ライフサイエンスコーパス: reductive amination

1 oup manipulations followed by ozonolysis and reductive amination.

2 reptococcal type III polysaccharide (III) by reductive amination.

3 direct, covalent coupling of II CPS to TT by reductive amination.

4 sulting in III-alpha2r conjugate vaccine) by reductive amination.

5 re coupled with 2-(dansylamido)ethylamine by reductive amination.

6 e modified with 2-(dansylamido)ethylamine by reductive amination.

7 isulfonate (APTS) at the reducing termini by reductive amination.

8 ethylation beyond classical hydroformylation/reductive amination.

9 nd subsequent one-pot catalytic deprotection-reductive amination.

10 trolled copper-catalyzed 1,4-addition, and a reductive amination.

11 label the amine groups on the monoamines via reductive amination.

12 epsilon-amino group of Lys in a peptide via reductive amination.

13 yl pyrroles that cannot be made via standard reductive amination.

14 tion reaction with N-Boc-ethylenediamine via reductive amination.

15 g the conjugation of the antigens to KLH via reductive amination.

16 plings, benzimidazole-forming reactions, and reductive aminations.

17 of [4 + 2] cycloadditions, N-acylations, and reductive aminations.

18 ng agents that are typically associated with reductive aminations.

19 Reductive amination afforded the desired N-methylated [2

20 Further elaboration by ozonolysis and reductive amination affords 2b in an overall yield of 28

21 which are characteristic of the Leuckart and reductive amination (Al/Hg) methods of preparation.

22 Three different bioconjugation techniques, reductive amination, amidation, and Huisgen cycloadditio

23 ) to allow for further functionalization via reductive amination, amidation, or other chemistry.

24 GSK852A (1) was obtained after reductive amination and mesylation with conditions amena

25 t the development of formal anti-Markovnikov reductive amination and oxidative hydration reactions to

26 nonradioactive standards were synthesized by reductive amination and subsequent alkylation of protect

27 nder modified conditions lead to an apparent reductive amination and the formation of o-hydroxybenzyl

28 tivity parameters of ICL formation by double reductive amination and yield a set of diverse ICLs that

29 oxy-Cope rearrangement, a one-pot ozonolysis-reductive amination, and a Lewis acid promoted cyclizati

30 ep protocol involving a Staudinger reaction, reductive amination, and benzyloxy carbonyl protection y

31 atowicz rearrangement, Michael addition, and reductive amination as key steps.

32 lizing a syn-selective Grignard addition and reductive amination as the key reactions.

33 rtwig, Ullmann, and classical amine-carbonyl reductive aminations, as it tolerates aryl halides and c

34 coccus capsular polysaccharide was linked by reductive amination at multiple sites to tetanus toxoid

35 ormaldehyde and sodium cyanoborohydride, the reductive amination-based method can be utilized to gene

36 for a high yield library of compounds via a reductive amination by flow hydrogenation.

37 oligosaccharides by conjugation to ADHP, by reductive amination, can be detected and quantified by s

38 cells primarily assimilated ammonia through reductive amination catalyzed by glutamate dehydrogenase

39 Reductive amination chemistry was used to synthesize all

40 We also describe optimized reductive amination conditions for linking 5'-aldehyde-D

41 Subsequently, when subjected to reductive amination conditions, each of these tetralones

42 fied vancomycin ABCD ring system featuring a reductive amination coupling of residues 4 and 5 for ins

43 Complementary to known reductive aminations, effective C-N bond construction pr

44 The asymmetric ruthenium-catalyzed reductive amination employing ammonia and hydrogen to pr

45 A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparati

46 ation on an aldehyde-active solid support by reductive amination; (ii) stabilization of fragile siali

47 th 2-aminoacridone (2-AMAC), using classical reductive amination in a nonaqueous solvent, led to the

48 residues and aliphatic chains to mannose via reductive amination in order to increase both the affini

49 by chiral auxiliary removal, ozonolysis, and reductive amination/intramolecular nucleophilic displace

50 Reductive amination is one of the most important methods

51 Sequential enzymatic aldol reaction and bis-reductive amination leads to the total syntheses of tetr

52 thod and one route specific impurity for the reductive amination method are reported.

