ライフサイエンスコーパス: recombinational repair

1 activation of the DNA damage checkpoints and recombinational repair.

2 r the function of human Rad51C in homologous recombinational repair.

3 of the complex to participate in homologous recombinational repair.

4 ailing to transform yeast cells deficient in recombinational repair.

5 a key factor in homologous recombination and recombinational repair.

6 regulation of two proteins that interact in recombinational repair.

7 tenance of chromosomes) complex required for recombinational repair.

8 Rad51 in the presynapsis stage of homologous recombinational repair.

9 ation of ssDNA for checkpoint activation and recombinational repair.

10 air (NER) pathway, ERCC1 is also involved in recombinational repair.

11 ndamental DNA pairing activity necessary for recombinational repair.

12 e paralogs play an early (pre-RAD51) role in recombinational repair.

13 or single-strand annealing in the eukaryotic recombinational repair.

14 age site on the plasmid, thereby stimulating recombinational repair.

15 caused by an inability to promote efficient recombinational repair.

16 ter chromatid as the template for homologous recombinational repair.

17 etic assays for homologous recombination and recombinational repair.

18 gene sequence to serve as a genetic donor in recombinational repair.

19 rate for DNA repair processes, in particular recombinational repair.

20 mosome condensation, dosage compensation and recombinational repair.

21 e for RAD51B in meiotic recombination and/or recombinational repair.

22 in yeast, may cooperate with HsRad51 during recombinational repair.

23 s behavior in recA mutant cells deficient in recombinational repair.

24 which are presumably repaired by homologous recombinational repair.

25 l analysis suggests a direct role for SSB in recombinational repair.

26 een sisters, opposite to the bias of mitotic recombinational repair.

27 ing pathway that is distinct from homologous recombinational repair.

28 anded DNA that is required for RecA-mediated recombinational repair.

29 es cerevisiae, are known to be essential for recombinational repair.

30 can be uncoupled from its role in homologous recombinational repair.

31 se) that is involved in the major pathway of recombinational repair.

32 n contrast to E. coli, H. pylori RecG limits recombinational repair.

33 recruited to the HO lesion during homologous recombinational repair.

34 oci, suggesting a role for these proteins in recombinational repair.

35 We suggest that nicks become substrates for recombinational repair after being converted into double

36 d functions during G2 in undamaged cells and recombinational repair after DNA damage.

37 that Rad55-S2,8,14 phosphorylation activates recombinational repair, allowing for faster recovery aft

38 d breaks, which are mended by RecA-catalysed recombinational repair and are lethal if not repaired.

39 romatin and nuclear matrix), and enables its recombinational repair and checkpoint functions.

40 ation, cell division, DNA damage monitoring, recombinational repair and detoxification.

41 cells, consistent with coordination between recombinational repair and DNA replication.

42 ght modulate the ability of RAD51 to promote recombinational repair and lead to an increased risk of

43 ir, FANCJ encodes a DNA helicase involved in recombinational repair and replication stress response.

44 nction of Mre11 is required for RMX-mediated recombinational repair and telomere stabilization in mit

45 distinct pathways in replication-associated recombinational repair and that the Smc5/6 complex and E

46 cules may be generated from blocked forks by recombinational repair and/or replication fork regressio

47 king protein involved in DNA replication and recombinational repair, and it is important for preserva

48 A (ssDNA) are essential for DNA replication, recombinational repair, and maintenance of genomic stabi

49 luding those involved in mismatch repair and recombinational repair, and that is noted for high level

50 A functional recombinational repair apparatus decreases sensitivity t

51 DNA damage checkpoint and recombinational repair are both important for cell survi

52 amage, but the effects of phosphorylation on recombinational repair are unknown.

53 iety of mutant forms of Brh2 for activity in recombinational repair as measured by DNA repair profici

54 nown as the RAD51 paralogs are important for recombinational repair, as paralog-defective cell lines

55 We have developed plasmid and chromosomal recombinational repair assays to assess coordination of

56 To determine whether mammalian cells use recombinational repair at a significant level, we have a

57 ks and the consequential failure to initiate recombinational repair at these sites.

