ライフサイエンスコーパス: recurrent

1 Three of the variants were recurrent.

2 of 275 patients still needed insulin or had recurrent abdominal pain or both.

3 clone-specific effects play a strong role in recurrent aberrant methylation at specific CpG sites acr

4 ration, decreased mucociliary clearance, and recurrent acute bacterial infections.

5 long-standing persistent], and ER-AF = early recurrent AF), had better predictive ability for VLRAF (

6 Treated BCCs (including those recurrent after surgery, radiotherapy, systemic chemothe

7 1.56 and AKIN 2/3: HR, 2.13; CI, 2.01-2.26), recurrent AKI (AKIN 1: HR, 1.70; CI, 1.64-1.76; AKIN 2/3

8 tic transition is accompanied by massive and recurrent alterations in enhancer activity.

9 However, it remains unclear whether this recurrent amplification is solely a manifestation of inc

10 dition, this analysis allowed us to evidence recurrent and ethnic-specific mutations: p.Phe223Leu in

11 dentification of alterations associated with recurrent and metastatic disease.

12 n papillomavirus (HPV)-positive tumors, many recurrent and metastatic HPV-positive tumors exhibited a

13 y number of previous lines of therapy in the recurrent and metastatic setting and study site.

14 th histologically or cytologically confirmed recurrent and metastatic squamous cell carcinoma of the

15 sent multiple cancer types, and include both recurrent and non-recurrent events.

16 Given the highly recurrent and progressive course of bipolar disorder som

17 The discovered CNVs are recurrent and rare (0.01-0.2%), with large effects on he

18 Recurrent and/or antecedent hypoglycemia causes blunting

19 ive crises (VOCs) characterized by episodic, recurrent, and unpredictable episodes of acute pain.

20 conducted on species that are not subject to recurrent annual human harvest.

21 spholipid syndrome (APS) is characterized by recurrent arterial/venous thrombosis and miscarriages in

22 For both clinical indications in recurrent as well as in primary prostate cancer, prelimi

23 he proportion of patients with cirrhosis and recurrent ascites who survive transplantation-free for 1

24 essive blood pressure (BP) lowering prevents recurrent atrial fibrillation (AF) after catheter ablati

25 proportion of these individuals will develop recurrent BC and will eventually succumb to the disease.

26 ography (ERCP) with stone extraction reduces recurrent biliary events compared to expectant managemen

27 The primary outcome measure was the rate of recurrent biliary events in the 365 days after discharge

28 ents with early CCY had an 87% lower risk of recurrent biliary events than patients with no CCY (P <

29 ts with delayed CCY had an 88% lower risk of recurrent biliary events than patients with no CCY (P <

30 e was seen in consultation for management of recurrent bladder cancer.

31 o-controlled trial enrolled 31 patients with recurrent Canadian Cardiovascular Society II-IV angina,

32 thin tumors that are thought to give rise to recurrent cancer after therapy.

33 years, 256 recipients died, 35 (13.7%) from recurrent cancer and 27 (10.5%) from de novo cancer.

34 ells (TIC) is vital to combat advanced-stage recurrent cancers.

35 Recurrent cases occurred among children of all ages; 5 (

36 INTERPRETATION: The risk of residual or recurrent CIN2+ is significantly greater with involved m

37 ure was defined as occurrence of residual or recurrent CIN2+.

38 tion (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI).

39 nalyzed a cohort of 109 subjects treated for recurrent Clostridium difficile infection with fecal mic

40 on 100 consecutive, evaluable patients with recurrent Clostridium difficile infection.

41 robiota transplantation led to resolution of recurrent Clostridium difficile, significantly decreased

42 Recurrent CMV occurred in 30.5% patients at a median of

43 Recurrent CMV occurs in a significant percentage of pati

44 eral blood in 9.6% of them, and was the only recurrent CNV in constitutional DNA samples.

45 PR-based mouse systems to engineer and study recurrent colon cancer-associated EIF3E-RSPO2 and PTPRK-

46 ised learning scheme for the feedforward and recurrent connections in a network of heterogeneous spik

47 zontal, and feedback interactions with local recurrent connections, via synaptic mechanisms involving

48 Functional analyses show six genes that have recurrent copy-number variants in three squamous-cell ca

49 ificant reduction in both virus shedding and recurrent corneal herpetic disease.

