ライフサイエンスコーパス: rechallenge

1 es that had spontaneously cleared infection (rechallenged).

2 o induce somatic hypermutations upon malaria rechallenge.

3 unimpaired memory T cell responses to viral rechallenge.

4 ied MBC subsets with distinct functions upon rechallenge.

5 fected after intravaginal and/or intravenous rechallenge.

6 boosting effect normally observed following rechallenge.

7 f solidly protected animals following ocular rechallenge.

8 ns led to sensitization and anaphylaxis upon rechallenge.

9 tumors and promoted protection against tumor rechallenge.

10 -term survival, and protection against tumor rechallenge.

11 n specific IgE) following cutaneous allergen rechallenge.

12 s capable of robust secondary expansion upon rechallenge.

13 r antibody responses and resistance to tumor rechallenge.

14 rotected against a subsequent lethal WT CO92 rechallenge.

15 nced survival and a memory response to tumor rechallenge.

16 not affected by treatment with FTY720 before rechallenge.

17 everely impaired in secondary expansion upon rechallenge.

18 ere free of replicating virus at day 5 after rechallenge.

19 (+) T cells exhibit impaired expansion after rechallenge.

20 erved in lungs of HKCn-immunized mice during rechallenge.

21 on, leading to enhanced antigen binding upon rechallenge.

22 d despite the limited viral replication upon rechallenge.

23 lular heterogeneity when faced with pathogen rechallenge.

24 mice produced less cytokines upon antigenic rechallenge.

25 developed immunological memory against tumor rechallenge.

26 response is rapid and robust activation upon rechallenge.

27 d restored strong inflammation after antigen rechallenge.

28 virus infections and became immune to virus rechallenge.

29 ich mediate more effective protection during rechallenge.

30 ing adaptive immunity for protection against rechallenge.

31 y CD4(+) and CD8(+) memory T cells following rechallenge.

32 on of DEX-specific Ab titers upon E. cloacae rechallenge.

33 complete protection from intravesical tumor rechallenge.

34 il to express high levels of granzyme B upon rechallenge.

35 mice were protected long-term against tumor rechallenge.

36 capable of anamnestic responses to antigenic rechallenge.

37 imens and were sufficient to protect against rechallenge.

38 ected during the initial infection or during rechallenge.

39 provided long-lasting immunity against tumor rechallenge.

40 PA could have contributed to protection from rechallenge.

41 on and cytokine production in response to Ag rechallenge.

42 and treatment with isoniazid (INH) prior to rechallenge.

43 mes spores, and 100% of the rabbits survived rechallenge.

44 the GALT, and mediate protective immunity to rechallenge.

45 untransduced DCs in the presence of collagen rechallenge.

46 liferate and exert effector activity upon Ag rechallenge.

47 to enzalutamide in most patients undergoing rechallenge.

48 amnestic cell-mediated immune response after rechallenge.

49 ted rapid cytokine production at the site of rechallenge.

50 a latent effector program in anticipation of rechallenge.

51 ronic infections with the genotypes used for rechallenge.

52 iniscent of a secondary antibody response to rechallenge.

53 d avidity and sustained high protection upon rechallenge.

54 t secondary effectors following heterologous rechallenge.

55 memory T cell populations following a graft rechallenge.

56 ke effect that generated resistance to tumor rechallenge.

57 ts in increased CD8(+) T cell response to Ag rechallenge.

58 tly upregulated IL-2Ralpha expression during rechallenge.

59 development of memory CD8(+) T cells upon Ag rechallenge.

60 D-L1 blockade and protecting mice from tumor rechallenge.

61 o mount an NK cell memory response to hapten rechallenge.

62 ted the early secondary response to parasite rechallenge.

63 d at least one fatal case and 89% a positive rechallenge.

64 n category B, 54% had a fatal case and 41% a rechallenge.

65 ome refractory to; all four responded to the rechallenge.

66 njury was observed at 9 days after halothane rechallenge.

67 promote their longevity and fast response to rechallenge.

