ライフサイエンスコーパス: recognition site

1 location (25-27 bp downstream of one of the recognition sites).

2 cific overall structure and potential ligand recognition site.

3 bond as a binding element at the fibrinogen recognition site.

4 neously flips its binding orientation at the recognition site.

5 ealed a greater flexibility in its substrate recognition site.

6 head region that are clustered about the RGD recognition site.

7 s a transient, stretched conformation of its recognition site.

8 +) binding and probably represents a protein recognition site.

9 ys and by the identification of a beta-TrCP1 recognition site.

10 for a cytosine base upstream of the core RNA recognition site.

11 acts to the B-B' loop of CYP3A4, a substrate recognition site.

12 nuclease homodimer bound to its specific DNA recognition site.

13 he alpha(M)-I domain represents a major LRP1 recognition site.

14 the alpha(M)-I domain represent a major LRP1 recognition site.

15 t was abrogated by mutation of the consensus recognition site.

16 s phosphorylated at Ser-383, a consensus WNK recognition site.

17 c patch, created a new polysialyltransferase recognition site.

18 critical lysine residue in the Cdk substrate recognition site.

19 of both LTbetaR and NIK suggesting a common recognition site.

20 intaining the Ig5-FN1 interface and a polyST recognition site.

21 uence (5'-TGGTC-3') than for DNA lacking the recognition site.

22 s to show that FANCJ possesses a G4-specific recognition site.

23 acid residues 90-93 as the predominant furin recognition site.

24 generates a double-strand break (DSB) at the recognition site.

25 y cleavage-resistant as they lack a complete recognition site.

26 previously untargeted areas of the substrate recognition site.

27 observable when DNA ends are proximal to the recognition site.

28 ictated by the rate of dissociation from the recognition site.

29 DNA where both Myb-like domains bind to the recognition site.

30 le for a conserved tyrosine and distinct S1' recognition site.

31 d to DNA containing a consensus (5')GGAA(3') recognition site.

32 iR-430 seeds, AU-rich sequences, and Pumilio recognition sites.

33 h and without target RNAs representing miRNA recognition sites.

34 F mucins revealed mucin cleavage at antibody recognition sites.

35 recognition of DNA sequences resembling RAG recognition sites.

36 small insertion/deletions produced at CRISPR recognition sites.

37 can selectively target specific cell-surface recognition sites.

38 multaneously specify both amino acids and TF recognition sites.

39 o previously identified cholesterol and drug recognition sites.

40 on of differential RNA binding protein (RBP) recognition sites.

41 onal changes that lead to exposure of active recognition sites.

42 d may have altered aminoacyl-tRNA synthetase recognition sites.

43 rmitted the identification of putative dsRNA recognition sites.

44 precursors at related but distinct S/A/G-X-E recognition sites.

45 ed to include fifteen new restriction enzyme recognition sites.

46 s on the protein surface as potential ligand recognition sites.

47 ave substrates containing nicks within their recognition sites.

48 hould allow rapid methylation of host genome recognition sites.

49 adruplex structure flanked by nicking enzyme recognition sites.

50 1441C/G/H, which are part of a consensus PKA recognition site ((1441)RASpS(1444)).

51 ngement of residues forming the acetyllysine recognition site, affecting plasticity of the protein in

52 The presence of both a PUM recognition site and a recognition site for preferential

53 en designed to bind at the amyloid-beta self-recognition site and prevent amyloid-beta from misfoldin

54 conserved hydrophobic wedge next to the PI4P recognition site and ringed by a network of complementar

55 iations in the length and composition of the recognition site and the cluster template indicate that

56 re shows a scattered pattern, but the origin recognition site and the nuclease active site are invari

57 lecular axle comprised of a dibenzylammonium recognition site and two azobenzene end groups and a dib

58 een reported to contain the acceptor protein recognition site and/or catalytic site.

59 iments for seven systems featuring different recognition sites and backbones.

60 eric signaling between promiscuous molecular recognition sites and can inform the rational design of

61 isfolded proteins through distinct substrate recognition sites and conjugates these proteins with the

62 Type IIB nucleases require two recognition sites and cut both strands on both sides of

63 R372A/R1689A fVIII lacks proteolytic recognition sites and is not released from VWF.

64 hile also allowing for the generation of new recognition sites and specialized cellular functions.

