ライフサイエンスコーパス: recombination

1 D), and joining (J) subgenic elements (V(D)J recombination).

2 eminiscent of sex differences in Arabidopsis recombination.

3 of double stranded DNA breaks, and integron recombination.

4 proximation of the coalescent with crossover recombination.

5 lecular orientation on charge generation and recombination.

6 genes, arising from apparent microhomologous recombination.

7 that all domains are necessary for directing recombination.

8 yet they show extremely low levels of active recombination.

9 lomerase, telomere replication, and telomere recombination.

10 g intronic insertions via in vivo homologous recombination.

11 caused by defects in lymphoid-specific V(D)J recombination.

12 igases that are also essential for crossover recombination.

13 l silencing and repair of DSBs by homologous recombination.

14 ouble-strand break repair through homologous recombination.

15 edominantly to biallelic TCRbeta gene (Tcrb) recombination.

16 eatures of meiosis I, including synapsis and recombination.

17 w hotspots to proceed into the next phase of recombination.

18 enetic changes in the absence of interstrain recombination.

19 attR recombination and inhibits attP x attB recombination.

20 is-associated protein with a role in meiotic recombination.

21 ch as replication, transcription, repair and recombination.

22 ly of CNVs mediated by nonallelic homologous recombination.

23 e that likely hindered effective distal V-DJ recombination.

24 protein Msh2 does not discourage homeologous recombination.

25 strand DNA breaks for efficient class switch recombination.

26 signed to suppress transposon expression and recombination.

27 to link changes in SC dynamics with meiotic recombination.

28 regions that are virtually devoid of meiotic recombination.

29 ng enzyme RecU is involved in DNA repair and recombination.

30 by nonhomologous end-joining and homologous recombination.

31 reaction that takes place during homologous recombination.

32 mechanisms that rearrange genomes and reduce recombination.

33 anscription and DNA replication, repair, and recombination.

34 mal events, including pairing, synapsis, and recombination.

35 ains exhibiting high levels of diversity and recombination.

36 spread to empty target sites via homologous recombination.

37 During meiotic recombination, a subset of programmed DNA double-strand

38 We crossed these CD79-GFP lines to a recombination activating gene (Rag)2:mCherry transgenic

39 eptor (TLR) 4 knockout (Tlr4(-/-)) mice, and recombination-activating gene (Rag2) knockout (Rag2(-/-)

40 in the DNA recombination machinery, such as recombination-activating gene 1 (RAG1), RAG2, or DNA cro

41 linker peptide did not affect fusion protein recombination activity.

42 nome-wide comparisons of sequence diversity, recombination, allele frequency, and selective pressures

43 chondrial genes uniparentally, often without recombination among genetically divergent organelles.

44 ative role of human mobility in facilitating recombination among MAYV strains from geographically dis

45 rthermore, we show that selection suppresses recombination among multiple co-modulated target loci, i

46 ify a late role of BRCA1-BARD1 in homologous recombination, an attribute of the tumour suppressor com

47 is independent of Rad51-directed homologous recombination and avoids the creation of double-strand D

48 major mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinase-mediated

49 e absence of grain boundaries reduces charge recombination and enables a linear response under strong

50 n, population size and structure, migration, recombination and environmental effects.

51 ated with repeats and non-allelic homologous recombination and furthermore that young repeats have al

52 C terminus is dispensable for cellular V(D)J recombination and in vitro nuclease assays with C-termin

53 ;Brca2 (-/-) cells have defective homologous recombination and increased sensitivity to both platinum

54 tion to integrase; RDF activates attL x attR recombination and inhibits attP x attB recombination.

55 que genetic environment defined by a lack of recombination and male-limited inheritance.

56 ction (HJ) is a hallmark intermediate in DNA recombination and must be processed by dissolution (for

57 Sexual recombination and mutation rate are theorized to play di

58 : Dual targeting of MYC-regulated homologous recombination and PARP-mediated DNA repair yields potent

59 ow that Escherichia coli RecQ, a central DNA recombination and repair enzyme, exhibits differential p

60 Homologous recombination and repair factors are known to promote bo

61 e catalyst to TiO2 is due to the slow charge recombination and the high oxidative power of the Re(II)

62 seful insights into the mechanism of meiotic recombination and the process of genome evolution.

63 tic processes, including homologous pairing, recombination, and chromosome segregation.

64 the widespread use of tamoxifen induction of recombination, and highlight the importance of including

65 s can cause large regions to have suppressed recombination, and inversions are sometimes involved in

66 es, methylglyoxal metabolism, DNA repair and recombination, and protein and nucleotide turnover.

