ライフサイエンスコーパス: receptor ligand

1 pound A, a novel nonsteroidal glucocorticoid receptor ligand.

2 ceptor type B (ETB(R)) and Jagged1, a Notch1 receptor ligand.

3 oprotease-mediated release of a presumed EGF receptor ligand.

4 which can be blocked by injection of mannose receptor ligands.

5 GF receptor when stimulated by the seven EGF receptor ligands.

6 l molecules, such as epidermal growth factor receptor ligands.

7 by (18)F-FDG- or (68)Ga-labeled somatostatin receptor ligands.

8 atory cytokines in response to the Toll-like receptor ligands.

9 nistration of selective D(2), D(3), and D(4) receptor ligands.

10 (IL-2), IL-7, or IL-15 but not by Toll-like receptor ligands.

11 for studying the affinity of putative sigma2 receptor ligands.

12 been identified as new potent sigma (sigma) receptor ligands.

13 chanical properties and coated with adhesion receptor ligands.

14 cting the antinociceptive efficacy of sigma1 receptor ligands.

15 ve stimulus effects with other reported I(2) receptor ligands.

16 us tumor cell lysate combined with toll-like receptor ligands.

17 namics in the mechanism of action of nuclear receptor ligands.

18 r antagonists alongside other established EP receptor ligands.

19 ture-based discovery and design of chemokine receptor ligands.

20 gnature included several proangiogenic CXCR2 receptor ligands.

21 of aminopyridines, including known estrogen receptor ligands.

22 ith the human endogenous guanylate cyclase C receptor ligands.

23 5-HT6R as potent dual 5-HT7/5-HT2A serotonin receptors ligands.

24 immuno-modulatory molecule programmed death receptor ligand 1 (PD-L1).

25 ed by higher levels of cytokines [CXCL1 (CXC receptor ligand 1), CCL2 (CC receptor ligand 2), and TNF

26 h a gamma-aminobutyric acid A-benzodiazepine receptor ligand, (11)C-flumazenil, and the reconstructed

27 nes [CXCL1 (CXC receptor ligand 1), CCL2 (CC receptor ligand 2), and TNFalpha] as quantified in cell-

28 -substituted analogues of the selective NMDA receptor ligand (2S,1'R,2'S)-2-(carboxycyclopropyl)glyci

29 The potent sigma1 receptor ligand 7c was able to inhibit selectively the g

30 tudy demonstrates that mammalian cannabinoid receptor ligands activate a conserved cannabinoid signal

31 providing the time needed for conformational receptor-ligand adjustments, typical of the induced-fit

32 ersus-leukemia activity modulated by NK cell receptor-ligand affinities in AHCT for AML.

33 ay, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response

34 (1),Ile(4),Ile(8)]-AngII has no effect on B2 receptor ligand affinity or bradykinin-induced arrestin3

35 ntagonized pbPPARG, although their predicted receptor-ligand affinity was weak.

36 citotoxic inflammation; and [5] kappa-opioid receptor ligands also modulate Type-I auditory neural ac

37 Addition of bivalent D2 receptor ligands also resulted in a large increase in D2

38 ted and releases the epidermal growth factor receptor ligand amphiregulin and tumor necrosis factor r

39 To optimize the structure of a mu-opioid receptor ligand, analogs H-Tyr-c[D-Lys-Xxx-Tyr-Gly] were

40 h capsaicin and the endogenous TRPV1 and CB1 receptor ligand anandamide (ACR neurons).

41 as an example of a new class of cannabinoid receptor ligand and allosteric modulator, with the poten

42 ata establish (R)-PZQ as a G-protein-coupled receptor ligand and suggest that the efficacy of this cl

43 phages in response to a variety of Toll-like receptor ligands and bacteria, without affecting their p

44 signaling, including epidermal growth factor receptor ligands and lysophosphatidic acid, have been id

45 r secretion after stimulation with Toll-like receptor ligands and M. tuberculosis whole-cell lysate,

46 ms induced in human DCs by pathogens, innate receptor ligands and vaccines.

47 ssembled nectin-2 oligomers, suggesting that receptor-ligand and ligand-ligand associations are mutua

48 amino acid neurotransmitter D-Ser is a GluD2 receptor ligand, and endogenous D-Ser signaling through

49 e stimulated by cholesterol loading, liver X receptor ligands, and cyclic AMP, and N-glycosylated SMP

50 and B6-RPE07) were stimulated with toll-like receptor ligands, and energetic pathways were assessed t

51 iability, CSC frequency, expression of death receptor ligands, and tumor burden.