65 he DNA, either downstream or upstream of the recognition site, and an acceptor placed on the catalyti

66 mination of the ligand mechanical footprint, recognition site, and binding orientation.Mapping the se

67 HEs) are compact endonucleases with 20-22 bp recognition sites, and thus are ideal scaffolds for engi

68 the N-terminal domain, and all carbohydrate recognition sites are available for binding glycans.

69 s studies suggested that the major substrate recognition sites are located within transmembrane domai

70 coli suggest that high and low affinity DnaA recognition sites are positioned within oriC to direct s

71 ion channels with single-file multiple anion-recognition sites are rare.

72 In the R series, the -NH(2)(+)- recognition sites are separated by trismethylene bridges

73 Although their recognition sites are separated by up to 90 bp, Fis repr

74 idea here is that in the former series, the recognition sites are strategically positioned 3.5 A apa

75 Tailor-made selective artificial recognition sites are thus introduced into the tubular m

76 two unusual "half-crown/two carbonyl" cation recognition sites as revealed by the combination of sing

77 The 3' recognition site associates with a complementary target

78 ically mutating the putative miR-275/miR-306 recognition site at the bam 3'UTR.

79 PS specifically and may serve as a substrate recognition site at the OM.

80 ologous templates, for insertion of an EcoRI recognition site at the RIF1 locus and introduction of a

81 Additional recognition sites at loci distant from oriC modulate Dna

82 d NIX expression vectors lacking the miR-137 recognition sites at their 3' UTR.

83 The tetramer bridges two recognition sites before eventually cutting the DNA in b

84 tions brought about by both pi-electron-rich recognition sites being part of a macrocyclic polyether.

85 l-defined mechanical states by incorporating recognition sites between the different components.

86 th a model where ATP hydrolysis activated by recognition site binding leads to release of the enzyme

87 3 associates with itself by the carbohydrate recognition site binding to another galectin-3 molecule,

88 An intrasubunit site is adjacent to the GABA-recognition site but faces the channel vestibule.

89 ]arene pseudodimer 2, bearing a strong anion-recognition site but not a weak cation-recognition site,

90 assembly is then guided by low-affinity DnaA recognition sites, but is also regulated by a switch-lik

91 nucleotides containing zero to five specific recognition sites, called metboxes.

92 e upstream cytosine relative to the core PUF recognition site can differ, which in the case of FBF-2

93 k, nitrone N bearing a 6-methylamidopyridine recognition site can participate in 1,3-dipolar cycloadd

94 The rates of the transitions between the recognition sites can be controlled by introducing steri

95 Our results suggest that sulfotyrosine recognition sites can be targeted for the development of

96 A oligonucleotides that contain endonuclease recognition sites can be used to achieve targeted hydrol

97 ency, strain specificity, restriction enzyme recognition site changes and flanking primers for all SN

98 em to select I-SceI derivatives that bind to recognition sites containing either the A:T(+4) or the C

99 inal half) and only one functional anticodon recognition site (contributed by the C-terminal half).

100 We identified a LonA-recognition site critical for oxidation-controlled PerR

101 ls of both cellular copy numbers and genomic recognition site densities.

102 oriC, closely spaced high- and low-affinity recognition sites direct DnaA-DnaA interactions and coup

103 events require binding of at least a second recognition site either in cis or in trans.

104 e relative position of their carboxylic acid recognition site: either para (M(p)) or meta (M(m)) rela

105 The metal recognition site exhibits small motions in the apo state

106 res long-range protein communication between recognition sites facilitated by thermally-driven 1D dif

107 he stable integration of endonuclease I-SceI recognition sites flanked by bacterial LacO/TetO operato

108 entified a common structure that serves as a recognition site for AP-1 binding and governs Golgi expo

109 activity, and those bases form an asymmetric recognition site for FlhD(4)C(2).

110 egron was identified as a putative molecular recognition site for glycogen synthase kinase-3beta (GSK

111 This signal patch forms a recognition site for interaction with the AP1 adaptor co

112 -domain of LFA-1 alpha(L) subunit is the key recognition site for ligand binding.

