ライフサイエンスコーパス: recurrently

1 f MAX-interacting proteins, was also deleted recurrently.

2 systems behaviors that have been discovered recurrently across signaling networks.

3 s the consequence of allergen exposures that recurrently activate memory B cells and identify these a

4 alf of all GWAS CRC risk loci co-localize to recurrently activated enhancers.

5 Of the enhancers highly recurrently activated in CRC, most are constituents of s

6 These mutations recurrently affect specific amino acid residues, leading

7 he focus has shifted to pinpointing the loci recurrently affected by LOH events across multiple tumor

8 We search for genes that are recurrently affected by rare variants (minor allele freq

9 r coactivators (SRCs; SRC-1, -2 and -3) were recurrently affected by these SiM-miRNAs.

10 In 35 NMZL patients, 41 genes were found recurrently affected in >/=3 (9%) cases, including highl

11 genetic mechanism by which PP2A function is recurrently affected in human cancer, involving haploins

12 Cancer Gene Census genes, many of which were recurrently affected in the set of 25 immortalized cell

13 pectively, with MEN1, PSIP1 and ARID1A being recurrently affected.

14 ified chromothripsis in 5 HCC genomes (5.7%) recurrently affecting chromosomal arms 1q and 8q.

15 ules by three criteria: (1) Member genes are recurrently altered across a set of tumor samples; (2) m

16 A subset of genes was recurrently altered across tumors derived from different

17 Further, nine recurrently altered genes in passaged D. rerio T-ALL wer

18 WGS and WES identified novel mutations in recurrently altered genes not previously implicated in T

19 brafish and 61 human samples), 10 genes were recurrently altered in > 3 zebrafish cancers and >/= 4 h

20 DH, a detailed review of chromosomal regions recurrently altered in CDH, a description of the retinoi

21 enomics approach identified cancer hallmarks recurrently altered in human HCC that may be targeted by

22 in several genes not previously known to be recurrently altered in SMZL.

23 nd somatic copy number variations identified recurrently altered mechanisms of carcinogenesis: chroma

24 ng and noncoding alteration and identify ten recurrently altered pathways, with associations between

25 161 putative driver genes associated with 11 recurrently altered pathways.

26 Transcriptional regulators are recurrently altered through translocations, deletions, o

27 Our analysis identified 29 recurrently amplified and 22 recurrently deleted regions

28 RNA interference library targeting 369 genes recurrently amplified and overexpressed in both ERBB2-am

29 screen we assessed whether genes found to be recurrently amplified and overexpressed in ERBB2+ve brea

30 associated factor 2), as an oncogene that is recurrently amplified and rearranged in 15% of human epi

31 , which is the ligand for the BMP family, is recurrently amplified and transcriptionally upregulated

32 RB2-associated binding protein 2 (GAB2) as a recurrently amplified gene that potently transforms immo

33 alysis of human cancers showed that PHGDH is recurrently amplified in a genomic region of focal copy

34 e antiapoptotic BCL2 family member BCL2A1 is recurrently amplified in approximately 30% of melanomas

35 There are several, recurrently amplified oncogenes throughout the human gen

36 zebrafish melanoma model to test genes in a recurrently amplified region of chromosome 1 for the abi

37 creens to pinpoint driver genes within large recurrently amplified regions of DNA.

38 rogramming of somatic stem cells to produce, recurrently and reversibly, a bewildering array of diffe

39 eage; and (iv) MUC7 PTS-repeats have evolved recurrently and under adaptive constraints.

40 phisms (STRPs), which can mutate rapidly and recurrently, and SNPs in 721 regions across the human ge

41 Recurrently appearing post-chemotherapy mutations are ra

42 Bs in P. autumnale probably form recurrently as by-products of the extensive genome restr

43 aberration and showed this aberration to be recurrently associated with morphologic and clinical fea

44 apply this method to identify CNVs that are recurrently associated with postglacial adaptation of ma

45 This process operates recurrently at discrete genomic regions and generates dr

46 and observed that the genetic adaptation was recurrently based on a strategic mutation that changed t

47 ation using the cghMCR method and identifies recurrently broken genes that may be disrupted or fused.

48 e agents, a proportion of which is imprinted recurrently by gene dosage changes in the resistant glio

49 ecological niche, whose divergence is purged recurrently by natural selection.

50 However, one undisputable observation recurrently confirmed during influenza seasons of the la

51 bursting cells and regular firing cells are recurrently connected among themselves but connections b

52 ed input patterns arriving onto dendrites of recurrently connected CA3 neurons.

