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1 rmation, which triggers MAPK recruitment and receptor internalization.
2 tein- or beta-arrestin-mediated signaling or receptor internalization.
3 spinal cord by visualizing neurokinin type 1 receptor internalization.
4 cruitment of beta-arrestin-2, and subsequent receptor internalization.
5 companied chemical induction of LTD and AMPA receptor internalization.
6 signaling in the pIIb cell by driving Notch receptor internalization.
7 osphorylation on S351, a residue crucial for receptor internalization.
8 r recycling but has no effect on transferrin receptor internalization.
9 ole in SDF-1alpha signaling via CXCR4 and/or receptor internalization.
10 tein or second-messenger pathway followed by receptor internalization.
11 marked functional selectivity of cannabinoid receptor internalization.
12 ulation, [(35)S]GTPgammaS binding, and CB(1) receptor internalization.
13 vation is inhibited correlating with reduced receptor internalization.
14 PCR to facilitate effective NHERF1-dependent receptor internalization.
15 agonist-induced receptor phosphorylation or receptor internalization.
16 asurements of beta-arrestin2 association and receptor internalization.
17 regions influence the overall efficiency of receptor internalization.
18 n uncover unique ligand efficacies linked to receptor internalization.
19 ed by receptor activation, without affecting receptor internalization.
20 341/343 and then on Thr-353/354, followed by receptor internalization.
21 be, at least in part, the consequence of M1 receptor internalization.
22 its endocytic adaptor activity to facilitate receptor internalization.
23 density membrane domains and to TNF-induced receptor internalization.
24 membrane, is also thought to be involved in receptor internalization.
25 mulated cell migration and in regulating EGF receptor internalization.
26 valent CCK(2) antagonist 2 did not stimulate receptor internalization.
27 help to sustain TcR/CD3 signaling after the receptor internalization.
28 indicating that the antagonist could induce receptor internalization.
29 ow that full VEGFR3 signalling is coupled to receptor internalization.
30 tures, Abeta treatment failed to induce NMDA receptor internalization.
31 of chemokines did not significantly enhance receptor internalization.
32 the dynamin inhibitory peptide, which blocks receptor internalization.
33 ires sodium influx, proteasomal activity and receptor internalization.
34 ncreased affinity for CXCR4 and to efficient receptor internalization.
35 with increases in cluster size and rates of receptor internalization.
36 utophosphorylation as well as ligand-induced receptor internalization.
37 arrestin 3 without affecting agonist-induced receptor internalization.
38 agonist-activated 7TMRs, thereby regulating receptor internalization.
39 f beta-arrestin2 to the plasma membrane, and receptor internalization.
40 trate underlying receptor desensitization is receptor internalization.
41 avy chain/beta-adaptin, thereby accelerating receptor internalization.
42 uitment of beta-arrestin-2 to the microOR or receptor internalization.
43 wing ligand binding but cap with CCR7 during receptor internalization.
44 itment of beta-arrestin-2 to the microOR and receptor internalization.
45 aling owing to its participation in TGF-beta receptor internalization.
46 vity-dependent versus constitutive glutamate receptor internalization.
47 e of ubiquitination and a complete rescue of receptor internalization.
48 a molecular chaperone for clathrin-mediated receptor internalization.
49 is critical for receptor degradation and not receptor internalization.
50 lly triggers EGFR Thr654 phosphorylation and receptor internalization.
51 ls, yet, ubiquitinylation is dispensable for receptor internalization.
52 and the ability to enhance beta2-adrenergic receptor internalization.
53 he role of receptor oligomerization in CXCL8 receptor internalization.
54 GluR1 serine 845 triggers NMDA-induced AMPA receptor internalization.
55 the EGFR, thus leading to the inhibition of receptor internalization.
56 t clathrin adaptor requirement for activated receptor internalization.
57 a treatment by suppressing the efficiency of receptor internalization.
58 -arrestin-2 to the muOR and does not lead to receptor internalization.