113 ein homology models that predict a plausible recognition site for lysophosphatidylcholine only in EcN

114 resence of both a PUM recognition site and a recognition site for preferentially co-occurring miRNAs

115 ecursor and the processed peptide contains a recognition site for site-1 protease (AtS1P), a plant su

116 The cyclin groove is an important recognition site for substrates of the cell cycle cyclin

117 vious biochemical studies suggested that the recognition site for TBZ and monoamines is different.

118 ted that the C terminus of PspC might be the recognition site for the FtsH protease and an interactio

119 dulated by changing the affinity of a remote recognition site for the interlocked crown ether ring th

120 ary and tertiary structure can also act as a recognition site for the transcription factor in a proce

121 methylome analysis was used to identify the recognition site for three key N. meningitidis methyltra

122 This strategy allowed us to map the recognition site for twin arginine signal peptides to th

123 This motif contains the consensus recognition sites for CK2 (SXXE), glycogen synthase kina

124 luster domain CCCCAACTCCTT with different 3' recognition sites for complementary oligonucleotides.

125 p accurate models of variation affecting the recognition sites for diverse transcription factors and

126 al fraction of regulatory DNA bases encoding recognition sites for each TF has been strictly conserve

127 IP) nanoparticles including highly selective recognition sites for fluoxetine were synthesized, utili

128 tes were enriched within 50 nts from the RBP recognition sites for PUM and UAUUUAU.

129 d two unmethylated CpG sites, which are also recognition sites for Sau96I and SacII, and is attached

130 Recognition sites for some of these RBPs tended to local

131 ing N- or C-terminal sequences that serve as recognition sites for specific peptide-binding proteins,

132 ates for chromophoric silver clusters and as recognition sites for target DNA strands, and communicat

133 eucine motifs, NPXY) that serve as universal recognition sites for the AP-2 adaptor complex or other

134 connect CNB domains A and B and are primary recognition sites for the C subunit.

135 17 precede a proline, making them potential recognition sites for the peptidyl-prolyl isomerase Pin1

136 rich tetrathiafulvalene and dioxynaphthalene recognition sites for the ring component (namely, a tetr

137 Substrate recognition sites for the SPRY domain are identified onl

138 with tetrathiafulvalene and dioxynaphthalene recognition sites for the tetracationic cyclophane, and

139 g of two nucleic acid scaffolds that include recognition sites for the two genes and replication trac

140 of two different circular DNAs that include recognition sites for two different target genes, comple

141 mains in the plasma membrane that constitute recognition sites for vesicle docking.

142 been engineered to carry an array of unique recognition sites for ZFNs and homing endonucleases and

143 sites was predicted to release nearby miRNA recognition sites from RNA secondary structures.

144 y of 9NL27 may be restored by expanding its "recognition site" from ATGT (as for 10MD5) to ATGTT or l

145 integrases (and their cognate attB and attP recognition sites), from which we build 11 memory switch

146 Upstream activating sequence (UAS) Gal4 recognition sites harbored on recipient plasmids were pr

147 genes in the hemiascomycetes because its DNA recognition site has evolved with it, preserving the pro

148 anion-recognition site but not a weak cation-recognition site, has been synthesized and characterized

149 usands of transgenic insertions carrying SSR recognition sites have been distributed throughout the g

150 ns harbor multiple transcription factor (TF) recognition sites; however, the contribution of individu

151 The recognition site hybridizes with complementary oligonucl

152 ication and characterization of an n-alkanol recognition site in a member of the voltage-gated TM6 ch

153 ture allows identification of a putative Chi-recognition site in an inactivated helicase domain of th

154 stent with studies suggesting that the MMP-1 recognition site in heterotrimeric collagen I is partial

155 maphorin 3F (Sema3F) possesses an RXRR furin recognition site in its C-terminus, and we demonstrate t

156 nces flanking the I-SceI homing endonuclease recognition site in the center of an intron artificially

157 ed on the evolutionary conservation of their recognition sites in 3'UTRs as the binding motifs for Pu

158 C) and a requirement for DNA cleavage of two recognition sites in an inverted head-to-head repeat.

159 the occurrence of both classes of Fkh domain recognition sites in association with binding sites for

160 ependent unbinding kinetics from chromosomal recognition sites in both their apo and holo forms.

