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1 tation assay to screen against this chimeric receptor.
2 ing of the human G protein-coupled adenosine receptor.
3 tors stimulates targeted modification of the receptor.
4 neage III KIR, likely encoding a C1-specific receptor.
5 synaptic TRPV1 channels by alpha2 adrenergic receptors.
6 ell; it also regulates the activity of these receptors.
7 t lacks the ability to interact with Fcgamma receptors.
8 data suggest the importance of delta-opioid receptors.
9 r effectively blocking both AMPA and kainate receptors.
10 od via downstream communication to mPFC NMDA receptors.
11 y a sustained coexpression of PD-1 and TIGIT receptors.
12 or (BCR), Fc receptors (FcRs), and toll-like receptors.
13 ing hypothalamic peptide orthologs and their receptors.
14 t off-rate antagonist of NMDA-type glutamate receptors.
15 he nervous and immune systems using distinct receptors.
16 an potentially inhibit both AMPA and kainate receptors.
17 eterotrimeric G-protein by G-protein coupled receptors.
18 IRI through bone marrow-derived adenosine 2a receptors.
19 2+) channels and synaptically activated NMDA receptors.
20 as hetero-oligomeric alpha1beta2gamma2 GABAA receptors.
21 o be required for binding of multiple glycan receptors.
22 y-5-methylisoxazole-4-proprionic acid (AMPA) receptors.
30 obilized upon inflammation in a CC-chemokine receptor 2-dependent manner, and the nonclassical blood
31 that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4) through its N terminal and modulates S
34 d 25 as a potent and selective A2A adenosine receptor (A2AAdoR) antagonist with reasonable ADME and p
37 ative Ly6C(low) Mos/Mps, indicating that Ep3 receptor activation may be a promising therapeutic targe
40 that up-regulates Id2, the repressor of the receptor activator of nuclear factor-kappaB ligand-media
42 ys statistical resampling to measure the Eph receptor aggregation distribution within each pixel of a
43 -4 (EX-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake a
45 enobiotic activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (T
47 we show that platelet-derived growth factor receptor alpha (PDGFRalpha) and its ligand platelet-deri
48 e report that platelet-derived growth factor receptor alpha (PDGFRalpha) positive ( + ) cells accumul
49 DF15 binds with high affinity to GDNF family receptor alpha-like (GFRAL), a distant relative of recep
51 also demonstrate that the PML retinoic acid receptor-alpha (PML-RARalpha) oncofusion protein, which
52 Y POINTS: The AMPA-type ionotropic glutamate receptors (AMPARs) mediate the majority of excitatory sy
54 ough heterologously expressed glucocorticoid receptor and degradation of a permanently misfolded prot
55 their functional roles in engaging the host receptor and in mediating membrane fusion, respectively.
56 xy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor and mammalian target of rapamycin (mTOR) signal
57 mary epithelial cells (MECs) via its cognate receptor and the downstream JAK2-STAT5a signalling pathw
58 the plasma membrane that segregate membrane receptors and affect membrane curvature and vesicle form
59 ence toward alphaVbeta3 (using both isolated receptors and alphaVbeta3-overexpressing endothelial pro
60 of glutamatergic N-methyl-D-aspartate (NMDA) receptors and decreased expression of alpha-amino-3-hydr
61 by their activation of different type I BMP receptors and distinct modulations of the cell cycle.