52 jawed vertebrates arose from closely linked receptor, ligand, and antigen-processing genes in the pr

53 an AEGIS-SELEX that could possibly generate receptors, ligands, and catalysts having sequence divers

54 critically on context, i.e. the interplay of receptors, ligands, and regulators that form the TGF-bet

55 differentially regulates expression of Notch receptors, ligands, and target genes.

56 ide effects; endogenous and exogenous opioid receptor ligands; and conventional and novel opioid comp

57 Four arginine-containing peptide receptor ligands (angiotensin II, neurotensin(8-13), an

58 l distinct physiological end points but FFA2 receptor ligands appropriate to test this hypothesis hav

59 f each form and whether this is regulated by receptor ligands are unknown.

60 a wide panel of protein kinase, enzyme, and receptor ligand assays.

61 oss-reactivity of therapeutically used GLP-1 receptor ligands at the glucagon receptor that is abolis

62 nd agonist behavior of these novel melatonin receptor ligands based on superposition models and confo

63 ve advantages over other dopamine (DA) D2/D3 receptor ligands because, as an agonist, it measures hig

64 dently of autocrine/paracrine loops of death receptor ligands, because blocking antibodies for TNFalp

65 method is ideal to probe the lipid effect on receptor ligand binding as demonstrated by antagonist bi

66 I genotypes predictive of varying degrees of receptor-ligand binding affinities influence clinical ou

67 chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to th

68 ysis and improve the quality of estimates of receptor-ligand binding kinetics.

69 g the AmAc concentration for quantifying the receptor-ligand binding strengths.

70 nvestigate this juxtacrine pathway, we mimic receptor-ligand binding within the cell-cell junction by

71 adigm for hierarchical mechano-regulation of receptor-ligand binding.Von Willebrand factor (VWF) is a

72 ta on how membrane-proximal domains modulate receptor ligand-binding affinity and dimerization effici

73 ulations of the GluA2 AMPA subtype glutamate receptor ligand-binding domain (LBD) dimers to character

74 the crystal structures of GluN1/GluN2A NMDA receptor ligand-binding domain (LBD) heterodimers in com

75 e the conformational dynamics of the nuclear receptor ligand-binding domain (LBD).

76 r, where EID1 mimics helix H1 of the nuclear receptor ligand-binding domain.

77 However, steroid receptor ligand-binding domains (LBDs) are inherently un

78 st cancer is strictly dependent on an intact receptor ligand-binding pocket and that FES binds to ERa

79 forms a coherent signaling pathway from the receptor ligand-binding pocket to the G-protein activati

80 d the surrounding amino acid residues in the receptor ligand-binding pocket.

81 ability of hydrogen bonds in the GluA2 (AMPA receptor) ligand-binding domain in the presence of sever

82 targeting, agonistic receptor engagement, or receptor-ligand blockade, having contrasting requirement

83 activation, where small numbers of antigenic receptor-ligand bonds at a cell-cell interface can stimu

84 The strength, availability, and number of receptor-ligand bonds regulate the rate by which tumor c

85 ution is especially important to noncovalent receptor-ligand bonds, because they become exponentially

86 data, we observed a distinct force range for receptor-ligand bonds, which allowed us to precisely ide

87 he vessel wall via the formation of specific receptor-ligand bonds.

88 tethers which report cell-exerted tension on receptor-ligand bonds.

89 rphine and methadone, and the selective I(2) receptor ligands BU224 and 2-BFI.

90 say uncovered the intrinsic nature of sigma1 receptor ligands by recording the ligand-mediated confor

91 responses elicited by the G protein-coupled receptor ligand, C3a, or by thapsigargin, which induces

92 The conjugation of ASOs to a receptor ligand can dramatically increase their entry in

93 Receptor ligands can be applied as early markers of irre

94 s in the tumor microenvironment by toll-like receptor ligands can lead to a powerful systemic antitum

95 models guided the design of novel melatonin receptor ligands characterized by a 2-acylaminomethyltet

96 MADD-4 and NLG-1, suggestive of a tripartite receptor ligand complex.

97 LECT-2 functions in a multi-protein receptor-ligand complex that also contains two transmemb

98 onalize these results, a homology model of a receptor-ligand complex was built using the published cr

99 pN, a force that also induces a state of the receptor-ligand complex with slower off-rate.

