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1 ygen species and exhibited less depletion of reduced glutathione.
2 l but shows a >100-fold lower k cat/ K m for reduced glutathione.
3 g it to a disulfide reductase that generates reduced glutathione.
4 in the presence of a mixture of oxidized and reduced glutathione.
5 zes the reduction of oxidized glutathione to reduced glutathione.
6 ation was not observed in cells treated with reduced glutathione.
7 neurons to maintain intracellular levels of reduced glutathione.
8 acid, coumaric acid, acetaldehyde, total and reduced glutathione.
9 -reducing agents, such as dithiothreitol and reduced glutathione.
10 and identified by the reaction of UQ(0) with reduced glutathione.
11 nd a marked increase in endogenous levels of reduced glutathione.
12 des, and TGFbeta1, and erythrocyte levels of reduced glutathione.
13 eurons, and MPP(+) failed to alter levels of reduced glutathione.
14 and not simulated by oxidized glutathione or reduced glutathione.
15 eversed by dithiothreitol, ascorbic acid, or reduced glutathione.
16 the oxidized Ng could be reduced by NADPH or reduced glutathione.
17 reduced rapidly by ascorbic acid but not by reduced glutathione.
18 K-edge spectrum is similar to that of fully reduced glutathione.
19 which was also significantly antagonized by reduced glutathione.
20 d that this is correlated with the levels of reduced glutathione.
21 -terminal kinase activation, or depletion of reduced glutathione.
22 ivity against DPPH radicals when compared to reduced glutathione.
23 increase in antioxidants including NADPH and reduced glutathione.
24 d to the increased production of taurine and reduced glutathione.
25 erine treatment with concomitant decrease in reduced glutathione.
26 n reactive oxygen species and a reduction in reduced glutathione.
27 ctaldehyde, which is paralleled by a loss of reduced glutathione.
28 oxidant-induced protein thiyl radicals with reduced glutathione.
29 ered in the presence of physiologic level of reduced glutathione (1 mmol/L), suggesting that selenocy
30 nd, glycine and the higher concentrations of reduced glutathione (1.0 and 2.0%) were able to promote
32 in a 35% decrease in the hepatic content of reduced glutathione 4 days after lipopolysaccharide chal
34 folding of RfBP even in the presence of 5 mM reduced glutathione, a competing ligand for As(III) spec
37 ctivity (complexes I-IV), ATP concentration, reduced glutathione (an intracellular antioxidant) conce
39 inetic constants of approximately 1.4 mM for reduced glutathione and approximately 6.5 microM for APS
41 the use of chemical trapping agents, such as reduced glutathione and cyanide, to form stable adducts
42 tol was unable to compensate for the lack of reduced glutathione and did not promote secretion of per
43 s judged by an elevated ratio of oxidized to reduced glutathione and enhanced oxidative folding in th
45 tion, CD34(+) AML cells have lower levels of reduced glutathione and increased levels of oxidized glu
46 ultures seeded on dicarbonyl-modified FN had reduced glutathione and increased levels of reactive oxy
48 valuate the ability of gallic acid, glycine, reduced glutathione and l-cysteine at 0.1, 0.5, 1.0 and
49 polynitroxyl albumin groups had hippocampal reduced glutathione and manganese superoxide dismutase a
51 hromate exposure depleted cellular levels of reduced glutathione and other free thiols to a greater e
52 ells offered protection against depletion of reduced glutathione and oxidative stress mediated by TNF
54 by initiating an enhanced generation of both reduced glutathione and oxidized glutathione and enhance
55 and simultaneously to quantify the levels of reduced glutathione and products of its oxidation as pot
56 rs after asphyxial cardiac arrest, levels of reduced glutathione and protein-thiols (fluorescent assa
58 h concentrations of oxidant scavengers (i.e. reduced glutathione and sodium azide) indicating a possi
59 levels of malondialdehyde and low levels of reduced glutathione and superoxide dismutase; these effe
61 rovides the site for entry of electrons from reduced glutathione and that the Cys166-Cys285 disulfide
62 tic hearts, as were the ratio of oxidized to reduced glutathione and the immunohistochemical staining
63 ng to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effe
64 NACA functioned by increasing the levels of reduced glutathione and the phase II detoxification enzy
65 tinamide nucleotides, acetoacetyl-CoA, H2O2, reduced glutathione, and 2-monoacylglycerol were not glu
67 electron donors, ascorbate, dithiothreitol, reduced glutathione, and NADH, were each able to provide
68 xidative stress parameters (malondialdehyde, reduced glutathione, and superoxide dismutase) and expre
69 ibited by dialysis of the cell interior with reduced glutathione, and were markedly enhanced by inhib
