ライフサイエンスコーパス: redesign

1 information to guide HIV-1 vaccine immunogen redesign.

2 e, Beta peptide design, NCBB design, and VIP redesign.

3 ying function and rationally guiding protein redesign.

4 before and 12 rounding events after process redesign.

5 kg/kg when all components are available for redesign.

6 ease in stability after a full computational redesign.

7 g and rationally tailored by structure-based redesign.

8 an be exploited for endonuclease specificity redesign.

9 are increasingly the focus of health system redesign.

10 ith various linkers in the context of an HR1 redesign.

11 esign, miniaturization processes and protein redesign.

12 , could be possible if the waste handling is redesigned.

13 The CATH website has been redesigned.

14 We then use the method to redesign a critical loop in human guanine deaminase such

15 First, we computationally redesign a largely disordered bend in heptad region 1 (H

16 Here, we computationally redesign a monomeric protein to form a symmetric homodim

17 rget for rational design of enzymes, showing redesigned activities to produce tailor-made fructooligo

18 One promising approach to this goal is to redesign adaptor proteins, which can regulate proteolyti

19 uctural ensemble-based computational protein redesign algorithm K* to encompass protein-protein and p

20 As a case study, the method is extended to redesign all 243 structurally resolved proteins in the p

21 an extended version of the Chado schema and redesigned all user and back end interfaces.

22 les which, if followed, will ensure that the redesigned allocation system is effective and efficient

23 Now we have redesigned an infrared fluorescent protein so that its c

24 The feasibility of the approach of redesigning an existing pharmaceutical through nontarget

25 ecies in mixed-species infections prompted a redesign and improvement of the assay.

26 lighting the importance of context-dependent redesign and optimization of protein-DNA interactions.

27 tions, using teamwork training (TT), systems redesign and standardization (SOP), Lean quality improve

28 e pool sizes are made possible using program redesign and supercomputing resources.

29 ayer channel formation without requiring the redesign and synthesis of the cyclic peptide core.

30 ibiotic selection, we identified extensively redesigned and highly convergent resolvase and invertase

31 In 2015, the database was redesigned and relocated to EMBL-EBI.

32 tiative, and to suggest how practice process redesigns and effective measurement of performance and d

33 The template was redesigned, and the resulting 5-azaindole 36 was a poten

34 or additional sample manipulation, microchip redesigns, and/or system expansions required for traditi

35 activity to all four serotypes, and that the redesigned antibody has potent antiviral activity in a m

36 ent of diabetes and later considered insulin redesign, as synthetic insulins became possible.

37 lows users to apply experimental outcomes to redesign assembly plans interactively.

38 The PDBe website has been redesigned based on an analysis of user requirements, an

39 Genes redesigned based on our analyses are transcribed with un

40 nt including added sources of research data, redesigned BioAssay record page, new BioAssay classifica

41 needs, we present BiGG Models, a completely redesigned Biochemical, Genetic and Genomic knowledge ba

42 uch as enzyme mechanistic studies and enzyme redesign by mutagenesis, are discussed.

43 The purification of biotinylated nuclei was redesigned by replacing the outer nuclear-envelope-targe

44 Sequence redesign calculations recovered native bases at 65% of r

45 Such redesigning can be performed by small molecular changes

46 lemedicine tools and new care models, we can redesign chronic disease management to include fewer in-

47 lling to collect it, analyse its meaning and redesign clinical practice and services to improve perfo

48 There is also increasing interest in redesigning clinical care to improve patient education,

49 at risk of stressful claims experiences and redesigning compensation processes to reduce their stres

50 g more elaborate computational approaches to redesign complex enzymes to catalyze the Kemp eliminatio

51 An X-ray crystal structure of the redesigned complex closely matches the computational mod

52 Our redesigned compounds possess a significantly focused act

53 l and antigenic analyses of two distinct HR1 redesigns confirm that redesigned Env closely mimics the

54 te interest in surgical trials by offering a redesigned cooperative framework that builds on a core o

55 lycans were posttranslationally added to the redesigned cores.

