ライフサイエンスコーパス: recombination repair

1 lication stress, suggesting a direct role in recombination repair.

2 te a direct role of RPA in homology directed recombination repair.

3 reinitiation of DNA synthesis by homologous recombination repair.

4 SSBs collapse replication forks, triggering recombination repair.

5 in EM9 causes more collapsed forks and more recombination repair.

6 ANCD2 and 10 proteins involved in homologous recombination repair.

7 RCA2 pathways as they function in homologous recombination repair.

8 n shown to be required for homology-directed recombination repair.

9 end resection, the first step of homologous recombination repair.

10 can be overcome partially by recA-dependent recombination repair.

11 nslesion DNA synthesis, excision repair, and recombination repair.

12 family, thought to be central to homologous recombination repair.

13 complement a yeast rad51 mutant deficient in recombination repair.

14 on-homologous end joining but not homologous recombination repair.

15 arly ATM checkpoint responses and homologous recombination repair.

16 rocessing that is a requisite for homologous recombination repair.

17 on studies) and together, promote homologous recombination repair.

18 CTIP)-dependent end resection and homologous recombination repair.

19 in human cells causes defects in homologous recombination repair.

20 lutionarily conserved function in homologous recombination repair.

21 primarily dependent on ERCC1 and homologous recombination repair.

22 n the choice of templates used in homologous recombination repair.

23 ive G2/M checkpoint, and impaired homologous recombination repair.

24 which is critically important for homologous recombination repair.

25 processing associated with failed homologous recombination repair.

26 equently recruit Rad51 to promote homologous recombination repair.

27 cd2 foci assembly and a defect in homologous recombination repair.

28 A1 and PALB2 is important for the homologous recombination repair.

29 e strain MS11 recB mutants were assessed for recombination/repair.

30 tions trigger genomic rearrangements through recombination-repair activities.

31 d51-dependent and BRCA2-dependent homologous recombination repair activity.

32 D51 protein (hRAD51), facilitates eukaryotic recombination/repair, although its ability to hydrolyze

33 ot SA1 decreased sister chromatid homologous recombination repair and affected repair pathway choice,

34 ctivation of this pathway rescued homologous recombination repair and allowed BRCA1-deficient cells t

35 BRCA1 promotes homologous recombination repair and antagonizes 53BP1-dependent non

36 and links BRCA1 and BRCA2 in DNA homologous recombination repair and breast cancer suppression.

37 icipation of H3K79 methylation in UV-induced recombination repair and checkpoint activation, and furt

38 R-155 decreased the efficiency of homologous recombination repair and enhanced sensitivity to IR in v

39 -helicase complex participates in homologous recombination repair and is essential for cellular prote

40 A helicase proposed to operate in homologous recombination repair and replicational stress response.

41 functions in genome maintenance via roles in recombination repair and resolution of recombination str

42 d processing that is required for subsequent recombination repair and restart of replication forks.

43 bility and, consequently, require homologous recombination repair and the DNA damage checkpoint for v

44 and WRN, play important roles in homologous recombination repair and they have been implicated in te

45 mination required to regulate transcription, recombination, repair and chromosome replication and seg

46 ses like transcription, DNA replication, DNA recombination, repair and modification.

47 molecular biological processes that mediate recombination, repair and replication of DNA have come f

48 iophage T4 UvsW protein is involved in phage recombination, repair and the regulation of replication

49 e active in many aspects of DNA replication, recombination, repair and transcription.

50 cellular survival and viability, homologous recombination repair, and genome instability.

51 Nucleotide excision repair, recombination repair, and highly accurate translesion sy

52 ntral role in DNA replication and homologous recombination repair, and is known to be involved in can

53 51 focus formation, inhibition of homologous recombination repair, and persistent gamma-H2AX expressi

54 break repair, XRCC3 and RAD51 in homologous recombination repair, and XRCC7 in nonhomologous end joi

55 he DNA metabolic processes of transcription, recombination, repair, and chromatin remodeling.

56 DNA helix during replication, transcription, recombination, repair, and chromatin remodeling.

57 ny other proteins important for replication, recombination, repair, and chromosome segregation contai

58 Elucidation of DNA recombination, repair, and diversification programs in t

59 in the machinery controlling cell cycle, DNA recombination, repair, and gene expression.

60 se activities are likely to be important for recombination, repair, and genomic stability.

