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1 se findings were corroborated by experiments redirecting a signal-peptide-containing FGF family membe
4 compounds, EGCG, resveratrol, and curcumin, redirect Abeta(17-36) from a fibrillar aggregate to an u
5 Most importantly, it was found that brazilin redirected Abeta42 monomers and its mature fibrils into
9 that intracellular antiviral immunity can be redirected against host-origin endopathogens involved in
10 study the phenotype and function of T cells redirected against the murine double minute protein 2 (M
11 dvantage of the dynamic nature of the MSC to redirect and coopt cellular translation factors to enhan
12 tentially serving as an early metric to help redirect and optimize therapy in this clinical setting.
13 fluorescein isothiocyanate (folate-FITC) can redirect and regulate FITC-specific CAR-T cell activity
14 eceptors (CARs) are synthetic receptors that redirect and reprogram T cells to mediate tumour rejecti
15 s affect wind dynamics and seed dispersal by redirecting and bellowing airflow and by increasing the
17 will inhibit the non-amyloidogenic pathway, redirecting APP to be cleaved by beta-secretase, leading
19 chanisms by which prostate cancer (PC) cells redirect AR signaling to genes that primarily support gr
20 Together, these results demonstrate that ERG redirects AR to a set of genes including SOX9 that are n
23 idden in America's drinking water supply and redirect attention to ensure safe water among affected h
24 le CD40L multimers to T cell/B cell cultures redirects B cell differentiation toward plasma cells, in
25 Drug Administration for brain aneurysms that redirects blood flow away from the aneurysm, thereby pro
26 (but not of the corresponding SEC24D mutant) redirected both endogenous SERT and heterologously expre
27 emphasize the potential of combining T-cell-redirecting bsAbs with antagonists or agonists that miti
28 us Vangl2 in the neuroectoderm was similarly redirected by an ectopic Wnt source and disrupted after
30 se integration activity could be rescued and redirected by fusion to a site-specific DNA-binding doma
32 ells could be more effectively activated and redirected by oncolytic adenoviruses that were armed wit
37 h switch formats can be readily optimized to redirect CAR-T cells (specific for the corresponding FIT
38 tion in patients with AML treated with CD123-redirected CAR T cells and mandates novel approaches for
42 itches capable of throttling and selectively redirecting carbon flux in Escherichia coli We anticipat
46 of a high-affinity Gag293-specific TCR also redirected CD8+ T cells to target HIV-1 capsid via nonco
47 phase III clinical trials, substituted for Y-redirected cells and enabled tumor debulking by tumor-re
48 teract cellular innate immune mechanisms and redirect cellular processes toward viral replication.
49 precision-medicine therapies to "rewire" or redirect cellular transitions at an early stage, such as
51 y to manipulate light-matter interactions to redirect chemical or spectroscopic outcomes through the
52 ported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in pr
53 roduct from human herpesvirus 7 binds to and redirects class I major histocompatibility complex (MHC)
54 noncytotoxic mechanism, the NS3-specific TCR-redirected CTLs were polyfunctional and inhibited HCV RN
56 develop innovative strategies to recruit and redirect cytotoxic effector cells to eliminate the HIV-1
57 form of chemically programmed biAbs aimed at redirecting cytotoxic T cells to eliminate cancer cells.
58 tunity to treat these patients with leukemia-redirected donor-derived T cells, which may be more func
59 gged DRs impaired DR expansion but failed to redirect DRs from biliary differentiation toward the hep
60 nd of gradual climate warming trends and can redirect ecosystem change along routes that are difficul
63 tamaterials have been proposed to reflect or redirect elastic waves at different length scales, rangi
66 nin (CCK)-8-stimulated apical exocytosis and redirects exocytosis to the basolateral plasma membrane,
67 nduction of adaptive programs, including the redirected expression of gene networks toward the synthe
69 gamma, required for basolateral trafficking, redirects FGF from T-tubules to surface, increasing trac
70 lent polymer-peptide conjugates (mPPCs) that redirect fibrillar assembly of Abeta to form discrete na
72 cer, thereby slowing acyl-ACP elongation and redirecting flux from phospholipid synthesis to MCFA pro
73 Further work is needed to determine whether redirecting flux into these pathways can effectively enh
74 us, and acute T cell-mediated rejection have redirected focus on long-term allograft structural integ
75 In adult erythroid cells, the LCR can be redirected from the adult beta- to the fetal gamma-globi
76 o certain cellular stimuli, but how LysRS is redirected from the MSC to viral particles for packaging
77 his study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways
79 where to look and can be invoked to rapidly redirect gaze in a context and task-appropriate manner.