59 nversely, dynamin-2 inhibition only affected receptor internalization.
60 the requirement of the actin cytoskeleton in receptor internalization.
61 on agonist binding, biological activity, or receptor internalization.
62 lp set BCR signaling threshold by regulating receptor internalization.
63 tivation is not dependent on agonist-induced receptor internalization.
64 pine cytoskeleton and facilitating glutamate receptor internalization.
65 has been shown to mediate synaptic glutamate receptor internalization.
66 ET-negative feedback loop, which accompanies receptor internalization.
67 , which then facilitates desensitization and receptor internalization.
68 lar applications of p4, a blocker of GABA(A) receptor internalization.
69 likely resulting from Nef- and Env-mediated receptor internalization.
70 : cAMP generation, MAP kinase activation and receptor internalization.
71 line behavior (i.e., "overshoot") was due to receptor internalization.
72 in and other proteins--eventually leading to receptor internalization.
73 that retains Akt at the membrane, and not by receptor internalization.
74 as analyzed the role of cell morphology and receptor internalization.
75 e activation in parallel with inhibited EGFR receptor internalization.
76 cling to the cell surface, with no effect on receptor internalization.
77 athogenesis driven by immunoglobulin-induced receptor internalization.
78 d downstream events: Akt phosphorylation and receptor internalization.
79 igands CCL17 and CCL22, in part by impairing receptor internalization.
80 of a muscarinic depolarizing current and M1 receptor internalization.
81 uired for G protein-independent constitutive receptor internalization.
82 d cognitive deficits and decreased glutamate receptor internalization.
83 ng receptor-G-protein coupling and promoting receptor internalization.
84 in signaling, beta-arrestin recruitment, and receptor internalization.
86 MI alone was found to be sufficient to drive receptor internalization acutely and a robust down-regul
87 ected cell-surface receptors, we discuss how receptor internalization affects signaling specificity a
89 hine and DAMGO display different profiles of receptor internalization and a similar ability to trigge
90 X-C chemokine ligand 12 (CXCL12), results in receptor internalization and activation of several signa
91 ist D-[Pen(2),Pen(5)]enkephalin could induce receptor internalization and adenylyl cyclase (AC) desen
93 of Akt but instead significantly compromised receptor internalization and arrestin 3 recruitment.
95 o residue 381 did not affect agonist-induced receptor internalization and beta-arrestin2 translocatio
96 S295D) of PSD-95 inhibited NMDA-induced AMPA receptor internalization and blocked the induction of LT
98 ncy was assessed by immunofluorescence-based receptor internalization and Ca(2+) mobilization assays.
99 he importance of these domains in regulating receptor internalization and cell activation, we lentivi
100 il of PAR1 and is essential for constitutive receptor internalization and cellular recovery of thromb
101 osphorylation sites on the beta(2)AR blocked receptor internalization and coupling to G(i) proteins,
102 ivity via a mechanism likely reflecting AMPA receptor internalization and creation of silent or immat
103 roligin-3 and AMPA receptors, increases AMPA-receptor internalization and decreases postsynaptic AMPA
104 n 17 (K17F) is crucial for triggering apelin receptor internalization and decreasing blood pressure (
105 with the group C adenovirus protein known as receptor internalization and degradation alpha (RIDalpha
106 tion of matrix adhesion promotes uniform FGF receptor internalization and degradation while enhanced
107 complex 10.4K/14.5K, also known as RID (for "receptor internalization and degradation"), is encoded b
108 and stimulation of tumor cells induces EphA2 receptor internalization and degradation, a process that
109 ephrin-A1 does not efficiently induce EphA2 receptor internalization and degradation, and does not a
113 this study, we investigated parameters of DC receptor internalization and determined how they impact
114 hanisms such as beta-arrestin recruitment or receptor internalization and endocytic trafficking.
