ライフサイエンスコーパス: reductively

1 With GTN, the secondary nitrate was removed reductively 6 times faster than the primary nitrate, wit

2 only constructs of the E. coli PDHc-E1 could reductively acetylate E. coli PDHc-E2.

3 e of PDHc-E2, as reflected by the ability to reductively acetylate the latter; and (2) amino terminal

4 ffect on the ability of the E2p domain to be reductively acetylated but did confer a slight increase

5 the lipoyl-lysine residue could no longer be reductively acetylated by E1p.

6 main significantly reduces its ability to be reductively acetylated by the cognate E1.

7 ihemoprotein oxidoreductase, EC 1.6.2.4) can reductively activate mitomycin antibiotics through a one

8 the wild-type rat enzyme in their ability to reductively activate the cytotoxic drug CB 1954 (5-(azir

9 '-deoxyguanosine adduct (C8-AP-dG) formed by reductively activated 1-nitropyrene (1-NP).

10 Reductively activated 1-NP forms a major DNA adduct, N-(

11 athway to the inhibition of transcription by reductively activated adriamycin and daunomycin.

12 toxic potency of MA is MA's propensity to be reductively activated by cellular thiols while MC is res

13 Mitomycin C (MC) was reductively activated by DT-diaphorase [DTD; NAD(P)H:qui

14 The PBIs are reductively activated by DT-diaphorase and alkylate the

15 ings for five of the seven iron sites of the reductively activated E(4) FeMo-co, and given the magnit

16 We show that a reductively activated pimonidazole metabolite can be ima

17 ed as prototypical members of a new class of reductively activated prodrugs of the duocarmycin and CC

18 Interestingly, MCRPS can also be reductively activated with analogues of CoBSH such as Co

19 show that holomycin, a prototypical DTP, is reductively activated, and reduced holomycin chelates zi

20 oli contains a dinuclear iron cluster, which reductively activates O2 to produce the enzyme's functio

21 f-1), which repairs oxidative DNA damage and reductively activates transcription factors including AP

22 dox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including a

23 R2 is capable of reductively activating O(2) to produce a stable tyrosine

24 ormed in situ such that the ligands could be reductively adsorbed onto glassy carbon electrode surfac

25 dervied from unstable parent aldehydes were reductively alkylated in a direct fashion with a variety

26 ine 6, containing an ester group at C-6, was reductively alkylated to give dihydroindolizines 8 and 9

27 n artifact of acid hydrolysis, proteins were reductively alkylated with formaldehyde to convert ornit

28 n 1e led to aniline derivative 1t, which was reductively alkylated with hexanal and coupled to l-prol

29 vealed that the active site Lys1003 had been reductively alkylated with the aldehyde inhibitor.

30 formation of alpha-ketoisocaproate, which is reductively aminated back to L-leucine by leucine dehydr

31 Acid hydrolysis of 6 gave 11, which was reductively aminated to give (+/-)-narwedine 2.

32 e fragmentation characteristics of N-glycans reductively aminated with 2-aminobenzoic acid and 2-amin

33 The resulting oligosaccharides were then reductively aminated with 2-aminopyridine and the struct

34 re released by treatment with N-glycanase F, reductively aminated with anthranilic acid, and fraction

35 Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondri

36 connection with both protease-cleavable and reductively cleavable antibody-drug conjugates that were

37 this reaction by using a [4Fe-4S] cluster to reductively cleave AdoMet to form a transient 5'-deoxyad

38 t) enzyme that uses a [4Fe-4S](+) cluster to reductively cleave AdoMet to methionine and a 5'-deoxyad

39 t several of the mutant enzymes were able to reductively cleave AdoMet, but none were able to produce

40 Additionally, they reductively cleave ArC-X, ArX-C (X = N or O) and ArC-C b

41 n at 365 nm, they are even more powerful and reductively cleave aryl chlorides.

42 al SAM superfamily, composed of enzymes that reductively cleave S-adenosyl-l-methionine (SAM or AdoMe

43 SPL utilizes a special [4Fe-4S] cluster to reductively cleave S-adenosylmethionine (SAM) to generat

44 ymes that contain an iron-sulfur cluster and reductively cleave S-adenosylmethionine, forming an enzy

45 cus infernus is a radical SAM enzyme able to reductively cleave SAM to 5'-deoxyadenosine radical and

46 employed dithiothreitol as a cosubstrate to reductively cleave the persulfide intermediate, and it h

47 The ability of professional APC to reductively cleave this peptide modification presumably

48 This ester is reductively cleaved by a thiol molecule (RSH) such as GS

49 reported as new members of a unique class of reductively cleaved prodrugs of the duocarmycin family o

50 site-differentiated [4Fe-4S] cluster and is reductively cleaved to generate a 5'-deoxyadenosyl radic

51 luster and S-adenosyl-L-methionine, which is reductively cleaved to L-methionine and 5'-deoxyadenosin

52 s 7 upon further reaction with NaTeC6H5 were reductively cleaved to provide 2 equiv of the correspond

53 f the alpha-ester at C16, the ether bond was reductively cleaved with TFA/Et3SiH in high yield.