80 to inhibit the initially planned saccade and redirect gaze toward the new location (redirect trial).
81 our module to identify the optimal point to redirect glycolytic flux into heterologous engineered pa
83 ing a drug-controlled polymerization domain, redirected GPP130 to lysosomes in the absence of Mn.
84 aching implications for marine ecosystems by redirecting grazing pressure and facilitating the format
92 nt AC133xCD3 bispecific antibody (bsAb) that redirects human polyclonal T cells to AC133(+) GBM stem
94 Fus3 and human MAPK ERK2 can be functionally redirected if only two conditions are met: the kinase an
95 4(gag) plasmid DNA (pDNA) vaccine is able to redirect immunodominant responses to otherwise subdomina
97 w that broadband light can be controlled and redirected in a volume of >10(5)lambda x 10(5)lambda x 1
98 ucing modulatory cytokines from innate cells redirects in vitro and in vivo pathogenic TH2 responses
99 erated therapy achieves tumor specificity by redirecting inflammation to a functional target fundamen
100 ng factor for the insulin receptor (IR) that redirects internalized receptor molecules from endosomes
102 ites, PVM-associated LC3 becomes immediately redirected into the TVN, where it accumulates distally f
103 A and AlsSD counters the effects of CidBC by redirecting intracellular carbon flux towards acetoin fo
106 D away from canonical MEF2 binding sites and redirects it to retina-specific enhancers that lack the
109 onarily conserved mechanism whereby the cell redirects its energy from maintaining its translational
110 o expansion of the stem cell compartment and redirects keratinocytes in the interfollicular epidermis
111 Indeed, the BsAbs were able to efficiently redirect killing of HLA-DR(+) leukemic cells by human CD
112 NK cell polyfunctionality in both direct and redirected killing assays with anti-NKp30 Abs (p = 0.009
115 ke some cell-penetrating peptides in that it redirected ligand-bound PDGF receptor (PDGFR) from the c
116 determine the mechanisms by which root cells redirect lipid biosynthesis during AMS we analyzed the r
117 the tumor site, where in synergy with tumor-redirected lymphocytes, they instructed TNFalpha express
120 ch points present favorable gene targets for redirecting metabolic flux toward specific secondary met
122 metabolic milieu during the perinatal period redirect mitochondrial substrate preference from carbohy
123 geting CD19 were tested for their ability to redirect mouse T cell function against established B cel
124 Differences in muscle stretch responses for redirected movements were observed ~75 ms after perturba
125 ctive infection, a virus must simultaneously redirect multiple cellular pathways to replicate itself
127 ENT Targeted muscle reinnervation surgically redirects nerves that lost their target in the amputatio
128 CARs) in NK cells is a promising strategy to redirect NK cells to otherwise NK cell-resistant tumor c
131 ed with host development can be exploited to redirect novel AAV vectors to specific cell types in the
132 Step 2 is a switch-of-function mutation that redirects NtrC away from nitrogen uptake and toward its
133 of primed pluripotency-associated genes, and redirect Oct4 to previously inaccessible enhancer sites.