68 ic IL-2 expression in pTregs after antigenic rechallenge.

69 were protected against an RMA lymphoma tumor rechallenge.

70 g, functionally asymmetric cell fates during rechallenge.

71 ntigen-specific for the control of MCMV upon rechallenge.

72 e resistance to infection when macaques were rechallenged.

73 ths were taken off treatment for 4 weeks and rechallenged.

74 struction and increased survival after tumor rechallenges.

75 Rechallenge 10 weeks after the initial challenge results

76 increased capacity to produce IFN-gamma when rechallenged 2 mo after priming.

77 initial challenge with C. jejuni CG8421 with rechallenge 3 months later.

78 When rechallenged 38 months later with 6000 RNA copies/mL fro

79 Two infected chimpanzees rechallenged 4, 10, or 24 mo later with NV were resistan

80 At rechallenge, 4 of 9 vaccine recipients in each group wer

81 Protected vaccine recipients were rechallenged 5 months later.

82 However, no bradycardia occurred following a rechallenge 8 weeks after the patient stopped taking ami

83 potential for anaphylaxis with azathioprine rechallenge, a better term for a Sweetlike presentation

84 st in animals exposed to acid neonatally and rechallenged, acutely, at P60.

85 arthritis since childhood and recurred with rechallenge, adding further evidence to support the exis

86 s and identify key risk factors for positive rechallenge, additional data are needed from controlled

87 f secondary infection following heterologous rechallenge adversely impacts the magnitude of CD4(+) T

88 Compound rechallenge after drug holidays can overcome such resist

89 Nearly 50 drugs are associated with positive rechallenge after drug-induced liver injury (DILI): anti

90 ents underwent trimethoprim-sulfamethoxazole rechallenge after protocol implementation (4/22 vs 23/27

91 (SLIT) or 2000 mg/d (OIT), and subjects were rechallenged after 6 and 12 months of maintenance.

92 However, on LPS rechallenge, AhR engaged in long-term regulation of syst

93 Here, we show that FtL rechallenge alone induces these PerC B-1a memory cells t

94 ly protected from residual disease and tumor rechallenge, an effect linked to activation of CD8(+) T

95 the remaining tumors, protect against tumor rechallenge and experimental metastases, and induce epit

96 gammadelta Trms produced IL-17A early after rechallenge and formed organized clusters with myeloid c

97 ntigen-specific CD8(+) T cells expanded upon rechallenge and generated increased protective memory T-

98 in protecting mice from tumor challenge and rechallenge and in treating established myeloma.

99 his, the cells undergo strong expansion upon rechallenge and provide protective immunity.

100 , early responders to a secondary Plasmodium rechallenge and should be targeted by vaccine strategies

101 ls in local tissue protective immunity after rechallenge and vaccination.

102 G ODN treatment were protected from leukemia rechallenge, and adoptive transfer of T cells from mice

103 emory cells were not fully protective during rechallenge, and memory cell characteristics were altere

104 ever or rash, does not recur more rapidly on rechallenge, and previous studies have failed to identif

105 2 weeks postchallenge in the vaccinated and rechallenged animals, coinciding with reductions in vira

106 d survivors were resistant to the same tumor rechallenge associated with enhanced IFN-gamma, but not

107 weeks, after which OIT was discontinued with rechallenge at month 32 to assess sustained unresponsive

108 The rechallenge at treatment reintroduction was positive in

109 ived at least one dose) and for enzalutamide rechallenge (based on intention-to-treat analysis).

110 on confers heightened resistance to pathogen rechallenge because of quantitative and qualitative diff

111 replication and spread after homologous HCV rechallenges but may not be sufficient for a long-term p

112 etected in liver for at least 3 months after rechallenge, but virus replication was suppressed, as re

113 his viremia-resolved marmoset was boosted by rechallenging, but no viremia was detected during 57 wee

114 the dynamic priming of genes for response to rechallenge by secondary stimuli.

115 therapy are protected from subsequent tumor rechallenge by the generation of a tumor-specific memory

116 Despite the delayed clearance, rechallenged C. muridarum-infected mice were highly immu

117 tive dechallenge case reports and 3 positive rechallenge case reports.