53 Before vision, a transient network of recurrently connected cholinergic interneurons, called s

54 tory inputs to layer 4 simple cells are from recurrently connected circuits of cortical neurons.

55 nsists of a functionally columnar network of recurrently connected excitatory and inhibitory neural p

56 Specifically, neurons in a recurrently connected network with excitatory connection

57 this, it induces global structures within a recurrently connected network.

58 gested that persistent activity can exist in recurrently connected networks as active reverberation.

59 e persistent activity hypothesis, holds that recurrently connected neural networks, presumably locate

60 a neuronal network model that represents two recurrently connected neural systems.

61 In addition, L4 recurrently connected neurons were driven by thalamocort

62 e how these concepts could be implemented by recurrently connected probabilistic population codes.

63 place through integrated competition between recurrently connected visual processing networks.

64 cular importance is the high excitability of recurrently connected, developing networks and the prese

65 lay between a network of specific genes that recurrently contribute to medulloblastoma formation.

66 ing experiments revealed that the epicardium recurrently contributes cells to the ventricular wall, i

67 en pairwise correlations and firing rates in recurrently coupled excitatory-inhibitory spiking networ

68 Recurrently coupled networks of inhibitory neurons robus

69 RNAs) targeting the mouse orthologs of genes recurrently deleted in a series of human hepatocellular

70 thus directly bind and inhibit K-Ras and are recurrently deleted in human cancer.

71 ate genes present within chromosomal regions recurrently deleted in human cancers, we coupled high-re

72 analyses have shown that the 12q22 region is recurrently deleted in male germ cell tumors (GCTs), sug

73 s identified 29 recurrently amplified and 22 recurrently deleted regions with a high level of copy nu

74 , Nf1, Flt3, Cbl, Notch1 and Mll2, which are recurrently deleted/mutated in human haematological mali

75 The expression patterns of 917 recurrently deregulated lncRNAs are correlated with clin

76 Many recurrently deregulated lncRNAs are enriched in co-expre

77 ), and CARD11 gain-of-function mutations are recurrently detected in human diffuse large B-cell lymph

78 Only RAS mutations were recurrently detected in patients and found to be associa

79 ci with aberrant copy numbers and identified recurrently disrupted genes in genomically unstable canc

80 ve identified many de novo mutations but few recurrently disrupted genes.

81 mutation analysis showed that 63 miRNAs were recurrently disrupted in DLBCL, including highly express

82 lation of KIT-MAPK signaling also feature as recurrently disrupted pathways.

83 rticipating in known human CRC pathways were recurrently disrupted, indicating that these pathways mi

84 Mating system shifts recurrently drive specific changes in organ dimensions.

85 the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human cancer.

86 entify pairs of metabolic genes which may be recurrently dysregulated.

87 cer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA) lev

88 specific T(regs) (termed MJ23 T(regs)) found recurrently enriched in the tumors of mice with oncogene

89 Such autoimmune risk alleles have recurrently evolved at the DANGEROUS MIX2 (DM2) nucleoti

90 c chromosomes in meiotic prophase provides a recurrently evolving trigger for the meiotic arrest of i

91 cific instance of such a model, in which two recurrently excited populations of neurons compete for h

92 The expansion occurred recurrently, explaining the seemingly non-mendelian inhe

93 Cystic fibrosis airways are recurrently exposed to noxious stimuli, leading to epith

94 scripts to support a viral etiology of SS or recurrently expressed gene fusions, but it did identify

95 B1 (Ribosomal protein S6 kinase beta-1) were recurrently expressed in a number of breast tumor cell l

96 Four out of nine transcripts were found recurrently expressed in an extended panel of primary TG

97 gical perspective predicts that species that recurrently faced similar adaptive problems may have evo

98 Many of these patients were rehospitalized recurrently for a problem in the same organ system.

99 One mutation (R96L) was recurrently found in three ethnically diverse families w

100 serine cluster (residues 271, 273, and 275) recurrently found to be phosphorylated in both human and

101 loid species are polyphyletic, having formed recurrently from genetically different diploid parents.

102 as a comparator, we identify enhancers with recurrently gained or lost activity across CRC specimens

103 it is becoming apparent that these mutations recurrently hijack the same hallmark molecular pathways

104 However, cIAP1 and cIAP2 are recurrently homozygously deleted in multiple myeloma (MM

105 contributes to counterregulatory failure in recurrently hypoglycemic (RH) and diabetic rats.

106 (62%) and ECF glucose changes in euglycemic recurrently hypoglycemic animals resembled those of 4-mo

107 Quantitative RT-PCR and immunoblots in recurrently hypoglycemic animals revealed that GAD(65) m

108 MH GABA levels decreased in both control and recurrently hypoglycemic animals with the onset of hypog

109 ntrations were more than threefold higher in recurrently hypoglycemic animals.