56 The main redesign criteria were to reduce the number of rotatable

57 The redesigned data model supports arbitrarily large, N-dime

58 linical information systems, delivery system redesign, decision support, organizational support, and

59 At room temperature, the redesigned devices require nearly two orders of magnitud

60 ts opportunities for a generalizable process redesign, differences in the criticality and nature of f

61 piece domains for operator recognition and a redesigned dimer interface to create a heterodimeric rep

62 ciplinary HCV Innovation Teams, whose system redesign efforts have produced innovative HCV practice m

63 might represent appropriate targets for care redesign efforts.

64 s of two distinct HR1 redesigns confirm that redesigned Env closely mimics the native, prefusion trim

65 The redesigned enzyme is 100-fold more active on ammelide an

66 Computationally redesigned enzymes that achieve new specificities on the

67 exclusively on DNA determinants, leading to redesigned enzymes that remained highly specific and dir

68 Here we computationally redesign essential enzymes in the first organism possess

69 lico predictions of assay success, and assay redesign exhibits improved coverage uniformity relative

70 eceptor, it may be possible to strategically redesign existing drugs and win the race against mutatio

71 easingly makes it possible to experimentally redesign existing pathways and implement de novo ones in

72 Recently, we redesigned ferric hydroxamate uptake component A (FhuA),

73 Various redesigned FhuA proteins were investigated, including si

74 We redesigned five segments of the Fab gene with a "codon h

75 ents undergoing total joint replacement were redesigned following the VA-TAMMCS model--the VA's offic

76 Work flow redesign for clinical effectiveness: multidisciplinary t

77 surgical outcomes is predicated on workflow redesign for dynamic risk stratification, coupled with "

78 h for cargo loading that avoids nanoparticle redesign for each individual application.

79 nd determined whether this iterative process redesign for surgery will be adaptable to disparate hosp

80 Middleware is redesigned for improved performance by using a hybrid of

81 t our approach using existing Gibbs samplers redesigned for parallel hardware.

82 ing and reporting interfaces, was completely redesigned for the IEDB 2.0 release, which became public

83 The forward primer and fusion probe were redesigned from the 2008 cormorant isolate sequence, and

84 arches, data sets and genome browser tracks; redesigned gene pages; effective integration of alternat

85 These findings point to the need of redesigning healthcare services to account for these ine

86 a chromophore inside the protein cavity, we redesigned human cellular retinol binding protein II (hC

87 c efficiencies that match the most-efficient redesigned hydrolases based on natural protein scaffolds

88 rant on the project, but you may face costly redesigns if you want to improve the system later.

89 LIS has been redesigned in the last three years both to better integr

90 Furthermore, the output format has been redesigned, in part, to facilitate comparison of multipl

91 nd highlight the new features in the website redesign, including new browse/search options, plasmid a

92 d utilize a synthetic biological approach to redesign inositol phosphate signaling pathways.

93 veloping evidence-based team guidelines, and redesigning inpatient care processes.

94 The redesigned interface allows researchers direct access to

95 (ET) within a protein-protein complex with a redesigned interface formed by physiological partner pro

96 A completely redesigned interface improves access for casual and powe

97 The completely redesigned interface, more intuitive and more integrativ

98 Such redesign is of great interest for diagnostic application

99 The program redesigned its incentive structure in 2006 to also rewar

100 In our redesign, LB [V(Ru(2+)X)2] was synthesized and treated w

101 The redesigned lens demonstrates operation with high directi

102 Redesigning lignin, the aromatic polymer fortifying plan

103 An integrative, modular redesign may help.

104 l design approach, Metal Templated Interface Redesign (MeTIR), that mimics the time course of a hypot

105 his restriction may have to be considered in redesigning minimal MPER immunogens aimed at exclusively

106 e experimental results demonstrated that the redesigned MM probes could yield more consistent hybridi

107 lity for computer-based protein engineering: redesigned models and redesigned X-ray structures exhibi

108 Redesign/modification of previous N3S tetradentate ligan

109 o create a shared vision for the health care redesign needed to more effectively care for our populat

110 otein decreases the abundance of RNAs in its redesigned network.