118 ently had instances of fatal (23% and 7%) or rechallenge cases (26% and 11%).

119 s of TNF ex vivo in response to heterologous rechallenge compared with high-affinity-primed memory T

120 the first time in the human system and under rechallenge conditions that targeting IL-2R by partial m

121 quality of CD8(+) T cell memory, even under rechallenge conditions.

122 xhibited impaired effector function after Ag rechallenge, correlating with defects in their ability t

123 azia onset, and the positive dechallenge and rechallenge data.

124 No subjects were colonized by experimental rechallenge, demonstrating the protective effect of init

125 earance of HCV reinfection upon heterologous rechallenge depends on the activation of both intrahepat

126 Increasing the rechallenge dose results in more potent boosting of CD4(

127 After rechallenge, effector CD8(+) T cells in mutant animals w

128 transferred memory cells responded to tumor rechallenge exerting long-term persistence.

129 Drugs associated with high rates of positive rechallenge exhibit multiple risk factors: daily dose >5

130 duction of protective immunity against tumor rechallenge, expansion of memory T cells, and significan

131 e this, flow cytometric analyses and antigen-rechallenge experiments indicated that myelin oligodendr

132 Rechallenge experiments revealed that high affinity, som

133 Conversely, a weaker homologous rechallenge failed to induce a stable secondary Th1 memo

134 are cleared as early as 2.5 weeks following rechallenge, followed by a rapid drop in IFN-gamma(+) CD

135 Drug rechallenge following drug-induced liver injury is assoc

136 With drug readministration, a positive rechallenge has recently been defined by an ALT level of

137 Upon rechallenge, however, CXCR4-deficient T cells can re-exp

138 Neither depletion of host NK cells nor rechallenging immunized mice with F(1) hybrid splenocyte

139 s, and antibody responses following SARS-CoV rechallenge in AGMs.

140 ation of potent immunological memory against rechallenge in cured mice accompanied these therapeutic

141 demonstrate that it protected against viral rechallenge in mice.

142 t observed because donor-specific skin graft rechallenge in nonrejecting animals resulted in rejectio

143 a on safety of intrathecal and high-dose MTX rechallenge in patients with neurotoxicity.

144 However, FtL rechallenge in the context of a Toll-like receptor 4 ago

145 rd approach to trimethoprim-sulfamethoxazole rechallenge in the context of both prior immune and non-

146 aining for either IFN-gamma or IL-2 after Ag rechallenge in vitro.

147 ccelerate memory B cell responses to antigen rechallenge in vivo.

148 l responses and an inability to resist tumor rechallenge in vivo.

149 nterleukin-2 and interferon (IFN)-gamma when rechallenged in the absence of A(2A)R stimulation.

150 demonstrating complete tumor regression were rechallenged in the contralateral flank.

151 nses developed during the initial homologous rechallenge, in particular in CH96A008, which developed

152 ating cells in the first 12-18 h after virus rechallenge indicating they may be required for rapid co

153 rejected tumors were protected against tumor rechallenge, indicating that sustained memory responses

154 re memory cells expanded equivalently during rechallenge, indicating that the robust proliferative ca

155 tized CD25-depleted T cells survived a tumor rechallenge, indicating the development of long-term CD8

156 umor inoculation were all resistant to tumor rechallenge, indicative of established adaptive memory i

157 e functional potential of these cells during rechallenge infection.

158 OT-I memory cells responded equally well to rechallenge infection.

159 quality of secondary immune responses during rechallenge infections.

160 On ED 19, a rechallenge injection of 2.5 mg/kg MPD was given and loc

161 All three groups received a rechallenge injection of 2.5 mg/kg on ED 19 and their lo

162 llenged, and of those with carriage, 10 were rechallenged intranasally with live 6B Streptococcus pne

163 ory T cells that cross-react weakly with the rechallenge ligand.

