ライフサイエンスコーパス: recombinant antigen

1 acids) was then designed and expressed as a recombinant antigen.

2 fic antibodies based on a WNV preM/E protein recombinant antigen.

3 (88.9%) contained antibodies to one or more recombinant antigens.

4 24 (80%) contained antibodies to one or more recombinant antigens.

5 41-G antigen and to one or more of the other recombinant antigens.

6 ts potency as a vaccine against poxvirus and recombinant antigens.

7 antage and enhance immunization of expressed recombinant antigens.

8 cted positively by an ELISA with one or more recombinant antigens.

9 Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mi

10 E cross-reactivity on molecular level, seven recombinant antigens 5 of the most important Vespoidea g

11 th venom extracts than in sIgE analyses with recombinant antigens 5.

12 No cross-reactivity with recombinant antigen 5a was found with sera from patients

13 Recombinant antigens 5a and 12a detected parasite-specif

14 sIgE against recombinant antigen 5s sensitization to be detected in 5

15 infection-primed lines were challenged with recombinant antigen 85 (Ag85) proteins.

16 ly higher CD8(+)-T-cell response against the recombinant antigen after challenge with recombinant L.

17 Five recombinant antigens (Ags; 85A, 85B, 85C, superoxide dis

18 binations of the previously described 27-kDa recombinant antigen and the 87-kDa heat shock protein we

19 The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic

20 s, levels of antibodies in pregnant women to recombinant antigens and to intact IEs but not of opsoni

21 of multigravidae are not depleted on VAR2CSA recombinant antigens, and hence development of VAR2CSA v

22 munosorbent assay (ELISA), immunoblotting of recombinant antigens, and immunoprecipitation of 35S-met

23 Mycobacteria expressing recombinant antigens are already being developed as vacc

24 These results suggest that none of the four recombinant antigens are immunodominant, and that the 10

25 In phase 1, recombinant antigens are screened for reactivity to the

26 Highly pure recombinant antigens are typically very poorly immunogen

27 of a cocktail of three to four synthetic or recombinant antigens, based on the diagnostic bands of t

28 we have evaluated the performance of the new recombinant antigen-based Abbott AxSYM CMV IgM assay and

29 Recombinant antigen-based assays significantly increase

30 tudinally by quantitative PCR and by the new recombinant antigen-based AxSYM immunoassay for IgM to H

31 nt assay (ELISA) also tested positive by the recombinant antigen-based immunoassay (VacRIA).

32 guide the design and engineering of improved recombinant antigen-based vaccines.

33 lin M (IgM) by use of a monoclonal antibody, recombinant-antigen-based IgM capture enzyme immunoassay

34 rage may affect development of antibodies to recombinant antigens, but levels of opsonizing IgG remai

35 dy has identified, for the first time, three recombinant antigens capable of inducing protective immu

36 oth the secreted and nonsecreted form of the recombinant antigen compared to the response of naive mi

37 In particular, by using a combination of recombinant antigens, competitive inhibition assays, and

38 Recombinant antigens comprising truncated capsid protein

39 es to native antigen 85, indicating that the recombinant antigen contained T-cell and B-cell epitopes

40 dual or combinations of purified leishmanial recombinant antigens delivered as plasmid DNA constructs

41 cteria could serve as a vaccine platform for recombinant antigens derived from other pathogens, aller

42 A panel of seven recombinant antigens, derived from Ehrlichia phagocytoph

43 The recombinant antigen elicited proliferation and gamma int

44 A cocktail of the recombinant antigens ESAT-6, MPB83, and MPB64 failed to

45 beta-glucosidases of other organisms, but a recombinant antigen expressed in a prokaryotic system sh

46 results show that CD4 T cells specific for a recombinant antigen expressed in Salmonella typhimurium

47 We describe a recombinant antigen for use in serologic tests for antib

48 using a model antigen and F1-V, a candidate recombinant antigen for Yersinia pestis, the causative a

49 These data identify new recombinant antigens for evaluation in vaccines and diag

50 To address this unmet need, we evaluated recombinant antigens for their ability to detect serum a

51 eins that should be considered for design of recombinant antigens for vaccine trials and that implica

52 ella enterica serovar Typhimurium expressing recombinant antigens from other pathogens elicits primar

53 heavy and light chains assembled to bind the recombinant antigen GA733-2E and specifically bound to h

54 This recombinant antigen has great potential to become the an

55 djuvants in enhancing the immune response to recombinant antigens has led many researchers to re-focu

56 ht influence the chosen strategy to localize recombinant antigen in RASVs.

