ライフサイエンスコーパス: recombination intermediate

1 embly of a replication complex onto a D-loop recombination intermediate.

2 ions affect the general conformation of this recombination intermediate.

3 st form and then resolve a Holliday junction recombination intermediate.

4 egulator of the pathway of resolution of the recombination intermediate.

5 of chemotheraputics on the structure of the recombination intermediate.

6 al role in promoting replisome assembly on a recombination intermediate.

7 ion, and gain insight into the nature of the recombination intermediate.

8 es branch migration of the Holliday junction recombination intermediate.

9 uired for protection of either type of V(D)J recombination intermediate.

10 , Slx4, and Msh2/Msh3 complex at a 3' tailed recombination intermediate.

11 host chromosome through a Holliday junction recombination intermediate.

12 , efficiently cleaving replication forks and recombination intermediates.

13 or modeling excisive rather than integrative recombination intermediates.

14 that Saw1 targets Rad1/Rad10 to Rad52-coated recombination intermediates.

15 in HR by facilitating the formation of early recombination intermediates.

16 he arrangement of heteroduplex DNA (hDNA) in recombination intermediates.

17 detectable Rad51 foci indicative of meiotic recombination intermediates.

18 A without any preference for DNA-replication/recombination intermediates.

19 ose resembling stalled replication forks and recombination intermediates.

20 ad to models of the structure of the full HJ recombination intermediates.

21 ion, possibly keeping the DNA clear of toxic recombination intermediates.

22 h strand exchange on complex replication and recombination intermediates.

23 cular molecules (many with tails) similar to recombination intermediates.

24 ing with the generation and/or processing of recombination intermediates.

25 eventing transpositional resolution of V(D)J recombination intermediates.

26 eria and plants, implicated in processing of recombination intermediates.

27 g that RRM3 helps prevent formation of toxic recombination intermediates.

28 romotes DNA-PK(cs)-independent resolution of recombination intermediates.

29 strand, allowing DNA synthesis to occur from recombination intermediates.

30 onsistent with localization of ATM to normal recombination intermediates.

31 cycle progression in response to unrepaired recombination intermediates.

32 the repair of mismatches present in meiotic recombination intermediates.

33 X- and Y-branched structures, reminiscent of recombination intermediates.

34 ismatch repair of heteroduplex DNA (hDNA) in recombination intermediates.

35 consistent with a role for Rad1 in cleaving recombination intermediates.

36 earrangements are formed by misprocessing of recombination intermediates.

37 and DnaT during replication fork assembly at recombination intermediates.

38 e recognition of these mismatches in mitotic recombination intermediates.

39 day junction translocation and resolution of recombination intermediates.

40 otein participates in replication restart at recombination intermediates.

41 t mismatch repair proteins can interact with recombination intermediates.

42 o push invading 3'-ended strands back out of recombination intermediates.

43 recruited to the sites of DSBs such as V(D)J recombination intermediates.

44 esis that FtsK acts on Holliday junction Xer recombination intermediates.

45 uct formation without altering the levels of recombination intermediates.

46 s that resemble D-loop and Holliday junction recombination intermediates.

47 he RAG proteins impairs proper processing of recombination intermediates.

48 eteroduplex DNA, or during the resolution of recombination intermediates.

49 nition of mismatches present in heteroduplex recombination intermediates.

50 ity, results in a dramatic increase in mtDNA recombination intermediates.

51 G1-3 tail generated during the processing of recombination intermediates.

52 oes not result from excessive degradation of recombination intermediates.

53 ed with RNAs resembling the putative in vivo recombination intermediates.

54 eterologous sequences in three-stranded RecA-recombination intermediates.

55 phosphotyrosine complexes characteristic of recombination intermediates.

56 due to observed changes in the processing of recombination intermediates.

57 ynaptic complexes with nicked catenanes were recombination intermediates.

58 e helicase, Gp41, onto replication forks and recombination intermediates.

59 ing the resolution of replication-associated recombination intermediates.

60 like reannealing denatured DNA and resolving recombination intermediates.

61 o chronic stress can be overcome by reducing recombination intermediates.

62 ructures that arise during the resolution of recombination intermediates.

63 nd its documented activity limiting aberrant recombination intermediates.

64 g stalled replication forks and disassembles recombination intermediates.

65 ility by preventing accumulation of aberrant recombination intermediates.

66 loading the replicative helicase, Gp41, onto recombination intermediates.