67 on of Utf1 resulting from Prdm1-Cre mediated recombination are born with significantly fewer gonocyte

68 Gene conversions resulting from meiotic recombination are critical in shaping genome diversifica

69 Coexisting in a DNA system, meiosis and recombination are two indispensible aspects for cell rep

70 otovoltaics is often limited by high carrier recombination arising from strongly bound excitons and l

71 n postmitotic neurons using Nex-Cre-mediated recombination as well as in utero electroporation of a C

72 play important roles in gene expression and recombination at immunoglobulin sites, their persistence

73 hus revealing an unexpected role for Red1 in recombination-based DNA repair.

74 We hypothesize that recombination-based DNA-repair mechanisms are at least p

75 own to promote both telomere replication and recombination-based telomere extension.

76 from spontaneous mutation, with interstrain recombination being more common in tumor-derived viruses

77 ng recombinant forms that are the product of recombination between different HIV subtypes.

78 we identified a special case of cross-order recombination between enterovirus G (order Picornavirale

79 us in every B cell clone by intrachromosomal recombination between two switch (S) regions upstream of

80 sequences revealed the existence of a single recombination breakpoint at the boundary of the non-stru

81 owever, tamoxifen is not an inert inducer of recombination, but an established endocrine disruptor wi

82 cells, which suggests that CNVs may repress recombination by altering chromatin structure in meiosis

83 enic method for controlling the induction of recombination by Cre at a specific time and in a specifi

84 in sequence and functional diversity, SCHEMA recombination can be used to gain insights into sequence

85 Indeed, in humans, aberrant recombination can lead to diseases such as cancer.

86 methods based on genealogical processes with recombination can uncover past population history in unp

87 and robust transcription throughout the Tcrb recombination center, spanning both DbetaJbeta clusters.

88 and the presence or absence of electron/hole recombination centers.

89 diates global chromosome compaction and post-recombination chiasma development.

90 e in a multi-host system, with low levels of recombination, consistent with real r/m estimates, incre

91 ed processes of DNA replication, repair, and recombination could be automated and establishes a gener

92 deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SHM) in a

93 In B cells, Ig class switch recombination (CSR) is initiated by activation-induced c

94 somatic hypermutation (SHM) and class switch recombination (CSR) pipeline.

95 somatic hypermutation (SHM) and class switch recombination (CSR).

96 udes overexpression of genes involved in VDJ recombination, CXCR4 pathway signaling, and BCL2 family

97 is as an unanticipated outcome of homologous recombination deficiency, which triggers cell lethality

98 gosity (LOH) might also represent homologous recombination deficiency.

99 Recombination did however blur intra-species relationshi

100 y shows that some of the basic properties of recombination differ considerably between single-copy an

101 res another phage-encoded protein called the recombination directionality factor (RDF) in addition to

102 While part of this diversity is generated by recombination during B-cell development and mutations du

103 However, in vitro recombination during PCR amplification could not be excl

104 rm the lasing by investigating the excitonic recombination dynamics of these lasing peaks.

105 reports a method for correlating the radical recombination efficiencies (FcP) of geminate radical cag

106 on in vivo and in vitro, whereas attP x attB recombination efficiency is reduced.

107 henotypes remains problematic due to low DNA recombination efficiency.

108 we show that increasing levels of homologous recombination enhance the efficiency with which selectio

109 s </=150 bp, efficient repair depends on the recombination enhancer, which tethers HMLalpha near the

110 h increased expression of the homologous DNA recombination enzyme RAD51 and tumors overexpressing bot

111 a patient spanning exon 35 as a result of a recombination event between flanking intronic Alu sequen

112 This naturally occurring recombination event may have broad implications for othe

113 ustering of new genomes, (iii) detect recent recombination events among different evolutionary lineag

114 Spatiotemporal characteristics of recombination events and the emergence of this previousl

115 ersification, supported by finding ancestral recombination events between isolates from different lin

116 lineages, (iv) manual inspection of detected recombination events by similarity plots and (v) annotat

117 By combining data sets, we have collected recombination events from over 100,000 meioses and have

118 Several recombination events have been detected in RHDV strains,

119 sfully detected multiple sub-populations and recombination events in these diverse mixtures.

120 In addition, two further interspecies recombination events involving the S gene were identifie

121 ting the cellular milieu toward illegitimate recombination events such as iHR and CN-LOH.

122 r chromatid recombination in the CUP1 array; recombination events that delete the URA3 insertion from

123 s or sequence fragments and detect candidate recombination events that may later be further analyzed

124 e used to recover relatively rare homologous recombination events.

