ライフサイエンスコーパス: reduced folate carrier

1 FPGS) but not intracellular transport by the reduced folate carrier.

2 nsport and how they differ from those of the reduced folate carrier.

3 -localized genes, carbonyl reductase and the reduced folate carrier.

4 ructure-function relationships of the murine reduced folate carrier 1 (RFC1), a glutamate to lysine m

5 methylenetetrahydrofolate reductase (MTHFR), reduced folate carrier 1 (RFC1), and glutamate carboxype

6 genes, folate binding protein 1 (Folbp1) and reduced folate carrier 1 (RFC1), on folate homeostasis t

7 uctase gene and the A80C polymorphism of the reduced folate carrier 1 gene were not statistically sig

8 ences due to homology with SLC19A1, encoding reduced folate carrier 1.

9 cused on a gene involved in folate transport-reduced folate carrier-1 gene (RFC1).

10 is a novel antifolate with high affinity for reduced folate carrier-1.

11 ity pattern quite different from that of the reduced folate carrier and folate receptors.

12 effectively transported into the cell by the reduced folate carrier and intracellularly sequestered b

13 gh affinity and specificity for folates, the reduced folate carrier and the folate receptors.

14 By transiently expressing PCFT in reduced folate carrier- and PCFT-null HeLa (R1-11) cells

15 and requires transport into the cell by the reduced folate carrier but, unlike 1, is independent of

16 quires polyglutamation and transport via the reduced folate carrier for cytotoxic potency.

17 tion or translation of the recently isolated reduced folate carrier gene (RFC1) was the cause of MTX

18 orter encoded by the newly discovered RFC-1 (reduced-folate carrier) gene.

19 The human reduced folate carrier (hRFC) facilitates membrane trans

20 promoters (designated A and B) for the human reduced folate carrier (hRFC) gene that result in hRFC t

21 eported an intricate regulation of the human reduced folate carrier (hRFC) gene, involving multiple p

22 hip between loss of functional p53 and human reduced folate carrier (hRFC) levels and function was ex

23 The human reduced folate carrier (hRFC) mediates the membrane tran

24 in the protein and mRNA levels of the human reduced-folate carrier (hRFC) and a decrease in the acti

25 pha and beta over the ubiquitously expressed reduced folate carrier is a paradigm for selective tumor

26 stream structure and regulation of the mouse reduced folate carrier (mRFC) gene was characterized.

27 on phase, when antifolates predominated, the reduced folate carrier polymorphism predicted gastrointe

28 ve documented the roles of transport via the reduced folate carrier, retention via polyglutamylation,

29 ine hydroxymethyltransferase (SHMT1 C1420T); reduced folate carrier (RFC G80A); and methionine syntha

30 The reduced folate carrier (RFC) 80A allele and the thymidyl

31 Decreased reduced folate carrier (RFC) activity has been associate

32 The basis for impaired reduced folate carrier (RFC) activity in methotrexate-re

33 ansporter (PCFT) uptake specificity over the reduced folate carrier (RFC) and inhibition of de novo p

34 cells engineered to express PCFT without the reduced folate carrier (RFC) and of HepG2 cells expressi

35 PMX is transported by the reduced folate carrier (RFC) and proton-coupled folate t

36 The reduced folate carrier (RFC) and the proton-coupled fola

37 thylenetetrahydrofolate reductase (MTHFR) or reduced folate carrier (RFC) genetic polymorphisms.

38 Reduced folate carrier (RFC) is the major membrane trans

39 The reduced folate carrier (RFC) is the major transport syst

40 The ubiquitously expressed reduced folate carrier (RFC) is the major transport syst

41 y (CHO) cells that expressed FRs but not the reduced folate carrier (RFC) or proton-coupled folate tr

42 mulation in T-lineage ALL, expression of the reduced folate carrier (RFC) was assessed by reverse tra

43 d transport due to a genomic deletion of the reduced folate carrier (RFC) was only 2-fold resistant t

44 x into CCRF-CEM human leukemia cells via the reduced folate carrier (RFC) were 0.28 and 1.1 muM, resp

45 s for this defect, Northern analyses for the reduced folate carrier (RFC) were performed on the RNA a

46 n-coupled folate transporter (PCFT) over the reduced folate carrier (RFC), 3a was not.

47 OV1 human tumor cells that express FR alpha, reduced folate carrier (RFC), and PCFT.

48 The reduced folate carrier (RFC), proton-coupled folate tran

49 ere found to have two point mutations in the reduced folate carrier (RFC), resulting in a replacement

50 h these compounds are not substrates for the reduced folate carrier (RFC), the major facilitative fol

51 roton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).

52 vary (CHO) and HeLa cells expressing PCFT or reduced folate carrier (RFC).

53 ue distribution and greatest activity is the reduced folate carrier (RFC).

54 vely transported into mammalian cells by the reduced folate carrier (RFC).

55 s via a plasma membrane protein known as the reduced folate carrier (RFC).

56 predicted transmembrane domain of the human reduced folate carrier (RFC).

57 tes and net uptake in cells that express the reduced folate carrier (RFC).

58 Methotrexate (MTX) enters cells through the reduced folate carrier (RFC-1) and exerts part of its ef

59 45 has low affinity for the widely expressed reduced-folate carrier (RFC).

60 kemia cells is mediated by the bidirectional reduced folate carrier (RFC1) and independent unidirecti

61 The reduced folate carrier (RFC1) is an important route by w

62 The reduced folate carrier (RFC1) is an integral membrane pr

63 The reduced folate carrier (RFC1) plays a major role in the

64 In previous reports, an E45K mutation in reduced folate carrier (RFC1) resulted in marked substra

65 iamin transporter encoded by SLC19A2 and the reduced folate carrier (RFC1) share 40% homology at the

66 yed to study the pattern of mutations in the reduced folate carrier (RFC1) that results in transport-

67 roton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort

68 PMT), gamma-glutamyl hydrolase (GGH) and the reduced folate carrier (SLC19A1) to assess the nature of

69 of hTHTR2 with that of hTHTR1 and the human reduced folate carrier (SLC19A1) to underscore commonali

70 found significantly lower expression of the reduced folate carrier (SLC19A1, an MTX uptake transport

71 genes responsible for pemetrexed transport (reduced folate carrier [SLC19A1]) and metabolism (folylp

72 olate designed to have high affinity for the reduced folate carrier type 1 (RFC-1).

73 which cannot be internalized by the cellular reduced folate carrier, with carboxypeptidase A (CPA), w