115 gnaling was limited to modest ligand-induced receptor internalization and ERK1/2 phosphorylation in r
116 sly unrecognized link between ARF6-regulated receptor internalization and events that drive dramatic
117 ctin polymerization, which resulted in rapid receptor internalization and failure to support downstre
118 eceptor and is required for a rapid phase of receptor internalization and for functional signaling vi
119 ptor sites within cluster 1 had no effect on receptor internalization and had a less extensive effect
120 l change of CXCR4 on Rac1 inhibition blocked receptor internalization and impaired CXCL12-induced Gal
121 mutation of Leu-773 but not Tyr-770 impaired receptor internalization and increased receptor stabilit
122 owth factor induced the kinase insert domain receptor internalization and interaction through C-termi
123 ic sites at the plasma membrane, followed by receptor internalization and intracellular sorting.
124 endogenous ARF6 activation and constitutive receptor internalization and is reversed by ARF6 inhibit
125 Loss of p85beta impaired ligand induced KIT receptor internalization and its overexpression enhanced
126 metabotropic glutamate receptor-induced AMPA receptor internalization and LTD both in wild-type and i
127 K activity was required for initiating micro receptor internalization and maintaining possible micro-
129 Moreover, excess cholesterol could evoke receptor internalization and protein kinase C-independen
130 changes in G protein localization depend on receptor internalization and receptor-Galpha coupling.
132 a(2)ARs underwent slow GRK2 phosphorylation, receptor internalization and recycling, and failed to co
133 iquitin, with AMPAR ubiquitination enhancing receptor internalization and reducing AMPAR cell surface
134 ction with arrestins, whose binding promotes receptor internalization and signaling through G protein
135 ate a novel role for Parkin in synaptic AMPA receptor internalization and suggest a Parkin-dependent
136 ry from desensitization are not dependent on receptor internalization and suggest that the activity o
137 ortant role of caveolin-1 (CAV1) in TGF-beta receptor internalization and TGF-beta signaling, the par
138 nding does not stimulate natriuretic peptide receptor internalization and that cellular environment d
139 We show that beta-arrestins are required for receptor internalization and that only beta-arrestin2 ca
140 ased with respect to the rate or duration of receptor internalization and that receptor internalizati
141 e found that IGF-1 and IGF-2 induced GFP-S1P receptor internalization and that the effect was blocked
142 ctively induces weak chemotaxis and leads to receptor internalization and the beta-arrestin 2 recruit
144 ion between the ability of agonist to induce receptor internalization and the magnitude of adenylyl c
145 urther show that KCTD12 reduces constitutive receptor internalization and thereby increases the magni
147 BDNF transiently activates TrkB, leading to receptor internalization and ubiquitination/degradation,
150 in a membrane-proximal locale independent of receptor internalization and upstream of dynamin action.
151 me agonist-induced beta-arrestin binding and receptor internalization, and (iii) serines 355, 356, an
152 LKIL motif resulted in only 50% reduction in receptor internalization, and a 50% reduction in Akt and
153 e requires transmitter-receptor interaction, receptor internalization, and a protein kinase C-depende
154 By contrast, the recruitment of arrestin 3, receptor internalization, and activation of Akt were reg
155 anslocation to the membrane, agonist-induced receptor internalization, and agonist-induced desensitiz
156 phosphorylation, beta-arrestin recruitment, receptor internalization, and beta-arrestin-dependent ER
157 ein activation to G-protein desensitization, receptor internalization, and beta-arrestin-dependent si
160 ed CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expres
161 d receptors at the membrane, did not enhance receptor internalization, and decreased the amount of ph
162 ated synaptic protein synthesis, excess AMPA receptor internalization, and increased spine density.