62 tor systems, notably including growth factor receptors and G protein-coupled receptors, control myeli
63 that binds with high affinity to GPIIb/IIIa receptors and has suitable pharmacokinetic properties to
64 emonstrate that clemizole binds to serotonin receptors and its antiepileptic activity can be mimicked
66 ich are internalized by binding to scavenger receptors and subsequently escape the early endosome thr
71 dicates that radiolabeled somatostatin (sst) receptor antagonists perform better than agonists in det
72 n the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell an
73 and TSPX competitively bind to the androgen receptor (AR) and AR variants, such as AR-V7, at their c
75 ring this process, key polarity proteins and receptors are recruited to the surface of mammary epithe
76 e examined the role of tumor necrosis factor receptor-associated factor 2 (Traf2) in regulating myoca
77 ontrolling the precise localization of these receptors at specific region of the cell; it also regula
78 cooperativity, renders our new cuboctahedral receptor attractive for incorporation into systems with
79 f p110alpha-p85 heterodimers bound to active receptors, augmenting PI3K signaling and oncogenic trans
81 fied an immune cell-specific, co-stimulatory receptor B7.2 (CD86) as a co-receptor of lymphotropic HC
82 regulate signaling downstream of the B-cell receptor (BCR), Fc receptors (FcRs), and toll-like recep
83 s the activity of the pivotal B-cell antigen receptor (BCR)-proximal effector spleen tyrosine kinase
85 detected in estrogen receptor, progesterone receptor, beta-catenin, or vimentin expression between p
87 bly located on the apex of the molecule; the receptor-binding mode might be different from that of re
88 RBDs mutated in multiple key residues in the receptor-binding motif (RBM) of RBD and demonstrated the
90 long-term bioluminescence recordings, GABAA receptor blockade desynchronized the Fbxl3(+/+) but not
93 l study indicates that use of angiotensin II receptor blockers might be associated with a lesser risk
94 ,637 controls, current use of angiotensin II receptor blockers was followed by a decreased risk of ac
95 d by their ability to couple to dopamine D1R receptors by real-time bioluminescence resonance energy
96 r both the insulin receptor (IR) and mannose receptor C-type 1 (MR), which functions to clear endogen
97 51) transgenic zebrafish that uses a mannose receptor, C type 1 (mrc1a) promoter to drive strong EGFP
98 lement anaphylatoxin C5a, which acts via two receptors, C5aR1 and C5aR2, expressed on immune and bone
99 er understand how loss of D2-family dopamine receptors can ameliorate tau toxicity, we screened a col
101 neurons (CCK-INTs), a prominent CB subtype-1 receptor (CB1R) expressing neuronal population throughou
103 identify five factors, including the HIV co-receptors CD4 and CCR5, that are required for HIV infect
105 cles onto spatially segregated post-synaptic receptors clusters, but a pre-synaptic segregation of ch
107 tudy found that ACh stimulation of nicotinic receptors comprised of alpha4 and beta2 subunits (alpha4
108 growth response 3 (EGR3) is increased in D1 receptor containing MSNs of mice susceptible to social d
111 ity, response to colony-stimulating factor 1 receptor (CSF-1R) blockade and nanoparticle-based drug d
113 ound that inhibitory odors triggered outward receptor currents by reducing the constitutive activitie
114 ession of the Th1-characteristic trafficking receptor CXCR3, which correlated with significant impair
116 al adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote epithelial repair mechanisms.
118 ptors, pathogen-associated molecular pattern receptors, cytokine receptors, adipokine receptors, and
119 (mGluRI) activation, facilitates D1 dopamine receptor (D1R) expression, and ensures long-term synapti
120 nditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expressing cells resulted in attenuation
122 e-blind, placebo-controlled pharmacology [D2 receptor (D2R) antagonist amisulpride] in humans with re
123 the expression of the Netrin-1 guidance cue receptor DCC (deleted in colorectal cancer) appear to co
127 ic constraint that is mediated by muscarinic receptor-dependent regulation of mitochondrial function
131 t the role of vacuole-related proteins in BR receptor dynamics and BR responses remains elusive.