67 ), which is part of a complex that dissolves recombination intermediates.

68 specific DNA substrates that represent some recombination intermediates.

69 on, inversion) and the accumulation of toxic recombination intermediates.

70 r, it is dispensable for the accumulation of recombination intermediates.

71 single and double HJs contained within large recombination intermediates.

72 tion for eliminating potentially deleterious recombination intermediates.

73 replication forks and illegitimately formed recombination intermediates.

74 y, crosslink repair and in the resolution of recombination intermediates.

75 nd promotes proper resolution of inversional recombination intermediates.

76 ed by population heterogeneity and transient recombination intermediates.

77 implicated in processing joint molecule (JM) recombination intermediates.

78 rexpression of RuvAB, suggesting that lethal recombination intermediates accumulate in the absence of

79 ogenous or wild-type transgenic RAG-2, V(D)J recombination intermediates accumulate preferentially in

80 a temperature-sensitive mutant, the knotted recombination intermediates accumulated whether or not g

81 ssover recombination and preventing aberrant recombination intermediate accumulation.

82 eractions of p53, for example, with Rad51 or recombination intermediates, also impacts on HR.

83 The Holliday junction recombination intermediate, an X-shaped DNA molecule (xD

84 and sliding-clamp formation between a D-loop recombination intermediate and linear duplex DNA.

85 veillance system in C. elegans that monitors recombination intermediates and couples their formation

86 Recombination intermediates and crossover formation was

87 d on experiments monitoring the formation of recombination intermediates and crossover products, we s

88 junctions are required for the resolution of recombination intermediates and for the restart of stall

89 Mlh1-Mlh3 endonuclease activity in resolving recombination intermediates and in DNA mismatch repair.

90 MUS81-EME1, however, MUS81-EME2 cuts D-loop recombination intermediates and in so doing disengages t

91 stalled replication forks, the resolution of recombination intermediates and in telomere length maint

92 imosomes to participate in the resolution of recombination intermediates and intermediates formed dur

93 The Mus81 endonuclease resolves recombination intermediates and mediates cellular respon

94 gamma) complex, which stabilizes CO-destined recombination intermediates and members of the Zip3/RNF2

95 ctions in S phase to both process homologous recombination intermediates and modulate checkpoint acti

96 ng phenotype nor do they accumulate the rDNA recombination intermediates and products that are found

97 ine the effects of truncated RAG proteins on recombination intermediates and products.

98 -linking of Int in trapped Holliday junction recombination intermediates and recombination reactions

99 the Fanconi Anaemia (FA) pathway can resolve recombination intermediates and remodel synthetic replic

100 ivery of DNA structures that mimic mammalian recombination intermediates and should be useful in assa

101 ions would allow PriA to act as initiator on recombination intermediates and stalled replication fork

102 ption of normal mechanisms needed to resolve recombination intermediates and to maintain chromosome s

103 rks, formation of fork-associated homologous recombination intermediates, and hydroxyurea sensitivity

104 sought using ligation-mediated PCR to detect recombination intermediates, and immunohistochemistry wa

105 lease that processes UV-induced DNA lesions, recombination intermediates, and inter-strand DNA crossl

106 gene conversion, the molecular structures of recombination intermediates, and the biochemical compete

107 y junctions--crossed DNA structures that are recombination intermediates--and promotes branch migrati

108 Persistent recombination intermediates are acted upon by structure-

109 These data indicate that most meiotic recombination intermediates are asymmetrically positione

110 essential for integration; both lysogens and recombination intermediates are detected when gyrase is

111 l-helicase mechanism explains how the looped recombination intermediates are generated and may serve

112 is report, we show that enzymes that process recombination intermediates are involved in the mutageni

113 , here we show that both TCR-gamma and -beta recombination intermediates are readily detectable in no

114 events to ensure that both (a) CO-designated recombination intermediates are reliably resolved as COs

115 Recombination intermediates are required to activate the

116 To ensure that persistent recombination intermediates are resolved prior to cell d

117 data indicate that single-base mismatches in recombination intermediates are substrates for at least

118 Predicted Ig switch recombination intermediates are substrates for both exon

119 ecific Ercc1/Xpf endonuclease, two potential recombination intermediates are substrates for misproces

120 recombination and replication machinery when recombination intermediates are used as substrates for D

121 cleolytic processing of telomeric homologous recombination intermediates, are suppressed.