125 y evolve in the host by random mutations and recombination events.

126 e demonstrate that balanced polymorphism and recombination evolve between a target locus that codes f

127 d that AhR negatively regulates class-switch recombination ex vivo by altering activation-induced cyt

128 tagonism using fungi that display suppressed recombination extending beyond loci determining mating c

129 illuminate a complex interplay of homologous recombination factors in fork remodeling and stability.B

130 Attenuation of the charge recombination for RSQ2 was revealed by electrochemical i

131 mum logarithm of odds (LOD) of 8 and maximum recombination fraction of 0.35.

132 outperformed the EM algorithm in estimating recombination fractions between dominant loci and recove

133 smaller variances in estimation of two-point recombination fractions than the EM algorithm.

134 density, GC content, housekeeping genes, and recombination frequency.

135 cular and evolutionary costs and benefits of recombination frequency.

136 inversion (Notch2(COIN) ) model in which Cre recombination generates a Notch2(DeltaPEST) allele expre

137 By monitoring recombination genome-wide using cytological assays and a

138 suggesting that this region may represent a recombination "hot spot" in CoV genomes.

139 -ZFPs, including genomic imprinting, meiotic recombination hotspot choice, and placental growth.

140 upporting the importance of this region as a recombination hotspot in lagoviruses.

141 genomes and 2500 sequence fragments, where a recombination hotspot was identified at the ORF1-ORF2 ju

142 meiotic Mer3 helicase, which recruits it to recombination hotspots, independently of mismatch recogn

143 on, speciation, population size changes, and recombination hotspots.

144 nd that the functions of BRCA1 in homologous recombination (HR) and replication fork protection are s

145 or mutants in two HDR mechanisms, homologous recombination (HR) and single strand annealing (SSA), an

146 ability.BRCA2 is involved in both homologous recombination (HR) and the protection of stalled replica

147 the clinic.Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast

148 allelic pathogenic alterations in homologous recombination (HR) DNA repair-related genes are prevalen

149 ce and cancer suppression require homologous recombination (HR) DNA repair.

150 Homologous recombination (HR) is a DNA double-strand break (DSB) re

151 Homologous recombination (HR) is a major mechanism to repair DNA do

152 or BRCA2 variants known to impair homologous recombination (HR) on the basis of this signature.

153 Current models of bacterial homologous recombination (HR) posit that extensive resection of a D

154 RAD52 is a homologous recombination (HR) protein that is conserved from bacter

155 Sirt1 interacts and deacetylates homologous recombination (HR) repair machinery proteins, including

156 ecially for tumors with deficient homologous recombination (HR) repair.

157 uble-strand break (DSB) repair by homologous recombination (HR) was compromised.

158 ys known to mend DNA DSBs, namely homologous recombination (HR), nonhomologous end-joining (NHEJ), an

159 NA double-strand breaks (DSBs) by homologous recombination (HR), the molecular mechanism underlying t

160 ks are most commonly repaired via homologous recombination (HR), which begins with 5' end resection,

161 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which is thought

162 erase PRMT5 as a key regulator of homologous recombination (HR)-mediated double-strand break (DSB) re

163 s during the multistep process of homologous recombination (HR).

164 is toxic to cells with defects in homologous recombination (HR).

165 stimulating DNA end resection and homologous recombination (HR).

166 and is required for DSB repair by homologous recombination (HR).

167 role in adaptive immunity by mediating V(D)J recombination in developing lymphocytes.

168 resent a novel scenario for the evolution of recombination in finite populations: the genomic storage

169 ic DSBs are normally repaired by intersister recombination in mice.

170 n or complete gene correction via homologous recombination in myogenic cells.

171 we demonstrate that the unproductive charge recombination in native photosystem I photosynthetic rea

172 nd there was evidence for local class switch recombination in NP.

173 ast, we pay special attention to the meiotic recombination in polyploidy, which is a common genomic f

174 zation of transcripts involved in homologous recombination in response to DNA damage.

175 We also used WGS to study recombination in selected colonizing strains from metrop

176 g (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory

177 been ineffectively purged, owing to limited recombination in the cassava genome; (iii) recent breedi

178 both interhomolog and intra/sister chromatid recombination in the CUP1 array; recombination events th

179 ress, indicating a reduction in nonradiative recombination in the perovskite film.