50 worldwide and can cause potentially blinding recurrent corneal herpetic disease.

51 exin (Cx) 26 revealed heterozygosity for the recurrent de novo germline mutation, c.148G > A, p.Asp50

52 We observe an identical recurrent de novo heterozygous c.892C>T (p.Arg298Trp) va

53 mation on seven unrelated individuals with a recurrent de novo nonsense variant (c.2737C>T [p.Arg913T

54 Recurrent de novo or case-private CNVs were found at 15q

55 Clinical predictors for recurrent de novo SCAD were tested using univariate and

56 n DNA methylation contribute to the observed recurrent deregulation of 235 lncRNAs.

57 ic attack is a wasted opportunity to prevent recurrent disabling stroke.

58 detected in tumor samples from patients with recurrent disease (five of 16) and only in cfDNA from pa

59 cancer at enrolment and without evidence of recurrent disease at any time before randomisation.

60 solid tumours is 75%, that of children with recurrent disease is below 30%.

61 individual experiencing multiple episodes of recurrent disease over time is not known.

62 ic solid tumours and establish new models of recurrent disease, here we develop a protocol to produce

63 S presenting with unresectable metastases or recurrent disease, or in those older than 40 years are g

64 rimary resistance and the rapid emergence of recurrent disease, which can result from tumor cell-intr

65 are usually drawn in the absence of visibly recurrent disease.

66 er kidney transplant predicts development of recurrent disease.

67 tomatic (SYMP) and develop frequent bouts of recurrent disease.

68 of acute diverticulitis allow prediction of recurrent diverticulitis and may be useful for stratifyi

69 Altogether, our findings demonstrate that recurrent DNA damage contributes to the chromatin landsc

70 ith brain hypomyelination, all with the same recurrent dominant mutation, c.754G>A p.(Asp252Asn), in

71 In conclusion, we report two recurrent dominant mutations in RAB11B leading to a neur

72 avorably altered clot properties may predict recurrent DVT after anticoagulation withdrawal.

73 that reduced Ks and prolonged CLT predicted recurrent DVT.

74 rn of rsc between LPFC neurons indicative of recurrent dynamics as a mechanism for WM-related activit

75 is study, we report a patient suffering from recurrent EBV-induced B cell proliferations including Ho

76 ifferences in early discharge, readmissions, recurrent emergency department visits, outpatient visits

77 A recurrent emerging theme is the targeting of proteins to

78 finding opens a new window for studying the recurrent epidemics in multi-layered networks.

79 that the CRC epigenome is defined by highly recurrent epigenetic alterations at enhancers which acti

80 Affected individuals experience recurrent episodes of depression and mania, disrupting n

81 omal-dominant skin disorder characterized by recurrent episodes of palmoplantar erythema and epiderma

82 in the AL+PQ arm) were followed for 1 y, and recurrent episodes were treated with the same treatment

83 ial healing with dendrites, and 3 (0.4%) had recurrent epithelial defects.

84 Using recurrent event analysis incorporating patient frailty,

85 er types, and include both recurrent and non-recurrent events.

86 tly elevated values and were at high risk of recurrent events.

87 olving both increased inhibition and reduced recurrent excitation.

88 n S1, the thalamic input is amplified by the recurrent excitatory connections of the L4 circuits.

89 rtical microcircuits are interconnected with recurrent excitatory synaptic connections that are thoug

90 In many settings, populations experience recurrent exposure to inflammatory agents that catalyze

91 The most recurrent expression gain was ERBB2/HER2, which showed a

92 the 100-year return value in the Amazon and recurrent extreme droughts in the Nordeste region, with

93 ticular, (1) why shamanic traditions exhibit recurrent features around the world, (2) why shamanism p

94 Accompanying symptoms were recurrent fever, fatigue, elevated liver enzymes, abdomi

95 73 recurrent fistulas occurred, corresponding to a cumulati

96 We also identify recurrent fusion genes that significantly impact both pr

97 Cox proportional hazards models for recurrent gap-time data were used to examine the associa

98 as associated with a relatively high rate of recurrent gastroesophageal reflux disease requiring trea

99 We observed recurrent gene losses in multiple independent longitudin

100 Recently, recurrent genetic alterations of potential importance fo

101 of HSPCs carrying specific, disruptive, and recurrent genetic variants, in individuals without clear

102 Murine and human ETV6-RUNX1 pB-ALL revealed recurrent genomic alterations, with a relevant proportio

103 Fewer patients in this study experienced a recurrent GI bleed compared with a matched historical co

104 b regimens are approved for the treatment of recurrent glioblastoma in many countries.