164 ion, the role of intentional and inadvertent rechallenge, liver histology, and host genetic polymorph

165 Following high-affinity rechallenge, low affinity-primed CD45RB(hi) cells became

166 en in the best-case scenario with autologous rechallenge, low-level viral persistence was seen in the

167 of the p50-p50 homodimer in LPS-primed and -rechallenged macrophages, impairing their ability to att

168 For critical medicines, drug rechallenge may be appropriate when 1) no safer alternat

169 d field potential, and (4) administration of rechallenge MDMA result in enhancement of the PFC sensor

170 tioned to one side of the mitotic spindle in rechallenged memory T cells, and two phenotypically dist

171 Upon antigen rechallenge, memory B cells rapidly expand and different

172 Upon rechallenge, memory CD8 T cells rapidly proliferate and

173 Likewise, following adoptive transfer and rechallenge, memory cells with high Wnt levels displayed

174 Rechallenged mice in RF ablation, ITDC, and combination

175 ong naive (n = 63), vaccinated (n = 53), and rechallenged (n = 36) animals, including peak RNA titer

176 In bats rechallenged (n = 4) on day 48 after infection, there wa

177 Notably, cured mice were resistant to rechallenge not only by WEHI-164 cells but also heterolo

178 ors were refractory to antitumor immunity if rechallenge occurred during the resolution phase of the

179 B. pertussis and proliferated rapidly after rechallenge of convalescent mice.

180 Antigenic rechallenge of equal numbers of cells stimulated at high

181 cs suggest that caution should be taken with rechallenge of high-risk drugs.

182 ltaDC mice during primary infection and upon rechallenge of memory mice.

183 Homologous rechallenge of mice immune to either lymphocytic choriom

184 In addition, rechallenge of mice with OVA resulted in airway inflamma

185 Tolerance was achieved because rechallenge of mice with the mimotope peptide in adjuvan

186 and total H3 decreased at the Il2 locus upon rechallenge of Pre-Ac CD4(+) T cells, whereas increased

187 s exhibit impaired IL-10 synthesis following rechallenge of T. gondii vaccine-primed mice.

188 Rechallenging of these tumour-free animals with TC-1 cel

189 mpleted BAT and 21 proceeded to enzalutamide rechallenge, of whom 15 (52%; 95% CI 33-71; p<0.0001) ac

190 s [LD50s] of B. anthracis Sterne and against rechallenge on day 20 with a more aggressive challenge d

191 After repeated OVA rechallenge or CD4(+) T cell ablation, the increase or l

192 To better understand rechallenge outcomes and identify key risk factors for p

193 During the 3-day rechallenge, participants' symptoms increased by similar

194 nti-inflammatory program that upon antigenic rechallenge prevents inflammation via pDC.

195 arance by secondary CTL following homologous rechallenge prevents optimal boosting of CD4(+) T cell r

196 and metabolic factors to influence positive rechallenge rates and outcomes.

197 However, high positive rechallenge rates with other innovative therapeutics sug

198 l exceeding 5 years; for these patients, FCR rechallenge represents a reasonable standard of care.

199 vered from both chimpanzees after homologous rechallenge resulting in persistent infection had numero

200 When rechallenged, RTE-derived memory cells generated seconda

201 fector cells during secondary Ag encounters (rechallenge self-renewal).

202 ug or allowing it to continue; if deliberate rechallenge should be done and under what circumstances;

203 es/macrophages or neutrophils at the time of rechallenge significantly diminished the response and, i

204 ed over time and were not protective against rechallenge, similar to their TRAIL-sufficient unhelped

205 In SARS-CoV homologous rechallenge studies, 11 of the 12 animals were free of r

206 In in vivo rechallenge studies, CD49b(+) T cells no longer expanded

207 ceptible to marmoset-adapted WT virus during rechallenge studies.