54 dical S-adenosylmethionine (SAM) enzyme that reductively cleaves S-adenosylmethionine, generating 5'-

55 However, although viperin reductively cleaves SAM to form 5'-deoxyadenosine in a s

56 yme superfamily in which a [4Fe-4S]+ cluster reductively cleaves SAM to produce the 5'-deoxyadenosyl

57 e thorium-bpy complex (1) that is capable of reductively cleaving the R-NC bond in a series of organi

58 d the precursors to P-clusters, which can be reductively coupled into the mature [Fe(8)S(7)] structur

59 scU homodimer and that these clusters can be reductively coupled to form a single [4Fe-4S] cluster.

60 ns, a variety of aryl and vinyl bromides are reductively coupled with alkyl bromides in high yields.

61 nalogue, (C(5)Me(5))(2)Sm(THF)(2), complex 1 reductively couples CO(2) to form the oxalate-bridged di

62 alpha-diimine chromium dimer [(H)L(iPr)Cr]2 reductively couples cyclohexyl isocyanide to produce var

63 complex, [Cu(I)(tmpa)(MeCN)](+), effectively reductively couples NO(g) at RT in methanol (MeOH), givi

64 Benzaldehyde reductively couples to stilbene with 100% selectivity an

65 wild-type Nei and Nei-Q261A mutants could be reductively cross-linked to damaged base-containing DNA.

66 atalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to gi

67 dibromoazabicyclo[2.1.1]hexanes 9 have been reductively debrominated to afford the first reported 2-

68 emonstrate that the D. mccartyi strain CBDB1 reductively debrominated two oligocyclic aromatic phenol

69 s ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tet

70 prominent groundwater pollutant that can be reductively dechlorinated by mixed anaerobic microbial p

71 DDT is reductively dechlorinated to DDD and dehydrochlorinated

72 h high total organic carbon (TOC) and VC was reductively dechlorinated to ethene.

73 This study suggests that PCDD/Fs are reductively dechlorinated to nontoxic non-2,3,7,8 PCDD/F

74 5-chloro-1,2, 4-trihydroxybenzene, which is reductively dechlorinated to produce the common key meta

75 2,6-dichloro-1,4-dihydroxybenzene, which is reductively dechlorinated to yield 2-chloro-1,4-dihydrox

76 of an anaerobic bacterium, strain TCA1, that reductively dechlorinates TCA to 1,1-dichloroethane and

77 Strain 11a reductively dechlorinates TCE, 1,1-DCE, cis-DCE, trans-D

78 ccurring Mn(III)-oxalic acid complexes could reductively decompose certain organic compounds in the e

79 3-dimethylimidazol-2-ylidene borane provides reductively decyanated products in good yields.

80 nt this difficulty by allowing the enzyme to reductively dehalogenate CHBr(2)NO(2), thereby generatin

81 nic chain reaction by which the precursor is reductively deiodinated with HI.

82 Since alkanethiolate surfactants reductively desorb at potentials close to the onset of C

83 ylthio-d-xylulose 5-phosphate (MTXu 5-P) and reductively dethiomethylated to 1-deoxy-d-xylulose 5-pho

84 After 300 days, ferric sorbents were reductively dissolved.

85 y = 4'-vinyl-2,2':6',2''-terpyridine) can be reductively electropolymerized on nanocrystalline TiO2 f

86 orizontal lineCH2)(O2CCH3-O,O')](-) (6) that reductively eliminate 1-butene, to form [(CH2CO2-C,O)M(O

87 These complexes reductively eliminate Ar-X (X = OH, Br, Cl) in water at

88 , reduce some nitrogenase substrates, and/or reductively eliminate H2 to generate reduced iron center

89 The platinum complexes reductively eliminated biaryl compounds in quantitative

90 Compound 2 reductively eliminates benzene upon addition of NCMe at

91 an Ir(V) complex ((carb)PNP)Ir(H)3(Et) which reductively eliminates ethane with a very low barrier to