105 ma subtype, echo time, and the proportion of recurrent glioma versus primary glioma.

106 ed into two groups with a total of 151 local recurrent HCC lesions abutting the diaphragm.

107 ultivariate predictors accurately stratified recurrent HCC patients into prognostic subgroups, with l

108 med a prospective study of 134 patients with recurrent HCV infection after liver transplantation who

109 a rationally derived stool donor is safe in recurrent HE compared to SOC alone.

110 n of palliative treatments for patients with recurrent head and neck cancer, we reviewed the evidence

111 Recurrent hepatic encephalopathy (HE) is a leading cause

112 venting HBV reactivation and graft loss from recurrent hepatitis B after liver transplantation in pat

113 d impact of treatment in patients developing recurrent hepatocellular carcinoma (HCC) following liver

114 nce-based recommendation for surveillance of recurrent hepatocellular carcinoma after liver transplan

115 with either HBsAg positivity or viremia had recurrent hepatocellular carcinoma diagnosed within a mo

116 munotherapeutic strategies to treat blinding recurrent herpes infection and disease.

117 ensory ganglia, the majority never develop a recurrent herpetic disease and remain asymptomatic (ASYM

118 Recurrent high-frequency epileptic seizures cause progre

119 status to predict occurrence of residual or recurrent high-grade cervical intraepithelial neoplasia

120 rformed whole-exome sequencing to identify a recurrent homozygous c.408+1G>A donor splice site loss-o

121 anscription factor binding, we observed that recurrent hotspot mutations resulted in decreased lucife

122 A novel, recurrent hotspot was identified at a posttranslationall

123 -inhibited (GI) neurons by low glucose after recurrent hypoglycemia (RH) in nondiabetic rats.

124 hypoglycemia and to elucidate the effects of recurrent hypoglycemia (RH) on this neurotransmitter.

125 iency and diabetes and reduced by antecedent recurrent hypoglycemia.

126 illary-leak syndrome is a very rare cause of recurrent hypovolemic shock.

127 is a plasma cell malignancy characterized by recurrent IgH translocations and well described genomic

128 r or the CDKN1B/p27 cell cycle inhibitor are recurrent in 16% of patients with HCL and likely coopera

129 hway activating mutations, though not highly recurrent in a single gene.

130 These infections are often chronic/recurrent in nature and typically involve bacterial pers

131 and targeted sequencing, here we identify a recurrent in-frame deletion (VAV1 Delta778-786) generate

132 rus-specific CD8 T cells home to the site of recurrent infection and participate in viral clearance.

133 A recurrent infection was defined as a MSSA blood culture

134 lates from 74 trainees, 6 (8.1%) of whom had recurrent infection, were subjected to WGS.

135 lower risk of mortality and similar odds of recurrent infections compared with nafcillin or oxacilli

136 fit in preclinical animal models and prevent recurrent infections in human clinical trials.

137 s a T-cell defect frequently presenting with recurrent infections, as well as associated immune dysre

138 Chronically critically ill patients have recurrent infections, organ dysfunction, and at least ha

139 ng patients had no evidence of persistent or recurrent infections.

140 therapy and a major cause of persistent and recurrent infections.

141 erized by impaired leukocyte recruitment and recurrent infections.

142 Hidradenitis suppurativa (HS) is a recurrent inflammatory follicular disease that commonly

143 d also activate Renshaw cells, which provide recurrent inhibitory feedback to the motor neurons.

144 hat the correlation instead may originate in recurrent input from other brain areas involved in the i

145 Because recurrent intractable seizures are a common feature of F

146 The risk of recurrent ischemic and bleeding events after primary per

147 Recurrent ischemic events because of persistent or new s

148 of 1-year MACE but a higher adjusted risk of recurrent ischemic events primarily because of nonstent-

149 coronary syndrome are at heightened risk of recurrent ischemic events, including stroke.