110 During hypoglycemia, recurrently hypoglycemic rats exhibited a 49-63% reducti

111 mic extracts that high-intensity exercise in recurrently hypoglycemic rats increases levels of a numb

112 alleling the cognitive findings: slices from recurrently hypoglycemic rats showed improved gamma-amin

113 carboxylase (GAD), in the VMH of control and recurrently hypoglycemic rats.

114 ypoglycemia, the fall was not significant in recurrently hypoglycemic rats.

115 Overall, 76 gene body promoters were recurrently hypomethylated, including TERT and the oncog

116 antly moderated neuroanatomical diagnosis as recurrently-ill patients had higher misclassification ra

117 Importantly, the EZH2(Y641) mutants recurrently implicated in lymphoma pathogenesis are unab

118 RC family kinases have been consistently and recurrently implicated in neurite extension events, yet

119 induced by NF-kappaB2 mutations, which occur recurrently in a variety of human lymphoid malignancies.

120 eview shows that new CHS genes are recruited recurrently in flowering plant evolution.

121 53, and NOTCH1, mutations were also observed recurrently in MEF2B, TRAF2, and TET2.

122 are bioactive metabolites that have evolved recurrently in plants, presumably for defense.

123 for the good of future patients, have arisen recurrently in the course of history and continue presen

124 ina-Pinb deletion occurred independently and recurrently in the four polyploid wheat species.

125 ny structural variations were shown to occur recurrently in the population.

126 Our findings define PARD3 as a recurrently inactivated cell polarity regulator in LSCC

127 nal (PSS) sequences at their breakpoints and recurrently inactivated tumor-suppressor genes.

128 etic alterations and genomic profiles, which recurrently involve multiple signaling pathways, have be

129 Nmp4/CIZ is recurrently involved in acute leukemia and it has been i

130 conserved phylogenetically, while others are recurrently involved in chromosomal rearrangement, resul

131 We present the discovery of genes recurrently involved in structural variation in nasophar

132 genes in endometrial stromal tumors, is also recurrently involved in the pathogenesis of OFMTs, irres

133 ations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent

134 Rociletinib resistance recurrently involves MET, EGFR, PIK3CA, ERRB2, KRAS and

135 eptibility testing (AST) when an organism is recurrently isolated from the same specimen source.

136 altered in PanINs and tumors, but few other recurrently modified genes were detected.

137 Dependent colony foundation (DCF) evolved recurrently multiple times across the ants, bees, and wa

138 /or lymphoma-associated genes, and nine were recurrently mutated (DNMT3A, TET2, JAK2, ASXL1, TP53, GN

139 nd only a few genes (TP53, ATRX, RB1) highly recurrently mutated across sarcoma types; (2) within sar

140 However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunctio

141 disclosed that the NOTCH1 proto-oncogene is recurrently mutated at CLL presentation.

142 e fewer genetic lesions overall and no known recurrently mutated cancer consensus genes.

143 n Braf(V600E) mutant mice and identify 1,232 recurrently mutated candidate cancer genes (CCGs) from 7

144 sites in the SB-induced tumors identified 45 recurrently mutated candidate cancer genes.

145 The SRE includes a recurrently mutated enhancer whose activity is also affe

146 s in CEBPZ, suggesting that CEBPZ is a novel recurrently mutated gene in AML.

147 ltraviolet pathogenesis and discovered a new recurrently mutated gene in melanoma.

148 CDK12 is a recurrently mutated gene in serous ovarian carcinoma, wh

149 In addition to discovering novel, recurrently mutated genes (for example, WAC, SMC3, DIS3,

150 Here we identify 44 recurrently mutated genes and 11 recurrent somatic copy

151 tical models to disentangle the effect of 12 recurrently mutated genes and 4 cytogenetic alterations

152 We identified recurrently mutated genes and assessed clonal structure

153 tumor cells, we identified additional novel recurrently mutated genes and confirmed mutations of one

154 have enabled the identification of a set of recurrently mutated genes central to the pathogenesis of

155 Screening of recurrently mutated genes in 48 additional FR-CLLs revea

156 ed the coding regions or hotspot areas of 68 recurrently mutated genes in a cohort of 664 patients ag

157 al PCR to broadly measure mutated alleles of recurrently mutated genes in CR marrows of AML patients

158 Unexpectedly, the majority of recurrently mutated genes in EAC were also mutated in ND

159 We report the identification of 15 novel recurrently mutated genes in FL.

160 FAM46C is one of the most recurrently mutated genes in multiple myeloma; however i

161 Recurrently mutated genes in myelodysplastic syndrome (M

162 cted before HSCT for somatic mutations in 34 recurrently mutated genes in myeloid neoplasms.