92 At much slower rates, hydride 20 reductively eliminates free ligand, which ultimately gen

93 of an unprecedented [10-S-4] sulfurane that reductively eliminates to afford a 3,6-dihydrothiazine,

94 oduce a seven-coordinate intermediate, which reductively eliminates to afford product with retention

95 C-H bond of a second styrene molecule before reductively eliminating product.

96 Reductively evolved linker sequence lengths in growth ra

97 ligand, is likely obtained from the in situ, reductively generated 16 VE Fe(0) complex, [Fe{((Dipp)C:

98 2) evolution likely occurs by protonation of reductively generated Co(II)H rather than homolysis of t

99 Thus, addition of the reductively generated trichloromethyl radical to a heme

100 imple triamidoamine uranium(III) complex can reductively homologate CO and be recycled for reuse.

101 at in spheroids, isocitrate/citrate produced reductively in the cytosol could enter the mitochondria

102 lecule that activates the drug metronidazole reductively in the treatment of trichomoniasis.

103 jor groove interactions, while the APBIs are reductively inactivated by this enzyme since only the qu

104 S](2+) and [4Fe-4S](2+) clusters in IscU are reductively labile and are degraded within minutes upon

105 omposition was developed that incorporates a reductively labile cross-linker to achieve activated rel

106 endered transiently insoluble using a novel, reductively labile disulfide-based cross-linker.

107 n originally introduced for formation of the reductively labile prodrug functionality are detailed.

108 Reductively metabolized glutamine is a major cellular ca

109 assigning the NMR peaks to the corresponding reductively methylated amine hinders its use.

110 However, reductively methylated apoE was unable to inhibit smooth

111 Additional experiments showed that reductively methylated apoE, which is incapable of recep

112 umulation because accumulation occurred with reductively methylated LDL and in the presence of an ant

113 e strategies used to assign the NMR peaks of reductively methylated protein amines.

114 oteins containing covalent cross-link(s) are reductively methylated to convert lysine residues to dim

115 free, ferritin bound (from which iron can be reductively mobilized), or transferrin bound (which gene

116 ed P(C) can be both oxidatively (p-type) and reductively (n-type) doped to a conductive state, wherea

117 These can be intercepted reductively or with organolithium reagents to produce di

118 avidus metallidurans, a bacterium capable of reductively precipitating toxic, aqueous gold(I/III)-com

119 y)2(dtbbpy)](+)* can be both oxidatively and reductively quenched by Ni4P2 and TEOA, respectively.

120 e about 70 ns, and this excited state can be reductively quenched by triethylamine or 1,4-diazabicycl

121 on collection at Rh in the excited state and reductively quenched state.

122 ain sufficient thioredoxin NADPH activity to reductively reactivate oxidized PTEN and oppose Akt down

123 The oligoglycosyl alditol reductively released from the least polar pGPL-I was ful

124 the bacterial and mammalian enzymes must be reductively remethylated.

125 The auxiliaries can be reductively removed or cleaved by nucleophilic acyl subs

126 study implied that Tc(VII) migration can be reductively retarded at Hanford site with a retardation

127 (VII) migration in the diffusion columns was reductively retarded with retardation degrees correlated

128 tress response in low-oxygen environments by reductively scavenging nitric oxide (NO).

129 Here, its catalytic A chain (RTA) is reductively separated from the cell-binding B chain, and

130 appearance of dTDP-hexopyranose-5,6-ene (the reductively stabilized dTDP-4-ketoglucose-5,6-ene), and

131 borohydride, which stopped the reaction and reductively stabilized the intermediates and product.

132 R-group" approach, high molecular weight and reductively stable conjugates were accessible without ex

133 The Te atomic layer was then reductively stripped from the deposit, leaving the Ge an

134 of producing large amounts of net acetyl-CoA reductively, the cells adapt by reducing their demand fo

135 ecursor is oxidized, decarboxylated and then reductively thiolated to form CoM.

136 The resulting cycloadducts are cleaved reductively to provide azapolycyclic scaffolds with stra

137 Characterization of MRD revealed that it reductively transforms MC into 1,2-cis-1-hydroxy-2,7-dia

138 ic changes allows the mutant IDH1 enzymes to reductively trap alphaKG directly into 2HG, rather than

139 studying the conformational propensities of reductively unfolded RNase A under folding conditions, s

140 s, the protein linkers of prokaryotes evolve reductively whereas those of eukaryotes do not.