208 In a placebo-controlled, cross-over rechallenge study, we found no evidence of specific or d

209 covered from CH1494 after the two homologous rechallenges that resulted in transient viremia were ide

210 In response to rechallenge, the magnitude of each clonotypic response w

211 with H1 and H3 influenza virus isolates and rechallenged them with a virus derived from the 2009 H1N

212 ity against CDI and did not develop CDI upon rechallenge; they generated systemic IgG and IgA as well

213 oxazole adverse drug reaction assessment and rechallenge to optimize prophylaxis in this patient coho

214 T cells were depleted 5 days after halothane rechallenge, trifluoroacetylated protein adduct-specific

215 sfer with wild-type counterparts and antigen rechallenge, TSC1-deficient memory cells showed moderate

216 le reduction of skin inflammation, even when rechallenged up to 3 wk after the last treatment.

217 T cell IL-17 production after collagen rechallenge was not inhibited by a lack of IL-23, since

218 ts managed with dose interruption, bosutinib rechallenge was successful in 74%.

219 s seen when a second tumor implantation (ie, rechallenge) was attempted.

220 Drugs with fatal cases or with rechallenge were noted.

221 ntly higher survival, and rejection of tumor rechallenge were obtained with P815, which were not seen

222 onse, and provide superior protection to Mtb rechallenge when compared to terminally differentiated T

223 tions was assessed, as well as the effect of rechallenging when vemurafenib was reintroduced.

224 nt of allergic airway disease after allergen rechallenge, whereas mice treated with R848 did not deve

225 ared the virus from all organs, and survived rechallenge with 10(5) PFU of IHD-J-Luc VACV without add

226 pecific CD4(+) T cells that are recruited on rechallenge with a drifted vaccine variant and contribut

227 -1R-/- mice were fully protected from lethal rechallenge with a high dose of VSV.

228 fection fails to afford protection against a rechallenge with a homologous virus.

229 In contrast, heterologous rechallenge with a pathogen sharing only a CD4(+) T cell

230 biting antibodies and were solidly immune to rechallenge with A/Cal.

231 However, after rechallenge with adalimumab, he developed similar findin

232 Survivors were fully protected from rechallenge with aerosolized F. novicida.

233 r death by IL-4 produced by Th2 cells during rechallenge with Ag, hence the Th2 bias of murine neonat

234 as a death marker for these Th1 cells during rechallenge with Ag.

235 capable of forming Ab-secreting cells after rechallenge with Ags.

236 , but instead renders them hyporesponsive to rechallenge with alloantigen.

237 This cutaneous eruption recurred after rechallenge with an alternate anti-TNF agent.

238 failed to mediate T cell unresponsiveness to rechallenge with antigen.

239 DCs) that mediate T cell unresponsiveness to rechallenge with antigen.

240 ence of diarrhea or colitis after subsequent rechallenge with C. difficile.

241 llmarks of immunologic memory in response to rechallenge with C. neoformans: 1) the secondary cryptoc

242 Tumor-free mice were resistant to rechallenge with cognate tumor cells, suggesting that a

243 the CDT-deficient mutant were protected from rechallenge with either mutant or wild-type H. hepaticus

244 mechanisms controlling B-2 memory responses, rechallenge with FtL in an inflammatory context is requi

245 Subsequent rechallenge with FVIII following MZ B-cell reconstitutio

246 site control compared with WT mice following rechallenge with homologous malaria parasites.

247 survived challenge were also protected from rechallenge with IHD-J-Luc or WRvFire VACV without addit

248 hibition in immunocompetent mice following a rechallenge with live cancer cells of the same type.

249 ymptoms, which cleared within 2 to 3 days on rechallenge with low-dose naltrexone.

250 We found that upon rechallenge with M. tuberculosis, both WT and TLR2KO imm

251 es were generated, and all macaques survived rechallenge with MARV, suggesting that they generated an

252 Delayed rechallenge with MB49 cancer cells injection in mice tha

253 so prevented reemergence of the disease upon rechallenge with mTg.

254 en days later, sensitization was assessed by rechallenge with OVA.

255 Tumor-free mice were able to reject a rechallenge with ovarian tumor cells 225 days after orig

256 nses can be simultaneously induced following rechallenge with peptide-pulsed dendritic cells.