163 Screening for recurrently mutated genes in the mononuclear cell fracti

164 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in these tumors.

165 % of mutations were seen in both groups, and recurrently mutated genes include NRAS, KRAS, BRAF, and

166 shing cancer-driving genes from thousands of recurrently mutated genes remains a significant challeng

167 creatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathway

168 ematological malignancies identified several recurrently mutated genes that may be disease initiators

169 We identified recurrently mutated genes that showed positive associati

170 H (cnLOH) together with sequence analysis of recurrently mutated genes to characterize paired AML gen

171 Recurrently mutated genes were investigated by targeted

172 nes, which are shown to interact with highly recurrently mutated genes yet have been ignored by conve

173 nic DNA from prostate cancers has identified recurrently mutated genes, but the spectrum of genome-wi

174 ondary-AML samples contained mutations in 11 recurrently mutated genes, including 4 genes that have n

175 While ICC and HCC share recurrently mutated genes, including TP53, ARID1A, and A

176 residues, rather than methods that identify recurrently mutated genes, may uncover new biologically

177 No exome-sequenced TMD/AMKL sample had other recurrently mutated genes.

178 f cancer driver genes, although enriched for recurrently mutated genes.

179 MML carried at least 1 somatic mutation in 9 recurrently mutated genes.

180 aracterized by low mutational burden and few recurrently mutated genes.

181 tations outside of these previously reported recurrently mutated genes.

182 n pattern, sharing only one of their 15 most recurrently mutated genes.

183 Genomic studies have identified a number of recurrently mutated genes; in order of descending freque

184 Additionally, 40 amino acid sites were recurrently mutated in 36 genes, and targeted sequencing

185 Genes that are recurrently mutated in a particular form of human cancer

186 the human homologue, SETD2, was found to be recurrently mutated in a significant percentage of renal

187 JAK1 and JAK3 are recurrently mutated in acute lymphoblastic leukemia.

188 decades have identified many genes that are recurrently mutated in acute myeloid leukemia (AML).

189 It was recurrently mutated in advanced human cancers and signif

190 equently harbored somatic mutations in genes recurrently mutated in AML or myelodysplastic syndromes

191 these, an average of 5 are in genes that are recurrently mutated in AML.

192 ssor gene, joining the growing list of genes recurrently mutated in AML.

193 It is now clear that many genes are recurrently mutated in AML; moreover, individual leukemi

194 Finally, we report that KLHL6, which is recurrently mutated in B cell lymphomas, is an off-targe

195 We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3,

196 atically identify noncoding regions that are recurrently mutated in cancer.

197 we identify to be essential for cohesion, is recurrently mutated in chronic lymphocytic leukaemia.

198 Mutations in genes that are recurrently mutated in de novo AML were underrepresented

199 he screen with a panel of 264 genes that are recurrently mutated in de novo AML, we identified rare,

200 locus has previously been demonstrated to be recurrently mutated in GCB DLBCL; the transcriptional si

201 r mutations, and in 31 nodules, for 10 genes recurrently mutated in HCC.

202 nsertions or deletions in 160 genes that are recurrently mutated in hematologic cancers.

203 tion sequencing (NGS) of a panel of 28 genes recurrently mutated in hematologic malignancies in a coh

204 ploinsufficient transcription factor that is recurrently mutated in hematopoietic and solid tumors.

205 hese data extend the range of genes that are recurrently mutated in high-risk childhood B-precursor a

206 a specific codon; the corresponding codon is recurrently mutated in human cancer.

207 onarily conserved residues in SETD2 that are recurrently mutated in human cancers.

208 The NF-kappaB2 gene is recurrently mutated in human lymphoid malignancies.

209 vel genes, isocitrate dehydrogenase (IDH) is recurrently mutated in intrahepatic cholangiocarcinomas.

210 In addition, the human KAT6 HATs are recurrently mutated in leukemia and solid tumors.

211 The NFE2L2-KEAP1 and MLL pathways are recurrently mutated in multiple cohorts of HCC.

212 e further identified a number of novel genes recurrently mutated in patients with MCL including RB1,

213 identified 322 DLBCL cancer genes that were recurrently mutated in primary DLBCLs.

214 subunit of a Polycomb repressor complex, is recurrently mutated in several forms of cancer and is hi

215 mon gamma chain of cytokine receptors and is recurrently mutated in T-cell acute lymphoblastic leukem

216 CREB binding protein (CREBBP) and EP300 are recurrently mutated in the activated B cell-like and ger

217 tations identified were in genes known to be recurrently mutated in the tumor type tested.

