ライフサイエンスコーパス: reduced-intensity conditioning

1 n Idua(-/-) recipient BM, particularly under reduced intensity conditioning.

2 o received HCT following nonmyeloablative or reduced-intensity conditioning.

3 ho received T-replete stem cell grafts after reduced-intensity conditioning.

4 This effect was absent when they received reduced-intensity conditioning.

5 ould the transplantation be myeloablative or reduced intensity conditioning?

6 hat prospectively compares tandem autologous/reduced intensity conditioning allogeneic transplantatio

7 The first prospective study for reduced-intensity conditioning allogeneic hematopoietic

8 h lymphoid malignancies being considered for reduced-intensity conditioning allogeneic hematopoietic

9 We studied the effects of a reduced-intensity conditioning allogeneic HSCT from dono

10 We report the outcomes after reduced-intensity conditioning allogeneic stem cell tran

11 mtuzumab at lympholytic concentrations after reduced-intensity conditioning allogeneic stem cell tran

12 HDM/ASCT (16 of whom subsequently received a reduced-intensity conditioning allograft and seven a sec

13 As consolidation, young patients received a reduced-intensity conditioning allograft, whereas the re

14 For adults with ALL in CR, reduced intensity conditioning allografting results in m

15 and methotrexate for GVHD prophylaxis after reduced-intensity conditioning alloSCT using human leuko

16 reduction to 30 mg is safe in the context of reduced intensity conditioning and HLA-identical sibling

17 e, disease-free full donor engraftment using reduced intensity conditioning and mobilized peripheral

18 B is sufficient to engraft most adults after reduced-intensity conditioning and is associated with a

19 Use of unrelated donors, reduced-intensity conditioning and the blood cell grafts

20 nsduced HSCs in transplant recipients, using reduced-intensity conditioning and varying gene transfer

21 of hematopoietic stem-cell transplantation, reduced-intensity conditioning, and the use of antithymo

22 ve therapy for these patients and the use of reduced-intensity conditioning blood or marrow transplan

23 The use of reduced-intensity conditioning blood or marrow transplan

24 ) could promote allogeneic engraftment after reduced-intensity conditioning by enhancing the GVH effe

25 Reduced-intensity conditioning consisted of high-dose fl

26 INTERPRETATION: In patients with reduced-intensity conditioning, EASIX-GVHD is a powerful

27 1 of 22 in complete remission [CR]) received reduced-intensity conditioning followed by allogeneic tr

28 all survival was significantly better in the reduced-intensity conditioning group: 31 (94%) of 33 pat

29 of GVHD in patients undergoing related-donor reduced-intensity conditioning haemopoietic stem-cell tr

30 tandard GVHD prophylaxis after related-donor reduced-intensity conditioning haemopoietic stem-cell tr

31 l malignant diseases who were candidates for reduced-intensity conditioning haemopoietic stem-cell tr

32 These data suggest that reduced-intensity conditioning haploidentical transplant

33 Reduced-intensity conditioning has improved survival aft

34 Reduced-intensity conditioning has minimized nonrelapse-

35 ective studies using either myeloablative or reduced intensity conditioning have shown disease-free s

36 hematopoietic stem cell transplantation with reduced-intensity conditioning have altered the landscap

37 ased availability of alternative donors, and reduced-intensity conditioning, have improved the safety

38 To prospectively assess the applicability of reduced-intensity conditioning hematopoietic stem cell t

39 Reduced-intensity conditioning HSCT to maintain remissio

40 The role of allogeneic transplantation with reduced-intensity conditioning in diffuse large B-cell l

41 topoietic cell transplantations (HCTs) after reduced-intensity conditioning in patients who experienc

42 ng-term disease control can be achieved with reduced-intensity conditioning in this population.

43 effective treatment for Hurler patients, but reduced intensity conditioning is a risk factor in trans

44 ioning regimens is difficult to justify, and reduced intensity conditioning is used.

45 LA)-matched bone marrow transplantation with reduced-intensity conditioning is a cure for several non

46 The decreased toxicity of reduced-intensity conditioning is more applicable to the

47 In contrast, after reduced intensity conditioning, KIR-L mismatch between t

48 ose total body irradiation (TBI) (2-4 Gy) to reduced intensity conditioning may reduce the rate of re

49 Reduced-intensity conditioning may reduce transplantatio

50 o independent cohorts of adult patients with reduced-intensity conditioning (n=141, n=173) and in a c

51 In patients who received reduced-intensity conditioning (n=239), EASIX-GVHD was a

52 sed prognostic scoring system), and consider reduced intensity conditioning/nonmyeloablative conditio

53 le agreement on the patient factors favoring reduced intensity conditioning or myeloablative conditio

54 RAS pathway mutations, was evident only with reduced-intensity conditioning (P<0.001).

55 vs 160 x 10(9) cells per L [90.0-250.5] for reduced-intensity conditioning; p<0.0001).