53 hloride were synthesized by the Leuckart and reductive amination methods (20 batches per method).

54 e, we immobilized glycoproteins on resin via reductive amination, modified alpha2,6-linked sialic aci

55 central 5'-CAp sequence under conditions of reductive amination (NaCNBH(3), pH 5.2) generated much h

56 e irreversibly converted under conditions of reductive amination (NaCNBH(3)/pH 5.2) to a stable amine

57 -alkyne, tetrazine-trans-cyclooctene, oxime, reductive amination, native chemical ligation, Suzuki, S

58 Reductive amination of 15 with the appropriate benzaldeh

59 Reductive amination of 19 with 3,4,5-trimethoxyaniline a

60 synthesis of analogues 2-4 was achieved via reductive amination of 2,4-diamino-5-methyl 6-carboxalde

61 Reductive amination of 2-formylphenylmethane sulfonamide

62 nthetic route to compounds 5-12 involved the reductive amination of a common intermediate, 2,4-diamin

63 irst example of an intramolecular asymmetric reductive amination of a dialkyl ketone with an aliphati

64 Stannous chloride catalyzed chemoselective reductive amination of a variety of carbonyl compounds w

65 Direct reductive amination of a wide range of ketones has been

66 The key step involved rapid reductive amination of aldehyde 8 with aniline 5 by sodi

67 structing the diazepanone ring system: (a) a reductive amination of an epoxy aldehyde with N-methylam

68 p to 96% ee) were achieved in the asymmetric reductive amination of aryl ketones in the presence of T

69 The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an irid

70 e revealed here to be good catalysts for the reductive amination of benzaldehydes using formate salts

71 Asymmetric reductive amination of beta-keto amides catalyzed by the

72 The aminotransferase OxyQ catalyzes the reductive amination of C4-keto of 2, yielding 4-amino-AT

73 of Mycobacterium tuberculosis catalyzes the reductive amination of glyoxylate to glycine but not the

74 responsible for the physiologically relevant reductive amination of glyoxylate.

75 ogues 14 and the phenols 15 were obtained by reductive amination of ketones 13 and 6, respectively.

76 Reductive amination of oligosaccharides with fluorophore

77 The reductive amination of polymer-bound linkers by amines a

78 tri(picolyl) derivative was synthesized via reductive amination of pyridine carboxaldehyde.

79 activity at about 82 degrees C (203 U/mg for reductive amination of pyruvate) yet still retained 30%

80 e oxidative deamination of L-alanine and the reductive amination of pyruvate.

81 Reductive amination of repromicin with polyfunctional am

82 Double reductive amination of the 1,4-dicarbonyl (from the gamm

83 Double reductive amination of the 1,5-dicarbonyl (from the delt

84 ation with glycolaldehyde followed by tandem reductive amination of the 2-oxoethyl intermediate 4.

85 The key steps in the synthesis are the reductive amination of the alpha,beta-unsaturated aldehy

86 theses of the analogues were accomplished by reductive amination of the appropriate anilines with 2-a

87 Compounds 3-5 were prepared by reductive amination of the appropriate anilines with 8-o

88 -H analogues were obtained via regiospecific reductive amination of the appropriate benzaldehydes wit

89 Reductive amination of the common intermediate 2,4-diami

90 s capable of producing d-amino acids via the reductive amination of the corresponding 2-keto acid wit

91 by employing a simultaneous Zn reduction and reductive amination of the resulting aldehyde.

92 the resulting nitrogen intermediate, and (4) reductive amination of the tetrahydroquinoline with form

93 Double reductive amination of two molecules of aldehyde 29 with

94 Using either reductive amination or amine acylation chemistries, we o

95 lylacetone followed by hydride reductions or reductive amination, or by Curtius degradations of alpha

96 o undergo homologation to a terminal alkyne, reductive amination, oxidation and olefination.

97 ed propylamines in a one-pot hydrosilylation/reductive amination process.

98 oborates to the corresponding amines through reductive amination protocols.

