ライフサイエンスコーパス: reconstitution

1 er RCI by regulating myelopoiesis and immune reconstitution.

2 innate immune activation, and reduced immune reconstitution.

3 into fibroblasts and keratinocytes for skin reconstitution.

4 ry or worsen outcomes associated with immune reconstitution.

5 nitor cells, ADA gene expression, and immune reconstitution.

6 wn step of modified GSH, and thus its timely reconstitution.

7 phenotype, and was restored upon eosinophil reconstitution.

8 ression with rapamycin could restore NK-cell reconstitution.

9 c oxide, which was restored after eosinophil reconstitution.

10 disorders, is intertwined with T cell immune reconstitution.

11 acterial pathogens, even after hematopoietic reconstitution.

12 imerism result in clinically relevant immune reconstitution.

13 patient T cells were restored by retroviral reconstitution.

14 odeficiency that is caused by delayed immune reconstitution.

15 resolution of viremia without T-cell immune-reconstitution.

16 lonal succession after initial hematopoietic reconstitution.

17 t a bias exists in CD45.1 versus CD45.2 cell reconstitution.

18 results stress the importance of timely CD4 reconstitution.

19 protein, essential for liposome or nanodiscs reconstitutions.

20 CD4+ T-cell reconstitution, a key function of ART, causes significan

21 robust multilineage repopulation and serial reconstitution ability in immunocompromised mice.

22 Adiponectin reconstitution abolished these metabolic defects in Adip

23 Concomitant CD4 reconstitution abolished this negative effect of adenovi

24 miR-99 maintains HSC long-term reconstitution activity by inhibiting differentiation an

25 mechanisms of human Treg cell depletion and reconstitution after anti-CD25 monoclonal antibody (mAb)

26 TEC axis may be useful for augmenting immune reconstitution after clinical hematopoietic transplantat

27 target to accelerate balanced hematopoietic reconstitution after myelosuppression.

28 s or haematopoietic stem cell (HSC)-mediated reconstitution after transplantation is unclear.

29 LV-mediated GT allowed immunologic reconstitution, although it was suboptimal compared with

30 After lyophilization and reconstitution an ~10% loss of alpha-helical conformatio

31 This study reports on the in vitro reconstitution and activation of a prFMN-dependent enzym

32 Using systematic reconstitution and analysis of vertebrate APC/Cs under p

33 A series of reconstitution and depletion studies defined a role for

34 tivity for transfection after lyophilization/reconstitution and during storage at 4 degrees C for up

35 of class I vs class II on human T and B cell reconstitution and function has not been investigated in

36 ], respectively) after accounting for immune reconstitution and graft-versus-host disease.

37 Exploiting in vitro reconstitution and in vivo analysis of INM targeting, we

38 This continuous model is based upon in vitro reconstitution and in vivo ensemble experiments.

39 In vitro reconstitution and in vivo targeting assays show that Se

40 Using reconstitution and knock-in models, we report that mutat

41 Using a combination of biochemical reconstitution and mammalian cell culture, we elucidate

42 From adoptive reconstitution and mixed bone-marrow chimera studies in

43 re, we investigated their role during immune reconstitution and re-establishment of immune tolerance

44 c clones capable of long-term, multi-lineage reconstitution and serial transplantation.

45 In the wake of reconstitution and super-resolution imaging studies, we

46 NK cells and not only showed impaired T cell reconstitution and thymus regeneration after allogeneic

47 The 2 groups had comparable immune-reconstitution and viral burden.

48 ase, as well as in cell-based influenza vRNP reconstitution and virus yield assays.

49 with target gene inactivation, heterologous reconstitution, and biochemical characterization.

50 raftment, lineage-specific chimerism, immune reconstitution, and discontinuation of immunoglobulin re

51 ft can negatively impact HSC activity, blood reconstitution, and engraftment of donor HSCs.

52 ly mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment.

53 re we have established an efficient in vitro reconstitution approach based on two ATP-grasp ligases t

54 Through refined in vitro reconstitution approaches and multiple independent assay

55 me longevity and robust potential for immune reconstitution, are central players in many physiologica

56 developed a novel ex vivo cell fractionation/reconstitution assay.