161 ycle-regulated genes, and shares hundreds of recognition sites in common with known master regulators

162 ajor conformational change exposing receptor recognition sites in each of its four subunits.

163 om three widely separated high-affinity DnaA recognition sites in oriC.

164 A microfragments released from individual TF recognition sites in regulatory DNA, to the surrounding

165 Forster resonance energy transfer to define recognition sites in signaling proteins that may be targ

166 leotides residing between adjacent POT1-TPP1 recognition sites in single-stranded telomere DNA that a

167 concentration of free galectin carbohydrate recognition sites in solution.

168 We identified recognition sites in the 3' untranslated region of Twist

169 first and given sufficient time to methylate recognition sites in the bacterial genome before the tox

170 the CBPQT(4+) rings between the DNP and TTF recognition sites in the GSCC.

171 ng provided a very well defined locations of recognition sites in the MIP molecular cavities.

172 requires the presence of both Smad and AP-1 recognition sites in the promoter.

173 al that Sox9 protein dimers bind to multiple recognition sites in the SOM sequence and are thereby bo

174 emplate, (3) selection of restriction-enzyme recognition sites in the spacer between the TAL monomer

175 s R and R' that contain -CH(2)NH(2)(+)CH(2)- recognition sites in their dumbbell components have been

176 re known, recent evidence suggests that DnaA recognition sites, in multiple genomic locations, also p

177 l I-SceI proteins isolated using the C:G(+4) recognition site included small side-chain substitutions

178 arginine residues that compose the protease recognition site increases on cleavage of F protein.

179 ge genomic segment that lies between two SSR recognition-site insertions can be "captured" as a targe

180 Given the high density of SSR recognition-site insertions in Drosophila, our method af

181 cal cation as three very different potential recognition sites, interlocked mechanically with the tet

182 We propose that these substrate-recognition sites, interspersed among flexible, disorder

183 e variations flanking an I-SceI endonuclease recognition site into I-SceI expressing Drosophila embry

184 Introduction of two specific recognition sites into the primary sequence of the polyp

185 (five or more rotatable bonds separating the recognition sites), intramolecular H-bonding is favored,

186 e of uracils either within or outside of the recognition site is detrimental for binding with SRSF1.

187 ggest that an alpha helix containing the ATM recognition site is disrupted in the serine isoform of R

188 he N domain of Escherichia coli Lon, and the recognition site is identified by cross-linking and scan

189 is over-represented in many protein-protein recognition sites, making the methyl group of this resid

190 ds into a naive host with unmodified genomic recognition sites, methyltransferase should be synthesiz

191 chemical sensors with specifically patterned recognition sites might be realized across a single grap

192 arget analytes to their fragments' cavities (recognition sites) modulated the selective aggregation o

193 tively, we find that Dam travels between its recognition sites most efficiently when those sites are

194 the CT-alpha-syn that lacked the 118-126 aa recognition site needed for antibody binding.

195 platelet inhibitors act by occupying the RGD recognition site of alpha(IIb)/beta(3) integrin (GPIIb/I

196 occupy additional sites within the substrate recognition site of BRD4(1).

197 The recognition site of GrB that resulted in the cleavage of

198 no acid (AA) mismatches (MMs) at the antigen recognition site of HLA molecules represent independent

199 The principle recognition site of MAP kinases, the common docking (CD)

200 The recognition site of partial complex 1 can be completed b

201 ation of ultrafast solvation dynamics at the recognition site of photoantenna molecule and at the act

202 The substrate recognition site of Pin1 performs specific and nonspecif

203 ins contained the lipoprotein signal peptide recognition site of signal peptidase II (SpII).

204 at positions 33 to 45, corresponding to the recognition site of the beta-catenin destruction complex

205 site in the three states and at the related recognition site of the cofactor, ranging from a few to

206 is, which suggested a significantly enlarged recognition site of the high-specificity affinity clamps

207 ate and nitrite complexation at the triamide recognition site of the receptor.