122 role for topoisomerase III in disentangling recombination intermediates as an alternative to RuvABC

123 n both mismatch repair and the resolution of recombination intermediates as predicted by genetic stud

124 ver strongly implicates crossover-designated recombination intermediates as the sites of SC initiatio

125 ese checkpoints are blind to replication and recombination intermediates as well as to rearranged chr

126 Mutating Smc6 results in the accumulation of recombination intermediates at centromeres and other uni

127 re reorganization on CSHJ is exerted through recombination intermediates at interstitial chromosomal

128 of the TCR-gamma locus was observed, whereas recombination intermediates at the TCR-beta locus could

129 he factors that coordinate conversion from a recombination intermediate back to a replication fork to

130 pe did not result from accumulation of toxic recombination intermediates, because it was not relieved

131 e necessary for the processing of persistent recombination intermediates before cell division.

132 d recombination and may specifically resolve recombination intermediates before partitioning.

133 s, and cells lacking SLX4 or SAW1 accumulate recombination intermediates blocked at the Rad1/Rad10-de

134 uction of steady-state levels of bimolecular recombination intermediates (BRIs), which block chromoso

135 ersity during NHEJ-dependent repair of V(D)J recombination intermediates, but the roles of the templa

136 dictates the pathway of replication from the recombination intermediate by inhibiting a nonspecific,

137 at the damage arose as a result of repair of recombination intermediates by host cell pathways.

138 suggest that surveillance of T cell receptor recombination intermediates by NBS1 and gamma-H2AX may b

139 emia virus, we show that large quantities of recombination intermediates can be generated, and their

140 ion, coupled with the modest accumulation of recombination intermediates, can suppress defects caused

141 Consistent with a role in processing recombination intermediates, cells depleted of SLX4 are

142 sociated with Sgs1, most notably as an early recombination intermediate chaperone, promoting regulate

143 IIIalpha together effect the resolution of a recombination intermediate containing a double Holliday

144 double-displacement loop (double-D-loop), a recombination intermediate containing two single-strande

145 somerase IIIalpha (TOPO IIIalpha) to resolve recombination intermediates containing double Holliday j

146 th artificial Holliday junctions and meiotic recombination intermediates containing four-way junction

147 ct SPO11-induced double-strand breaks and/or recombination intermediates containing free 3' hydroxyl

148 The resolution of recombination intermediates containing Holliday junction

149 he Msh proteins act with Sgs1p to unwind DNA recombination intermediates containing mismatches.

150 HU (DrHU), which binds preferentially to DNA recombination intermediates, contains a 47-amino acid ex

151 y release the third strand of the homologous recombination intermediate D-loop structure irrespective

152 vidual replication problems or the resulting recombination intermediates delay the cell cycle.

153 le of robust DNA synthesis at RAD51-mediated recombination intermediates dependent on the processivit

154 pendent shuttling and directed processing of recombination-intermediate [displacement loop (D-loop)]

155 ility complex, we observe persistent meiotic recombination intermediates (DNA joint molecules) resemb

156 sed to extend the displacement loop (D-loop) recombination intermediate, does not influence the lengt

157 ate of Mus81-Mms4 and Sgs1-Top3 is a 3' flap recombination intermediate downstream of replication for

158 during lymphocyte development, joining V(D)J recombination intermediates during antigen receptor gene

159 the processing of DNA ends and resolution of recombination intermediates during double-strand gap rep

160 RuvABC proteins of Escherichia coli process recombination intermediates during genetic recombination

161 ct independently to promote the formation of recombination intermediates during impaired replication.

162 4 is required for the processing of specific recombination intermediates during meiosis.

163 -annealing activity that hastens the rate of recombination intermediate formation.

164 We show here that recombination intermediates formed between linear duplex

165 Here we address the nature of the recombination intermediates formed by phiC31 integrase w

166 y of the helicase component and ensures that recombination intermediates formed by uvsX/uvsY will eff

167 he two 400-kDa multiprotein Holiday junction recombination intermediates formed during lambda integra

168 cessing of damaged replication forks, or the recombination intermediates formed from damaged forks.

169 esigned substrates representing illegitimate recombination intermediates formed when a displaced DNA

170 that the Sgs1 helicase prevents a subset of recombination intermediates from becoming crossovers, an

171 F/ERCC1 is the active species that processes recombination intermediates generated during the repair

172 x and Esc2 prevent the accumulation of toxic recombination intermediates generated in these processes

173 ity for the Holliday junction (HJ)-a key DNA recombination intermediate-have been purified and charac

174 ith two tetramers of RuvA binding to the DNA recombination intermediate in a co-operative manner.