70 ck(Delta19) mice, the levels of NRF2 and the reduced glutathione are constitutively low, associated w
73 ic green alga Enteromorpha intestinalis uses reduced glutathione as the electron donor for the reduct
74 tected from dopamine-induced inactivation by reduced glutathione, ascorbic acid, and dithiothreitol b
75 n of p21(ras) and p21(rac), protected nigral reduced glutathione, attenuated nigral activation of NF-
78 A reduction depends not only on the level of reduced glutathione, but also on the rate of NADPH produ
79 hrough the increase in soluble lens protein, reduced glutathione, catalase and SOD activity on in vit
80 ied by increased intracellular ROS level and reduced glutathione concentration in intestinal epitheli
81 significant decrease (approximately 50%) in reduced glutathione concentration, along with the rapid
84 ol treatment further decreased mitochondrial reduced glutathione content and exacerbated mitochondria
85 reatment with l-buthionine-(S,R)-sulfoximine reduced glutathione content by 99% and prevented glucose
87 slices of EAAC1(-/-) mice were found to have reduced glutathione content, increased oxidant levels an
88 el of the primary intracellular antioxidant, reduced glutathione, corresponding to increasing AH resi
91 s a His-tagged recombinant protein catalyzes reduced glutathione-dependent reduction of APS to sulfit
92 p38 kinase because of its ability to prevent reduced glutathione depletion and scavenge hydrogen pero
94 diated dichlorodihydrofluorescein oxidation, reduced glutathione depletion, aconitase inactivation, T
97 wild-type mice had similar levels of hepatic reduced glutathione, endogenous reactive oxygen species,
98 The highest level of 2.0% for glycine and reduced glutathione favored protein extractability and a
100 f thiol-containing model substrates, namely, reduced glutathione (gamma-Glu-Cys-Gly) and the carrier
101 drolyze the unique N-terminal amide bonds of reduced glutathione (gamma-L-glutamyl-cysteinyl-glycine)
102 creasing glycolysis and increasing levels of reduced glutathione, generated by metabolism of glucose
104 ve at preventing a decrease in intracellular reduced glutathione:glutathione disulfide ratios, protec
107 ons of two major non-enzymatic antioxidants, reduced glutathione (GSH) and ascorbate, and completely
109 e is characterized by glutathione imbalance, reduced glutathione (GSH) and cysteine were quantified i
111 superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GP
112 ion of individual ingredients disclosed that reduced glutathione (GSH) and lactobionate in UW solutio
113 ed in significant increases in the levels of reduced glutathione (GSH) and NAD(P)H:quinone oxidoreduc
114 In this study, we investigated the role of reduced glutathione (GSH) and nuclear factor-kappaB (NFk
115 re used to assess relative concentrations of reduced glutathione (GSH) and oxidized disulfide glutath
120 er on platelet aggregation and the effect of reduced glutathione (GSH) and platelet activation on sul
121 ductase (GSR) activities, while the level of reduced glutathione (GSH) and the activities of superoxi
122 rph2(rds/rds)) and compared the abundance of reduced glutathione (GSH) and the activity of mitochondr
123 This shift, in turn, caused an increase in reduced glutathione (GSH) and, ultimately, resulted in R
126 its biospecific interaction with tripeptide reduced glutathione (GSH) bioreceptor directly immobiliz
130 ADP(+) to NADPH and promotes regeneration of reduced glutathione (GSH) by supplying NADPH to glutathi
134 orrelated with a deficiency in intracellular reduced glutathione (GSH) concentrations in diabetic pat
135 tathione-S-Transferase (GST) activities, and reduced glutathione (GSH) content, higher level of malon
137 esis that depolarization-enhanced release of reduced glutathione (GSH) contributes to this phenomenon
139 ells to toxic chemical species can result in reduced glutathione (GSH) depletion, generation of free
141 t systems involved in the export of cellular reduced glutathione (GSH) have not been identified, alth
142 as the rate of depletion of the antioxidant reduced glutathione (GSH) in a model of human respirator
145 for low-potential amperometric detection of reduced glutathione (GSH) in pH 7.2 phosphate buffer sol
146 opeptidase (FCGAP) with BOC-Leu-Met-CMAC and reduced glutathione (GSH) in the absence of Ca(2+).
149 ) increased metal donation fourfold, whereas reduced glutathione (GSH) inhibited donation by approxim
151 ng to the presence of high concentrations of reduced glutathione (GSH) inside the cells, thereby faci
152 rons and contributes to injury, we delivered reduced glutathione (GSH) into microglia, again using li
156 ition to its intracellular antioxidant role, reduced glutathione (GSH) is released by CNS cells and m
157 ciation with a decrease in the mitochondrial reduced glutathione (GSH) level and activity of MnSOD.