163 ts, including ligand binding, ligand-induced receptor internalization, and ligand-stimulated intracel
165 Treatment with doxazosin triggered EphA2 receptor internalization, and suppressed haptotactic and
166 ions to recruit endocytic machinery for AMPA receptor internalization, and this action, together with
167 on of beta-arrestin2 to the plasma membrane, receptor internalization, and uncoupling from G proteins
168 ection, including attachment to the cellular receptor, internalization, and virus genome transfer int
169 tment of beta-arrestin to the beta2AR; (iii) receptor internalization; and (iv) activation of extrace
171 re we show that drug-specific differences in receptor internalization are determined by a conserved,
172 on on membrane translocation of arrestin and receptor internalization are due, at least in part, to d
173 kinase phosphorylation of beta(2)AR and the receptor internalization are much slower than that induc
175 e now examine the effect of these ligands on receptor internalization as a mechanism of receptor regu
176 heless, activation does increase the rate of receptor internalization as does disruption of rafts wit
181 ggering via antibody binding rapidly induces receptor internalization but does not affect TLR-induced
182 and CC chemokines to undergo ligand-induced receptor internalization, but is not coupled to trimeric
183 immunoreceptor aggregates and a trigger for receptor internalization, but is not required for tyrosi
184 n (8-OH-DPAT) inhibited the evoked mu-opioid receptor internalization by about 50%, with an approxima
185 intracellular sorting steps that occur after receptor internalization by endocytosis provide a critic
187 estin translocation, ERK phosphorylation and receptor internalization confirmed that GPR35 functions
188 at both beta-arrestin recruitment and apelin receptor internalization contribute to the K17F-stimulat
189 igh-throughput flow cytometry measurement of receptor internalization described by Wu et al. in the c
190 proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II
191 ntion of beta1AR-EGFR interaction throughout receptor internalization, direct EGF ligand stimulation
193 f surface alpha(1a)AR levels indicate modest receptor internalization during the 10 min following sti
194 50]: 0.21 +/- 0.18 vs. 1.38 +/- 0.54 nM) and receptor internalization (EC50: 41.9 +/- 29.8 vs. 455 +/
195 the ability of these new agonists to induce receptor internalization, ERK activation, and chemotaxis
196 inase-interacting protein 2 (GIT2) regulates receptor internalization, focal adhesion dynamics, cell
197 cipates in many cellular functions including receptor internalization, focal adhesion remodeling, and
200 This study highlights the importance of receptor internalization for full functionality of GLP-1
202 By comparing stimulus bias factors among receptor internalization, G protein activation, extracel
203 well described components of MOP signaling: receptor internalization, G protein coupling, and activa
204 vities of LPA(4) that include the following: receptor internalization; G(12/13)- and Rho-mediated neu
205 is finding is potentially important, because receptor internalization has been associated with develo
207 e actin cytoskeleton to facilitate glutamate receptor internalization has not been demonstrated.
208 ation provokes PAR-2 activation, as shown by receptor internalization (i.e. receptor movement from LR
209 ead compound 2 potently inhibits S1P-induced receptor internalization in a cell-based assay (EC50 = 0
210 n p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization in a clathrin/dynamin-dependent
211 th a number of compounds that might regulate receptor internalization in a nontraditional manner.
212 n, but its last eight amino acids facilitate receptor internalization in concert with beta-arrestin2.