208 f capsids from AAV serotypes and homology of recognition sites of AAV Nab located on different capsid

209 However, due to the similarity between recognition sites of enantiomers and common conformation

210 olution and mapped the specific carbohydrate recognition sites of OAA by NMR spectroscopy.

211 haracterized immune-dominant IgE- and T-cell-recognition sites of Phl p 5.

212 determine the overall structure and specific recognition sites of small molecules or proteins.

213 dues, notably Arg15 and Arg16, which are the recognition sites of the kinases phosphorylating at Ser1

214 e exclusion chromatography shows that the 3' recognition sites of the single-stranded conjugates hybr

215 The recognition sites of these enzymes generally require two

216 Identification of a specific recognition site on PrP(C) that traps Abeta in an oligom

217 d that the alkyl side chains of the viologen recognition site on the molecular axle act as strict kin

218 sidues contribute to and form a Set2 docking/recognition site on the nucleosomal surface so that prop

219 We defined the recognition site on VP6 as a quaternary epitope containi

220 MCC inhibits the APC/C by obstructing degron recognition sites on Cdc20 (the substrate recruitment su

221 uences of the MCC subunit BubR1 block degron recognition sites on Cdc20, the APC/C coactivator subuni

222 e bimodal configuration to mask key cellular recognition sites on dsRNA.

223 1 was prepared, which revealed specific RvD1 recognition sites on human leukocytes.

224 aneous utilization of two distinct substrate recognition sites on Lon, an HspQ binding site and an Hs

225 t specifically bind acetyl-lysine containing recognition sites on proteins.

226 ule biophysical methods that FokI aligns two recognition sites on separate DNA molecules in parallel

227 NA triplex and a repressor protein to distal recognition sites on supercoiled DNA minicircles using M

228 unctions by either forming or masking glycan recognition sites on the cell surface or secreted glycoc

229 t occurs when Type I enzymes bind unmodified recognition sites on the host genome.

230 in terms of their ability to bind to the BH3-recognition sites on two partner proteins, Bcl-x(L) and

231 igh degree of sequence variability, antibody recognition sites or antigenic hotspots on AAVs and othe

232 ctive, catalytically active, or redox-active recognition sites, or even charges and dipoles.

233 rtion of mutations, insertion of recombinase recognition sites, or large DNA elements.

234 The wide variability of oriC DnaA recognition site patterns seen in nature may reflect myr

235 dimeric IRF-3 bound to the PRDII-PRDI tandem recognition sites placed at the middle of a 300 bp DNA p

236 lso not known whether all high-affinity DnaA recognition sites play an equivalent role in oligomer fo

237 t that binding of such a dimer to its tandem recognition sites PRDIII and PRDI, which are located on

238 The simultaneous presence of two recognition sites produces a small-amplitude macrocycle

239 p to 4+ and simultaneously generated two new recognition sites (pyridinium motifs) that are in compet

240 reassociate with it, and diffuse back to the recognition site rather than bind to an oligonucleotide

241 However, their recognition site remains active upon complexation with t

242 or of Tlx or cyclin D1 that lacks the let-7b recognition site rescued let-7b-induced proliferation de

243 a LSD1 expression vector lacking the miR-137 recognition site rescued miR-137-induced precocious diff

244 f the receptor at Arg-46 and Arg-41 protease recognition sites, respectively.

245 ne resolvase CinH recombinase (CinH) and its recognition sites RS2 were constructed and transformed i

246 equence conservation that serve as substrate-recognition sites San1 uses to target its different subs

247 ces is a recognized important feature of the recognition site search process.

248 A pair of TALENs binds to two DNA recognition sites separated by a spacer sequence, and th

249 rries tandem copies of exon 2, with an ISceI recognition site situated between them.

250 ils and monomers, HSA targets key Abeta self-recognition sites spanning the beta strands found in cro

251 ected by a decapeptide containing a protease recognition site specific for factor Xa, thrombin, or ca

252 TCC blocking activity and the existence of a recognition site specific for this scaffold.

253 how homing endonucleases undergo changes in recognition site specificity will facilitate efforts to

254 hr498 --> Ser498 substitution in a substrate recognition site (SRS).

