ライフサイエンスコーパス: recombinogenic

1 ression and that they are also intrinsically recombinogenic.

2 , with the former being 10 to 100 times more recombinogenic.

3 5'-nuclease, which permits the generation of recombinogenic 3'-overhanging, single-stranded DNA (ssDN

4 s unaffected, resulting in the production of recombinogenic 3'-terminated ssDNA tails.

5 s of a repeat motif highly homologous to the recombinogenic 76-bp repeat sequences present upstream o

6 In contrast, 12 base recombinogenic acceptors were utilized poorly and no acc

7 d with DNA duplication initiated by elevated recombinogenic activities in Alu clusters.

8 During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribut

9 ce reporter transgenes, we demonstrate a new recombinogenic activity of AID leading to intra- and int

10 ing that Smc5/6 does not simply restrain the recombinogenic activity of Mph1 via direct binding.

11 gene-containing ecotropic virus demonstrated recombinogenic activity with endogenous FeLV sequences i

12 e that combining RNP delivery with naturally recombinogenic adeno-associated virus (AAV) donor vector

13 Recombinogenic Alu sequences bracketed the breakpoints i

14 veillance, transcription-coupled repair, and recombinogenic and meiotic processes.

15 single-stranded gene insertion cassettes are recombinogenic and that these cassettes preferentially t

16 HSV-1 has been shown to be highly recombinogenic, and recombination itself appears to be a

17 The undesirable mutagenic, recombinogenic, and toxic incorporation of purine base a

18 ls how genomic plasticity within lineages of recombinogenic bacteria can permit adaptation to clinica

19 tanding of diversification and speciation in recombinogenic bacteria.

20 baylyi strain ADP1 is a highly competent and recombinogenic bacterium.

21 ondary structure thus formed and generates a recombinogenic break in the DNA.

22 tream of ScaI cleavage sites, confirming the recombinogenic character of DSBs in mtDNA.

23 mice that could be exploited as an assay for recombinogenic chemicals.

24 s at an early step of recombination in a pro-recombinogenic complex with Rlp1 and Rdl1, two RecA-like

25 Int protomers, within a multiprotein 400-kDa recombinogenic complex, is thought to bind and, with the

26 ducing DNA bends necessary to form an active recombinogenic complex.

27 rdinates Int functions within the multimeric recombinogenic complex.

28 anging Int protomers within the higher-order recombinogenic complex.

29 rm-type sites in integrative versus excisive recombinogenic complexes reflects the regulation of reco

30 tically about the global architecture of the recombinogenic complexes.

31 es and afford a new view of the higher-order recombinogenic complexes.

32 ns that along with Int comprise higher-order recombinogenic complexes.

33 leost fish IgL each contain only two to four recombinogenic components (one to three V, one J) and ex

34 Here we show that the recombinogenic cores of active hot spots in mice harbor

35 ibution but harbor CO repulsion zones within recombinogenic cores.

36 UMO-PCNA signals for recruitment of the anti-recombinogenic DNA helicase Srs2.

37 idence that marker exchange is stimulated by recombinogenic DNA lesions formed as intermediates in th

38 ry of replicative DNA polymerases results in recombinogenic DNA lesions, presumably double-strand DNA

39 Topoisomerase IB catalyzes recombinogenic DNA strand transfer reactions in vitro an

40 ication efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gen

41 y Ref reflects the introduction of directed, recombinogenic double-strand breaks.

42 ms might favor genetic transfer by producing recombinogenic double-stranded DNA ends.

43 iety of cells and cell types by delivering a recombinogenic DSB to the targeted chromosomal locus, us

44 Cleavage of this hairpin results in a recombinogenic DSB.

45 lines will enhance the utility of the hyper-recombinogenic DT40 cell line as a system for the geneti

46 genetic study was undertaken using the hyper-recombinogenic DT40 chicken cell line and a series of mu

47 e from these findings that the mutagenic and recombinogenic effects of msDNAs are due to titrating ou

48 or MutS protein suppresses the mutagenic and recombinogenic effects of msDNAs.