175 pproximately -4 kcal/mol to stabilizing this recombination intermediate in inverted-repeat sequences.

176 les are consistent with their being an early recombination intermediate in the Red recombination path

177 I stimulates the dissolution of a homologous recombination intermediate in vitro and is essential for

178 Current mechanisms posit a recombination intermediate in which both 5' ends of doub

179 ishable from the eclipse complex formed as a recombination intermediate in wild-type competent cells.

180 Here we report the first analysis of V(D)J recombination intermediates in a Ku-deficient cell line.

181 es HR by promoting the disassembly of D loop recombination intermediates in a reaction dependent upon

182 elta, and shu1Delta each reduce the level of recombination intermediates in an smc6 mutant when cells

183 itivity to DNA damage or the accumulation of recombination intermediates in cells lacking Sgs1, which

184 ons in the proper assembly and resolution of recombination intermediates in endogenous antigen recept

185 Resolution of Holliday junction recombination intermediates in most Gram-negative bacter

186 the accumulation of potentially deleterious recombination intermediates in mutants of the Smc5/6 com

187 Here, we compare recombination intermediates in pat1-as2 at 25 degrees C

188 ion and the accumulation of V(beta)-DJ(beta) recombination intermediates in peripheral CD4(+) T cells

189 The presence of recombination intermediates in plant mitochondria prepar

190 The level of recombination intermediates in rho+ mtDNA of Deltamgt1 c

191 s confirm the validity of previous assays of recombination intermediates in S. pombe and provide new

192 mph1 is known to reduce the levels of recombination intermediates in smc6 mutants.

193 over together with evidence for accumulated recombination intermediates in syp-1 mutants indicate th

194 single-strand branch that resembles putative recombination intermediates in the RAD1 RAD10-mediated s

195 We investigated yeast Msh2p association with recombination intermediates in vivo using chromatin immu

196 Repair of single-base mismatches formed in recombination intermediates in vivo was investigated in

197 ructures, we produced test circuits based on recombination intermediates in which 1D translocation ac

198 hat poleta extends DNA synthesis from D loop recombination intermediates in which an invading strand

199 ere we report the first examination of V(D)J recombination intermediates in XRCC4-deficient cells.

200 structure (a model for the Holliday junction recombination intermediate) in which each 'arm' of the 4

201 -6 nt of homology, followed by resolution of recombination intermediates into chromosomal rearrangeme

202 mm proteins promote the biased resolution of recombination intermediates into crossovers that are dis

203 d ERCC1 form a complex that resolves meiotic recombination intermediates into crossovers.

204 hich the 3'-OH of the invading strand in the recombination intermediate is used as a primer.

205 The efficient and timely resolution of DNA recombination intermediates is essential for bipolar chr

206 The efficient removal of replication and recombination intermediates is essential for the mainten

207 We have examined formation of joint molecule recombination intermediates (JMs) between homologs and b

208 ts show that ICP8 catalyzes the formation of recombination intermediates (joint molecules) between ci

209 Recombination intermediates (joint molecules, JMs) accum

210 NA, an in vitro mimic of the in vivo genetic recombination intermediate known as the Holliday junctio

211 s of minimized and symmetrized surrogates of recombination intermediates lacking the accessory protei

212 nhance checkpoint signaling without reducing recombination intermediate levels.

213 a model in which BLM selectively dissociates recombination intermediates likely to be unfavorable for

214 omologous chromosomes, while crossover-bound recombination intermediates locally stabilize interactio

215 e- and four-strand exchange reactions, using recombination intermediates made by the E. coli RecA pro

216 tion to clear DNA of proteins and to migrate recombination intermediates may be of critical importanc

217 oth enzymes have profound defects in meiotic recombination intermediate metabolism and crossover (CO)

218 esponse and the formation of RecA*-dependent recombination intermediates necessary for PriA/Pol II-de

219 either differential control of resolution of recombination intermediates or alternative pathways of r

220 ence of DNA damage in the form of unrepaired recombination intermediates or defects in homologous chr

221 ifferential stability of crossover-competent recombination intermediates, or alternatively, the prese

222 We further show that in the absence of recombination intermediates, polycomplexes recapitulate

223 ce of chi recognition is the production of a recombination intermediate possessing a 3'-ssDNA overhan

224 play an essential role in the resolution of recombination intermediates prior to chromosome segregat