100 sest atoms (200-1000 atoms), or for the full receptor-ligand complex, but it is likely that with a pr

101 ification onto three-dimensional models of a receptor-ligand complex.

102 drive affinity and enhance stability of the receptor-ligand complex.

103 re of an intact, full-length, and functional receptor.ligand complex.

104 s phosphorylation by segregating the engaged receptor/ligand complex from receptor protein tyrosine p

105 gest a systemic alteration of the CCR3/CCL11 receptor/ligand complex in patients with neovascular AMD

106 to EPCR may promote the endocytosis of this receptor/ligand complex.

107 Examination of the x-ray structures of the receptor-ligand complexes further showed two distinct fo

108 at of unliganded receptors, agonist-bound D2 receptor-ligand complexes resulted in an increase in dim

109 the prediction of the structure of chemokine receptor-ligand complexes that have not been crystallize

110 ptor activation triggered by bridging of TAM receptor-ligand complexes to the 'eat-me' signal phospha

111 t and integrates the information from sparse receptor-ligand complexes, coordinating the progression

112 on observed in the crystal structures of the receptor-ligand complexes.

113 may lead to increased success in determining receptor-ligand complexes.

114 formed, including the equilibrium number of receptor-ligand connections.

115 dy examined whether a novel imidazoline I(2) receptor ligand CR4056 could serve as a discriminative s

116 Parabens and human epidermal growth factor receptor ligand cross-talk in breast cancer cells.

117 er infection, as did expression of the Cxcr2-receptor ligands Cxcl1 and Cxcl2.

118 increased expression of the CXCR3 chemokine receptor ligands CXCL9 and CXCL10 in VV-infected skin.

119 rfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalN

120 duction profile matches the P. angustum CqsS receptor ligand-detection capability.

121 of testosterone to the more potent androgen receptor ligand dihydrotestosterone.

122 of counterintuitive mechanical regulation of receptor-ligand dissociation have been described.

123 ing mice with multivalent forms of the Notch receptor ligand DLL-1, but the immunologic correlates of

124 etic analyses to delineate the rules for TAM receptor-ligand engagement and find that the TAMs segreg

125 er extended well beyond the perimeter of the receptor-ligand engagement zone.

126 These cell signals are propagated following receptor-ligand engagement, controlling recruitment and

127 We also show that HER receptor ligands exert unique effects on signaling by mo

128 erent growth factors suggests that these EGF receptor ligands fall into two major groups as follows:

129 neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells was needed to restric

130 The Fas receptor ligand FasL regulates immune cell levels by ind

131 to functional LRP1 clusters was tested in a receptor-ligand fluorometric assay made by immobilizing

132 ecific membrane or gastrin-releasing peptide receptor ligands for the imaging of prostate cancer.

133 h spawned an explosion of small-molecule NOP receptor ligands from discovery programs in major pharma

134 or transduction in the presence of Toll-like receptor ligands further enhanced IFN-gamma production.

135 Specifically, we demonstrate that the receptor ligand G-CSF selectively activates STAT3 within

136 Galectin-3-binding protein (gal3bp) and its receptor/ligand, galectin-3 (gal3), are secreted protein

137 neurogenesis is normally driven by both TAM receptor ligands Gas6 and protein S.

138 be loss of function of the ATP-gated P2X(2) receptor (ligand-gated ion channel, purinergic receptor

139 modulators are over-represented in membrane receptors, ligand-gated ion channels and nuclear recepto

140 The TAM receptor ligand, growth arrest specific 6, re-establishe

141 K11195), a typical peripheral benzodiazepine receptor ligand, has been established as a potent hCAR d

142 [3,2-b]carbazole (FICZ), an aryl hydrocarbon receptor ligand, has been found to be a potent UVA photo

143 IL-1beta), an inflammatory cytokine and IL-1 receptor ligand, has diverse activities in the brain.

144 inositol and interacts with cannabinoid (CB) receptor ligands, has been proposed as a new potential d

145 ls elicited in the presence of C-type lectin receptor ligands have an increased ability to produce cy

146 In particular, we found that the MET receptor ligand hepatocyte growth factor (HGF) was espec

147 included missing killer immunoglobulin-like receptor ligand, human antimouse antibody response, and

148 hese results suggest that HCV disables a key receptor ligand in infected hepatoma cells, thereby inhi

149 rformed by injecting cytokines and Toll-like receptor ligands in close vicinity to the graft causes r

150 enylalanine (FDOPA), and (68)Ga somatostatin-receptor ligands in NETs has been expanding.