58 CC2 mutant cells appears to be restricted to recombinational repair because NHEJ is normal.

59 eas DSBs in unique sequences are confined to recombinational repair between the large regions of homo

60 ric repeat tracts become uncapped, promoting recombinational repair between them to regenerate length

61 ive to gamma-radiation (suggesting defective recombinational repair) but not UV light (suggesting int

62 involved in the early stage (presynapsis) of recombinational repair, but it has a RecN homologue with

63 ly conserved Smc5/6 complex is implicated in recombinational repair, but its function in this process

64 2, rad5, and rdh54 strains, suggest roles in recombinational repair, but not in NHEJ.

65 the Rad50/Mre11/Xrs2 complex is required for recombinational repair, but not NHEJ.

66 compete for Holliday junction structures in recombinational repair, but since a classic RecG resolva

67 BRCA2 protein regulates recombinational repair by interaction with RAD51 via a s

68 A exonucleases, exonuclease X may facilitate recombinational repair by pre-synaptic and/or post-synap

69 ible for inhibition of phage growth and that recombinational repair can reduce sensitivity to the ant

70 that each Rad52 focus represents a center of recombinational repair capable of processing multiple DN

71 on in separate, though possibly overlapping, recombinational repair complexes.

72 strain, suggesting that increased levels of recombinational repair could account for its increased r

73 s, mismatch repair deficiency and homologous recombinational repair deficiency, as well as mutational

74 Recombinational repair-dependent mutants identify ways t

75 NA helicases, and is proposed to function in recombinational repair during DNA replication.

76 We propose a model in which recombinational repair during S phase coupled with failu

77 on (HJ) processing pathways are required for recombinational repair, each can act during genetic tran

78 In contrast to recombinational repair, end-joining was found to be seve

79 red following synapsis for completion of the recombinational repair event.

80 of histone H2A S129 and concomitant with the recombinational-repair factor Rad52p.

81 The REC2 recombinase is essential for recombinational repair following DNA damage as well as f

82 Furthermore, the importance of recombinational repair for cellular survival of NO(.) ex

83 ction by RecJ and RecQ permits initiation of recombinational repair from all dsDNA ends: 5'-overhangs

84 a, but not ackA, mutants also depend on late recombinational repair functions RuvABC or RecG.

85 ne have been isolated based on homology to a recombinational repair gene from the corn smut Ustilago

86 s were isolated based on their homology to a recombinational repair gene from Ustilago maydis and con

87 Mutations in recBCD recombinational repair genes increase sensitivity to thy

88 Several studies have revealed that the recombinational repair genes, RAD51 and BRCA1, and the D

89 otic DNA double-strand breaks (DSBs) undergo recombinational repair, genetic crossovers (COs) may be

90 1Delta and deletions of members of the RAD51 recombinational repair group.

91 inhibitor, DNA damage, and homology-directed recombinational repair (HDR) in human breast cancer cell

92 R) (rad6, rad18, mms2, and rad5), homologous recombinational repair (HRR) (rad51 and rad54), base exc

93 tra-S-phase checkpoint, decreased homologous recombinational repair (HRR) activity, down-regulated XI

94 Homologous recombinational repair (HRR) of DNA damage is critical f

95 h plays a central role in homology-dependent recombinational repair (HRR) of DNA double-strand breaks

96 In vertebrates, homologous recombinational repair (HRR) requires RAD51 and five RAD

97 Homologous recombinational repair (HRR) restores chromatid breaks a

98 The mechanisms of recombinational repair in bacteriophage T4, Escherichia

99 We propose that the up-regulation of recombinational repair in dam mutants allows for the eff

100 The RecF pathway has many parallels with recombinational repair in eukaryotes.

101 interacts with Rad60, a protein required for recombinational repair in fission yeast.

102 us linking checkpoint proteins directly with recombinational repair in G(2).

103 epair, nucleotide excision repair (NER), and recombinational repair in preventing NO(.)-induced toxic

104 These results suggest that recombinational repair in the context of heterochromatin

105 levels of DnaA, indicating a requirement for recombinational repair in these cells.

106 s, and this activity enhances early steps of recombinational repair in vitro.