135 on of N-terminal interactions is a switch in redirecting of amyloids form the neurotoxic aggregation
136 itiate pedagogical episodes, and monitor and redirect ongoing instruction is critical to understandin
137 n demand of isoprene biosynthesis, NE plants redirected only approximately 0.5% of this saved carbon
138 lures and the message this is providing, and redirect our approaches likely with a paradigm shift in
140 that increases the excitation efficiency and redirects part of the laterally-emitted fluorescent ligh
143 introducing the cosmid St4A10lsp, as part of ReDirect PCR mutagenesis protocol, which transiently dup
144 ralized strategy among marine cyanophages to redirect photosynthesis to support phage development, wh
145 gineered to express synthetic receptors that redirect polyclonal T cells to surface antigens for subs
149 al of the local electrostatic potential then redirects prothrombinase toward Arg-320, leading to thro
151 rafficking by cleaving RILP, which serves to redirect Rab7-containing vesicles to a kinesin-dependent
152 ur results expand on potential strategies to redirect recombinant AAV vectors toward more productive
153 After cross-linking, via a bispecific Ab, redirected regulatory T cells upregulate the activation
156 s my responsibility as a program director to redirect residents who should not be surgeons." The over
158 ver, disrupting starch biosynthesis does not redirect resources to other bioproducts (lipids or prote
159 to heading deviations and uses optic flow to redirect self-movement toward the intended destination.
162 tion of Crk at Y221 is not an off switch but redirects signaling from the SH2-SH3N axis to a phosphoS
163 ng to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent p
164 utilization of the entire solar spectrum by redirecting solar photons to maximize FEW production fro
165 ere we ask whether and how motor control and redirected somatosensory stimulation provided via TMSR a
168 ogenitors, but not in committed osteoblasts, redirects SSC fate decisions from osteogenesis to adipo-
171 rom antibodies to CD3 and CD123, designed to redirect T cells against acute myeloid leukemia blasts.
174 thetic chimeric antigen receptors (CARs) can redirect T cells to recognize and eliminate tumor cells
176 ric antigen receptors (CARs) can effectively redirect T lymphocytes to eradicate lymphoid malignancie
177 vely short period of time, the technology to redirect T-cell function has moved at pace facilitating
178 CD123(dim) populations, and that human CD123-redirected T cells (CART123) eradicate primary AML in im
180 alignancies infused with autologous CAR.CD19-redirected T cells expanded ex vivo using IL-2, and foun
181 ing mRNA electroporation to engineer HBV TCR-redirected T cells in patients with chronic HBV infectio
184 efficacy of chimeric antigen receptor (CAR)-redirected T cells remains marginal in solid tumors comp
185 tive on how expanding the use of genetically redirected T cells to treat the majority of patients wit
186 ents treated on clinical trials of anti-CD19 redirected T cells, and preliminary results on many more
188 transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less stri
191 Among different forms of immunotherapy, redirecting T cells to hematological malignancies with b
192 l immunology and have clinical relevance for redirecting T cells to target virally infected hepatoma
195 BiFab-BCMA), which potently and specifically redirects T cells to lyse malignant multiple myeloma cel
196 stimulates CD8 T-cell effector function and redirects T cells to lyse these previously latent-infect
197 a version of the double-step task called the redirect task, in which monkeys were trained to modify a
198 s isolated from omental fat and lung did not redirect testicular cells to a MEC fate, indicating the
199 from adult mice and rats were sufficient to redirect testicular derived cells to produce normal mamm
200 tly, orthogonal induction of Irf4 expression redirected Tfh cell fate trajectories toward those of Te
202 types of receptor systems have been used to redirect the activity of T cells, normal heterodimeric T
203 gallate (EGCG) has previously been shown to redirect the aggregation of alphaSN monomers and remodel
204 t different chaperones could be exploited to redirect the amyloid-elicited immunity both for basic st
205 requires Laminin1, and ectopic Laminin1 can redirect the apicobasal orientation of eye field cells.
210 results will help guide therapies that will redirect the gut microbiome towards a healthy state and
211 Vpx that bind the SAMHD1 N or C terminus and redirect the host cullin-4 ubiquitin ligase to target SA
215 with a specific inhibitor could effectively redirect the mating differentiation, confirming the caus
216 tain substitutions on the 2-indolyl position redirect the mode of cytotoxicity from methuosis to micr
217 suggests that tumor vascular remodeling may redirect the organism-wide signaling activity of tumor-d
218 ession of tumors depends on their ability to redirect the polarization state of tumor-associated macr
220 nslatable synthetic fusion proteins that can redirect the specificity of T cells toward designated an
222 nversely, immunotherapy and chemotherapy may redirect the tumor microenvironment and allow the activa
223 try, combined with very low CCR5 levels, may redirect the virus to different cell targets in natural
224 mated in WinSAAM software.VA supplementation redirected the flow of CM-REs from peripheral to central
225 Participants initiated straight reaches and redirected the hand toward a target presented in midflig
226 atment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells.