56 Reduced intensity conditioning preceded a kidney allogra

57 ither myeloablative or non-myeloablative (or reduced intensity) conditioning preparative regimens bef

58 support the feasibility and effectiveness of reduced-intensity conditioning prior to allogeneic HSC t

59 BMT to treat hematological malignancies, the reduced intensity conditioning regimen used in the conte

60 younger than 45 years (P = .003) and after a reduced-intensity conditioning regimen (P = .03).

61 Purpose To compare a reduced-intensity conditioning regimen (RIC) with a myel

62 Patients received a melphalan-based reduced-intensity conditioning regimen and posttransplan

63 b; BC8) that can be combined with a standard reduced-intensity conditioning regimen before allogeneic

64 ildren with primary immunodeficiency using a reduced-intensity conditioning regimen between 1998 and

65 ls transduced with lentiviral vector after a reduced-intensity conditioning regimen combined with ant

66 We examined the effect of a reduced-intensity conditioning regimen designed to enhan

67 We sought to evaluate the efficacy of a reduced-intensity conditioning regimen for allogeneic HS

68 This reduced-intensity conditioning regimen is safe and effic

69 We conclude that the reduced-intensity conditioning regimen results in improv

70 4 patients with IPEX syndrome using a novel reduced-intensity conditioning regimen that resulted in

71 d radiotherapy can be safely combined with a reduced-intensity conditioning regimen to yield encourag

72 s frontline therapy have been performed with reduced intensity conditioning regimens using unmanipula

73 ents received myeloablative and 737 received reduced intensity conditioning regimens.

74 ients received myeloablative and 88 received reduced intensity conditioning regimens.

75 gimen (n = 873; 87%); the remainder received reduced-intensity conditioning regimens (n = 125; 13%).

76 tations was similar in patients who received reduced-intensity conditioning regimens and those who re

77 Reduced-intensity conditioning regimens are a reasonable

78 Reduced-intensity conditioning regimens are associated w

79 Thus, reduced-intensity conditioning regimens are being explor

80 and transplant-related mortality; therefore, reduced-intensity conditioning regimens are being used t

81 In addition, utilization of reduced-intensity conditioning regimens has been success

82 The development of non-myeloablative and reduced-intensity conditioning regimens has enabled olde

83 Reduced-intensity conditioning regimens have allowed the

84 Low and reduced-intensity conditioning regimens have allowed to

85 ver the past decade the development of safer reduced-intensity conditioning regimens, expanded donor

86 cifically the development of nonablative and reduced-intensity conditioning regimens, have enabled th

87 in allogeneic transplantation, particularly reduced-intensity conditioning regimens, have increased

88 lated and unrelated allogeneic SCT following reduced-intensity conditioning regimens.

89 HCT (n = 180) or MSD-HCT (n = 807) following reduced-intensity conditioning regimens.

90 ithymocyte globulin (ATG; n = 491) following reduced-intensity conditioning regimens.

91 ication of SCT has been further increased by reduced-intensity conditioning regimens.

92 ng the ASCT conditioning phase or the use of reduced-intensity conditioning regimens.

93 logeneic stem-cell transplantation that uses reduced-intensity conditioning regimens.

94 acute graft-versus-host disease (GVHD) after reduced-intensity conditioning, related donor hematopoie

95 + nonTBI + PBSCs, (4) MA + nonTBI + BM, (5) reduced intensity conditioning (RIC) + PBSCs, and (6) RI

96 Reduced intensity conditioning (RIC) allogeneic hematopo

97 ient (ADA-deficient) SCID when combined with reduced intensity conditioning (RIC) and ERT cessation.