107 nto minichromosomes regulates early steps of recombinational repair in vitro.

108 BRCA1, Rad51, and CHK2 contribute to recombinational repair, in part independently of H2AX.

109 vation of Yen1, likely to resolve persistent recombinational repair intermediates.

110 l fragmentation, which becomes inhibitory if recombinational repair is also inactivated (the rdgB rec

111 Homologous recombinational repair is an essential mechanism for rep

112 recombination systems of organisms in which recombinational repair is BRCA2 dependent.

113 m long 3'-ssDNA overhangs in preparation for recombinational repair is catalyzed by the coordinated a

114 In eukaryotes, recombinational repair is choreographed by multiprotein

115 d for the repair of MMS-induced lesions when recombinational repair is compromised.

116 Replication-associated recombinational repair is important for genome duplicati

117 However, gene conversion (recombinational repair) is by far the most powerful expa

118 locked at cleavage complexes are resolved by recombinational repair, likely involving RDR.

119 cells with MMR defects, therefore, aberrant recombinational repair may be an additional mechanism th

120 esting that mutant spermatocytes have intact recombinational repair mechanisms.

121 ish a role for RadA/Sms in recombination and recombinational repair, most likely involving the stabil

122 Thus, DNA synthesis associated with recombinational repair must be largely error-free.

123 at BRCA1 plays essential roles in homologous recombinational repair, non-homologous end joining, and

124 Recombinational repair normally requires a battery of pr

125 BRE1 and DOT1 is mediated through homologous recombinational repair, not postreplication repair, and

126 We have found that allelic recombinational repair occurs in mammalian cells and is

127 2AX serine 139 enforces efficient homologous recombinational repair of a chromosomal double-strand br

128 RAD51AP1-depleted cells are impaired for the recombinational repair of a DNA double-strand break and

129 Mps3p, and Mps3p-dependent tethering delays recombinational repair of a DSB and enhances gross chrom

130 at another DNA polymerase also functioned in recombinational repair of a DSB.

131 ular events that occur during the homologous recombinational repair of a programmed double-strand chr

132 Recombinational repair of a site-specific DSB within the

133 Recombinational repair of a site-specific, double-strand

134 ombinase, we also show that Srs2 can aid the recombinational repair of camptothecin-induced collapsed

135 The DNA synthesis associated with recombinational repair of chromosomal double-strand brea

136 Thus, recombinational repair of chromosomal DSBs can occur at

137 of foreign linear DNA and in RecA-dependent recombinational repair of chromosomal lesions in E. coli

138 During genetic recombination and the recombinational repair of chromosome breaks, DNA molecul

139 Similar to Chk1 and Rad17, which enhance recombinational repair of collapsed replication forks, w

140 in the late stages of recombination and the recombinational repair of damaged DNA, bind to Holliday

141 of homologous genetic recombination and the recombinational repair of damaged DNA.

142 ion in multiple cellular processes including recombinational repair of DNA and nuclear export of mess

143 pathway of Escherichia coli is important for recombinational repair of DNA breaks and gaps.

144 formed between sister chromatids during the recombinational repair of DNA breaks or after replicatio

145 n and support two different functions during recombinational repair of DNA breaks.

146 e BRCA2 ortholog in Ustilago maydis, enables recombinational repair of DNA by controlling Rad51 and i

147 eins that are thought to be involved in both recombinational repair of DNA damage and meiotic recombi

148 cA, which has been shown to function in both recombinational repair of DNA damage and meiotic recombi

149 CA2 homolog in Ustilago maydis, functions in recombinational repair of DNA damage by regulating Rad51

150 liday junctions during recombination and the recombinational repair of DNA damage requires proteins n

151 ke ATPase with a specialized function in the recombinational repair of DNA damage.

152 cterial cells, as would be expected from the recombinational repair of DNA damage.

153 is a protein that regulates RAD51-dependent recombinational repair of DNA double strand breaks (DSB)

154 PALB2 links BRCA1 and BRCA2 in homologous recombinational repair of DNA double strand breaks (DSBs

155 ad51, demonstrates that Brca1 is involved in recombinational repair of DNA double strand breaks.