57 although no metabolism could be detected in reconstitution assays or role in growth on lipids.

58 Fluorescence microscopy-based in vitro reconstitution assays reveal that this interaction mode

59 Cell-free reconstitution assays show that addition of FBP disrupts

60 Comparative reconstitution assays support that the Osm1/fumarate cou

61 Correspondingly, the activity of Munc18-1 in reconstitution assays that require Munc18-1 and Munc13-1

62 This protocol describes reconstitution assays to study how the neurotransmitter

63 Here, using in vitro reconstitution assays, we show that Vpr mediates polyubi

64 ation and survival in vitro and in vivo upon reconstitution assays.

65 A microscale reconstitution baking test, using wheat flour defatted w

66 technology, molecular biology, and in vitro reconstitution biochemistry.

67 phosphatidylglycerol lipids favours protein reconstitution but is detrimental to topology and functi

68 , these mice can undergo human immune system reconstitution by the bone marrow, liver, and thymus (BL

69 Strategies to improve CD4 reconstitution can improve HCT outcomes, including survi

70 hat only the Hoxb5(+) HSCs exhibit long-term reconstitution capacity after transplantation in primary

71 L induction is associated with hematopoietic reconstitution capacity independently of age and may ide

72 However, for one reconstitution cohort, some mice immunized with iDCpp65

73 Lymphocyte reconstitution data from regulatory submissions of the p

74 Sensory profiles of aromatic reconstitutions demonstrated that the aromatic modulatio

75 In vitro reconstitution demonstrates that microtubule tips can tr

76 Muscle mass reconstitution did not correlate with resolution of weak

77 in, which has not previously been studied in reconstitution due to difficulties in purification.

78 vestigate how matrigel influences the tumour reconstitution dynamics of breast cancer cells in vivo.

79 re, we identify a sex-specific difference in reconstitution efficiencies, with female mice exhibiting

80 4Fe-4S and 3Fe-4S clusters, and the in vitro reconstitution experiment indicated an iron-sulfur scaff

81 Reconstitution experiments in the JAK1-deficient cells d

82 Reconstitution experiments indicated that CCND1 and p53

83 Here, we show using functional GFP reconstitution experiments that Kenyon cells and dopamin

84 In vitro reconstitution experiments with purified cyt b6f and rec

85 In in vitro reconstitution experiments, acetylation was sufficient t

86 Combined with in vitro reconstitution experiments, our data show that the polym

87 Through live cell and in vitro reconstitution experiments, we have discovered a major s

88 nstability (CIN) in vivo using hematopoietic reconstitution experiments.

89 re and electrostatic effects on the in vitro reconstitution, folding, stability and function of a rep

90 viral sequence expansion during CD4+ T-cell reconstitution following chemotherapy cessation.

91 ndothelial cells in regulating hematopoietic reconstitution following injury.

92 ol II, TFIID, and TFIIH have precluded their reconstitution from heterologous systems, and purificati

93 study of viruses where challenging receptor reconstitution has previously prevented single-virus fus

94 Images of in vitro reconstitutions have led to a model of how arrays assemb

95 neuronal cells overexpressing Tau, cell-free reconstitutions have not replicated either geometry.

96 Current reconstitutions have yet to faithfully replicate the fus

97 This reconstitution hypothesis considers RNA tertiary folding

98 VP1-specific T-cell responses during immune reconstitution in 1 of the patients.

99 Reconstitution in 100% H2O resulted in a higher number o

100 in situations that require membrane protein reconstitution in a lipid bilayer at high concentrations

101 ematopoietic engraftment and improved immune reconstitution in allo-HSCT recipients with aGVHD.

102 ro, after their biochemical purification and reconstitution in artificial lipid bilayers such as lipo

103 owever, current methods for their functional reconstitution in biomimetic membranes remain both chall

104 cal data, KIR and HLA genotypes, and NK-cell reconstitution in CBT patients (n = 110).

105 liferative capacity and exhibited heightened reconstitution in competitive transfer assays.

106 n of creating biomimetic reconstructs of PSI reconstitution in DPhPG liposomes is studied.