150 atients with 6 cases of MEL (1 patient had a recurrent lesion; mean [SD] age, 56.2 [15.5] years).

151 nulomatous disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infectio

152 This mechanism, which employs recurrent loops with an angular shift, bears a resemblan

153 ganglia with occasional reactivation causing recurrent lytic infections.

154 0.31/EY), epiretinal membrane (0.16/EY), and recurrent macular edema (0.09/EY).

155 Patients with bipolar disorder have recurrent major depression, residual mood symptoms, and

156 hizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common ps

157 hypothesis that sensory inputs are used in a recurrent manner to tune the position of the sensors.

158 nts were adult women (aged >/=18 years) with recurrent measurable or evaluable epithelial ovarian, pr

159 Genetic amplification of wild-type RAS was a recurrent mechanism of resistance in colorectal cancer p

160 e; 51 received chemotherapy for unresectable recurrent/metastatic disease.

161 nce was associated with a 36% higher rate of recurrent MI (41.1 vs. 30.1 per 1,000 person-years, resp

162 Recurrent MI, CHD events (recurrent MI or a coronary revascularization procedure),

163 confidence interval [CI]: 1.30 to 1.73) for recurrent MI, 1.51 (95% CI: 1.34 to 1.70) for CHD events

164 Recurrent MI, CHD events (recurrent MI or a coronary rev

165 cidua during early pregnancy, and women with recurrent miscarriage have lower endometrial expression

166 When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecu

167 Collectively, these recurrent missense mutations affect approximately 0.8% o

168 ultra-rare disorders caused by private, non-recurrent missense mutations that result in varying phen

169 granule cells born before SE form functional recurrent monosynaptic excitatory connections with other

170 the study of lithium for prophylaxis of the recurrent mood disorder and encouraged its greater use.

171 ohistochemistry for NKCC1, KCC2, and ectopic recurrent mossy fiber (rMF) sprouting as well as telemet

172 hey arise from common ancestral mutations or recurrent mutation events.

173 Novel recurrent mutational events in AML were identified in th

174 Recurrent mutations at R140 and R172 in isocitrate dehyd

175 The number of genes affected by recurrent mutations disrupting non-coding sequences was

176 All recurrent mutations identified in mononuclear cells coul

177 We identify novel and recurrent mutations in 16 participants with BSI.

178 Our analyses identify recurrent mutations in 4 genes not previously identified

179 ur study shows that promoter regions harbour recurrent mutations in cancer with functional consequenc

180 Recurrent mutations in core splicing factors have been r

181 We report recurrent mutations in NF1, SUZ12, EED, TP53 and CDKN2A

182 ng sequences was similar to that affected by recurrent mutations to coding sequences.

183 ous mutations in 42 genes were observed, and recurrent mutations were noted on eight genes, including

184 There were no significant differences in recurrent myocardial infarction, stent thrombosis, heart

185 ecurrence some time after primary diagnosis (recurrent; n = 2,498), were assessed.

186 tients who had a TE and were defined to have recurrent NAFLD.

187 In patients with recurrent nasal polyposis receiving topical corticostero

188 recruited patients aged 18 to 70 years with recurrent nasal polyposis requiring surgery.

189 The deep recurrent network architecture performs slightly better

190 isual cortical responses can be described by recurrent network connections with fixed synaptic weight

191 We trained a recurrent network model to perform DMC tasks and found t

192 We explicitly show how recurrent network structure produces pairwise and higher

193 s driven by correlated input-emerges in some recurrent networks but not in others.

194 cally plausible learning rule can train such recurrent networks, guided solely by delayed, phasic rew

195 ads of ANs arranged in both feed-forward and recurrent networks.

196 Recurrent neural network models trained to perform the t

197 Compared with other architectures of CNN, Recurrent Neural Network, and Random Forest, the simple

198 ising topographically organized and strongly recurrent neural networks can autonomously generate irre

199 er disease at LT >23, time to recurrence, >3 recurrent nodules, maximum recurrence size, bone recurre

200 Our data suggests that recurrent NPC may had more immunologic advantage than pr

201 y serve as a potential salvage treatment for recurrent NPC.