156 in both nonhomologous end-joining (NHEJ) and recombinational repair of DNA double-strand breaks (DSBs

157 Homologous recombinational repair of DNA double-strand breaks and c

158 /Rad51L3) play important roles in homologous recombinational repair of DNA double-strand breaks and i

159 n the histone H3 and HAT1 mutants was in the recombinational repair of DNA double-strand breaks.

160 sential for homologous recombination and the recombinational repair of DNA double-strand breaks.

161 sistent with gene conversion associated with recombinational repair of DNA double-strand breaks.

162 at HDAC enzymes are important for homologous recombinational repair of DNA double-strand breaks.

163 he bacterial RecN protein is involved in the recombinational repair of DNA double-stranded breaks, an

164 provided support for involvement of c-Abl in recombinational repair of DNA strand breaks.

165 ne is required for genetic recombination and recombinational repair of DNA strand breaks.

166 strand transfer step is not required during recombinational repair of double strand breaks in T7 but

167 To directly determine whether recombinational repair of double-strand breaks (DSBs) ca

168 Recombinational repair of double-strand breaks (DSBs), t

169 Recombinational repair of double-strand breaks in tandem

170 The rdgB mutants depend on recombinational repair of double-strand breaks.

171 Rad54 protein plays an important role in the recombinational repair of double-strand DNA (dsDNA) brea

172 evisiae is one of several genes required for recombinational repair of double-strand DNA breaks durin

173 Rad51 protein (Rad51) is central to recombinational repair of double-strand DNA breaks.

174 Rad52 performs multiple functions during the recombinational repair of double-stranded DNA (dsDNA) br

175 Rad51 is a conserved protein essential for recombinational repair of double-stranded DNA breaks (DS

176 cerevisiae Tid1 protein is important for the recombinational repair of double-stranded DNA breaks dur

177 During recombinational repair of double-stranded DNA breaks, RA

178 Recombinational repair of double-stranded DNA gaps was i

179 othesis that filamin-A influences homologous recombinational repair of DSB and the maintenance of gen

180 results in a 2-fold reduction of homologous recombinational repair of DSB.

181 und in both the xrs-6 and CHO-K1 cells, with recombinational repair of DSBs occurring in as many as 1

182 The involvement of hPso4 in the recombinational repair of DSBs provides an explanation f

183 functions in the post-synaptic phase during recombinational repair of DSBs.

184 now investigate the effect of heterology on recombinational repair of DSBs.

185 favor interhomolog, rather than intersister recombinational repair of genetically programmed DSBs in

186 is a prerequisite for the timely homologous recombinational repair of meiotic DNA double-strand brea

187 romyces pombe CDK, Cdc2-cyclin B, influences recombinational repair of radiation-induced DSBs during

188 Recombinational repair of replication forks can occur ei

189 Rad55 and Rad57 have different roles in the recombinational repair of stalled replication forks comp

190 It has recently become clear that the recombinational repair of stalled replication forks is t

191 The proteins participate in recombinational repair of stalled replication forks or D

192 y1 cDNA molecules are then used as donors in recombinational repair of the break before it is healed.

193 We show that Rad50 is necessary for recombinational repair of the DNA lesion at the mating-t

194 Recombinational repair of the DSB is strongly dependent

195 to the formation of a DNA joint molecule and recombinational repair of the DSB.

196 sae2 mutants to process the hairpins blocks recombinational repair of the DSBs and leads to generati

197 esis, we propose that TWINKLE is involved in recombinational repair of the human mitochondrial DNA.

198 D and RecFOR 'pathways' are required for the recombinational repair of these breaks.

199 be hypersensitive to UV, implicating Rnh in recombinational repair of UV-induced damage.

200 vity capable of substituting for ExoI in the recombinational repair of UV-induced lesions.

201 show that MutS2 plays no role in mismatch or recombinational repair or deletion between direct DNA re

202 s possible additional functions that include recombinational repair or homologous recombination.

203 -link on one strand (unhooking), followed by recombinational repair or lesion bypass synthesis.