158 ested a significant age-related reduction of reduced glutathione (GSH) level in all brain regions exa
159 dant defense function in cells by increasing reduced glutathione (GSH) levels and decreasing ROS leve
166 ceptor (IR) sulfhydryl groups in response to reduced glutathione (GSH) or N-acetyl-L-cysteine (NAC).
168 II iron-limited cells similarly oxidized the reduced glutathione (GSH) pool, phase II iron limitation
169 pectrofluorometrically by enzymatic methods, reduced glutathione (GSH) spectrofluorometrically with O
170 ition, antioxidant activity, effect on total reduced glutathione (GSH) synthesis and protective effec
171 active oxygen species (ROS) and depletion of reduced glutathione (GSH) that together inhibited histon
172 nstrated by (a) the ability of intracellular reduced glutathione (GSH) to eliminate EPR-detectable et
174 a chemical oxidant that selectively converts reduced glutathione (GSH) to its disulfide (GSSG) and pr
175 in increased ROS production and oxidation of reduced glutathione (GSH) to its oxidized form (GSSG).
177 lthough a similar rapid depletion of hepatic reduced glutathione (GSH) was found in both GstP1/P2((+/
179 minations of oxidized glutathione (GSSG) and reduced glutathione (GSH) were performed in monolayer cu
180 reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH) with the accompanying oxidatio
182 nicotinamide dinucleotide phosphate (NADPH), reduced glutathione (GSH), and shear-induced adenosine t
183 y efflux (countertransport) of intracellular reduced glutathione (GSH), and whether hydrophobic gluta
184 emical quantification of oxidized (GSSG) and reduced glutathione (GSH), biomarkers of oxidative stres
187 cetyl-p-benzoquinone imine, higher levels of reduced glutathione (GSH), centrilobular inflammation, a
188 hibition of K(+) channels of glomus cells by reduced glutathione (GSH), dithiothreitol (DTT) and by c
190 causes oxidative stress through depletion of reduced glutathione (GSH), increases the passive K+ perm
191 induction of oxidative stress, depletion of reduced glutathione (GSH), inhibition of IKK activity le
192 ighly sensitive and inexpensive detection of reduced glutathione (GSH), over its oxidized form (GSSG)
193 rs of NOx formation, levels of intracellular-reduced glutathione (GSH), protein nitrosothiols, and th
194 but the levels of an endogenous antioxidant, reduced glutathione (GSH), remained subnormal in the ret
195 a, interleukin (IL)-1beta, IL-6, IL-8, IL10, reduced glutathione (GSH), superoxide dismutase (SOD), a
196 of cancer cells by producing an antioxidant, reduced glutathione (GSH), through HIF-1-mediated metabo
197 ferase (GST) and non-enzymatic antioxidant - reduced glutathione (GSH), vitamin E and C generation in
198 recycling of oxidized glutathione (GSSG) to reduced glutathione (GSH), which is due to the augmented
206 M and APAP lead to a significant decrease in reduced glutathione (GSH)/glutathione disulfide (GSSG) r
207 er oxidative stress, the mean value for the [reduced glutathione (GSH)]/[oxidized glutathione (GSSG)]
208 l concentrations of either E2 (200 nM) or of reduced glutathione (GSH; 325 microM) can protect SK-N-S
209 hermore, cells sorted according to differing reduced-glutathione (GSH) contents exhibited differing s
211 ); and antioxidants, the sum of oxidized and reduced glutathione (GSSG and GSH) can be measured with
213 ow a similar pattern of responses to applied reduced glutathione, GSSG and MRP1 inhibitors (indometha
214 sported glutathione disulfide (GSSG) but not reduced glutathione in agreement with a 3-fold stimulati
217 ncrease in malondialdehyde and a decrease in reduced glutathione in most organs, as well as liver (in
218 treatment significantly increased levels of reduced glutathione in the liver and lowered levels of o
219 glutathione and a decrease in mitochondrial reduced glutathione in the WT, but not in the MT-TG, dia
220 mitation on the capacity for regeneration of reduced glutathione in this compartment may contribute t
222 ol, Tris(2-carboxyethyl)phosphine (TCEP), or reduced glutathione increased the fraction of anomalousl
225 n be partially reduced by monothiols such as reduced glutathione, L-cysteine or N-acetyl-L-cysteine a
226 which correlated with a greater decrease in reduced glutathione level in Raji clones expressing GSTP
227 modulation of trace elements, alteration in reduced glutathione level, glutathione-s-transferase and
228 e poorly and exhibit oxidative stress due to reduced glutathione levels and impaired expression of se
229 rly [altered oxidized glutathione (GSSG) and reduced glutathione levels and ratio; increased reactive
230 ne potential (DeltaPsim), and superoxide and reduced glutathione levels in individual dopaminergic an
231 d with 100% oxygen had decreased hippocampal reduced glutathione levels vs. sham (15.3 +/- 0.4 vs. 20
233 sults from exposure to H2O2, nor oxidized or reduced glutathione levels were responsible for activati
235 but not female, 17-day-old rats to maintain reduced glutathione levels within cerebral cortex acutel
240 -1beta), tumor necrosis factor-alpha, IL-10, reduced glutathione, malonaldehyde, and nitrate/nitrite
241 ility of natural host defenses to regenerate reduced glutathione may explain failure of recovery from