107 cells, and characterised haematopoietic cell reconstitution in dual-expressing CD45.1/2 host mice.

108 re demonstrated to be physically stable upon reconstitution in HP-ss-CD solutions, and are able to re

109 (i.e., mutations, paramagnetic labeling, and reconstitution in lipid bilayers) for both ssNMR and DEE

110 Upon reconstitution in lipid micelles, p75-TM-WT forms the di

111 it to noninvasively image human immune cell reconstitution in nonobese diabetic severe combined immu

112 nfected subjects generally allows for immune reconstitution in peripheral blood, reconstitution of th

113 NtPDR1 reconstitution in proteoliposomes stimulated its basal A

114 d Ca(2+)-dependent ATPase activity following reconstitution in proteoliposomes.

115 We report an increase in CD45.2 reconstitution in the bone marrow that persists in the s

116 We show that its correct reconstitution in the lipidic matrix can be used to gene

117 Vimentin reconstitution in VIM(-/-) fibroblasts restored both the

118 Formation of holoUbiD requires reconstitution in vitro of the apoUbiD with reduced prFM

119 d serial primary and secondary multi-lineage reconstitution, including antigen-dependent adaptive imm

120 n, known as cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS), upon init

121 Immune reconstitution inflammatory syndrome (IRIS) in human imm

122 tection of MRI findings suggestive of immune reconstitution inflammatory syndrome (IRIS) in natalizum

123 nagement of corticosteroid refractory immune reconstitution inflammatory syndrome (IRIS) is currently

124 of talaromycosis, development of the immune reconstitution inflammatory syndrome (IRIS), and the sid

125 patients is neurological tuberculosis-immune reconstitution inflammatory syndrome (IRIS), but its und

126 tcomes: mortality, drug toxicity, and immune reconstitution inflammatory syndrome (IRIS).

127 nslocation for their association with immune reconstitution inflammatory syndrome (IRIS).

128 koencephalopathy (PML) and full-blown immune reconstitution inflammatory syndrome (PML-IRIS).

129 nflammatory PML'), reminiscent of PML-immune reconstitution inflammatory syndrome (PML-IRIS).

130 -1-infected TB patients at risk of TB immune reconstitution inflammatory syndrome (TB-IRIS), in Cape

131 n treated HIV patients, including CNS immune reconstitution inflammatory syndrome and neurosymptomati

132 Incidence of paradoxical immune reconstitution inflammatory syndrome was 5% (two of 43 n

133 abilization, and crystallization, as well as reconstitution into bilayer membranes.

134 Reconstitution into cNDs enhanced the quality of nuclear

135 (F508-CFTR) at the plasma membrane and after reconstitution into phospholipid bilayer.

136 8), transduction and culture alone, or after reconstitution into the relevant subset-depleted populat

137 Timely immune reconstitution (IR) is suggested to prevent VR.

138 B-cell reconstitution is abrogated in both syngeneic and alloge

139 emonstrate the intrinsic bias towards CD45.2 reconstitution is independent of an immunogenic response

140 In vitro reconstitution is the fundamental test for identificatio

141 opathy may manifest as a result of an immune reconstitution-like syndrome after starting ART.

142 troviral therapy (ART), suggesting an immune reconstitution-like syndrome.

143 e boutons, with ultrastructural and synaptic reconstitution MB connectivity defects.

144 by the bone marrow, liver, and thymus (BLT) reconstitution method, in addition to lung tissue engraf

145 spectrometry, and direct stochastic optical reconstitution microscopy of cross-linked PSGs revealed

146 PCSK5 reconstitution mobilizes the latent TNBC reservoir of GD

147 By using murine reconstitution models that allow for selective deletion

148 To our knowledge, this is the first in vitro reconstitution of a cobalamin-dependent radical SAM enzy

149 those found in native receptors, enabled the reconstitution of a microdomain that consists of intrace

150 The successful in vitro reconstitution of a part of the GRM metabolism provides

151 en intermolecular recombination and activity reconstitution of a re-engineered component of glucomete

152 Herein, we describe the spontaneous reconstitution of adenosine A2A receptor (A2AR) during t

153 Here, we test this hypothesis via functional reconstitution of Aer into nanodiscs.

154 Reconstitution of all memory B cell subpopulations, numb

155 n factors necessary for affordable, scalable reconstitution of an in vitro transcription and translat

156 recipients and correlated these changes with reconstitution of antiviral T cell responses.