218 sucrose nonfermentable (SWI/SNF) complex are recurrently mutated in tumors, suggesting that altering

219 performance of these two tests, we simulated recurrently mutated loci each flanked by sites with neut

220 n RNA processing genes, ribosomal genes, and recurrently mutated MDS and acute myeloid leukemia-assoc

221 to the identification of many driver genes, recurrently mutated more than expected.

222 We sequenced 40 recurrently mutated myeloid malignancy genes in tumor DN

223 precise metabolic vulnerability imposed by a recurrently mutated oncogene.

224 rved the expected patterns of mutation, with recurrently mutated positions for oncogenes and evenly d

225 eveloped a statistical algorithm to identify recurrently mutated residues in tumor samples.

226 c locus-specific mutation rates, we identify recurrently mutated sites across individuals with cancer

227 ning homologous chromosome, however, are not recurrently mutated, and the identity of key 8p tumor-su

228 tion of tumours has uncovered numerous genes recurrently mutated, deleted or amplified, but gene fusi

229 One is the total number of mutants at a recurrently mutating locus among sampled sequences, whic

230 ven the states of the sampled sequences at a recurrently mutating locus and an incompletely resolved

231 inutes, 15.6% (24 of 154) of treated lesions recurrently narrowed by more than 50%, with a majority o

232 tients in whom findings at FNAC analysis are recurrently nondiagnostic.

233 Several CNAs recurrently observed in primary tumors gradually disappe

234 Recurrently observed loss-of-function mutations were ass

235 We also show that recurrently observed mutations are much more likely to b

236 The FBXW7 mutations recurrently occur in a specific codon; the corresponding

237 rement to consider the effect of the various recurrently occurring genetic lesions in AML on the init

238 of genes reveals human orthologs known to be recurrently overexpressed and/or amplified in tumors.

239 gulated lncRNA 1 (BANCR) was identified as a recurrently overexpressed, previously unannotated 693-bp

240 the serine at codon 34 (Ser34) in U2AF1 was recurrently present in 13 out of 150 (8.7%) subjects wit

241 They may have recurrently produced favourable deep-water formation con

242 ene encoding the transcription factor ERG is recurrently rearranged and plays a critical role in pros

243 D7 fusion genes, indicating that CHD7 may be recurrently rearranged in this disease.

244 In addition, HLXB9 is recurrently rearranged in young children with acute myel

245 3(91-105) (and overlapping H3(100-114)) were recurrently recognized by CD4 T cells from the patients

246 ular level, ranging from gene families being recurrently recruited to identical amino acid replacemen

247 f the transcriptome varied significantly and recurrently, reflecting large, reproducible cell-state t

248 However, many recurrently reported properties, such as the spatial clu

249 In particular, TE-derived proteins have been recurrently repurposed as part of defense systems that p

250 encoding NLR plant immune receptor genes are recurrently responsible for hybrid necrosis, highlightin

251 immunodeficiency virus (HIV), others may be recurrently risky.

252 Associated features that were recurrently seen in these individuals included hypotonia

253 vating receptors are short lived and evolved recurrently, showing they are subject to conflicting sel

254 NF1 was the only gene that was recurrently somatically inactivated in multiple tumors.

255 y genes in DNA repair and oncogenic pathways recurrently subject to MSI and uncover non-coding loci t

256 Here, we show that STING signaling is recurrently suppressed in melanoma cells, where this eve

257 dulators or members of the NOTCH pathway are recurrently targeted by genetic lesions in SMZL; these i

258 Our analysis defines 96 genomic regions recurrently targeted by homozygous deletions.

259 mic deletions, mutations, and rearrangements recurrently targeted genes encoding components of the SW

260 although widely distributed, SB integration recurrently targets certain genomic regions and shows a

261 otein kinase (MAPK) components are recruited recurrently to transduce signals of different origins, a

262 A rush followed to identify recurrently translocated genes in all types of cancer, w

263 MYC, BCL and immunoglobulin loci, which are recurrently translocated in various B-cell lymphomas, ar

264 Among the three TET genes, TET2 recurrently undergoes inactivating mutations in a wide r

265 ed research, the value of animal research is recurrently undermined.

266 Chemists recurrently utilize "fuzzy" chemical concepts (e.g. atom

267 goal-oriented motor behavior is regulated by recurrently wired sensory-motor neurons.

268 th T. aestivum and Ae. cylindrica originated recurrently, with at least two genetically distinct prog