61 and play essential roles in DNA replication, recombination, repair, and maintenance of genomic integr

62 erase activity is essential for replication, recombination, repair, and mutagenesis.

63 d to function in the genetic pathways of DNA recombination, repair, and replication which are importa

64 involved in DNA homologous and site-specific recombination, repair, and replication.

65 DNA (ssDNA) binding protein required for DNA recombination, repair, and replication.

66 iological processes including transcription, recombination, repair, and replication.

67 junctions are critical intermediates in DNA recombination, repair, and restart of blocked replicatio

68 biological functions during DNA replication, recombination, repair, and transcription.

69 rder, displaying defects in DNA replication, recombination, repair, and transcription.

70 the primary proteins involved in homologous recombination repair are RAD51 and the five RAD51 paralo

71 length at DSBs to the capability for global recombination repair between sister chromatids.

72 ing a sequence that could support homologous recombination repair between the two plasmids.

73 of Rad51 expression, required for homologous recombination repair, blocked the ability of mutant p53

74 s reparation of DNA lesions (e.g. homologous recombination repair), but also prolongs activation of c

75 double-strand break (DSB) during homologous recombination repair, but a role in DSB repair by nonhom

76 human Mus81-Eme1 endonuclease is involved in recombination repair, but the exact structures it acts o

77 In addition, INT3 is involved in homologous recombination repair by regulating Rad51 foci formation

78 prototypical bacterial RecA protein promotes recombination/repair by catalyzing strand exchange betwe

79 When the recombination/repair capacity of strain MS11 was compare

80 se that not all components of the homologous recombination repair complex can act as cancer susceptib

81 Homologous recombination repairs damage-induced DNA double-strand b

82 and P9 rec(+) bacteria presenting pronounced recombination/repair defects.

83 ational signature associated with homologous-recombination-repair deficiency.

84 depletion of BRCA1 and subsequent homologous recombination repair deficit was induced with either tru

85 Homologous recombination repairs DNA double-strand breaks and must

86 Homologous recombination repairs DNA double-strand breaks by search

87 cting stressed replication forks: homologous recombination repair, DNA inter-strand cross-link repair

88 rived growth factor and the Rad51 homologous recombination repair factor at DNA breaks.

89 ed by concomitant deletion of the homologous recombination repair factor, Rhp51 (Rad51).

90 litate the functional dissection of this DNA recombination/repair factor.

91 on the XPF-ERCC1 heterodimer, and homologous recombination repair factors XRCC2 and XRCC3.

92 vage, lesser focal recruitment of homologous recombination repair factors, impaired DNA double-strand

93 pathway; radC, which encodes a RecG-like DNA recombination/repair function; malE, which is the first

94 To investigate the importance of the recombination repair functions of Ercc1 we studied sperm

95 y conserved novel member of the recA / RAD51 recombination repair gene family.

96 (block size of six, stratified by homologous recombination repair gene mutation status, progression-f

97 ining does not involve all of the homologous recombination repair genes.

98 ws dynamic epistatic interactions with other recombination-repair genes.

99 Several isogenic strains with defects in recombination/repair genes (RAD1, RAD50, RAD51, RAD52, R

100 nalyses reveal that expression levels of the recombination/repair genes RAD51, RAD52 and RAD54 can af

101 xtracts from cells carrying mutations in the recombination/repair genes RAD51C or XRCC3 have reduced

102 an important role in nucleotide excision and recombination repairs, has a novel role to produce GCRs.

103 recombinase-mediated unfaithful homeologous recombination repair (HomeoRR) in a dosage-dependent man

104 t Ape1 facilitates BRCA1-mediated homologous recombination repair (HR), while counteracting error-pro

105 dominant-negative mutant inhibits homologous recombination repair (HRR) and increases sensitivity to

106 athways exist in mammalian cells: homologous recombination repair (HRR) and nonhomologous end joining

107 re repaired by BCR/ABL-stimulated homologous recombination repair (HRR) and nonhomologous end-joining

108 te, allowing for the detection of homologous recombination repair (HRR) by GFP expression.