99 ldehyde 7 is subjected to a ring closure via reductive amination, providing 1b in an overall yield of

100 The feasibility of the triple-reductive amination reaction for the synthesis of comple

101 An intramolecular reductive amination reaction has been used to prepare mo

102 e, trisaccharide, or heptasaccharide) in the reductive amination reaction.

103 e featuring an iterative double ring-closing reductive amination reaction.

104 thout hydroxyl group protection via a simple reductive amination reaction.

105 N7-guanine-conjugated DPCs were generated by reductive amination reactions between the Lys and Arg si

106 The reductive amination reactions were essentially complete

107 The amines are useful for acylation and reductive amination reactions, and the thiols participat

108 The kinetics of the reductive amination reactions, performed at 37 degrees C

109 he tricarbonyl precursors for the key triple reductive amination reactions.

110 two protecting groups and two intramolecular reductive amination reactions.

111 A sequence of oxidative cleavage/reductive amination/reductive cleavage enables the prepa

112 n batches synthesized using the Leuckart and reductive amination routes.

113 ers, and a one-pot oxidative olefin cleavage/reductive amination sequence that closes the piperidine

114 monstrated through a deprotection and double-reductive amination sequence to give 4,5,6,7-tetrahydrop

115 The synthetic sequence included reductive amination, stereoselective epoxidation, intram

116 formations including nucleophilic additions, reductive aminations, Stille couplings, and polymer-assi

117 Two complementary reductive amination strategies employing either aldehyde

118 otected phenylalanine, and an intramolecular reductive amination strategy used to convert the coupled

119 A similar intramolecular reductive amination strategy was used to synthesize a su

120 ethod and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequen

121 reaction conditions relating to the Pt/H(2) reductive amination synthesis were, for the first time,

122 e bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type a

123 The visible dye was coupled by a reductive amination to different sugars.

124 We also observed reductive amination to form alanine and reduction to for

125 f 3-pyrroline to perform the equivalent of a reductive amination to form alkyl pyrroles.

126 A diformylbacteriochlorin was subjected to reductive amination to give aminomethyl derivatives.

127 a coli K1 polysaccharide capsule, coupled by reductive amination to tetanus toxoid and purified recom

128 A reduction and intramolecular reductive amination transformed the intermediate disacch

129 e nitro group in 13 to an amine, followed by reductive amination under acidic conditions, arrives at

130 This work describes the combination of reductive amination using 3-amino-9-ethylcarbazole, with

131 ubstituted diazatrithiacrown ethers 17-19 by reductive amination using 8-hydroxyquinoline-2-carboxald

132 been synthesized by periodate oxidation and reductive amination using a variety of R-NH2 substituent

133 some of the desired aminoimidazoles, a novel reductive amination utilizing a trityl-protected aminoim

134 Reductive amination was employed to attach each strand o

135 four garlic organosulfur compounds (OSCs) by reductive amination with (13)C, D2-formaldehyde, and dev

136 y, two glycan samples to be compared undergo reductive amination with 2-aminobenzoic acid and 2-(13)[

137 ary strands and ICL formation using a double reductive amination with a variety of amines.

138 diate is converted to the final products via reductive amination with an appropriately functionalized

139 Initial N-alkylation via reductive amination with anthracene-9-carbaldehyde provi

140 folate analogues on a slightly larger scale, reductive amination with either N2-acetyl or N2-pivaloyl

141 side to the four-carbon aldehyde followed by reductive amination with ethylenediamine.

142 Reduction and a second reductive amination with formaldehyde yielded the corres

143 e treatment with aldehyde silane followed by reductive amination with heterobifunctional amine-poly(e

144 ndards (ISs) for absolute quantification via reductive amination with isotopic formaldehydes.

145 minopyrido[2,3-d]pyrimidine (8), followed by reductive amination with the appropriate benzaldehydes o

146 GRIL), where free glycans are derivatized by reductive amination with the differentially coded stable

147 NaIO4 oxidation of the third digitoxose and reductive amination with various R-NH2 substituents and

148 ction conditions were also applied to facile reductive aminations with anilines known to have little

149 We also demonstrate preparative scale reductive aminations with wild-type and Q240A variant bi