49 targeting vector was constructed with small recombinogenic ends (500 bp) derived from flanking seque

50 ectively cloned by recombination between the recombinogenic ends in the targeting vector and homologo

51 linear DNA containing YAC-specific, unique, recombinogenic ends, thereby ensuring co-integration of

52 lanking the inserts in P1 and PAC vectors as recombinogenic ends.

53 te full-length 3'-UTR reporter constructs by recombinogenic engineering (recombineering) in vivo clon

54 Greater microcolinearity in recombinogenic (euchromatic) than nonrecombinogenic (het

55 ergoing transformation into yeast are highly recombinogenic, even when diverged.

56 alters the chromosomal architecture in that recombinogenic factors accumulate, fostering large-scale

57 ombinogenic form of the RecBCD enzyme into a recombinogenic form by causing two distinct enzymatic ch

58 This important anti-recombinogenic function cannot be performed by Top3beta,

59 Smc5/6 complex can counteract/modulate a pro-recombinogenic function of Mph1 or facilitate the resolu

60 s RecBCD from a destructive exonuclease to a recombinogenic helicase, we mutated the nuclease catalyt

61 Swi5 and Rad57 (HR-mediators) plus the anti-recombinogenic helicases Srs2 and Rqh1.

62 metabolic burden imposed by the plasmid in a recombinogenic host, rather than to ensure plasmid stabi

63 HSV-1 has been shown to be highly recombinogenic; however, to date, there has been no geno

64 tability yet revealed that this locus may be recombinogenic in a primarily clonal population structur

65 The enzyme-DNA covalent adduct is recombinogenic in cells, because the nicked strand downs

66 ich causes DNA strand breakage and is highly recombinogenic in some model organisms, was tested for i

67 he repeats at the replication fork creates a recombinogenic intermediate that can be differentially p

68 tioning and spatial proximity of potentially recombinogenic intrachromosomal loci.Oncogene advance on

69 he potential of a donor sequence to act as a recombinogenic, invasive end is determined by the stabil

70 sulted in the presence of large and probably recombinogenic LCRs across the region, the creation of t

71 mutation, rfa1-D228Y, causes an increase in recombinogenic lesions as well as the activation of a RA

72 ation, suggesting that replication generates recombinogenic lesions.

73 checkpoint mutants suppress the formation of recombinogenic lesions.

74 by the idea that p53 suppresses formation of recombinogenic lesions.

75 nsights into the genetic structure of highly recombinogenic loci responsible for combinatorial geneti

76 ic region encoding these proteins revealed a recombinogenic locus with PfRh2a and PfRh2b in a head-to

77 tional allele in which an exon is flanked by recombinogenic loxP sites.

78 ne, suggesting involvement of a common novel recombinogenic mechanism that might also contribute to t

79 PCR to reconstruct missing elements from the recombinogenic middle region of pspB, SP85 was shown to

80 his method exploits the highly efficient and recombinogenic nature of DNA uptake during natural trans

81 These findings highlight the recombinogenic nature of the MSY, as intrachromosomal NA

82 recombination, and monoadducts were neither recombinogenic nor mutagenic.

83 telomeres after DNA replication, creating a recombinogenic nucleoprotein structure.

84 he recombinase to assemble into higher-order recombinogenic nucleoprotein structures.

85 e tracing of this bacterium and other highly recombinogenic pathogens.

86 Linearized, recombinogenic pClasper targeting vector and native geno

87 eral previous studies have indicated a hyper-recombinogenic phenotype in the absence of active PARP1

88 us recombination, in contrast with the hyper-recombinogenic phenotype of yeast SWR1 mutants.

89 cally unstable, exhibiting mutator and hyper-recombinogenic phenotypes.