151 rgues for evaluating the implication of UNC5 receptor ligands in other oncogenic microbial species.

152 ely induced by EGFR (epidermal growth factor receptor) ligands in vitro and oncogenic Kras(G12D) in v

153 We developed a screening method for orphan receptor ligands, in which cell-surface proteins are exp

154 uman primary hepatocytes with most Toll-like receptor ligands increased hepcidin mRNA within 6 h.

155 ar to consist of autoinhibited resting-state receptors, ligand-induced conformational changes, and hi

156 This receptor ligand interaction is highly specific, and the

157 n lipid A molecules using multiple sites for receptor-ligand interaction and propose that host-specif

158 on of Notch signaling occurs following Notch receptor-ligand interaction and subsequent enzymatic pro

159 t peptide-Fc fusion protein, neutralizes the receptor-ligand interaction between Tie2 and angiopoieti

160 We apply the method to analyze a key receptor-ligand interaction in the early stage of hemost

161 tions for these two proteins is based on the receptor-ligand interaction observed in the crystal stru

162 ty shift assay, we show that TH has a direct receptor-ligand interaction with the Mafa promoter and,

163 ubes provide a novel mechanism for selective receptor-ligand interaction, contributing to the short-r

164 splaying cell-like behavior through a native receptor-ligand interaction.

165 TcSKR1 was more flexible than TcSKR2 during receptor-ligand interaction.

166 CR7 signaling following ligation by CCL19, a receptor:ligand interaction critical for T-cell migratio

167 In this study, we demonstrate that Notch receptor-ligand interactions allow for efficient differe

168 tem from multiple factors, including complex receptor-ligand interactions among CD28 family members,

169 rehensive structural basis for understanding receptor-ligand interactions and designing subtype-selec

170 irect signal-processing role for promiscuous receptor-ligand interactions and establish operational p

171 ur results reveal a mechanical regulation of receptor-ligand interactions and identify a molecular me

172 These receptor-ligand interactions are in competition with the

173 ethods to explore conformational changes and receptor-ligand interactions associated with LRH-1 activ

174 surface that directly implicates Skint-1 in receptor-ligand interactions crucial for DETC selection.

175 of type I IFNs, TNF-alpha, and cell surface receptor-ligand interactions in triggering the antidengu

176 Receptor-ligand interactions induce changes in gene expr

177 To identify distinct receptor-ligand interactions leading to these difference

178 nation of tumor secreted soluble factors and receptor-ligand interactions mediate activation of Src w

179 Our findings reveal that differential Notch receptor-ligand interactions mediate human TCR-alphabeta

180 ulation is dynamically tuned by steady-state receptor-ligand interactions of an NK cell with its cell

181 by computational docking studies, revealing receptor-ligand interactions similar to KOR agonist dyno

182 further establish the requirement for Notch receptor-ligand interactions throughout T cell different

183 Although the contribution of receptor-ligand interactions to leukocyte extravasation

184 In order to understand receptor-ligand interactions, many groups working with d

185 thogen vs sterile inflammation, inflammatory receptor-ligand interactions, microbial-associated molec

186 ersal as we demonstrate using two additional receptor-ligand interactions, P-selectin &PSGL-1 and Not

187 ial role of cytokines including TNFalpha and receptor-ligand interactions, such as the receptor activ

188 ain have provided atomic-scale insights into receptor-ligand interactions, while high-resolution stru

189 hod" for the biochemical characterization of receptor-ligand interactions.

190 e cell and provide a better understanding of receptor-ligand interactions.

191 the potential for regulation by and of other receptor-ligand interactions.

192 ses, which are likely the result of multiple receptor-ligand interactions.

193 from diffusion and the stochastic nature of receptor-ligand interactions.

194 lls and uninfected erythrocytes via distinct receptor-ligand interactions.

195 , despite considerable noise from stochastic receptor-ligand interactions.

196 nation of tumor secreted soluble factors and receptor-ligand interactions.

197 ands and can arise directly from competitive receptor-ligand interactions.

198 The receptor/ligand interactions and intracellular signaling

199 G-CSF and MPO, and on the role of E-selectin receptor/ligand interactions in leukocyte migration and

200 Receptor/ligand interactions of the TNF family are physi

201 Our results provide evidence that receptor/ligand interactions, involving alphavbeta3 and

202 vely charged iron, independent of biological receptor/ligand interactions.