57 ycobacterium tuberculosis was expressed as a recombinant antigen in the nonpathogenic mycobacterial h

58 and appropriate subcellular location of the recombinant antigen in the Salmonella vaccine strain may

59 idence is presented for immune protection by recombinant antigens in a mouse model of C. ruminantium

60 ave evaluated the diagnostic utility of five recombinant antigens in enzyme-linked immunosorbent assa

61 Purified preparations of recombinant antigens included outer surface protein A (O

62 noblotting were performed by using purified, recombinant antigens including F1, V antigen, YpkA, YopH

63 This recombinant antigen induced strong humoral and cellular

64 Since production of recombinant antigen is faster and less expensive than pr

65 A recombinant antigen (Ll-SXP-1), preferentially recognize

66 n that a cocktail containing two leishmanial recombinant antigens (LmSTI1 and TSA) and interleukin-12

67 uman B cells and antibodies, using viral and recombinant antigens, mainly led to the isolation of dom

68 us), a reservoir host species, with either a recombinant antigen of the pathogen, outer surface prote

69 to ehrlichiae revealed IgM antibodies to all recombinant antigens of B. burgdorferi except OspB and I

70 nosorbent assays (ELISAs) with whole-cell or recombinant antigens of Borrelia burgdorferi sensu stric

71 immunosorbent assays (ELISAs) with purified recombinant antigens of Borrelia burgdorferi sensu stric

72 Recombinant antigens of Cryptosporidium parvum, Cp900 an

73 In contrast to earlier studies based on recombinant antigens of M. tuberculosis which suggested

74 Recombinant antigens of outer surface proteins (Osps) Os

75 The recombinant antigens of this library were used to stimul

76 igens on persistently HIV-infected cells and recombinant antigens on Env-transfected cells.

77 be used in a QCM assay, in lieu of native or recombinant antigens or capture antibodies, to rapidly d

78 is system provides a method by which several recombinant antigens or reporter constructs can be seque

79 Five recombinant antigens, Ov7, Ov64, OvB8, Ov9M, and Ov73k,

80 The second recombinant antigen, pAg-1C, contained the remaining C-t

81 The first recombinant antigen, pAg-1N, contained the N-terminal 33

82 The availability of recombinant antigen [particularly thyroid peroxidase and

83 ely high degrees of specificity, ELISAs with recombinant antigens, particularly OspC and p41-G, can h

84 nd the IFA titers when greater than 50 ng of recombinant antigen per dot was used.

85 were analyzed in parallel using immobilized recombinant antigens (rAgs) of HEV genotypes 1 and 3 and

86 tigens affinity purified with MAb 4F11 and a recombinant antigen reactive with MAb 4F11.

87 (87%) of 15 serum samples had antibodies to recombinant antigens; reactivity to p22, p39, p41-G, Osp

88 ied and sequenced a subset of genes encoding recombinant antigens recognized by antibody and peripher

89 Nanobodies are the recombinant antigen-recognizing domains of the minimalis

90 n the present study, a series of overlapping recombinant antigens representing the polymorphic outer

91 In addition to two MSP recombinant antigens (rHGE-1 and -3) and a fusion protei

92 The final two recombinant antigens (rHGE-9 and -17) represent overlapp

93 These recombinant antigens should be useful in diagnostic and

94 ctivities to rK39 were tested with the novel recombinant antigens, some of the sera showed stronger a

95 mice were immunized with the five individual recombinant antigens, statistically significant reductio

96 cause it is thus far the only E. chaffeensis recombinant antigen that has been shown to work in an EL

97 ouis encephalitis virus (SLEV) noninfectious recombinant antigen that is a safe and easily produced a

98 was studied previously in L. aethiopica as a recombinant antigen that reacts with human antibodies.

99 velop a vaccine against this infection using recombinant antigens that are expressed in the early lar

100 Only recombinant antigens that contain a nine-amino acid (AA)

101 full-length protein and was not induced with recombinant antigens that contained only the C-terminal

102 frequently reacted positively to one or more recombinant antigens, the inclusion of OspF and p41-G an

103 sponses by facilitating adequate exposure of recombinant antigen to antigen-presenting cells for proc

104 be a powerful platform that can both deliver recombinant antigen to DCs for presentation and provide

105 capacity of four Mycobacterium tuberculosis recombinant antigens to elicit proliferation and cytokin

106 urium has been used for targeted delivery of recombinant antigens to gut- and nose-associated lymphoi

107 nt vaccines to serve as factories to produce recombinant antigens to induce the desired protective im

108 urium has been used for targeted delivery of recombinant antigens to the gut-associated lymphoid tiss

109 A recombinant antigen vaccine against Schistosoma mansoni

110 ions are described and initial success using recombinant antigen vaccines in these models is reviewed

111 Using newly generated recombinant antigen variant-expressing chronic lymphocyt

112 The recombinant antigen was reactive in IgM immunoblots usin

113 ermine whether the protective epitope of the recombinant antigen was sensitive to denaturation, recom

114 The gene encoding the recombinant antigen was sequenced, and database analysis

115 This recombinant antigen was subsequently used to design an a

116 gh the results of class-specific ELISAs with recombinant antigens were comparable to those recorded f

117 Purified recombinant antigens were employed to detect antibodies

118 mmunosorbent assay and western blotting, all recombinant antigens were shown to be antigenic.

119 The proliferative responses to the four recombinant antigens were similar in all patient groups,

120 om the CDC, comparing ELISAs using these two recombinant antigens with the 2-tier test method.

121 None of the recombinant antigens yielded false-positive results.