225 ecG mutation, which promotes accumulation of recombination intermediates proposed to prime replicatio

226 Early recombination intermediates (RAD-51 foci) increase conco

227 vo but does not influence the high levels of recombination intermediates readily detected in the mtDN

228 nt with hemicatenane-related template switch recombination intermediates (Rec-Xs) but not Holliday ju

229 in vitro BLM helicase promotes disruption of recombination intermediates, regression of stalled repli

230 s are reliably resolved as COs and (b) other recombination intermediates reliably mature into noncros

231 1-independent functions that ensure complete recombination intermediate resolution and chromosome seg

232 logous chromosomes and altered processing of recombination intermediates, resulting in increased chia

233 ease Rad1-Rad10 and enzymes known to disrupt recombination intermediates (Sgs1-Top3-Rmi1, Srs2, and M

234 Analysis of recombination intermediates showed defects at the cleava

235 Accumulation of recombination intermediates similarly leads to the demis

236 he recombinase machinery and the presence of recombination intermediates strongly suggest that TCR re

237 The recombination intermediate structure between a donor p44

238 To determine whether the p44 recombination intermediate structure can be generated in

239 LM is well equipped to deal with alternative recombination intermediate structures.

240 UvsW-catalyzed unwinding of recombination intermediates such as D-loops and static X

241 f PriA-directed replication fork assembly at recombination intermediates such as D-loops.

242 t a model in which Mus81-Mms4 cleaves nicked recombination intermediates such as displacement loops (

243 ng enzymes participate in recombination, and recombination intermediates supply substrates for replic

244 nerate 10-fold higher levels of one class of recombination intermediates, termed signal ends.

245 s that when annealed in vivo approximate the recombination intermediate that Exo should create.

246 These results show that pilin Av produces a recombination intermediate that must be processed by eit

247 repair of a single DSB, suggesting that the recombination intermediates that accumulate cannot be pr

248 the complex is dissolution of toxic X-shaped recombination intermediates that accumulate during repli

249 endent Ddc2 foci, indicating the presence of recombination intermediates that are sensed by checkpoin

250 that these complexes are required to resolve recombination intermediates that arise in response to DN

251 strates fully recapitulate the properties of recombination intermediates that arise within a physiolo

252 to a complementary ectopic DNA site, forming recombination intermediates that can lead to genomic ins

253 erase IIIalpha (hTOPO IIIalpha), can process recombination intermediates that contain double Holliday

254 In order to isolate and characterize recombination intermediates that contain Holliday juncti

255 ctor MSH2-MSH3 binds and stabilizes branched recombination intermediates that form during single stra

256 Gene conversion might accompany recombination intermediates that resolve without translo

257 romosome breakage and the formation of toxic recombination intermediates that undermine genomic stabi

258 a transposase capable of inserting the V(D)J recombination intermediate, the signal end DNA fragment,

259 We identify a novel meiotic recombination intermediate, the single-end invasion (SEI

260 not reflect the accumulation of unprocessed recombination intermediates: the delays in meiotic progr

261 straints on which enzymes gain access to the recombination intermediate, thereby controlling the mann

262 male germ cells to promote repair of meiotic recombination intermediates, thereby improving the fidel

263 36 may play an important role in stabilizing recombination intermediates through solvent-mediated pro

264 ut also on antirecombinases, which dismantle recombination intermediates to allow completion of repai

265 el in which CDK activity links processing of recombination intermediates to cell cycle progression vi

266 The liability of recombination intermediates to damage is consistent with

267 fluences the choice of proteins that resolve recombination intermediates to form crossovers.

268 system can remove mismatches in heteroduplex recombination intermediates to generate gene conversion

269 that mismatch repair proteins interact with recombination intermediates to prevent recombination, or

270 essentiality of replication fork restart at recombination intermediates under normal growth conditio

271 escuing a proportion of crossover-designated recombination intermediates via a route that is likely A

272 The recombination intermediate was recovered in an E. coli s

273 Repair of all 12 single-base mismatches in recombination intermediates was investigated in Chinese

274 studies showed that AtRECQ4A associates with recombination intermediates, we found no evidence that i

275 s regulate recombination by interacting with recombination intermediates, we investigated whether the

276 During resolution of Holliday junction recombination intermediates, wild-type Int, but not R169

277 Recombination intermediates with a maximum heteroduplex

278 ling the formation and processing of meiotic recombination intermediates with DNA-strand interruption