111 system of today, efforts are now underway to redesign nutrition delivery so as to provide the contemp

112 Here we report the redesign of a current state-of-the-art soluble Env mimic

113 rts and represent the first complete, global redesign of a genetic circuit of such widespread importa

114 study provides an approach for the rational redesign of a given pharmaceutical (Propranolol as an ex

115 These findings will guide the redesign of a probe set to optimize an openly available

116 A regions, an important finding for rational redesign of aptamers and their incorporation into sensin

117 ring the assembly process, and a significant redesign of assembly steps that enables multi-threaded e

118 The redesign of azamacrocyclic CXCR4 chemokine receptor anta

119 strategies demonstrated in this article, the redesign of beta-sheets to contain a global, or local, p

120 The redesign of biological nanopores is focused on bacterial

121 proaches from engineering and computation to redesign of biology, with goals such as generating new c

122 al structure, and by structural model-guided redesign of channelrhodopsins for altered ion selectivit

123 g the potential for the rational and focused redesign of cleavage specificity in MMPs.

124 clinical trials and tissue procurement; and redesign of clinical trials in metastatic breast cancer.

125 This in turn allowed mutational redesign of disassembly and testing in both bacterial an

126 lly-guided approach that can enable both the redesign of endogenous promoter sequences and the de nov

127 gy for catalysis has direct relevance to the redesign of endonucleases to cleave genomic target sites

128 tal structures permit the identification and redesign of Env elements involved in trimer stability.

129 The redesign of enzyme active sites to alter their function

130 k illustrates the power of Rosetta for major redesign of enzyme specificity and introduces a tool for

131 esign of new pharmaceutical molecules or the redesign of existing pharmaceutical molecules that prese

132 olic and membrane contaminants, as well as a redesign of existing RhoA and Rho GEF activity assays so

133 The redesign of FluoRender not only maintains the existing m

134 ts, predicts function, guides the mutational redesign of functional and allosteric specificity, and i

135 ased efficiency of business practices and/or redesign of fund flows may be necessary to sustain recru

136 ganizations have advocated for comprehensive redesign of graduate medical training, but the effect th

137 These insights allow the redesign of hairpin polyamides with different turn units

138 rase-mediated site-specific recombination by redesign of higher-order protein-DNA architectures.

139 Redesign of hospital care delivery model: patient cohort

140 use of time and technology, but involves the redesign of how in person time between faculty and resid

141 sed algorithms, SEQUEST, through a wholesale redesign of its processing architecture.

142 o-inspired light-harvesting antennas and the redesign of natural photosynthetic systems.

143 erally applied to specificity prediction and redesign of other protein-protein interfaces that have s

144 re will require an integrated, systems level redesign of our socio-ecological regime focused explicit

145 bl since our previous report include a major redesign of our website; generation of multiple genome a

146 United States because of new legislation and redesign of payments from the Centers for Medicare and M

147 B, new opportunities emerge for the rational redesign of plant Phys with novel photochemistries and s

148 technical improvements that we propose, the redesign of pMHCT-2 will give us the tools to evaluate t

149 The strategy combines redesign of protein-protein interaction specificity with

150 nd are an attractive target for the rational redesign of proteins.

151 ropriate mutations paves the way to targeted redesign of signaling pathways to achieve desired functi

152 ns, provides evidence for extensive adaptive redesign of snake metabolic pathways.

153 ized for thermodynamic stability by rational redesign of surface charge-charge interactions is charac

154 utations remains sparse, limiting the design/redesign of synthetic catalysts in a predictable way.

155 , which will provide the opportunity for the redesign of systems to enhance patient safety.

156 low-nanomolar binding affinity by in silico redesign of the CDRH3 sequences.