180 Results suggest that recombination in the two sexes proceeds analogously and

181 proteins that catalyse efficient attL x attR recombination in vivo and in vitro, whereas attP x attB

182 se activities together suppress illegitimate recombination in vivo, whereas unregulated duplex unwind

183 ifen less than 10% of the mean dose used for recombination induction, caused adverse effects to the t

184 Meiotic recombination initiates following the formation of DNA d

185 SYP-4, in negatively regulating formation of recombination-initiating double-strand breaks (DSBs) via

186 ease Rad1-Rad10 and enzymes known to disrupt recombination intermediates (Sgs1-Top3-Rmi1, Srs2, and M

187 The efficient removal of replication and recombination intermediates is essential for the mainten

188 Homologous recombination involving sister chromatids is the most ac

189 A critical step in the homologous recombination is a search for a corresponding homologous

190 e genomes is large chromosomal regions where recombination is absent or strongly reduced, but the fac

191 cquisition of alternative RNA polymerases by recombination is an important mechanism for norovirus ev

192 Suppressed recombination is favored because it allows associations

193 Sex chromosomes evolve once recombination is halted between a homologous pair of chr

194 Homologous recombination is inhibited during the G1 phase of the ce

195 example, we find that the inhibition of LoxP recombination is not due to DNA methylation.

196 mechanism, combined with frequent homologous recombination, is likely responsible for the high divers

197 ion in the semiconductor and suppresses bulk recombination, is responsible for the outstanding photoc

198 e frameworks have long lifetimes and display recombination kinetics typical of dissociated charge car

199 etic mapping, can reveal new features of the recombination landscape.

200 the role of genetic variation in shaping the recombination landscape.

201 nction through gene disruption by homologous recombination leads to normal development of motile ooki

202 bcells show high fill factors due to reduced recombination loss under diluted light intensity.

203 arge generation at the cost of non-radiative recombination loss.

204 n, which otherwise would cause non-radiative recombination losses).

205 While recruitment of the homologous recombination machinery is well characterized, it is not

206 ction mutations in genes involved in the DNA recombination machinery, such as recombination-activatin

207 These results suggest that interspecies recombination may play an important role in CoV evolutio

208 nd have led to new and refined insights into recombination mechanisms, including a detailed understan

209 mals with respect to telomere regulation and recombination mechanisms.

210 rate, and thus most frequently used, form of recombination-mediated DNA repair.

211 Although natural crossover recombination modifier loci have been detected in plants

212 hromosomes to meiotic non-allelic homologous recombination (NAHR) events and thus lead to genomic dis

213 The massive increase in recombination observed in recq4 figl1 hybrids opens the

214 The recombination occurs pairwise, resembling the formation

215 When recombination occurs without a protruding nonhomologous

216 y make use of visible light and decrease the recombination of excitons, respectively.

217 induced electron transfer (PeT), followed by recombination of the resulting charge-separated states (

218 r by respiration or combustion, leads to the recombination of the stored hydrogen with oxygen, releas

219 a 118,098-variant library designed by SCHEMA recombination of three parent ChRs.

220 demonstrate state-to-state chemistry for the recombination of three spin-polarized ultracold rubidium

221 a mechanism for how MRN promotes homologous recombination on nucleosome-coated DNA.

222 m acquired alleles and assess the effects of recombination on phylogenetic inference.

223 tant tumor cells occurred by either telomere recombination or telomerase activation mechanisms.

224 creased mutation rate, and capable of sexual recombination, outperform all the other populations.

225 ive nonhomologous end-joining and homologous recombination pathways.

226 Third, after completion of recombination, potentially dependent on SUMOylation, Mer

227 egulated duplex unwinding is detrimental for recombination precision.

228 hat backtracked RNA polymerase can stimulate recombination presents a DNA transaction conundrum: a tr

229 ble-strand break repairs in the class-switch recombination process in vivo.

230 ent ages, we quantify the changes in the VDJ recombination process that occur from embryo to young ad

231 break repair via facilitating DNA homologous recombination processes and highlighted the great potent

232 data show that GATA3 abundance regulates the recombination propensity at the Tcrb locus and provide n

233 only a partial but conserved ortholog share recombination properties with PRDM9 knock-outs.

234 een advanced, with recent efforts focused on recombination proteins and replication origin (oriC) deg

235 that serves as a scaffold for Zhp3 and other recombination proteins.