257 these long-term survivors were resistant to rechallenge with RMA tumor cells (NKG2D ligand-negative)

258 the polymerase gene mutant as well as after rechallenge with serum-derived wild-type HBV (5,000 chim

259 animals (23/24) were completely resistant to rechallenge with spores by either respiratory challenge

260 disease, long-term prognosis and effects of rechallenge with statins or other cholesterol-lowering d

261 elded rapid and robust memory responses upon rechallenge with suboptimal dose of Ag.

262 ylactic shock resulting in death occurs upon rechallenge with the encephalitogenic peptide.

263 PHV infection, horses were protected against rechallenge with the homologous as well as a distinct is

264 esis and management, and recommendations for rechallenge with the offending chemotherapy.

265 doxine became resistant against subcutaneous rechallenge with the same (but not with an unrelated) ca

266 loma-bearing mice and provided resistance to rechallenge with the same tumor cells through a CD8(+) T

267 Rechallenge with the statin that was previously associat

268 ith the protection from tumor development on rechallenge with TRAMP-C2 tumor cells.

269 remission posttherapy were protected against rechallenge with viable leukemia cells.

270 ses capable of protecting against subsequent rechallenge with virulent parasites through gastric, con

271 standardized systems have enabled safer drug rechallenge with weekly liver chemistry monitoring durin

272 Moreover, when the senescent rats were rechallenged with a nominal dose of the barbiturate, mal

273 s who had received RRx-001 were subsequently rechallenged with a treatment that they had become refra

274 When mice were rechallenged with A/PR/8/34 virus, SDR-MEM mice terminat

275 Four patients were subsequently rechallenged with aflibercept, and 1 developed inflammat

276 ounted a more effective memory response when rechallenged with antigen.

277 s alum/Aspergillus-sensitized mice that were rechallenged with Aspergillus developed IL-13Ralpha1-ind

278 contralateral inguinal LN) were removed and rechallenged with BALB/c alloantigen in vitro with subse

279 showed markedly decreased tumor growth when rechallenged with EMT6-HER2 or EMT6 cells, whereas both

280 recovered from genotype 1b infection and was rechallenged with genotype 6a) did not develop viremia b

281 tective levels of anti-HBsAg antibodies were rechallenged with HBV after antibody-mediated CD4(+) T-c

282 h previously resolved HCV infection who were rechallenged with HCV.

283 Four of the 11 chimpanzees rechallenged with heterologous genotypes developed chron

284 Of 13 patients rechallenged with intrathecal and/or high-dose MTX, 12 d

285 The activated CD4(+)CD44(+) lymphocytes were rechallenged with IRBP(161-180) in vitro to assess their

286 Cured animals were rechallenged with J774 cells, and the tumors were reject

287 monoclonal H77C (genotype 1a) infection were rechallenged with low-dose homologous H77C virus about 1

288 Upon progression after BAT, men were rechallenged with oral enzalutamide 160 mg daily.

289 ls were the only source of TIM-3, cells were rechallenged with peptide-loaded artificial APCs in the

290 When rechallenged with Ras or DNA-damaging agents, the surviv

291 he electrophysiological recording system and rechallenged with saline and the identical MPD doses as

292 ective in WT and p47(phox-/-) mice that were rechallenged with secondary lethal Lm infection.

293 CT), such that they undergo anaphylaxis when rechallenged with the sensitizing allergen.

294 bacteria faster when the immunized mice were rechallenged with virulent L. monocytogenes.

295 antitumor immunity also protected mice when rechallenged with wild-type CT26 tumor; strong CD8(+) T

296 or polyclonal H77 and after six heterologous rechallenges with HC-J4 (genotype 1b) or HC-J6 (genotype

297 mpletely protected following five homologous rechallenges with monoclonal H77C or polyclonal H77 and

298 is study, we report that repeated intranasal rechallenges with only OVA Ag were sufficient to trigger

299 i-toxin Abs and were protected from CDI upon rechallenge, with protection dependent on major histocom

300 that survived infection were protected from rechallenge without additional treatment.