213 d EGFRvIII and demonstrate the importance of receptor internalization in distinguishing their specifi
215 e 2 (SphK2) in vitro, and did not cause S1P1 receptor internalization in HCC cells or T lymphocyte ho
218 o the membrane and decreased agonist-induced receptor internalization in human embryonic kidney 293 c
220 tion, we did not detect any Abeta-evoked NK1 receptor internalization in neurons from laminas I, III,
223 cellular calcium, ERK1/2 phosphorylation, or receptor internalization in receptor-bearing COS or CHO-
224 so looked for evidence of neurokinin 1 (NK1) receptor internalization in the dorsal horn after electr
226 n occurs through Src-family kinase-dependent receptor internalization in vitro and in vivo, presumabl
227 The D2/D3 agonist quinpirole, which induces receptor internalization in vitro, was administered at g
231 the dynamics of agonist-induced cell surface receptor internalization, in which lack of phosphorylati
233 urface expression of CXCR7 without affecting receptor internalization, indicating that receptor recyc
234 ly attenuates the DNIC and neurokinin type 1 receptor internalization induced either by heat or mecha
239 alterations are accompanied by growth factor receptor internalization into signaling endosomes and re
241 These results demonstrate that engineered receptor internalization is an effective strategy for re
243 zation was not as efficient, suggesting that receptor internalization is required but not sufficient
246 , we show that adhesion inhibits mitotic FGF receptor internalization, leading to receptor enrichment
247 Inhibition of CD13 abrogates bradykinin B(2) receptor internalization, leading to the attenuation of
248 or (EGFR) has been implicated in EGF-induced receptor internalization, lysosomal degradation, and dow
250 uration of receptor internalization and that receptor internalization may be independent of activatio
254 of fibrinogen to its alphaIIbbeta3 integrin receptor, internalization of the alphaIIbbeta3 complex,
256 ns, induced chemotaxis, but failed to induce receptor internalization or beta-arrestin 2 recruitment.
257 lly restricted arrestin mutant did not cause receptor internalization or desensitization but did prom
259 pO specifically blocks Rac-dependent Fcgamma receptor internalization pathway but not complement rece
261 n-coupled receptor action by enabling faster receptor internalization, possibly through a direct asso
262 inhibition of opioid release and not of the receptor internalization process, because 8-OH-DPAT did
264 ormation, whereas Bcr prevents Rac1-mediated receptor internalization, promoting spine growth over re
265 diverse functions, including ligand binding, receptor internalization, proper folding, and export, as
266 cognate cell-surface receptor often promotes receptor internalization, protecting cells from prolonge
267 o recruit beta-arrestins, and did not induce receptor internalization, providing the first clear exam
268 differential STAT phosphorylation profiles, receptor internalization rates, and downstream gene expr
269 the general concepts of receptor signaling, receptor internalization, regulation of distinct signali
271 a-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogen
272 was also observed, as CXCL11 induced faster receptor internalization, slower recycling, and longer i
273 -phosphate (S1P)(1) receptor, induces S1P(1) receptor internalization sufficiently in the presence or
274 , into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of acti
275 tibody was shown to induce a higher level of receptor internalization than the combination of two par
276 s a gateway for cellular control of synaptic receptor internalization through second messenger signal
277 isrupted later steps of MC4R and transferrin receptor internalization to endosomes as well as traffic
279 sphorylation of gamma2 Y365 and Y367 reduces receptor internalization, to understand their importance
280 ced inhibition of ACh currents is because of receptor internalization trigged by protein tyrosine pho
281 ependence arises from the effects of CXCR1/2 receptor internalization, TyrRS(Mini) does not induce in
282 the critical role of beta-arrestin 2 in CB1 receptor internalization upon treatment with CP55940 (ag
283 the structural determinant(s) that modulate receptor internalization, various chimeric and point mut
286 ion of receptor immunoreactivity, whereas M1 receptor internalization was not affected by loss of GRK
287 f G(s) signaling, arrestin mobilization, and receptor internalization was observed upon alanine subst
290 d methodologies, including a novel assay for receptor internalization, we show that the majority of k
292 ts with regard to cAMP production and apelin receptor internalization, whereas 21 is a biased agonist
293 r aminoalkylindoles) failed to promote CB(2) receptor internalization, whereas 5-(1,1-dimethylheptyl)
294 ypertonic sucrose or dynasore, which prevent receptor internalization, whereas dephosphorylation of S
295 inity for beta-arrestin proteins and limited receptor internalization, whereas enkephalin analogs pro
296 ary and sufficient for efficient Epo-induced receptor internalization, whereas ubiquitination at Lys(
297 ructural determinants regulating the rate of receptor internalization, which in turn controlled the a
299 e desensitization of G-protein signaling and receptor internalization while simultaneously eliciting
300 ist-induced beta-arrestin2 translocation and receptor internalization yet significantly attenuated re
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