227 genus may share the same Achilles' heel, we redirected the scheme to see whether similar assays coul
229 on the laser irradiation wavelength, thereby redirecting the ablation process through photochemical o
230 mics to aid push-off late in single support, redirecting the body's center-of-mass (COM) motion upwar
235 folded prion proteins (PrP(Sc)) replicate by redirecting the folding of the cellular prion glycoprote
237 Here, we summarize rapid progress made in redirecting the nuclease activities of these microbial i
238 ologic intervention in tuberculosis involves redirecting the outcome of the host immune response from
239 pathways are both central to this phenomenon redirecting the P. aeruginosa population toward a biofil
241 e histone tail domains with nucleosomal DNA, redirecting the tails to more interior positions within
243 ven by the RNAi response to the virus, which redirects the Argonaute protein RDE-1 from its endogenou
244 reduces vindoline accumulation in leaves and redirects the biosynthetic flux toward the production of
249 IFN-I signaling during persistent infection redirects the immune environment to enable control of in
250 not interact directly with ErmBL, but rather redirects the path of the peptide within the tunnel.
251 s' pi*-orbitals makes reductions easier, but redirects the protonation and reduction to sites that po
253 ered G protein-coupled receptor allows us to redirect their migration to a bioinert drug-like small m
254 express chimeric antigen receptors (CARs) to redirect their specificity to target tumor-associated an
255 its receptor on non-professional phagocytes redirected their phagocytosis, such that uptake of large
256 positioned in the inner retina before birth, redirecting their dendrites into the inner plexiform lay
258 motility of breast cancer cells, but simply redirects their migration to produce largely one-dimensi
259 primed vesicles from fusing prematurely, and redirecting them to refill the readily releasable pool a
262 ing events, suggesting that existing PEN3 is redirected through an unknown trafficking pathway to sit
263 ase domains are modular payloads that can be redirected through different import pathways when fused
264 by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p
266 ansporter (Protective antigen, PA) which was redirected to Epidermal Growth Factor Receptors (EGFR) o
268 his miR-122 "sponge" effect was relieved and redirected to miR-15 targets by swapping the miRNA tropi
269 ected to the closest target could be quickly redirected to other potential targets after a perturbati
271 e spinal segment whose axons were surgically redirected to remnant muscles (targeted muscle reinnerva
274 4 expression upon positive selection and are redirected to the CD8 lineage after MHC class II-restric
275 erminal fragment, the C-terminal fragment is redirected to the cell surface, where it is functionally
276 cal rivers, DSi in groundwater and runoff is redirected to the combined stormwater-sewage overflow sy
277 2-oxoglutarate aminotransferase pathways and redirected to the de novo synthesis of nitrogen assimila
279 order to sustain rapid proliferation but are redirected to triacylglycerol (TAG) stored in lipid drop
280 can no longer be used for cell division are redirected toward carbohydrates and triacylglycerols (TA
281 lular matrix; however, new interest has been redirected toward deciphering and understanding the enig
282 ally destined for growth and development are redirected toward elevated accumulation of specialized m
284 e nuclear membrane, but lipid precursors are redirected toward phospholipids, resulting in nuclear de
285 presenting the highest sum/mean before being redirected toward the choice representing the maximal re
286 ooling process in which the excess energy is redirected toward the retinal surrounding, e.g., the pro
289 r initiation, the translational apparatus is redirected towards unconventional upstream initiation si
290 ivities in TLR3 signaling and that LL-37 can redirect trafficking of poly(I:C) to effect signaling by
292 med -1 ribosomal frameshift (-1 PRF) signals redirect translating ribosomes to slip back one base on
298 eratrol nullifies the catalytic activity and redirects TyrRS to a nuclear function, stimulating NAD(+
300 ith established tumors, TH17 cells that were redirected with ICOS-based CARs mediated efficient antit
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