157 A modeling study and redesign of the core scaffold led to the stereoselective

158 arning healthcare system requires systematic redesign of the current healthcare system, focusing on 4

159 gies to stimulate and seed this evolutionary redesign of the current socio-ecological regime to achie

160 payers are in a better position to guide the redesign of the health care delivery system than governm

161 We report herein a critical redesign of the HPD chemotype featuring an additional wi

162 mbination with the other strategies based on redesign of the interactions in the protein core.

163 eta-barrel membrane proteins to the complete redesign of the lipid-facing surface of Escherichia coli

164 These transpositions enable rapid redesign of the main aromatic skeleton to generate good

165 in the first and second cases, extension and redesign of the N-terminus were used to expand the hydro

166 This article describes the recent redesign of the NDB Web site with special emphasis on ne

167 of unknown function, and facilitate rational redesign of the NTR scaffold.

168 We report a computational, structure-based redesign of the phenylalanine adenylation domain of the

169 The redesign of the previously reported thiophene-3-yl-methy

170 e energy values for compounds and reactions; redesign of the primary gene/protein page; addition of a

171 micromolar concentrations, and an empirical redesign of the protein exterior produced a stable monom

172 omprehensive dataset in the IEDB, a complete redesign of the query and reporting interface has been p

173 Recent changes to PATRIC include a redesign of the web interface and some new services that

174 es against multiple sequence alignments; the redesign of the web pages and download site.

175 ersible peptide-peptide interaction, through redesign of this domain and genetic dissection into thre

176 We pioneered the redesign of this targeting ligand by altering the ligand

177 To meet these demands, a redesign of translational approaches is urgently needed.

178 cumented as instrumental in the designing or redesigning of macrocyclic frames, particularly in the s

179 Various enzyme redesigns of the active sites indicate that the degree a

180 lturally important processes, their rational redesign offers great promise toward accelerating crop i

181 ple Fe(II) am(m)ines how LFMM can be used to redesign "old" systems to generate novel, potential SCO

182 port quantitative fitness measurements in 27 redesigned operons that suggested that protein productio

183 modifications to our production pipeline and redesigned our website with improved gene tree visualiza

184 the size of our database, we have continued redesigning our website http://www.genenames.org and hav

185 d in 3 phases: hospital-based inpatient care redesign, outpatient-based care enhancements, and commun

186 We redesigned parts of the original Balding algorithm to im

187 Unless significantly redesigned, pay-for-performance may not be a successful

188 The redesigned peptide possessed a 4.5-fold improvement in p

189 ultidisciplinary collaboration among systems redesign personnel, clinicians, and surgical staff to re

190 After 5 multicenter design-test-evaluate-redesign phases with a total of 319 BCP-ALL patients at

191 ng-term potential for both interrogating and redesigning phosphorylation dependent signaling pathways

192 te the entire ImageJ codebase, engineering a redesigned plugin mechanism intended to facilitate exten

193 An improved multiplex PCR, using redesigned primers targeting the serovar 3 capsule locus

194 ion EHV-1 rPCR assay (E(1)) was developed by redesigning primers and probes specific to ORF30.

195 The Joint Replacement Program system redesign project was initiated following the Vision-Anal

196 The redesigned protein decreases the abundance of RNAs in it

197 formed to probe the folding mechanism of the redesigned protein revealed a conserved mechanism involv

198 only against the BH3 region of Bim, the best redesigned protein was globally specific against binding

199 In particular redesigning protein surfaces to bind to unrelated recept

200 Redesigned proteins could be used as research tools, dia

201 However, many de novo and redesigned proteins exhibit poor hydrophobic packing in

202 The redesigned proteins harbor mutations at up to 53 residue

203 very long molecular dynamics simulations in redesigning proteins well beyond their evolved stability

204 g key signatures of toxicity can also aid in redesigning proteins, so as to maintain their desirable