244 AIIt-mediated liposome aggregation, whereas reduced glutathione, nitrate, or nitrite had no effects.
245 but was significantly enhanced by 500 microM reduced glutathione or 100 microM dithiothreitol, agents
246 by preincubation with antioxidants including reduced glutathione or by expression of a dominant-negat
247 atment with the reductants dithiothreitol or reduced glutathione or by incubation with the thioredoxi
249 by treatment with GSSG, while treatment with reduced glutathione or other sulfhydryl-reducing agents
251 fect on longevity, protein carbonyl content, reduced glutathione, or glutathione disulfide content, a
252 the cellular contents of total glutathione, reduced glutathione, oxidized glutathione, and intracell
253 nse enzyme activities rather than changes in reduced glutathione, oxidized glutathione, ascorbate and
254 sympathetic neuronal marker profiles, tissue-reduced glutathione/oxidized glutathione (GSH/GSSG) rati
255 in bronchial epithelial cells, and increased reduced glutathione/oxidized glutathione following Cl2 e
256 ficantly lower mean plasma concentrations of reduced glutathione (P < 0.0001), GluCys (P < 0.0001), a
259 urce of cysteine; however, in the absence of reduced glutathione, pertussis toxin was not efficiently
261 nt Zn(2+) release from the vesicles, whereas reduced glutathione prevents TRPM7-dependent cytosolic Z
262 , whilst oxidized Tim10 cannot be reduced by reduced glutathione, reduced Tim10 is effectively oxidiz
264 y absorption near-edge structure spectrum of reduced glutathione resembles that of cysteine, whereas
265 sults suggest that the autism LCLs exhibit a reduced glutathione reserve capacity in both cytosol and
266 s of histones, tubulin, and lumican and (ii) reduced glutathione S-transferase, annexin, and dermatop
268 age loss of freely diffusing thiols (chiefly reduced glutathione) that have been derivatized with the
269 esence of a low concentration of diamide and reduced glutathione, the kinase was rapidly and reversib
270 m disulfides in the presence of oxidized and reduced glutathione, the native disulfides were not form
271 in a significant depletion of intracellular reduced glutathione (thiol) content at 72 and 96 h and d
273 duced a significant increase in the ratio of reduced glutathione to oxidized glutathione consistent w
274 e stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children
275 vated lipid peroxidation, decreased ratio of reduced glutathione to oxidized glutathione, and up-regu
278 with a significant decrease in the ratio of reduced glutathione-to-oxidized glutathione (GSH/GSSG),
280 two endogenous channel effectors, MgATP and reduced glutathione, using the planar lipid bilayer meth
281 Mg2+ deprivation causes release of neuronal reduced glutathione via a mechanism involving excessive
283 d 1.0 +/- 0.2 mM in normal prostate, whereas reduced glutathione was 2.0 +/- 0.3 mM and 0.8 +/- 0.3 m
287 ant activity was enhanced by the addition of reduced glutathione, was proteinase K sensitive and heat
288 s (ROS) levels was reduced whereas levels of reduced glutathione were elevated in TIGAR-expressing ce
289 e, cystathionine, cysteine, and oxidized and reduced glutathione were measured in 20 children with au
290 ric acid-reactive substance and oxidized and reduced glutathione were measured on frozen brains.
292 intracellular and extracellular oxidized and reduced glutathione were temporally associated with eGPx
293 ing in HepG2 cells by MR was associated with reduced glutathione, where it functions as a cofactor fo
295 iotics and oxidatively produced compounds to reduced glutathione, which facilitates their metabolism,
296 ucing equivalents, which generates NADPH and reduced glutathione, which in turn activates sentrin/SUM
297 nd NAD-binding (KTN) domains that sense both reduced glutathione, which inhibits Kef activity, and gl
298 PI activity was inhibited by incubation with reduced glutathione while bacterial TPI was unaffected.
299 roteins also shared the same specificity for reduced glutathione, with no activity against either gam
300 iciencies are up to 100-fold higher than for reduced glutathione, with typical K(m) values of about 1
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