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1 g mechanism for ERK signaling activation and receptor down-regulation.
2 and used them to obtain mutants defective in receptor down-regulation.
3 receptor clustering does not correlate with receptor down-regulation.
4 as necessary for optimal internalization and receptor down-regulation.
5 receptor (MOR) resulted in agonist-dependent receptor down-regulation.
6 plified by failure to attenuate signaling by receptor down-regulation.
7 inity and elimination of the agonist-induced receptor down-regulation.
8 in uncoupling, receptor internalization, and receptor down-regulation.
9 tion mechanisms: growth factor depletion and receptor down-regulation.
10 g both of these kinases in the M2 muscarinic receptor down-regulation.
11 es from the COOH terminus is involved in the receptor down-regulation.
12 were examined for their ability to modulate receptor down-regulation.
13 or cells, sometimes as a result of decreased receptor down-regulation.
14 at de novo protein synthesis is required for receptor down-regulation.
15 ells were less sensitive to ligand-dependent receptor down-regulation.
16 s, probably due in part to the difference in receptor down-regulation.
17 i-IGF-1R antibodies, it induces agonist-like receptor down-regulation.
18 receptor clustering, leading to synergistic receptor down-regulation.
19 osomal pathways and affect the efficiency of receptor down-regulation.
20 ot explain prolonged recovery rates from CB1 receptor down-regulation.
21 and chemokine expression without evidence of receptor down-regulation.
22 ylation and activation, which is followed by receptor down-regulation.
23 only CRF-induced internalization results in receptor down-regulation.
24 egative mutant of NHERF enhances EGF-induced receptor down-regulation.
25 tors (EGFRs) at the cell surface to restrict receptor down-regulation.
26 in ligand-stimulated epidermal growth factor receptor down-regulation.
27 lation, signal transduction and, indirectly, receptor down-regulation.
28 may be an important regulatory mechanism in receptor down-regulation.
29 s including nutrient uptake and cell surface receptor down-regulation.
30 SNX1 deletion mutant significantly inhibited receptor down-regulation.
31 regulation, whereas it inhibited EGF-induced receptor down-regulation.
32 igh rates of undirected song cause mu-opioid receptor down-regulation.
33 auses inositol 1,4,5-trisphosphate (InsP(3)) receptor down-regulation.
34 degradation occurs during hormone-induced LH receptor down-regulation.
35 ses had little effect on mu and delta opioid receptor down-regulation.
36 ated the mechanism of agonist-induced opioid receptor down-regulation.
37 tors attenuated agonist-induced mu and delta receptor down-regulation.
38 ndependent of mechanisms and measurements of receptor down-regulation.
39 , which in mammalian systems would result in receptor down-regulation.
40 -derived protein Tat in HIV-mediated mannose receptor down-regulation.
41 lly and completely prevents ligand-dependent receptor down-regulation.
42 the type II receptor suggest ligand-mediated receptor down-regulation.
43 n, and is therefore likely to be mediated by receptor down-regulation.
44 e (InsP3) receptors and, thus, lead to InsP3 receptor down-regulation.
46 molecular mechanism underlying tolerance and receptor down-regulation after long-term use of cannabin
47 ell responses, this activity is regulated by receptor down-regulation and a feedback loop involving t
48 Wortmannin reversed the IL-4-induced TNF receptor down-regulation and all other measured cellular
49 and that proteasome inhibitors block InsP(3) receptor down-regulation and cause the accumulation of p
50 e results reveal the mechanism of CP-induced receptor down-regulation and characteristics that functi