202 ected HLA-A*0201-transgenic mice and reduced recurrent ocular herpes following UV-B-induced reactivat

203 mes that of the Sun, all classical novae are recurrent, on timescales of months to millennia.

204 score to 9,176 cancer patients across 1,018 recurrent oncogenic mutations.

205 ancer history may be more prone to develop a recurrent or a new cancer.

206 d >/=18 years) with histologically confirmed recurrent or metastatic colorectal cancer locally assess

207 imary prostate cancer (PCa) and diagnosis of recurrent or metastatic PCa.

208 with paclitaxel and placebo in patients with recurrent or metastatic squamous cell carcinoma of the h

209 , open-label, phase 3 trial in patients with recurrent or metastatic squamous cell carcinoma of the h

210 improving quality of life for patients with recurrent or metastatic squamous cell carcinoma of the h

211 Identifying recurrent or persistent EMPD is challenging because the

212 75% and a specificity of 100% in identifying recurrent or persistent EMPD.

213 inum-based chemotherapy, and disease status (recurrent or persistent vs metastatic).

214 Studies of recurrent or subsequent disease events may be susceptibl

215 highest risk in children exposed to severe, recurrent, or clinically undetected (interstitial episod

216 merase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation o

217 Recurrent PEDV outbreaks have resulted in enormous econo

218 lity rates as high as 20% being reported for recurrent penetrating trauma.

219 embolic venous/arterial events, amputations, recurrent/persistent thrombocytopenia, skin lesions) and

220 ed chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma.

221 .9 times higher rate (95% CI 21.9-33.2) of a recurrent postpartum episode after their second birth co

222 lso found to be associated with multiple and recurrent PPGL.

223 = 40), full-thickness macular hole (n = 33), recurrent proliferative vitreoretinopathy (PVR)-related

224 A PET is a promising modality in biochemical recurrent prostate cancer patients for N staging.

225 ed management of patients with biochemically recurrent prostate cancer.

226 nt upregulation of these genes was linked to recurrent prostate cancers.

227 Recurrent Pseudomonas aeruginosa infections coupled with

228 CAG and AMT had been compared for primary or recurrent pterygia.

229 For 96 eyes with recurrent pterygium, the risk of recurrence 6 months aft

230 patients with increased eosinophil activity, recurrent pulmonary infections, or both, as evident by t

231 No single case of recurrent RD was seen whilst mixed oil remained in situ.

232 death, myocardial infarction, bleeding, and recurrent renal injury after discharge.

233 otective chromatin environment at regions of recurrent replication stress (RS).

234 We studied a child with life-threatening, recurrent respiratory tract infections, caused by viruse

235 er genome sequencing efforts have identified recurrent Rheb Tyr35Asn mutations in kidney and endometr

236 cell intrinsic excitability and a failure in recurrent RT synaptic inhibition.

237 scular outcomes and assess the predictors of recurrent SCAD.

238 ecting cancer genes, yet the extent to which recurrent SCNAs exert their influence through rearrangem

239 sion of bumetanide reduced rMF sprouting and recurrent seizures in the chronic epileptic phase.

240 Recurrent seizures in TLE are associated with disturbanc

241 nitive deficits in conditions accompanied by recurrent seizures.

242 ld of the mice but induced neither acute nor recurrent seizures.

243 urological disease, manifested in unprovoked recurrent seizures.

244 enerated pure breeding hybrid mimic lines by recurrent selection and also selected a pure breeding sm

245 otential to assemble practical pipelines for recurrent selection and hybrid seed production in wheat.

246 followed by hospital readmissions, often for recurrent sepsis.

247 on causing choroidal lesions, complicated by recurrent serous retinal detachment (SRD).

248 No highly recurrent single gene or pathway level mutations associa

249 One recurrent site substitution (p.A636T) occurs in a glutam

250 weeks, including overnight hospitalization, recurrent skin infections, and similar infection in hous

251 a relatively easy and economic technique for recurrent small HCC abutting the diaphragm, and both CT-

252 (L-RFA) have been used to treat intrahepatic recurrent small hepatocellular carcinoma (HCC) against t

253 co-occurs either with genomic instability or recurrent SMARCB1 mutations.