203 In both processes, the only known Toll receptor ligand is the human nerve growth factor-like cy

204 hiregulin (AREG), an epidermal growth factor receptor ligand, is implicated in tissue repair and fibr

205 ntroduced into the endogenous peptide opioid receptor ligand Leu-enkephalin as a model compound.

206 We show that the Toll-like receptor ligands lipopolysaccharide and CpG DNA, which a

207 peptides (C-type natriuretic peptide and EGF receptor ligands) maintain the low level of cGMP in the

208 nces in biological response to different EGF receptor ligands may result from partial agonism for dim

209 f arrestin pathway-selective and neutral AT1 receptor ligands may translate into different pharmacolo

210 ioid receptor, and injection of human opioid receptor ligands mimics exogenous opiates, highlighting

211 d a KIR2DL1-R(245)-positive graft with HLA-C receptor-ligand mismatch had the best survival (P = .000

212 Here, we developed a novel receptor-ligand model of the adenosine system to test th

213 We also reveal novel candidate receptor-ligand networks involving SSCs and the developi

214 The kinase activity responses to receptor ligand occupancy changes can be highly cooperat

215 In contrast, receptor ligand occupancy did not have a discernable eff

216 this approach, a systemic injection with the receptor ligand octopamine leads to increased cAMP level

217 shed reports describing activity of oxytocin receptor ligands on mammalian circadian rhythms and that

218 of different adhesion molecules and NK cell receptor ligands or the release of different soluble fac

219 satisfied for specific interactions such as receptor-ligand or protein-drug.

220 Using a model receptor-ligand pair (FRB-FKBP), we first test physical

221 se results reveal a role for a conserved MIP receptor-ligand pair in regulating marine annelid settle

222 mplying that the intracellular route of this receptor-ligand pair is largely independent of the TGN/E

223 od, Fan et al discover the presence of a new receptor-ligand pair that inhibits platelet activation.

224 The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental proc

225 and allele combinations of the most diverse receptor-ligand pair, KIR3DL1 and HLA-B, correspond to h

226 We use a receptor-ligand pairing analysis and a high-throughput i

227 nt clinical trials targeting these promising receptor/ligand pairings in cancer.

228 t follows that the reproducibility of orphan receptor ligand pairs should be of fundamental importanc

229 eractome by assessing the gene expression of receptor-ligand pairs across cell types.

230 amilies, which constitute genetically linked receptor-ligand pairs and are thought to allow for NK ce

231 regarding the identification of new cognate receptor-ligand pairs and reduces the pool of possible i

232 Receptor-ligand pairs are ordinarily thought to interact

233 s and semaphorins comprise a large family of receptor-ligand pairs controlling cell guidance in nervo

234 Costimulatory and coinhibitory receptor-ligand pairs on T cells and APC control the imm

235 e that the binding energies of physiological receptor-ligand pairs on the T cell are sufficient to cr

236 d temporal dynamics of tension among various receptor-ligand pairs remains a significant challenge.

237 ng that the parasite may utilize alternative receptor-ligand pairs to complete the erythrocyte invasi

238 reconstitute segregation of CD45 from bound receptor-ligand pairs using purified proteins on model m

239 Nkrp1g was previously shown to form several receptor-ligand pairs with the CLEC2 proteins Clr-d, Clr

240 t studies have indicated specificity between receptor-ligand pairs within each subfamily, the functio

241 We identified ~50 previously-unknown receptor-ligand pairs, including new interactions among

242 ve conservation and long-term coevolution of receptor-ligand pairs.

243 rticle and a substrate due, for instance, to receptor/ligand pairs on particle and substrate.

244 ceptor and FGF receptor activity domains) to receptor-ligand parameters.

245 entification of additional immune regulatory receptor/ligand pathways.

246 cyte antigen-4 (CTLA4) or programmed death-1 receptor/ligand (PD-1/PD-L1) improve patient outcomes by

247 (68)Ga-labeled somatostatin receptor ligand PET imaging has recently been shown in p

248 Several I(2) receptor ligands (phenyzoline, tracizoline, RS45041, and

249 The two nuclear hormone receptor ligands progesterone and vitamin D (vit.D) play

250 HC-I) have been described, whereas other KIR receptor-ligand relationships, including those associate

251 ssays that monitor cAMP inhibition by opioid receptor ligands require second-messenger accumulation o

252 drocarbon receptor, and the aryl hydrocarbon receptor ligand restores FLG expression in SIRT1-inhibit

253 Activation of this reporter, using Toll-like receptor ligands, resulted in GFP expression, which coul

254 cripts identified protein-modifying enzymes, receptors, ligands, RNA-binding proteins, transcription

255 atocyte growth factor beta-chain reveals the receptor-ligand selectivity determinants.