51 Glu-122, and also Gln-109 enhanced the EphA2 receptor down-regulation and decreased p-ERK and p-AKT.
57 dly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynapt
58 Rab5-positive membranes and thus facilitates receptor down-regulation and recycling at the late endos
62 g surfaces are important for ligand-mediated receptor down-regulation and suggest that receptor and c
63 easomal pathway had a role in glucocorticoid receptor down-regulation and the subsequent transcriptio
64 MP-dependent kinase and PKC in M2 muscarinic receptor down-regulation and their functional desensitiz
65 trate a paradoxical coupling between steroid receptor down-regulation and transcriptional hyperactivi
66 le cellular processes including cell surface receptor down-regulation and viral budding from host cel
67 gulated N-terminal cleavage participating in receptor down-regulation and, moreover, that the recepto
68 ver, proteasome inhibitors did not block IP3 receptor down-regulation, and phospholipase Cbeta1 and p
70 emerged as a physiological mechanism of ErbB receptor down-regulation, and this mechanism appears to
71 e in RNA binding activity during hCG-induced receptor down-regulation; and 4) limited tissue expressi
74 ne secretion, which correlate with iNKT cell receptor down-regulation, are induced within narrow bioc
75 ess was reproduced by ligand-dependent EP(2) receptor down-regulation as assessed by immunohistochemi
76 sphorylation were reduced more than 90%, and receptor down-regulation as well as colony formation wer
80 ndicate that TRPV1 agonists induce long-term receptor down-regulation by modulating the expression le
81 2)YIY(614) was also an important process for receptor down-regulation by TRACON105 (TRC105), an endog
85 ed antagonistic effects on EGF-dependent EGF receptor down-regulation, cell proliferation, and activa
87 ed EGFR tyrosine phosphorylation and delayed receptor down-regulation despite receptor occupancy by l
88 er hand, one could conclude that cannabinoid receptor down-regulation does not account for the develo
89 onsequently loss of RIN1 blocks surface AMPA receptor down-regulation evoked by chemically induced lo
90 characterized by cytokine secretion, surface receptor down-regulation, expansion, and secondary activ
92 The presence of caspase inhibitors blocked receptor down-regulation in a pattern similar to poly(AD
97 ht a potential role for rapid Ins(1,4,5)P(3) receptor down-regulation in homologous and heterologous
99 of beta-adrenergic receptor kinase restores receptor down-regulation in the presence of mutants to t
100 Similar to UVA, both UVB and UVC induced receptor down-regulation, in which receptor kinase activ
102 , Rab5 overexpression reversed the deficient receptor down-regulation induced by alendronate, suggest
105 These results indicate that UVA-induced receptor down-regulation is dependent on caspase activat
108 biochemical activation of IGF1R, then causes receptor down-regulation, making MCF-7 cells refractory
109 ressant-like effect in mice and suggest that receptor down-regulation may be an essential part of the
110 determinants of RIDbeta that are involved in receptor down-regulation, mutations within the cytoplasm
111 pared with normal PE glands, suggesting that receptor down-regulation occurs at the transcriptional l
112 inations show similar internalization rates, receptor down-regulation occurs only after activation of
113 IFNAR1, endocytosis of the type I interferon receptor, down-regulation of IFNAR1 levels, and IFNAR1 p
114 ent cells, these data suggest that transient receptor down regulation on microglia aids in establishi
115 ght to play an important role in controlling receptor down-regulation, previous studies disagree on w
116 mplexes to mediate 125I-EGF internalization, receptor down-regulation, receptor degradation, and rece
118 lation, we sought to determine whether EP(2) receptor down-regulation results in increased invasivene
119 re, in Neuro2A cells, agonist-induced opioid receptor down-regulation seems to depend directly on the
120 olar residues into the wild-type TR promotes receptor down-regulation that can be demonstrated by cha
121 H8 provided a significant protection against receptor down-regulation, the protein kinase C inhibitor
122 antibody (h10H5) that induces more efficient receptor down-regulation to show that IGF-IR is promptly
123 involves in cellular phenomena ranging from receptor down-regulation to viral budding to cytokinesis
124 unterbalanced by increased posttranslational receptor down-regulation, to skin chemical carcinogenesi
125 or receptor, Nedd4 reverses Cbl-b effects on receptor down-regulation, ubiquitylation, and proximal e
126 or a variety of cellular functions including receptor down-regulation, viral budding, antigen present
128 unctional MOR but not DOR in agonist-induced receptor down-regulation was further demonstrated by sit
131 requirements for measles virus (MV)-induced receptor down regulation, we transfected the human CD46
132 ) receptor mRNA stability during hCG-induced receptor down-regulation, we have identified an LH/hCG r
133 eceptors are known to undergo ligand-induced receptor down-regulation, we sought to determine whether
135 ivity inhibitor AG1478 increased UVA-induced receptor down-regulation, whereas it inhibited EGF-induc
136 flammation and reveals a unique mechanism of receptor down-regulation, which can be used therapeutica
137 of beta2AR by beta-agonists is attenuated by receptor down-regulation, which ensures transient stimul
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