90 mechanism that might also contribute to the recombinogenic potential of Alu repeats.

91 locus in CHO cells can be used to study the recombinogenic potential of defined DNA sequences.

92 The recombinogenic potential of these 50-mers is not parasit

93 The hyper-recombinogenic properties of an E. coli strain in which

94 lity in strand transfer have illuminated the recombinogenic properties of type IB topoisomerases and

95 Intramolecular recombinogenic recircularization (IRR) of linearized pla

96 Although critically short telomeres are very recombinogenic, recombination among telomeres that have

97 plasmid recombination events in this highly recombinogenic region, even in the absence of viral enzy

98 nation hotspot is located within the 'highly recombinogenic' region of the full-length CaMV RNA that

99 in the large internal repeats, as well as to recombinogenic regions of cellular DNA, such as variable

100 netically dissect and molecularly manipulate recombinogenic regions to test their roles in regulating

101 etained at a higher frequency in the distal, recombinogenic regions.

102 rent Alu elements, combined with a potential recombinogenic role of retrotransposon target-site dupli

103 by ATP hydrolysis, is essential for its pro-recombinogenic role.

104 Sgs1 has both pro- and anti-recombinogenic roles, and therefore its activity must be

105 ertheless offers a potential approach to map recombinogenic sequences in BACs and PACs.

106 (TRBP) was found to recognize several G-rich recombinogenic sequences in the EBV genome and in cellul

107 This gap may act as a recombinogenic signal to initiate cross-link removal.

108 ation hotspots (5'-GCTGGTGG-3') to produce a recombinogenic single-stranded DNA 3'-end.

109 ent processing of broken DNA ends to produce recombinogenic single-stranded DNA competent for HR.

110 RecBCD generates recombinogenic single-stranded DNA ends by unwinding DNA

111 ture is the narrow 1.5-2.5-kb width of these recombinogenic sites, these analyses revealed that hot s

112 lly evolving the naturally transformable and recombinogenic species Acinetobacter baylyi with a cockt

113 he genetic macrovariation within a low-level recombinogenic species would accurately be characterized

114 ith PriB being required to limit exposure of recombinogenic ssDNA.

115 these changes is the production of a highly recombinogenic structure known as the presynaptic filame

116 g stop transfer, and can include additional, recombinogenic switches.

117 ase, gammadelta resolvase, form a simplified recombinogenic synaptic complex containing a tetramer of

118 To test the recombinogenic systems, we next used the overlapping BAC

119 yeast-bacterial shuttle vector, pClasper, by recombinogenic targeting in yeast.

120 nto a yeast-bacteria shuttle vector by using recombinogenic targeting.

121 m that murine leukemia virus replicative and recombinogenic template switches differ in homology requ

122 By implying that recombinogenic template switching occurs roughly four ti

123 emplate and primer strand complementarity on recombinogenic template switching.

124 tep process, few seek to exploit the natural recombinogenic tendencies and exponential amplification

125 ipeline showed generally higher abundance in recombinogenic than in nonrecombinogenic regions of the

126 f the proposal that broken DNA ends are more recombinogenic than internal sequences, we have investig

127 tors that make wild-type female meiosis less recombinogenic than male wild-type meiosis do not apply

128 s better guide studies of related genomes in recombinogenic than nonrecombinogenic regions.

129 aking HIV-1 up to an order of magnitude more recombinogenic than recognized previously and demonstrat

130 TMPRSS2-ERG genomic breakpoints, triggering recombinogenic TOP2B-mediated DSBs.

131 te homology facilitates both replicative and recombinogenic transfers, but homology-independent deter

132 ype cells that are normally removed in a non-recombinogenic way, possibly by Rqh1 catalysing their re

133 Plant mitochondrial genomes are highly recombinogenic, with a variety of species-specific direc

134 The plant mitochondrial genome is recombinogenic, with DNA exchange activity controlled to