236 thaliana accessions, we identified two major recombination quantitative trait loci (rQTLs) that expla

237 ing data, we estimated the population-scaled recombination rate (rho) and found it to be significantl

238 Is the observed within-species variation in recombination rate adaptive?

239 e current data on intraspecific variation in recombination rate and discuss the molecular and evoluti

240 The variation of recombination rate at both fine and large scales cannot

241 formed simulations to assess the accuracy of recombination rate inference in the presence of phase er

242 impact of large tandem repeat arrays on the recombination rate landscape in an avian speciation mode

243 In this study, we constructed fine-scale recombination rate maps for a natural population of the

244 Recombination rate valleys show increased DNA methylatio

245 l distances was examined and the genome-wide recombination rate was found to be much smaller than mos

246 With this ABC we infer recombination rate, mutation rate, and recombination tra

247 Loci involved in recombination rate, which is an interesting trait for pl

248 been proposed to influence the variation in recombination rate.

249 In humans, males have lower recombination rates than females over the majority of th

250 short-circuit current, open-circuit voltage, recombination rates, and variations of the difference be

251 c islands in general, have exceptionally low recombination rates, which may play a role in their esta

252 iting in founder animals, and low homologous recombination rates.

253 l G+C-rich context of mammalian class switch recombination regions, R-loops are obligatory intermedia

254 th previously described contributions of the recombination regulator Cst9 (also known as Zip3).

255 uced OFD1 impaired DSB repair via homologous recombination repair (HRR).

256 s (TLS), Fanconi anemia (FA), and homologous recombination repair pathways.

257 ntral role in DNA replication and homologous recombination repair, and is known to be involved in can

258 ons are structures present during homologous recombination, repair of double stranded DNA breaks, and

259 ational signature associated with homologous-recombination-repair deficiency.

260 address the diverse contributions of several recombination/repair proteins to telomere maintenance in

261 Homologous recombination repairs DNA double-strand breaks and must

262 s not opened at the position adjacent to the recombination signal sequence, but rather is trimmed bac

263 I in mice with a T cell-specific deletion of recombination signal-binding protein for immunoglobulin

264 The ways in which recombination sites are determined during meiosis are be

265 PRDM9 binding localizes almost all meiotic recombination sites in humans and mice.

266 olecular evidence that in addition to sexual recombination, somatic exchange can play a role in the e

267 challenge to acquire the information of DNA recombination spots because it can timely provide very u

268 , whereas the decay is limited by the charge recombination step.

269 on tight physical and functional coupling of recombination steps at the DNA level with specific organ

270 Taste recombination studies further confirmed the contribution

271 owever, heterochromatic centromeres remained recombination-suppressed.

272 The results suggest recent recombination suppression in S. latifolia, since its spl

273 ion on haploids could drive the evolution of recombination suppression on the sex chromosomes, as has

274 virus (AAV) with the Cre-loxP site-specific recombination system to selectively knock down either Bd

275 Using a Gli1-driven Cre-mediated recombination system, our results provide the first in v

276 be a potent driver of the strata and reduced recombination that characterize many sex chromosomes.

277 tinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and shares fe

278 Somatic DNA recombination, the hallmark of vertebrate adaptive immun

279 nome shows some degree of sexually dimorphic recombination, the vast majority of hotspots are shared

280 rylpropargyl cation dissociation followed by recombination through cation addition to the diazo carbo

281 spin-transfer torque acts over a picosecond recombination time of the spin-polarized photo-carriers

282 NA structures during replication, repair and recombination to avoid genomic instability.

283 embryonic lethality we used Tie2CRE-mediated recombination to conditionally delete Id1 against global

284 We have used structure-guided SCHEMA recombination to create a large set of functionally dive

285 We used Dlx5/6-mediated recombination to create conditional Oprm1 mice in gamma-

286 ybrids opens the possibility of manipulating recombination to enhance plant breeding efficiency.

287 bp) HSV-1 x HSV-2 crossover followed by back-recombination to HSV-2.

288 We used homologous recombination to precisely delete foraging, generating t

289 Paternal leakage provides opportunity for recombination to slow down the mutation accumulation, bu

290 infer recombination rate, mutation rate, and recombination tract length of Bacillus cereus from a who

291 In the absence of recombination, uniparental inheritance of freely-segrega

292 Efficiency and specificity of Cre-mediated recombination was assessed by using Cre-reporter mice, p

293 ated with B cell activation and class switch recombination was measured by qRT-PCR.

294 udies involving hetDNA formed during mitotic recombination were restricted to one locus.

295 is, homologous chromosomes undergo crossover recombination, which creates genetic diversity and balan

296 ral part of a new regulatory step of meiotic recombination, which has implications to prevent rapid a

297 gregation in meiosis requires crossover (CO) recombination, which is regulated to ensure at least one

298 transfer among redox cofactors versus charge recombination with nearby donors can explain the range o

299 We show EVEs are acquired through recombination with specific classes of long terminal rep

300 nking genome-wide patterns of divergence and recombination with the underlying evolutionary mechanism