such as in
126 a containing deposits in wild-type mice that recapitulates major retinal pathophysiological features
128 pression of iron regulatory protein 2 (IRP2) recapitulates many aspects of the alterations in free ir
129 enotypes in the Scn1a (+/-) mouse model that recapitulates many features of Dravet syndrome, includin
130 hemogenetic stimulation of nNOS interneurons recapitulated MMP activation and t-SP induction (increas
133 oid corticosterone (CORT) in adolescent mice recapitulates multiple neurobehavioral consequences of s
135 of 3D bioengineered ovarian constructs that recapitulate native cell-cell interactions between ovari
137 and indicate that our mouse model is able to recapitulate neurodegenerative changes observed in FTD.
138 e is a lack of model systems that accurately recapitulate normal tissue function of human organs and
140 cessible BM microenvironment that faithfully recapitulates normal BM niche morphology and function.
142 p-coverage network resource we call AtTFIN-1 recapitulates one-third of previously reported interacti
143 onses observed in the absence of Dnmt3a were recapitulated or enhanced by treatment with the demethyl
145 -synuclein amounts in mouse midbrain neurons recapitulated pathological phenotypes observed in human
147 ous loss-of-function (LOF) variant in SLIT3, recapitulating phenotypes reported with Slit3 inactivati
148 alysis based upon this element alone largely recapitulates phylogenies inferred from much larger geno
151 form three-dimensional liver organoids that recapitulated several aspects of hepatobiliary organogen
153 icantly reduced in a cGVHD murine model that recapitulates several aspects of autoimmunity and organ
154 ratable expression of DUX4, and show that it recapitulates several features of the human pathology.
155 Our model, composed of 3-D EEC aggregates, recapitulates several functional/structural characterist
156 cle diseases, but also provide a roadmap for recapitulating skeletal myogenesis in vitro from pluripo
157 assemble in solution to form oligomers that recapitulate some of the higher-order assemblies observe
158 emporal regulation during induction in vitro recapitulated some aspects of native cartilage developme
159 in development models, but they have not yet recapitulated some essential features of brain circuit f
160 BV infection completes a full life cycle and recapitulates some of the immunopathology observed in pa
161 s and ocular and craniofacial abnormalities, recapitulating some of the features of zebrafish embryos
162 afish with a mutation in the SCN1A homologue recapitulate spontaneous seizure activity and mimic the
165 strand behavior in fibroblasts may not fully recapitulate that of epithelial tight junction strands,
167 th maternal blood, and show that these cells recapitulate the antiviral properties of primary trophob
168 olated from human cord blood that may better recapitulate the behavior of latently infected cells in
169 onstrate that CDC-secreted exosomes (CDCexo) recapitulate the cardioprotective effects of CDC therapy
170 loping in vitro models of HIV-1 latency that recapitulate the characteristics of latently infected ce
172 ial to generate constructs that more closely recapitulate the complexity and heterogeneity of tissues
173 Our data indicate that CB-BFs are able to recapitulate the conditions by which the bone marrow mic
174 C-deficient mouse embryonic fibroblasts that recapitulate the defective nuclear organization of lamin
175 However, these models have struggled to recapitulate the defining features of JMML due to in ute
178 evelopment require robust model systems that recapitulate the full span of thymopoiesis, from hematop
180 We generated Pex19 Drosophila mutants, which recapitulate the hallmarks of PBDs, like absence of pero
181 ions of tau neuropathology in our model that recapitulate the heterogeneity seen in these human disea
182 siological levels of FUS expression and that recapitulate the human disease-with progressive loss of
183 an immunocompetent rat model was designed to recapitulate the human IgE-Fcepsilon receptor system for
185 Genetic ablation of Ocrl in mice failed to recapitulate the human phenotypes, possibly because of t
186 o leukemogenesis, these models may not fully recapitulate the human system due to immunophenotypic, a
187 ithelial cells using siRNA was sufficient to recapitulate the increased motility and invasive phenoty
188 We have engineered a microdevice platform to recapitulate the intratumor oxygen gradients that drive
190 Because MRL-Atp6v1b1vxt/vtx mice do not recapitulate the metabolic acidosis of dRTA patients, th
192 Simulation of this model can accurately recapitulate the observed spatiotemporal expression of t
193 of the wild-type PRKACA was unable to fully recapitulate the oncogenic activity of DNAJB1-PRKACA, im
195 ly lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor.