157 Reconstitution of BAMBI expression in NSCLC cells result

158 Finally, reconstitution of beta2ARKO BM with rescued expression o

159 used phylogenetic analysis and heterologous reconstitution of bilin biosynthesis to investigate bili

160 These features were not altered by the reconstitution of bone marrow cells from IDO(+/+) mice.

161 Indeed, we have reported that reconstitution of CD3+ T cells in immunodeficient mice m

162 om GVHD was attributable to augmented global reconstitution of CD4(+) natural regulatory T cells (nTr

163 Genetic reconstitution of CD55 or treatment with a complement-in

164 Reconstitution of ClC-3 expression with ClC-3 expression

165 Immune reconstitution of CMV-specific CTLs (CMV-CTLs) is essent

166 Here, we demonstrate the reconstitution of conformational coupling in tsA201 cell

167 optimal methods for large-scale production, reconstitution of cryopreserved cells for clinical use,

168 As with lipid nanodiscs, reconstitution of detergent-solubilized MsbA into the po

169 Here we report the reconstitution of DNA replication free in solution with

170 The reconstitution of DNA replication in vitro has establish

171 transplantation (HSCT) requires the balanced reconstitution of donor-derived CD4 regulatory T cells (

172 noculum UTI model (P < 0.001 to 0.048), that reconstitution of empA restored virulence in the UTI mod

173 Using in vitro reconstitution of fission yeast contractile ring precurs

174 Reconstitution of FN levels in the aged niche remobilize

175 Reconstitution of GF mice with a Nod2 agonist or monocol

176 treated with allogeneic HSCT with sustained reconstitution of hematopoietic defects.

177 Prospective reconstitution of human PanIN development from primary c

178 Whereas sestrin ablation resulted in broad reconstitution of immune function in stressed T cells, i

179 However, delayed reconstitution of innate and adaptive immunity often cau

180 Reconstitution of irradiated Panx1 knockout mice with he

181 Reconstitution of KLF6 attenuates their malignant phenot

182 scussion of commonly used strategies for the reconstitution of LDL, we highlight the applications of

183 high-fat diet-induced atherosclerosis, while reconstitution of Ldlr-/- Arhgef1-/- with WT BM exacerba

184 Moreover, reconstitution of Ldlr-/- mice with Arhgef1-deficient BM

185 Reconstitution of MC-deficient Wsh mice with Fyn(-/-) MC

186 acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs.

187 Functional reconstitution of membrane proteins within lipid bilayer

188 us membrane formation can be applied for the reconstitution of membrane proteins, encapsulation and c

189 Reconstitution of membrane-protein binding in a liposome

190 Phloem-specific reconstitution of Met Cycle activity in mti1 and dep1 mu

191 Furthermore, reconstitution of methylation-deficient p53 mutants into

192 Finally, co-reconstitution of Min proteins and FtsZ-mts in droplets

193 Reconstitution of mitochondrial-targeted GCN5L1 blunts m

194 Through genetic reconstitution of mTORC1 downstream targets, we identify

195 We show that reconstitution of NMDA-gated current in Xenopus oocytes,

196 A translation and can be prevented by either reconstitution of OLA1 expression or treatment with an e

197 In the knockout mice, reconstitution of Ormdl3 transcript levels specifically

198 Reconstitution of PAX5 and IKZF1 in samples from patient

199 effects of miR-140-5p are largely rescued by reconstitution of Pin1.