204 her error-prone gap filling synthesis during recombinational repair or mismatch repair within a heter

205 suggesting that there is a defect in either recombinational repair or the production of double-stran

206 ect interaction with PALB2, BRCA1 fine-tunes recombinational repair partly through its modulatory rol

207 llapsed replication forks, (d) the number of recombinational repair paths available and their mechani

208 nd rnh mutations impair a common step in the recombinational repair pathway for m-AMSA-induced damage

209 To examine the role of the RAD52 recombinational repair pathway in compensating for DNA r

210 tes a protein with a significant role in the recombinational repair pathway in U. maydis, and imply t

211 se results suggest that members of the RAD52 recombinational repair pathway inhibit Ty1 post-translat

212 together, these data suggest that the RAD52 recombinational repair pathway is required to prevent or

213 germ line, like yeast, employ the homologous recombinational repair pathway more often than imperfect

214 , reinforcing our previous findings that the recombinational repair pathway plays a minor role in M.

215 ally, dut mutants depend on the RecBC-RuvABC recombinational repair pathway that mends double-strand

216 ated in cells mutated for genes in the RAD52 recombinational repair pathway, such as RAD50, RAD51, RA

217 se and play a crucial role in the homologous recombinational repair pathway.

218 nonmutagenic nucleotide excision repair and recombinational repair pathways and by mutagenic pathway

219 ents result in the abolition of NER, but not recombinational repair pathways, which are likely to be

220 naA was tested by using mutants in different recombinational repair pathways.

221 L repair have been identified in addition to recombinational repair pathways.

222 itive to NO(.), indicating that both SOS and recombinational repair play important roles in defense a

223 epair, nucleotide excision repair (NER), and recombinational repair, plays a critical role in maintai

224 Thus, H. pylori RecN, as a component of DNA recombinational repair, plays a significant role in H. p

225 enes involved in nucleotide excision repair, recombinational repair, postreplication repair including

226 Homologous recombinational repair preserves chromosomal integrity b

227 In wild-type cells the recombinational repair process is efficient and fairly a

228 heless, few genes encoding components of DNA recombinational repair processes have been identified in

229 on strand invasion intermediate in these two recombinational repair processes.

230 the enzymes involved are those that catalyze recombinational-repair processes.

231 Biochemical interaction with the recombinational repair protein Rad51, demonstrates that

232 eukaryotic proteins related to the bacterial recombinational repair protein RecA.

233 PF/ERCC1 is stably associated with hRad52, a recombinational repair protein, in human cell-free extra

234 Recombinational repair provides accurate chromosomal res

235 members of the RAD52 epistasis group for DNA recombinational repair (rad50, rad52 and rad57).

236 the DNA polymerase delta (POL3) gene and the recombinational repair RAD52 gene were studied in combin

237 t high temperature, suggesting dependence on recombinational repair rather than on the RecBCD-catalyz

238 Testing known mutants in recombinational repair revealed an additional interactio

239 ed in nucleotide excision repair (rad13) and recombinational repair (rhp51) are much more alkylation

240 ns in additional components of the bacterial recombinational repair system and the replication restar

241 Furthermore, by comparison, its recombinational repair system seems to be only minimally

242 ad51 complex and balances a finely regulated recombinational repair system.

243 mechanism for p53-mediated regulation of DNA recombinational repair that involves p53 post-translatio

244 suggest that RadC functions specifically in recombinational repair that is associated with the repli

245 gmentation, making seqA mutants dependent on recombinational repair (the seqA recA colethality).

246 s a structure-specific mediator that targets recombinational repair to ssDNA-dsDNA junctions.

247 mode of genomic maintenance by "error-free" recombinational repair, to one of "error-prone" DNA repl

248 te by the intron RNP particles, gapping, and recombinational repair using homologous sequences in don

249 The possibility that recombinational repair was responsible for the survival

250 s that MMR sensitization is due to decreased recombinational repair, we used a RecA-mediated strand e

251 that both Ung and Fpg create substrates for recombinational repair, which is consistent with the obs

252 n and the up-regulation of genes involved in recombinational repair with the level of DNA damage, we

253 that heterology decreases the efficiency of recombinational repair, with 1.2% sequence divergence re