196 lycomplexes, three-dimensional lattices that recapitulate the periodic structure of SCs but do not as
197 ACH/ACH)) mice expressing human FGFR3(G380R) recapitulate the phenotypes observed in ACH patients, in
198 I in normal rodent hearts has been shown to recapitulate the reduced fat oxidation and elevated atri
199 terozygous Scn1a knockout (Scn1a (+/-)) mice recapitulate the severe epilepsy phenotype of Dravet syn
201 s (MPS), also known as organs-on-chips, that recapitulate the structure and function of native tissue
205 However, the adequacy of these markers to recapitulate the whole CD3(+)CD4(+) T cell compartment r
208 ical inhibitors of Nav1.7 have not yet fully recapitulated the dramatic analgesia observed in Nav1.7-
209 re carried out in a mouse model of HS/T that recapitulated the early increase in IL33 and delayed inc
211 , suppressing either Bcl-2, Bcl-xL, or Mcl-1 recapitulated the effects of BH3 mimetics and enhanced t
213 Furthermore, Faecalibacterium prausnitzii recapitulated the effects of MET-1 on excitability of DR
214 overexpression of RCAN1 in naive DRG neurons recapitulated the effects of pharmacological CaN inhibit
215 simulations of the biophysical observations recapitulated the elevated action potential and repetiti
217 mouse models that do not overexpress tau, we recapitulated the formation of three major types of AD-r
220 ut not Sertoli cell-specific Nhe8 disruption recapitulated the globozoospermia phenotype, demonstrati
223 create a blueprint for IBD therapeutics and recapitulated the mechanism of the CARD9 protective vari
224 MT and adipogenesis of HemECs have, in part, recapitulated the natural history of hemangioma regressi
228 ed Ca(2+) dynamics and insulin secretion and recapitulated the pattern of improved proinsulin process
229 VAP-A impaired viral genome replication and recapitulated the perinuclear redistribution of NS5A see
230 infection, Ifnlr1 depletion in IECs largely recapitulated the phenotype seen in Ifnlr1(-/-) mice of
231 in vitro phosphorylation of the ABD closely recapitulated the previously described in vivo phosphory
232 tion of a natural ERV1 agonist, resolvin E1, recapitulated the pro-resolving actions gained by ERV1 o
233 ansfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when adminis
235 tely neutralized several primary viruses and recapitulated the serum neutralizing antibody response.
236 cancer specimens (n = 37) revealed the model recapitulated the spatial layout typically found in huma
237 erm three-dimensional tumoroid culture which recapitulated the tumor invasion front, allowing for bot
238 IL-17 receptor C and Pten double KO mice recapitulated the weak EMT characteristics observed in M
239 elium and lacrimal gland cell spheroids, and recapitulates the aqueous and mucin layers of the tear f
240 We demonstrate that our preclinical model recapitulates the cardio-respiratory decompensation obse
242 Addition of 2-HG to glioblastoma cultures recapitulates the effects of the IDH mutation on intrins
243 roadly usable immunocompetent CRC model that recapitulates the entire adenoma-adenocarcinoma-metastas
244 c implantation model in mice, which uniquely recapitulates the entire multistep process of CRC metast
247 us expression of HNF4G at physiologic levels recapitulates the gastrointestinal transcriptome, chroma
248 t known whether fibroblast dedifferentiation recapitulates the generation of multipotent progenitors
249 to Synechococcus 7942 of 2.03, which nearly recapitulates the in vivo growth rate ratio of 2.13.
250 re a reliable preclinical model that closely recapitulates the main characteristics of the parental t
251 els, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents.
253 whether spontaneous disease in Was(-/-) mice recapitulates the pathology of a conventional disease mo
254 deletion of Smurf2 in the osteoblast lineage recapitulates the phenotype of germline Smurf2-deficient
256 D patients as well as in a murine model that recapitulates the polyQ pathology of HD (R6/2 mice).
257 three-dimensional extracellular matrix that recapitulates the primary tumor stroma, adopt a basal-li
259 in a simple two-dimensional projection that recapitulates the relationship among the different folds
260 in-mediated, dynamic chromosomal cross-links recapitulates the segregation, morphology and self-inter
261 p/Elp1 conditional-knockout mouse model that recapitulates the selective death of sensory (dorsal roo
262 oding variation in the murine integrin beta3 recapitulates the sex-dependent neurochemical and behavi
264 generation of constructs that come close to recapitulating the complex structure of heart muscle and
266 roglial and oligodendroglial tau inclusions, recapitulating the diversity of neuropathology in human
267 l remodeling in experimental MI swine models recapitulating the effects of left ventricular (LV) dysf
268 entiated from stem cells still fall short of recapitulating the full mature hepatocellular phenotype.
270 ibular process fusion and micrognathia, thus recapitulating the most penetrant phenotypes of the synd
271 e in tissue engineering biomimetic models is recapitulating the physiological complexity associated w
272 disease-related mutations in human proteins, recapitulating the profiles of the corresponding mutated
273 metastases and macrometastases in the brain, recapitulating the progression of multifoci metastases s
275 association of the C-terminal peptide fully recapitulated their effects on the subcellular localizat
285 emonstrate that (13)C patterns of fungal FAs recapitulate those of wild-type hosts, indicating cross-
286 a methylation of TIL (MeTIL) signature that recapitulates TIL evaluations and their prognostic value
287 osomes from TLR stimulated cells can largely recapitulate TLR activation in distal cells in vitro.
288 acologically or genetically is sufficient to recapitulate transient synaptic potentiation and reinsta
290 wo pore-domain K(+) channel isoform 1 (K2P1) recapitulate two levels of resting membrane potential, i
291 tes with ectopic expression of K2P1 channels recapitulate two levels of resting membrane potential.
292 n at the third zero-current potential, again recapitulating two levels of resting membrane potential.
294 cell lines is dependent on their ability to recapitulate underlying genomic aberrations and primary
295 ture of VX-787 bound to a PB2 construct that recapitulates VX-787's biological antiviral activity in
299 itization observed in wild type mice was not recapitulated with this method of receptor expression.
300 hened coupling is rapid, dynamic, and can be recapitulated without cilium-specific proteins or lipids
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