200 Here we describe the reconstitution of Pol epsilon-dependent MMR using S. cer

201 ous expression, purification, and functional reconstitution of Populus tremula x tremuloides CesA8 (P

202 binding represents a novel strategy for the reconstitution of potent therapeutic activity at the sit

203 Genome-wide reconstitution of promoter nucleosome organization with

204 itional insight was achieved by the in vitro reconstitution of protein integration into chloroplast m

205 Reconstitution of PTEN-null cells with either wild-type

206 of idiopathic pulmonary fibrosis (RAGE-/-), reconstitution of RAGE efficiently restored DSB-repair a

207 Furthermore, reconstitution of reactive oxygen species (ROS), whose p

208 The subsequent reconstitution of SC mTORC1 hyperactivity in adult anima

209 We show that reconstitution of specific niche signals can restore met

210 However, only delayed reconstitution of switched memory B cells, independent o

211 Reconstitution of T cell immunity is absolutely critical

212 The in vitro reconstitution of TbtI, a class C rSAM methyltransferase

213 Herein, we report the in vitro reconstitution of TbtI, the responsible radical S-adenos

214 Absence of DraRnl elicts a delay in reconstitution of the 10 kGy IR-shattered D. radiodurans

215 ability to produce VY* from MftA by in vitro reconstitution of the activities of MftB, MftC, and MftE

216 Furthermore, reconstitution of the basement membrane leads to charact

217 Through total in vitro reconstitution of the biosynthesis of 1 using purified e

218 r immune reconstitution in peripheral blood, reconstitution of the GI tract occurs at a much slower p

219 Reconstitution of the glycosyltransferase reactions in e

220 se biosynthetic enzymes and the heterologous reconstitution of the indole-sulfur phytoalexin pathway

221 Moreover, reconstitution of the IRE1-signaling pathway, by express

222 orce of 3.6 mVmin(-1) Remarkably, the facile reconstitution of the photosynthetic reaction center in

223 esis in vivo Our results represent the first reconstitution of the proteolytic activity of MamE and s

224 Reconstitution of the SMURF2.RNF11 complex in vitro unex

225 Reconstitution of Tpl2 or the NF-kappaB1 p105, but not p

226 d KLF4-mediated repression of Thbs1 In vitro reconstitution of TSP1 with either full-length TSP1 or 3

227 Here we report the in vitro reconstitution of two YcaO proteins, BmbD and BmbE, resp

228 ctal cancer cells that could be recovered by reconstitution of wild-type APC.

229 ted ceramide-dependent lethal mitophagy, and reconstitution of WT-Drp1 or phospho-null S637A-Drp1 but

230 , to eight different wine models (WM), close reconstitutions of red wines differing in levels of frui

231 e artificial cell through bottom-up in vitro reconstitution offers a way to understand how mixtures o

232 asizing the critical impact of robust immune reconstitution on efficient control of viral infection.

233 Genetic reconstitution only of the oxidative TCA cycle function

234 ipheral blood without impairing early immune reconstitution or increasing risk for infections.

235 preparative chemotherapy, other immunologic reconstitution parameters were not affected, and the pot

236 ent of GVHD after allo-BMT prevented NK-cell reconstitution, particularly within the maturing M1 and

237 does not appear to be an alternative in vivo reconstitution path, most likely due to greater protein

238 ing, increased lethality, and delayed T-cell reconstitution postirradiation and hematopoietic stem ce

239 including skewing to myeloid lineages, lower reconstitution potential and loss of protein polarity.

240 e this bias has been demonstrated by reduced reconstitution potential in B cells of CD45.1 origin, di

241 Delayed CD4 reconstitution predicted reactivation of adenovirus (haz

242 resonance (PWR) allows following GPCR lipid reconstitution process without any labeling and with hig

243 Despite the immune reconstitution promoted by combined antiretroviral thera

244 Using physiological Rab-GEF reconstitution reactions, we now provide definitive evid

245 In contrast to non-reconstituted mice, hPBMC reconstitution reduced neointima formation after femoral

246 % v/v) and 1083microg/L in a fruity aromatic reconstitution, reflecting its presence in wines at subt

247 Parkin reconstitution rescued this phenotype and the contributi

248 t rechallenge with FVIII following MZ B-cell reconstitution resulted in a primary antibody response,

249 Bone marrow reconstitutions showed that a lncRNA expressed across al

250 In this study, we combine biochemical reconstitutions, single-particle electron cryomicroscopy

251 samples, highlighting the importance of the reconstitution solvent composition for untargeted discov

252 udy was to evaluate the impact of the sample reconstitution solvent composition on metabolome coverag