255 Identification and mapping of critical recognition sites suggest that ATR1 detection by the RPP

256 to a merocyanine species activating a second recognition site, suitable for the formation of a pseudo

257 he long-distance interaction between the two recognition sites takes place.

258 main that complexes silver clusters and a 3'-recognition site that hybridizes with a target oligonucl

259 tains a unique KpnI restriction endonuclease recognition site that is not present in otherwise wild-t

260 hat the A1 domain of VWF contains a receptor-recognition site that plays a key role in regulating the

261 ains the tag of interest flanked by two gRNA recognition sites that allow excision of the tag from th

262 stems in part from mutations to restriction recognition sites that disrupt data generation, an addit

263 uman erythroid enhancer, revealing single TF recognition sites that gate the majority of downstream r

264 short or long and each bearing complementary recognition sites-that react pairwise through 1,3-dipola

265 consists of a knock-out CORE (an18-bp I-SceI recognition site, the SCEI gene under the control of the

266 Upon association of the target with its recognition site, the sensor strand opens to expose the

267 fulvalene, dioxynaphthalene and bipyridinium recognition sites, the position of the ring can be switc

268 the other, tetrathiafulvalene and butadiyne recognition sites--the values for K are orders (one and

269 alectin-3 entail binding of its carbohydrate recognition site to glycans of a glycoprotein, resulting

270 d U1 small nuclear ribonucleoprotein (snRNP) recognition sites to be the most depleted and enriched s

271 alogen bonding iodo-triazolium station anion recognition sites to form a unique 1:1 stoichiometric ni

272 by using proteases with mutually orthogonal recognition sites to modulate brush height in situ to pr

273 quinolines by overlapping and nonoverlapping recognition sites to which murine loss-of-function mutat

274 bind the P3 sequence, which contains the HD recognition site, unless it is preincubated with nuclear

275 by a clipping strategy around each and every recognition site using equimolar amounts of 2,6-pyridine

276 t transcript decay, with the rescue of miRNA recognition sites via RBP binding as one possible mechan

277 d molecular beacon (MB) with an endonuclease recognition site was designed for strand cycle amplifica

278 To address this issue, a furin recognition site was located between the ODD domain and

279 -occurring miRNAs, binding of the RBP to its recognition sites was predicted to release nearby miRNA

280 A specific group of miRNA recognition sites were enriched within 50 nts from the R

281 IP-QDs) with customized selective artificial recognition sites were fabricated in this study by optim

282 Three matriptase recognition sites were identified in ASIC1 (Arg-145, Lys

283 d substituted with both neutral and cationic recognition sites, were shown to be effective receptors

284 ear plasmid DNA containing two terminal loxP recognition sites when packaged in vitro.

285 e of a handful molecules that can expose new recognition sites when undergoing force-induced mechanic

286 uctures, and we propose a putative phosphate recognition site where a chloride ion is coordinated nea

287 challenged to digest DNA duplexes containing recognition sites where individual Cs and Gs were replac

288 nhibits CN by occupying a critical substrate recognition site, while leaving the catalytic center ful

289 y by recoding the gene sequence to eliminate recognition sites, while preserving the amino acid seque

290 This host combines two isophthalamide anion recognition sites with two unusual "half-crown/two carbo

291 ies can be trapped in a DNA domain without a recognition site, with a non-specific DNA association li

292 hus involve two A(2)B units, each bound to a recognition site, with two more A(2)B units bridging the

293 ent redox states among these three potential recognition sites, with corresponding color changes, is

294 e essential exoribonuclease RNase D, and its recognition site within RNase E is identified.

295 The importance of the location of the recognition site within the DNA sequence is discussed.

296 t correlation between the number of cleavage recognition sites within a given transcript and its susc

297 l activation of PKA as it occludes C-subunit recognition sites within CBD-A.

298 d from rebinding due to incorporation of its recognition sites within nucleosomes.

299 The mutation of two predicted miR-K10a recognition sites within the 3' UTR of TWEAKR completely

300 aA, bound to specific high- and low-affinity recognition sites within the unique oriC locus, comprise