256 Moreover, regulatory circuits that include receptors, ligands, signal transduction components, epig

257 lation afforded by transcription factors and receptor-ligand signaling pathways in specifying, mainta

258 the in vivo consequences of activating these receptors, ligands specific for TLR2 or dectin-1 were mi

259 and suggest that modification of endothelin receptor-ligand specificity was a key step in the evolut

260 ence of a midline signal provided by the EGF receptor ligand Spitz.

261 The TNF receptor-ligand superfamilies (TNFRSF/TNFSF) are central

262 surrogate ligands in a prototypical dimeric receptor-ligand system, the cytokine Erythropoietin (EPO

263 significant because the mouse NKR-P1B:Clr-b receptor:ligand system represents the closest homolog of

264 Synthetic receptor-ligand systems that remove the native ligand-re

265 there is no cross-reactivity between the two receptor-ligand systems.

266 and outputs has applications to many dimeric receptor-ligand systems.

267 Thus, these two receptor:ligand systems appear to have complementary fun

268 erves as an autonomous gauge to restrict the receptor-ligand tension.

269 a-derived polyphenol, is an aryl hydrocarbon receptor ligand that attenuated inflammatory responses a

270 agonistic interactions with ephrinB1, an Eph receptor ligand that has a key role in regulating the se

271 A somatostatin receptor ligand that is easily radiolabeled with (18)F-f

272 ing the first class of potent pan-xenobiotic receptor ligands that can serve as potential antidotes b

273 Non-peptide oxytocin receptor ligands that cross the blood brain barrier were

274 emerging Rho-kinase inhibitors and adenosine receptor ligands that offer the potential to improve aqu

275 ges, including the correct classification of receptor ligands, the identification of the signaling pa

276 diated by cell surface upregulation of NKG2D receptor ligands, thereby sensitizing melanoma cells to

277 pound: inhibits necroptosis induced by death receptors ligands TNF-alpha (Tumor Necrosis Factor) or T

278 glucocorticoid-induced tumor necrosis factor receptor-ligand (TNFsf18) on dendritic cell.

279 To determine if the conjugation of a small receptor ligand to a peptidic carrier to potentially fac

280 -33 (IL-25/IL-33), or a mixture of Toll-like receptor ligands to evaluate their ability to produce cy

281 ique insights into the selective capacity of receptor ligands to promote and/or stabilize receptor di

282 This receptor-ligand topology defines a previously unidentifi

283 In response to toll-like receptor ligands, TRAF6 is demethylated by the Jumonji d

284 is of ligands, but is required for efficient receptor ligand transendocytosis and Notch activation up

285 Primary HSCs were treated with nuclear receptor ligands, transfected with small interfering RNA

286 g the expression of natural killer (NK) cell receptor ligands, type I interferons protect responding

287 eving targeted delivery without the need for receptor-ligand-type targeting strategies.

288 Equimolar infusion of the VPAC1/2 receptor ligand vasoactive intestinal polypeptide (VIP)

289 ockdown results in overexpression of the EGF receptor ligand vein (vn), which further activates EGF r

290 cells migrating along gradients of adhesion receptor ligands vs. any soluble cue.

291 exposure to innate stimuli such as Toll-like receptor ligands was not sufficient.

292 Using standard receptor ligands we have validated pharmacological respo

293 To study cannabinoid receptor ligands, we have developed a novel plate-based

294 To obtain selective and potent opioid receptor ligands, we synthesized dehydro derivatives of

295 rly imprinted polymers (MIPs) are artificial receptor ligands which can recognize and specifically bi

296 nd repertoire includes the typical scavenger receptor ligands, whole bacteria, and purified Gram-nega

297 nuclein toxicity and suggest that retinoid X receptor ligands with appropriate pharmacological proper

298 ent the first example of mirror image opioid receptor ligands with both optical antipodes having high

299 eutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selective properties

300 k was uniquely sensitive to modulation by D3 receptor ligands, yet these drugs did not alter decision