254 Clonal hematopoiesis (CH), as evidenced by recurrent somatic mutations in leukemia-associated genes

255 ancer, malignant clones are characterized by recurrent somatic mutations in specific sets of genes, b

256 extensive copy-number alterations and highly recurrent somatic mutations.

257 th histologically or cytologically confirmed recurrent stage IIIb or stage IV, chemotherapy-naive NSC

258 ent foramen ovale (PFO) in the prevention of recurrent stroke after cryptogenic stroke is uncertain.

259 sed after stroke is an important hallmark of recurrent stroke risk.

260 f less than 140 mm Hg to reduce the risk for recurrent stroke.

261 troke that is associated with a high risk of recurrent stroke.

262 -stroke (late AF) was highly associated with recurrent stroke/TIA (hazard ratio, 2.0; 95% confidence

263 ng total events, including the first and all recurrent strokes, ezetimibe/simvastatin reduced stroke

264 Here, we examine impacts of recurrent sublethal warming on development and survival

265 icular tachycardia (lasting >/=30 seconds or recurrent symptomatic).

266 hinoconjunctivitis (ARC) patients experience recurrent symptoms after successfully completing allerge

267 acing was associated with a 70% reduction in recurrent syncope (relative risk [RR]: 0.30; 95% confide

268 Recurrent tandem duplications intersecting with a TAD bo

269 focus groups were analysed thematically for recurrent themes.

270 ntiphospholipid syndrome is characterized by recurrent thrombosis and gestational morbidity in patien

271 We found that two recurrent Treg cell clones, one prevalent in prostate tu

272 Most of the eyes with recurrent tumor can be salvaged by conservative methods.

273 eparated, multifocal tumors and/or long-term recurrent tumors are seeded from different clones.

274 Patients die from recurrent tumors that have become resistant to therapy.

275 initial tumors was similarly deregulated in recurrent tumors thereby indicating that the latter can

276 0% of primary tumors but in more than 70% of recurrent tumors, regardless of breast cancer subtype.

277 C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused by unc

278 umab and docetaxel for patients with locally recurrent, unresectable, or metastatic HER2-positive bre

279 ostridium difficile, significantly decreased recurrent UTI frequency, and improved antibiotic suscept

280 The primary outcome was a composite of recurrent venous thromboembolism or major bleeding durin

281 a biomarker for predicting initial, but not recurrent, venous thromboembolism (VTE) in cancer, a set

282 ents with structural heart disease (SHD) and recurrent ventricular tachyarrhythmias (VT).

283 of IRF8, which is present in a patient with recurrent viral infection, granuloproliferation, and int

284 The remaining 5 patients with late recurrent viremia had virologic relapse in which the HCV

285 ers measured at the time of initial VTE with recurrent VTE in a prespecified analysis of the CATCH (C

286 ounty, Minnesota, residents with incident or recurrent VTE over the 6-year period 2005-2010.

287 We estimated VTE attack (incident plus recurrent VTE) rates and the total annual number of US V

288 The study population comprised 900 patients (recurrent VTE, n = 76; 8.4%).

289 Recurrent wheeze (RW) is frequent in childhood.

290 Overall, 166 (36%) children had recurrent wheeze at age 3 years.

291 els of greater than 30 ng/mL, reduced asthma/recurrent wheeze in the offspring through age 3 years, s

292 g in early pregnancy is necessary for asthma/recurrent wheeze prevention in early life.

293 he development of allergic sensitization and recurrent wheeze.

294 of severe RSV-induced illness and subsequent recurrent wheeze.

295 pregnancy and early life are associated with recurrent wheezing and aeroallergen sensitivity and alte

296 ntal report of physician-diagnosed asthma or recurrent wheezing and allergic sensitization to food or

297 he relation of maternal stress/depression to recurrent wheezing and peripheral blood mononuclear cell

298 Asthma and recurrent wheezing until age 3 years were recorded.

299 he airways to promote airway obstruction and recurrent wheezing.

300 Many of these recurrent within-host mutations also reach a high global