253 As compared to a commonly used reconstitution solvent mixture of 50/50 MeOH/H2O, our re

254 After immune reconstitution, some of these cases may show long-term p

255 These findings show that the sample reconstitution step has a clear impact on the metabolome

256 w, such as metabolite extraction, the sample reconstitution step has not been optimized for maximal m

257 Time-consuming solvent evaporation and reconstitution steps were eliminated successfully from t

258 Here we used a reconstitution strategy with highly purified mammalian G

259 In vitro reconstitution studies have shown that human MCC-APC/C c

260 ombining in vivo observations in kidney with reconstitution studies in cell culture, we found that WN

261 Bone marrow reconstitution studies showed that deficiency of both no

262 In reconstitution studies with reduced Tim13, Mia40, and Er

263 ne proteins in lipid systems but usually the reconstitution success is tested at the end of the exper

264 arly HPCs that are defective in multilineage reconstitution, suggesting a differentiation block.

265 s highly invasive and, conversely, PGC1alpha reconstitution suppresses metastasis.

266 ulous mycobacteria, old PTB scar, and immune reconstitution syndrome.

267 We used a MT-actin dynamics co-reconstitution system to observe CLIP-170-mDia1 complexe

268 By titrating PD-1 signaling in a biochemical reconstitution system, we demonstrate that the co-recept

269 have been extensively studied with in vitro reconstitution systems using purified components.

270 Using in vitro reconstitution techniques including biomimetic assays an

271 In situ lipid synthesis for protein reconstitution technology proceeds in the absence of dia

272 lubility and absorption, pasting properties, reconstitution test, proximate composition, amino acids,

273 ice exhibiting a greater bias towards CD45.2 reconstitution than males.

274 thereby inducing profound defects in NK-cell reconstitution that compromise both leukemia and pathoge

275 s remained unchanged after CD8 depletion and reconstitution, the frequency of SIV-infected CD4(+) T c

276 Using several rounds of reconstitution, the protein concentration in the bilayer

277 rts of individuals have linked suboptimal GI reconstitution to residual inflammation and heightened m

278 Overall the in vitro folding, reconstitution, topology, stability and function of lact

279 l (HSC) that supports long-term multilineage reconstitution upon transplantation into adult recipient

280 Immune reconstitution was demonstrated by normalization of T-ce

281 NK-cell reconstitution was quantitatively, phenotypically, and f

282 Using metagenomics and precision microbiota reconstitution, we identified a single commensal strain

283 Through reconstitution, we show that motors not only can pull ou

284 Using in vitro reconstitution, we show that Mps1 promotes APC/C inhibit

285 king analysis in human cells and biochemical reconstitution, we show that the Astrin-SKAP complex bin

286 ies through fresh and industrial preparation/reconstitution were assessed.

287 cells, capable of multilineage and long-term reconstitution when transplanted in immunodeficient mice

288 rus reactivation was shorter with timely CD4 reconstitution, which was defined as 50 x 10(6) cells/L

289 We found that co-reconstitution with 2 KIR ligand-mismatched compartments

290 Despite the immune-reconstitution with antiretroviral therapy (ART), HIV-in

291 s impaired in CXCR3(-/-) mice, and transient reconstitution with circulating CXCR3-replete monocytes

292 owed during nucleosome formation in in vitro reconstitution with either the canonical "Widom" sequenc

293 e capable of stable, polyclonal multilineage reconstitution with follow-up of more than 1 year.

294 By combining in vitro reconstitution with measurements of intracellular concen

295 Using cell-free reconstitution with purified Vps13p, we show that Vps13p

296 We found that partial bone marrow reconstitution with TET2-deficient cells was sufficient

297 nt of atherosclerosis, which is prevented by reconstitution with wild type but not Il5(-/-) or Il13(-

298 65-deficient murine embryonic fibroblasts by reconstitution with wild-type but not mutant FKBP65 that

299 Kit(W-sh/W-sh) mice and restored by means of reconstitution with wild-type but not ST2-deficient BMMC

300 These antitumor effects were reversed upon reconstitution with wild-type, but not enzyme-active sit

301 lipids, lowers lactose permease folding and reconstitution yields but stabilises the folded state.