ライフサイエンスコーパス: recombination-activating gene-1

1 tigen receptor loci and the discovery of the recombination activating gene-1.

2 regulatory conditions caused by mutations in recombination activating gene 1/2 (RAG 1/2), IL-2 recept

3 th patients with T(-)B(-)NK(+)SCID caused by recombination activating gene 1/2 (RAG1/2) deficiencies.

4 The presence of recombination activating gene 1 and 2 proteins in CD4(+)

5 e recombination signal sequences targeted by recombination activating genes 1 and 2 during antigen re

6 cleavage step of V(D)J recombination by the recombination-activating gene 1 and 2 (RAG1/2) proteins

7 ntigen receptors by the reactivation of RAG (recombination-activating gene)1 and RAG2 and secondary V

8 RSSs) requires the coordinated action of the recombination-activating genes 1 and 2 (RAG1/RAG2) recom

9 Both recombination-activating genes 1 and 2 were expressed in

10 re-B cell involving diminished expression of recombination-activating genes 1 and 2.

11 ymphoblastic leukemia (T-ALL) model onto the recombination-activating gene 1(-/-) background, we show

12 observed in these mice were abrogated on the recombination-activating gene 1(-/-) background.

13 In this study, we used Rag1(-/-) (recombination activating gene 1(-/-)) blastocyst complem

14 y the transplantation of a segment of RAG-1 (recombination-activating gene 1) deficient intestine, wh

15 and wild-type CD4(+) T cells into nephritic recombination activating gene 1-deficient (Rag-1(-/-)) m

16 es that are required for NEC development, as recombination activating gene 1-deficient (Rag1-/-) mice

17 ytes from severe combined immunodeficient or recombination activating gene 1-deficient mice expressed

18 Although the acquired phenotype is stable in recombination activating gene-1-deficient (RAG-/-) recip

19 fusion in wild-type mice (P<0.01) but not in recombination activating gene-1-deficient mice (P<0.05).

20 Adoptive transfer of T-cells to recombination activating gene-1-deficient mice restored

21 roxyproline content, in wild-type but not in recombination activating gene-1-deficient mice.

22 IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) re

23 ive transfer of IL-9(+)IL-10(+) T cells into recombination-activating gene 1-deficient mice induced c

24 umonitis was induced in C57BL/6 wild-type or recombination-activating gene 1-deficient mice treated p

25 arly phases of disease and were abrogated in recombination-activating gene 1-deficient mice.

26 efined amounts of naive TCR-transgenic (TCR) recombination-activating gene-1-deficient T cells into a

27 talytically inactive RAG1 (dominant-negative recombination activating gene 1 [dnRAG1] mice) that deve

28 es and T cells in both wild-type C57BL/6 and recombination activating gene 1-/- irradiated hosts.

29 macrophages derived from primitive yolk sac, recombination activating gene 1(+) lymphomyeloid, and Fm

30 hally irradiated mature lymphocyte-deficient recombination-activating gene-1(-/-) mice.

31 e cultivated T cells induced mild colitis in recombination-activating gene 1 mutant mice.

32 roximately 0.4 muM) (where RAG1 and RAG2 are recombination activating genes 1 or 2).

33 Recombination-activating gene 1 protein (RAG1) and RAG2

34 Here, we identify the recombination-activating gene 1 protein (RAG1) as a subs

35 oth cortical TEC subsets are also present in recombination activating gene 1 (RAG-1(-/-)) and TCRbeta

36 Recombination activating gene-1 (RAG) knockout (KO) (no

37 examined IEL from knockout mice lacking the recombination activating gene-1 (rag-1), CD3epsilon, or

38 ymic-deprived nude and old mice express less recombination-activating gene-1 (RAG-1) mRNA than they d

39 Colitis was induced in recombination-activating gene-1 (RAG-1-/-) mice by the t

40 Recombination activating gene 1 (RAG1) and RAG2 are crit

41 Recombination activating gene 1 (Rag1)(-/-) mice, which

42 describe a third phenotype for mutations in recombination activating gene 1 (RAG1), in addition to t

43 Sequencing of Recombination activating gene-1 (Rag1) showed compound h

44 The products of recombination-activating gene 1 (Rag1) and Rag2 are requ

45 The recombination-activating gene 1 (RAG1) and RAG2 proteins

46 nts and transcription control binding of the recombination-activating gene 1 (RAG1) and RAG2 proteins

47 Mutations in recombination-activating gene 1 (RAG1) and RAG2 result i

48 vel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lym

49 ling by this pathway inhibited expression of recombination-activating gene 1 (Rag1) and Rag2.

50 Recombination-activating gene 1 (RAG1) deficiency presen

51 Recombination-activating gene 1 (RAG1) deficiency result

52 PSCs) generated from patients with different recombination-activating gene 1 (RAG1) mutations to asse

53 Recombination-activating gene 1 (RAG1), as well as RAG2,

54 in the DNA recombination machinery, such as recombination-activating gene 1 (RAG1), RAG2, or DNA cro

55 to the B cell lineage in the context of the recombination-activating gene 1 (RAG1)-deficient backgro

56 Moreover, Pax5 interacted with the recombination-activating gene 1 (RAG1)-RAG2 complex to e

57 nduced demyelination were investigated using recombination-activating gene 1-/- (RAG1-/-) mice infect

58 studied Rag1 knockout mice deficient in the recombination activating gene 1 required for development

59 For example, a specific recombination-activating gene 1 variant protein with par

60 cells as a consequence of deletion of Rag1 (recombination-activating gene 1), with infection in norm