133 e sequence of gene activation/expression and receptor editing of these isotypes have not been studied
135 late the function of epidermal growth factor receptor (EGFR), the effect of protein methylation on it
136 aloglycoprotein receptor, or the transferrin receptor eliminates intramembrane proteolysis, as does l
137 ity of breast cancers expresses the estrogen receptor (ER(+)) and is treated with anti-estrogen thera
138 er expression of the IL-4Ralpha and estrogen receptor (ER) alpha compared with macrophages from male
141 studies and functional assays that use human receptors expressed in Chinese hamster ovary cells demon
143 ly relevant Ezh2 inhibitors restore androgen receptor expression and sensitivity to antiandrogen ther
144 receptor family serve as pattern recognition receptors facilitating pathogen uptake, antigen processi
146 instructing T reg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake of allergen
150 ane glycoprotein dystroglycan functions as a receptor for multiple extracellular matrix proteins and
153 or alpha-like (GFRAL), a distant relative of receptors for a distinct class of the TGF-beta superfami
154 Toll-like receptors (TLRs) are innate immune receptors for sensing microbial molecules and damage-ass
155 precise mechanism by which the bacterial SRP receptor, FtsY, interacts with and is regulated at the t
158 y, we investigate the effect of loss of P2X7 receptor function on retinal structure and function duri
159 riched for DC-lineage cells expressing Notch receptors further validates the human thymus as a DC-poi
160 peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are members of the secretin-like class B
161 rsification of structurally distinct antigen receptor genes evolved independently in jawless and jawe
164 tin-like class B family of G-protein-coupled receptors (GPCRs) and have opposing physiological roles
166 croarray analyses revealed G-protein-coupled receptor (GPR) signaling as a prominent EVI1 effector me
167 atty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3'
170 together, these findings show that the sigma receptor has a key role in METH dysregulation of dopamin
173 Insulin-like growth factor type 2 (IGF2) receptor (IGF2R) recognizes mannose 6-phosphate-containi
175 gical inhibition or gene ablation of the Ep3 receptor in mice suppresses accumulation of Ly6C(low) Mo
179 ) in rodents and selectively binds to TrkB/C receptors in vivo, as evidenced by entrectinib blocking
180 /mTOR pathway mediates signals from multiple receptors including insulin receptors, pathogen-associat
181 inetics revealed downregulation of select P2 receptors, including P2Y2R, in slow-growing hCPCs compar
182 part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activat
184 re we report a physiologically relevant NMDA-receptor-independent mechanism that drives increased AMP
185 s to demonstrate that metabotropic glutamate receptor-induced sensitization of TRPA1 nociceptors stim
187 ucing the constitutive activities of odorant receptors, inhibiting the basal spike firing in olfactor
188 of IFN-regulatory factors (DAI) that contain receptor-interacting protein (RIP) homotypic interaction
190 g serine/threonine-protein kinase 1 (RIPK1), receptor-interacting serine/threonine-protein kinase 3 (
192 n-like (MLKL) protein, which is triggered by receptor-interactive protein kinases (RIPK) 1 and 3.
193 activation of the heavily glycosylated Notch receptor involved in normal and malignant development.
194 n analogs with affinity for both the insulin receptor (IR) and mannose receptor C-type 1 (MR), which
199 viding a first glimpse of what an active TAM receptor kinase may look like and suggesting a potential
200 -dependent binding of the activating NK cell receptor KIR2DS1, providing new insights into the underl
201 ocannabinoid activation of cannabinoid (CB1) receptors known to inhibit presynaptic GABA release was
202 nd murine forms of the myeloid C-type lectin receptor langerin for simple and complex ligands augment
205 an interaction between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spre
207 sin-(1-7) by ACE2 and its binding to the Mas receptor (MasR) improves glucose homeostasis, partly by
209 EAAC1 limits group I metabotropic glutamate receptor (mGluRI) activation, facilitates D1 dopamine re
211 matrices and its interaction with a natural receptor molecule has tremendous importance in cell sign
212 Finally, we evaluated the capacity of anti-receptor monoclonal antibodies to deliver vaccine compon
213 physical exercise on the cerebral mu-opioid receptors (MOR) of 22 healthy recreationally active male
215 ions provide a mechanistic link between EPHB receptor mutations and metastasis in colorectal cancer.