205 The website was redesigned providing new query options.

206 Based on this architecture, we redesign Puf2p to bind UAAG and identify the targets of

207 ET) algorithm previously proved effective in redesigning receptors to mimic the ligand specificities

208 The redesigned rrnDB brings a substantial increase in the nu

209 e a computational protocol, called DDMI, for redesigning scaffold proteins to bind to a specified reg

210 clear Magnetic Resonance-derived structures, redesigned search and browse interfaces, and new or upda

211 in particular, our heavily used and recently redesigned search tool QuickSearch, found on the FlyBase

212 Testing the impact of the individual redesigned segments revealed that the most significant e

213 Here, we show completely redesigned selenium devices with improved back and front

214 A second SIRPalpha Syk-iSNAP with redesigned sensor and activator modules can likewise rew

215 This redesign serves as a model for improving our understandi

216 The surgery service and systems redesign service held a value stream analysis in FY 2013

217 ettings and include care standardization and redesign, shared decision making, palliative care, care

218 A redesigned SNP reference panel with additional functiona

219 lt, a number of monitoring programs may need redesigning, some sampling and analytical procedures may

220 e inhibitors of ataxin-3 expression and then redesign ss-siRNAs to optimize their selectivity.

221 our-helix bundle protein Rd-apocyt b(562), a redesigned stable variant of apocytochrome b(562), exhib

222 supportive Brownian Dynamics (BD) interface redesign strategies, one a new "heme-filtering" approach

223 An electrostatic interface redesign strategy has led to the introduction of positiv

224 lights the benefit of a mechanism-based drug redesign strategy that can maximize the translational va

225 Using the redesigned subtype B and C trimer representatives as res

226 escribe an effective strategy to extensively redesign such an extensive biomolecular interface.

227 When modelling or redesigning such systems, functional subsystems are ofte

228 " of biocatalysts opens new opportunities to redesign synthetic strategies to target molecules by inc

229 nce for Academic Internal Medicine Education Redesign Task Force II does not favor reducing internal

230 nce for Academic Internal Medicine Education Redesign Task Force II examines the advantages and chall

231 to the methodology for computational enzyme redesign that are experimentally shown to result in sign

232 are examined, prompting recommendations for redesign that would facilitate future reuse.

233 used the Rosetta Molecular Modeling Suite to redesign the active site of the acid-active gliadin endo

234 tween structure and sequence optimization to redesign the C-terminal portion of the RGS14 GoLoco moti

235 n this large class of enzymes and completely redesign the mechanism of allosteric transduction leadin

236 Here we redesign the molecule in such a way that its anti-tumor

237 ibraries to engineer a more stable NEDD8 and redesign the NEDD8-NAE interface.

238 use they provide a wide researching space to redesign the textured structures.

239 e investigators a second chance to modify or redesign the trial while the study is still ongoing.

240 In next-generation (NG) Capture-C, we have redesigned the Capture-C method to achieve unprecedented

241 We redesigned the DAP synthetic pathway to generate L,L-NSD

242 We have also redesigned the HUGO Gene Nomenclature Committee website

243 To experimentally test the DDMI protocol, we redesigned the human hyperplastic discs protein to bind

244 ing a Rosetta fixed backbone design, we have redesigned the subtilisin BPN' propeptide structure to g

245 y (NTRL) and National TB and Leprosy Program redesigned the tuberculosis specimen transport network a

246 ddition to an update of the data content, we redesigned the website interface to improve both user ex

247 numerous different target enzymes by simply redesigning the overhang sequence of detection probe, wh

248 When applied to redesigning the provider-based, influenza-like-illness s

249 nucleic acid mimics provide opportunity for redesigning the specificity and affinity of hybridizatio

250 We set the task of redesigning the surface of Mb so that its reaction with

251 We show that in nearly all of our redesigns the sequence found by the continuous-rotamer m

252 gnaling and provide an essential scaffold to redesign their activities for agricultural benefit and a

253 These new discoveries outline the need to redesign therapeutic strategies to target this underappr

254 e to recipients, and the organisation should redesign this system to explicitly link a portion of the

255 In particular, we redesign three singular omnidirectional devices: the Eat

256 t (QI), namely behavioral change and systems redesign to improve patient outcomes.