98 When adjusted for age, reduced intensity conditioning (RIC) has shown superior

99 oietic stem cell transplantation (HSCT) with reduced intensity conditioning (RIC) is scarce, a retros

100 Use of a reduced intensity conditioning (RIC) regimen has now bec

101 (haploBMT) has seen a revival, thanks to the reduced intensity conditioning (RIC) regimens and graft-

102 -graft (HvG) tolerance is the primary aim of reduced intensity conditioning (RIC) regimens for alloge

103 Eleven patients underwent reduced intensity conditioning (RIC) regimens predominan

104 The success of reduced intensity conditioning (RIC) transplantation is

105 Reduced intensity conditioning (RIC) was used with eithe

106 cuss the rationale and potential benefits of reduced intensity conditioning (RIC), nonmyeloablative (

107 e conditioning (SMC), and 833 (62%) received reduced intensity conditioning (RIC).

108 Tyrosine kinase inhibitors (TKIs) and reduced intensity conditioning (RIC)/nonmyeloablative (N

109 Reduced-intensity conditioning (RIC) allogeneic hematopo

110 nancies remain at risk for relapse following reduced-intensity conditioning (RIC) allogeneic hematopo

111 This review examines reduced-intensity conditioning (RIC) allogeneic hematopo

112 The introduction of reduced-intensity conditioning (RIC) alloSCT led to thei

113 s adapted from a preclinical model that used reduced-intensity conditioning (RIC) and protected again

114 conducted a 45 patient prospective study of reduced-intensity conditioning (RIC) and transplantation

115 ord blood transplantation (UCBT) following a reduced-intensity conditioning (RIC) consisting of low-d

116 Despite the widespread adoption of reduced-intensity conditioning (RIC) for myeloma, there

117 The trial compared reduced-intensity conditioning (RIC) for patients older

118 enefit was restricted to patients undergoing reduced-intensity conditioning (RIC) HSCT (3-year OS, 66

119 hematopoietic stem cell transplantation with reduced-intensity conditioning (RIC) in 186 patients wit

120 Reduced-intensity conditioning (RIC) included fludarabin

121 ransplants (alloHCT) are now performed using reduced-intensity conditioning (RIC) instead of myeloabl

122 evaluated the feasibility and efficacy of a reduced-intensity conditioning (RIC) regimen of fludarab

123 s (range, 27-68 years), were prepared with a reduced-intensity conditioning (RIC) regimen.

124 Reduced-intensity conditioning (RIC) regimens allow incr

125 Reduced-intensity conditioning (RIC) regimens are increa

126 Recent experience suggests that reduced-intensity conditioning (RIC) regimens can improv

127 Reduced-intensity conditioning (RIC) regimens extend HSC

128 The safety and efficacy of reduced-intensity conditioning (RIC) regimens for the tr

129 s who received an allograft for myeloma with reduced-intensity conditioning (RIC) regimens from 33 ce

130 The role of reduced-intensity conditioning (RIC) regimens in pediatr

131 TBI) doses (0-1575 cGy), with an emphasis on reduced-intensity conditioning (RIC) regimens.

132 All patients received reduced-intensity conditioning (RIC) regimens.

133 th bone marrow (BM) grafts in the setting of reduced-intensity conditioning (RIC) transplantations fo

134 to 81 patients (median age, 50 years) after reduced-intensity conditioning (RIC) transplantations pe

135 In 18 allograft recipients (72%), reduced-intensity conditioning (RIC) was used.

136 phase 1/2 study assessed the augmentation of reduced-intensity conditioning (RIC) with total marrow a

137 lower treatment-related mortality (TRM) with reduced-intensity conditioning (RIC) would result in imp

138 In reduced-intensity conditioning (RIC), neither ex vivo no

139 conditioning (MAC), and 21 patients received reduced-intensity conditioning (RIC).

140 ial hemophagocytic lymphohistiocytosis using reduced intensity conditioning SCT results in much impro

141 ions to high-intensity preparative regimens, reduced intensity conditioning should be considered.

142 Following reduced-intensity conditioning, there was rapid engraftm

143 Moreover, we show a novel model using reduced-intensity conditioning to determine genetically

144 oved supportive care, decreased toxicity and reduced intensity conditioning), transplantation worldwi

145 Corresponding rates after reduced intensity conditioning transplants were 46% (95%

146 Corresponding rates after reduced intensity conditioning transplants were 93% and

147 Similar differences were observed after reduced intensity conditioning transplants, 19% vs 28% (

148 ic stem-cell transplantation (alloSCT) after reduced-intensity conditioning using either unrelated um

149 TBI administered in reduced-intensity conditioning was most strongly associa

150 d unfractionated marrow from brother A after reduced-intensity conditioning with cyclophosphamide and

151 gnancies underwent transplantation following reduced-intensity conditioning with fludarabine and eith