216 characterization of nicotinic acetylcholine receptor (nAChR) structure and function and have potenti
218 had been considered mediated by neurokinin-1 receptor (NK-1R), we sought to determine whether itch in
219 CE STATEMENT Memantine and ketamine are NMDA receptor (NMDAR) channel-blocking drugs with divergent c
220 The activation of the N-methyl D-aspartate receptor (NMDAR) is controlled by a glutamate-binding si
222 to show that activation of the transmembrane receptor NOTCH1 directly regulates vascular barrier func
228 mbrane domain of CD4, the asialoglycoprotein receptor, or the transferrin receptor eliminates intrame
230 of systemic or centrally administered orexin receptor (OXR) antagonists on measures of impulsive-like
231 by targeting proregenerative P2Y2 nucleotide receptor (P2Y2R) activated by extracellular ATP and UTP
232 ls from multiple receptors including insulin receptors, pathogen-associated molecular pattern recepto
234 y in humans for the highly selective sigma-1 receptor PET agent (18)F-6-(3-fluoropropyl)-3-(2-(azepan
236 in mice led to sustained expansion of IL-33 receptor-positive kidney ILC2s and ameliorated adriamyci
237 f the nonselective cation channel, transient receptor potential canonical channel 6 (Trpc6), in isola
239 binding of all investigated products to the receptor presented on cells with a similar potency (pEC5
240 ic and phenotypic analyses of FCGR3A/CD16 Fc-receptor profiles were compared in CAV-positive (n=52) a
241 No differences were detected in estrogen receptor, progesterone receptor, beta-catenin, or viment
242 tated 231 G521R ER cells despite appropriate receptor protein expression and nuclear localization.
244 al. reveal a role for parathyroid hormone 2 receptor (PTH2R) in extracellular matrix production in w
248 e is hypomethylation of the aryl hydrocarbon-receptor repressor (AHRR) locus, which is observed in bl
249 e potential of sphingosine 1-phosphate (S1P) receptor (S1PR) agonism in the treatment of infectious d
250 owed subnanomolar affinity and excellent KOP receptor selectivity acting as full or partial agonists,
252 Dysregulation of tumor necrosis factor (TNF) receptor signaling is a key feature of various inflammat
253 ndergo the peroxisome proliferator-activated receptor signaling-dependent switch from glycolysis to f
255 thors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation s
257 generate A2AR embedded phospholiposomes from receptor solubilized in n-dodecyl-beta-d-maltoside analo
258 ation of the three-dimensional structure and receptor specificity of the H15 hemagglutinin, revealing
259 that designing compounds to target specific receptor states, rather than specific receptor types, ma
260 sion of the key downstream messenger insulin receptor substrate-1 phosphorylated at serine residue 31
261 alue of 233 nM, selectivity versus other P2Y receptor subtypes, and is thought to act as an allosteri
263 n implicated in interactions with the CD3 co-receptor, suggests a possible role for an allosteric mec
265 by exponential enrichment with a single AMPA receptor target (i.e. GluA1/2R) to isolate RNA aptamers
266 ults suggest the potential of using a single receptor target to develop RNA aptamers with dual activi
269 The interaction between the T cell antigen receptor (TCR) expressed by natural killer T cells (NKT
270 titis B virus-specific (HBV-specific) T cell receptor (TCR) may supplement HBV-specific immune respon
272 is facilitated by peroxins including PEX5, a receptor that delivers cargo proteins from the cytosol t
273 ainst the alpha subunit of the interleukin-5 receptor that significantly reduces the incidence of ast
274 receptors (NMDARs) are ionotropic glutamate receptors that are crucial for neuronal development and
276 of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusc
279 The retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum prevents t
281 , we conclude that nucleotides activate P2Y6 receptors to suppress GC growth through a novel SOCE/Ca(
283 ure, we demonstrate that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4) through its N termi
287 ecific receptor states, rather than specific receptor types, may be a viable strategy for future drug
289 a key regulator of not only GPCRs, but also receptor tyrosine kinases, including the highly cancer r
290 din-2 expression in colon and that bile salt receptors VDR and Takeda G-protein coupled receptor5 (TG
292 ing of a transcription factor, the vitamin D receptor (VDR), whose activating ligand vitamin D has be
294 ical for synchrony in the adult SCN, and its receptor, VPAC2R, reached detectable levels after birth
296 inflammatory cytokines and various toll-like receptors were overexpressed in SAH neutrophils compared
299 ane domain of CD74 or the asialoglycoprotein receptor with Astn2 TM2 leads to the appearance of a car
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