109 cell lines are also defective in homologous recombination repair (HRR) induced by DNA double-strand

110 peculate that the contribution of homologous recombination repair (HRR) is at a stage after the initi

111 ng of DNA double-strand breaks by homologous recombination repair (HRR) is critical to the long-term

112 Homologous recombination repair (HRR) is functional during the S- a

113 Homologous recombination repair (HRR) is required for both the repa

114 A role for D1-D2-G-X3 in homologous recombination repair (HRR) is supported by our finding t

115 Homologous recombination repair (HRR) maintains chromosomal stabili

116 lvement of BRCA1 and BRCA2 in the homologous recombination repair (HRR) of double-strand breaks in DN

117 ortant factor in the ATM-mediated homologous recombination repair (HRR) pathway.

118 Flp recombinase and the cellular homologous recombination repair (HRR) pathway.

119 Homologous recombination repair (HRR) protects cells from the letha

120 dependent DNA damage response and homologous recombination repair (HRR) via decreasing DICER-generate

121 homologous end-joining (NHEJ) and homologous recombination repair (HRR), contribute to repair ionizin

122 51 homolog XRCC2 and defective in homologous recombination repair (HRR), displays significantly dimin

123 romoting RAD51 foci formation and homologous recombination repair (HRR), EGFR-mutant cells also exhib

124 e unfaithful DSB repair pathways, homologous recombination repair (HRR), nonhomologous end-joining (N

125 of BRCA1, an important factor of homologous recombination repair (HRR), preferentially sensitized st

126 SHU genes have been implicated in homologous recombination repair (HRR), their precise role(s) within

127 Hus1 decreases the efficiency of homologous recombination repair (HRR), which is associated with the

128 ndent on Exo1- and Shu1-dependent homologous recombination repair (HRR).

129 pse replication forks and trigger homologous recombination repair (HRR).

130 rotein) filament is essential for homologous recombination repair (HRR).

131 ed viability and failed to induce homologous recombination repair (HRR).

132 homologous end-joining (NHEJ) and homologous recombination repair (HRR).

133 homologous end joining (NHEJ) and homologous recombination repair (HRR).

134 ays-nonhomologous end-joining and homologous recombination repair (HRR).

135 uced OFD1 impaired DSB repair via homologous recombination repair (HRR).

136 gle-strand break (SSB) repair and homologous recombination repair (HRR).

137 d its loss or inhibition disrupts homologous recombination repair (HRR).

138 previously unidentified role for homologous recombination repair in correct neuronal development.

139 air of DSBs by not only promoting homologous recombination repair in G2/M phase but also facilitating

140 ether these data support a role for Mus81 in recombination repair in higher eukaryotes.

141 helicases BLM and WRN that are required for recombination repair in human cells colocalize with Mus8

142 with etoposide), up-regulation of homologous recombination repair in response to p53 disruption becom

143 consistent with a role for the XRCC2 gene in recombination repair in somatic cells, suggesting that i

144 Both recombination and recombination repair in T4 rely on UvsX, a RecA-like rec

145 To elucidate the role of recombination repair in the cellular response to UV, we

146 DNA double-strand breaks through homologous recombination repair, increasing the involvement of erro

147 at G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensi

148 Homologous recombination repair is likely to be intact as basal and

149 e structural conservation of DNA replication/recombination/repair machineries among microorganisms, t

150 f the CCTG*CAGG repeats may be mediated by a recombination-repair mechanism that is influenced by DNA

151 pport is presented for the suggestion that a recombination/repair mechanism was used by the intron fo

152 osis, with proposed roles in DNA pairing and recombination/repair mechanisms.

153 While all DSB recombination repair models include 5'-3' resection, the

154 Owing to their function in homologous recombination repair, much research has focused on the u

155 many processes in mammalian cells, including recombination, repair, mutagenesis and apoptosis.

156 BRCA2 is necessary for homologous recombination repair of DNA and the prevention of diseas

157 ce of BRCA2 substantially reduced homologous recombination repair of DNA breaks, whereas the absence

158 protein complex is essential for homologous recombination repair of DNA damage and maintaining genom

159 has no effect on BRCA2-dependent homologous recombination repair of DNA damage.

160 nction together with Rhp51 in the homologous recombination repair of DNA double strand breaks.

161 on-induced cell death and reduced homologous recombination repair of DNA double-strand breaks and pro

162 he latter of which is involved in homologous recombination repair of DNA double-strand breaks.

163 away from the eukaryotic model of homologous recombination repair of DNA double-strand breaks.