257 Austerity measures and health-system redesign to minimise hospital expenditures risk adversel

258 tion genetics with applications from protein redesign to the clinical assessment of human genetic var

259 mplex multilocus sequence typing scheme were redesigned to (i) more reliably amplify these loci from

260 ity of the rrnDB, the search engine has been redesigned to allow database searches based on 16S rRNA

261 The server's webpage is now redesigned to allow users easier access to data for diff

262 randomization of 34 patients, the trial was redesigned to also include patients who had stable COPD

263 ain, and in the third case, the termini were redesigned to be adjacent in space so that the domain co

264 The enzyme has been redesigned to catalyse the oxidation of non-natural subs

265 Its introduction pages have been redesigned to enable the user to easily navigate between

266 itions in the soil, the root architecture is redesigned to generate numerous lateral roots (LRs) that

267 The METLIN Exposome database has been redesigned to help identify environmental toxicants, foo

268 The website is redesigned to improve accessibility and ease of use, inc

269 A THPI selective for MMP-2 and MMP-9 was redesigned to incorporate non-native amino acids (Flp an

270 e and analysis tool set have been completely redesigned to increase speed, flexibility and user frien

271 otein Data Bank (RCSB PDB) web site has been redesigned to increase usability and to cater to a large

272 Finally, the entire web site has been redesigned to make it substantially easier to use for ex

273 ture of NV protease with the C-terminal tail redesigned to mimic P4 to P1 of another substrate site p

274 Decitabine regimens can be redesigned to minimize cytotoxicity and increase exposur

275 ce of an antigen outside a target epitope is redesigned to obtain variants that maintain only the tar

276 to a different antigen, were computationally redesigned to predict antibodies that could engage multi

277 nation: the web frontend has been completely redesigned to reduce dependency on outdated browser tech

278 regulatory proteins, but few aTFs have been redesigned to respond to new effectors beyond natural aT

279 This public version has been redesigned to run in a wide range of parallel Linux comp

280 The website has been significantly redesigned to take advantage of current web technologies

281 In addition, its interface has been redesigned to take advantage of flexible web services, p

282 analogue Gal-B2 (or NAX 5055) was rationally redesigned to yield GalR2-preferring analogues.

283 o adaptive, permitting them to be instantly "redesigned" to respond to individual storms and evolving

284 mical studies was achieved by expressing the redesigned Urzyme as a maltose-binding protein fusion.

285 New features include a completely redesigned user interface with an interactive tutorial a

286 arget a genomic region; that protein is then redesigned using iterative rounds of in vitro selections

287 best energy conformations in 69 protein-core redesigns using a rigid-rotamer model versus a continuou

288 We describe a new, substantially redesigned version of our tool Metscape that allows user

289 l design approach (Metal-Templated Interface Redesign), we describe the transformation of a monomeric

290 clusion of siRNA interactions we introduce a redesigned web interface to enhance viewing, filtering a

291 , as a web-service, and through a completely redesigned web interface.

292 A redesigned, weekly phase I/II study established an MTD o

293 ical training, but the effect that residency redesign will have on measures of patient satisfaction,

294 The web interface has been improved/redesigned with a quick search option to rapidly extract

295 The microelectrodes were redesigned with compact size, fabricated using an improv

296 (-) side do so by modulating K(M)*, whereas redesigns with altered specificities on the (+) side mod

297 Much of the design/redesign work on overcoming this resistance has been foc

298 d protein engineering: redesigned models and redesigned X-ray structures exhibit very similar native

299 , D(2)-symmetrical tetramer are subsequently redesigned, yielding unique protein architectures that s

300 provides new drug targets and guidelines to redesign Zn-ejecting compounds with improved specificity