164 The fact that this pathway mediates recombination repair of DNA DSBs suggests that DNA DSBs

165 4, plays an important role in the homologous recombination repair of double strand breaks.

166 sibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as

167 find that SETD2 is necessary for homologous recombination repair of DSBs by promoting the formation

168 and TRIP13, proteins normally essential for recombination repair of meiotic DSBs, is substantially b

169 toproducts, the FA/BRCA pathway mediates the recombination repair of replication forks stalled at DNA

170 essing of other types of DNA damage, such as recombination repair of replication forks stalled at DNA

171 interstrand cross-links, involvement in VDJ recombination, repair of DNA double-strand breaks, and p

172 ons are structures present during homologous recombination, repair of double stranded DNA breaks, and

173 nctional phospho-protein with roles in V(D)J recombination, repair of double-strand breaks by nonhomo

174 , TOP3, SRS2 and CTF4, which are involved in recombination, repair of replication forks and the estab

175 During V(D)J recombination, repair of these RAG-generated double-stra

176 SOS response and are defective in homologous recombination, repair of UV damaged DNA, double-strand b

177 ty to nucleotide excision repair, homologous recombination repair, or postreplication repair when com

178 sal of damage, excision repair, conventional recombination repair, or translesion synthesis.

179 RCA1-mediated DDR events: (i) the homologous recombination repair pathway and (ii) the arrest of cell

180 hereby impaired the high-fidelity homologous recombination repair pathway and sensitized cells to sma

181 We therefore studied activation of the recombination repair pathway by solar available doses of

182 host polymerases, proteins of the homologous recombination repair pathway may be considered essential

183 r, especially the RAD51-dependent homologous recombination repair pathway, is executed in vivo.

184 erase RAD51 is a component of the homologous recombination repair pathway.

185 itotic cells preferentially use a homologous recombination repair pathway.

186 refore directly competes with the homologous recombination repair pathway.

187 f DNA double-strand breaks in the homologous recombination repair pathway.

188 epair and the double-strand break/homologous recombination repair pathways.

189 proteins, Ercc1 and Xpf are also involved in recombination repair pathways.

190 s (TLS), Fanconi anemia (FA), and homologous recombination repair pathways.

191 RAD51 family may also function in homologous recombination-repair pathways.

192 he spindle assembly checkpoint, numerous DNA recombination/repair pathways, and the initiation of aut

193 the helicases Rqh1 and Srs2 but not on other recombination/repair pathways.

194 Recombination repair plays an important role in the proc

195 ught to affect genomic stability through DNA recombination/repair processes.

196 use of competition between DNA synthesis and recombination/repair processes?

197 to function in vivo to stimulate homologous recombination repair proficiency.

198 Recombination repair protein 1 (Rrp1) includes a C-termi

199 Drosophila Rrp1 (recombination repair protein 1) is a DNA repair enzyme w

200 ces a distinct set of foci of the homologous recombination repair protein Rad51 that are colocalized

201 d DNA binding protein RPA and the homologous recombination repair protein Rad52.

202 ructural homolog of Saccharomyces cerevisiae recombination/repair protein Rad54, was cloned and expre

203 We show, in normal human cells, that the recombination/repair proteins hRAD51 and replication pro

204 address the diverse contributions of several recombination/repair proteins to telomere maintenance in

205 omplexes formed by the human Rad51 and Rad52 recombination/repair proteins.

206 camptothecin-induced DSBs and the resulting recombination repair require replication, showing that a

207 Successful recombination/repair requires the formation of a presyna

208 nts of the nucleotide excision repair (NER), recombination repair (RR), and translesion synthesis (TL

209 A binding and help direct DrRecQ to specific recombination/repair sites.

210 eduction in MRN/ATM signaling and homologous recombination repair, suggesting that Thr622 phosphoryla

211 Although components of the homologous recombination repair system are also involved in NHEJ, t

212 stalled replication forks by the homologous recombination repair system in humans.

213 mologue Swi5-Sfr1 is critical for homologous recombination repair, the budding yeast counterpart Sae3

214 nents have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in t

215 t function in a common pathway in homologous recombination repair to ensure accurate nuclear division

216 H1 acts independently of 53BP1 in homologous recombination repair to promote RAD51 loading.

217 estrating basic cellular processes (e.g. DNA recombination, repair, transcription, RNA processing, si

218 onsistent with the involvement of homologous recombination repair, we observed extensive sister chrom