ライフサイエンスコーパス: reengineer

1 of spatial patterns in proliferation may be reengineered.

2 ts from the same vector without the need for reengineering.

3 n excellent example of how to systematically reengineer a pharmacophore in order to overcome toxicolo

4 ortance of stability differences in vivo, we reengineered a partially humanized variant of the amino-

5 We have reengineered a red-emitting dicyanomethylenedihydrofuran

6 f promoting CST axon regeneration in vivo by reengineering a developmentally down-regulated, growth-p

7 we compare the efficacy of these methods in reengineering a protein homodimer into a heterodimer.

8 ABY-025 is a small reengineered Affibody molecule targeting a unique epitop

9 The anticancer activity of the reengineered agent, called WBZ_4, was instead preserved

10 ate mechanisms of mAb-mediated protection to reengineer an anti-stalk bNAb to selectively enhance Fcg

11 nize biotechnology by providing the means to reengineer and reprogram cellular regulatory mechanisms.

12 elements align with the concept of knowledge reengineering and represent a sharp departure from top-d

13 ved after the implementation of a systemwide reengineering and, during the period from 1997 through 2

14 ve and noninvasive assay that uses nontoxic, reengineered anthrax toxin-beta-lactamase fusion protein

15 the hypothesis that it should be possible to reengineer archetypal enzymes to achieve substrate speci

16 The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription factor.

17 g the applicability of synonymous codon pair reengineering as a strategy to effect phenotypic endpoin

18 ions in cells has important applications for reengineering biological functions.

19 Thus, genetically reengineered BoNTs can be targeted to nonneural cells to

20 de that retroviral tropism can be rationally reengineered by insertion of short peptide ligands and w

21 elusive in molecular terms and has not been reengineered by site-directed mutagenesis.

22 ors for systemic or hepatic gene transfer by reengineering capsid-glycan interactions.

23 ote efforts to block viral propagation or to reengineer capsids for gene therapy applications.

24 More broadly, the reengineered carboxysomes represent a proof of concept f

25 proteins have become prospective targets for reengineering cell wall biosynthetic pathways for the ef

26 evelopment of fermentation processes for the reengineered CEN.PK2 amorpha-4,11-diene strain led to pr

27 tructure-activity relationship to rationally reengineer cisplatin could have a major impact globally

28 ntibodies (mAbs) have become one of the most reengineered classes of biological molecules.

29 roposed Cro evolutionary code can be used to reengineer Cro specificity.

30 Successful reengineering depended on choosing a thermostable starti

31 helator or anionic lipids, respectively, the reengineered dynamin displayed the capacity to constrict

32 Expanding the genetic code rested on reengineering EF-Tu to relax its quality-control functio

33 ims to design de novo biological systems and reengineer existing ones.

34 ecades, protein engineers have endeavored to reengineer existing proteins for novel applications.

35 plications of DNA electrophoresis can now be reengineered for lower ionic strength, higher field stre

36 vivo RNA binding sites of wild-type (WT) and reengineered forms of the PUF protein Saccharomyces cere

37 chnologies that are capable of fundamentally reengineering genomes from the nucleotide to the megabas

38 We used the atomic-level structure to reengineer gp120 cores to preferentially present the cys

39 These reengineered gp120s are prospective immunogens that may

40 We have reengineered granulocyte colony-stimulating factor to im

41 DOTA (ABY-027), was created by fusion of the reengineered HER2-binding Affibody molecule ZHER2:2891 t

42 An evolved and reengineered high-specificity M6P/IGF2R domain 11 bindin

43 These reengineered human A1 ARs revealed orthogonality similar

44 These findings identify the reengineered imatinib as an agent to treat GISTs with cu

45 We show that heat sensitivity can be reengineered in both TRPV1 orthologs by a single amino a

46 s of the TS structure, based on their highly reengineered interfaces.

47 use of computational protein design tools to reengineer its specificity toward immunogenic elements f

48 As the US health care system begins to reengineer itself to address the need for quality improv

49 rategy that, by truncation and computational reengineering, led to a stable construct where both can

50 ce, making them among the most significantly reengineered ligand-binding proteins to date.

51 ther, these data support the hypothesis that reengineered ligand-mediated gene delivery should be con

52 Our methods for reengineering lipid A structure may be useful for genera

53 Our most potent reengineered molecules contain three essential design fe

54 nalyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics.

55 tive, and readily generalizable strategy for reengineering NHRs to respond specifically to a selected

56 wild-type v-Src despite the proximity of the reengineered nucleotide binding site to the phosphoaccep

57 The efficacy and efficiency of the reengineered obligate heterodimer variants of the FokI c

58 The study shows that structural reengineering of a kinase-inhibitory drug to improve tol

59 Minor reengineering of a powerful inhibitor guided by wrapping

60 tion of T-cell epitopes to achieve extensive reengineering of a protein sequence for reduced MHC-II b

61 Protein reengineering of cellular retinoic acid binding protein

62 Reengineering of cellular retinoic acid binding protein

63 , and have become exemplary scaffolds in the reengineering of new RNA specificities.

64 PSs) and lay the groundwork for the rational reengineering of NRPSs by swapping domains handling diff

65 The reengineering of protein-small molecule interfaces repre

66 The discovery, design and reengineering of riboswitches offer an alternative means

67 ly focused on transcriptional circuits, with reengineering of signaling circuits hampered by limited

68 y of conventional agonist therapy can be the reengineering of the GPCRs and their agonists.

69 mpanying manuscript, Tanaka et al. show that reengineering of the isoprenoid biosynthetic pathway in

70 erminus of the NKG2D ectodomain should allow reengineering of the membrane anchoring from a native N-

71 Here we showed that reengineering of the receptor binding surface of arresti

72 l recognition particle pathway combined with reengineering of the signal peptide sequence results in

73 out domain or module interactions may enable reengineering of this assembly line enzymatic organizati

74 partment assembly, our results may guide the reengineering of viruses as nanoreactors that self-assem

75 smate mutase activity in Escherichia coli by reengineering parts of the aromatic amino acid biosynthe

76 uccessful policies do not seem to culturally reengineer people.

77 ntially scalable and cost-effective promoter reengineering platform should streamline the discovery o

78 s identified, the product was submitted to a reengineering process.

79 into a gene cluster, thereby expediting the reengineering process.

80 (4) Reengineer products and systems to make prevention simpl

81 putational approaches have been developed to reengineer promising chimeric proteins one at a time thr

82 The chemical design strategy used to reengineer protein-small molecule interfaces is particul

83 Reengineering protein-protein recognition is an importan

84 cal activity, measured as the ability of the reengineered proteins to stimulate the proliferation of

85 o bind UAAG and identify the targets of this reengineered PUF in vivo.

86 A reengineered receptor (neoceptor) could be selectively a

87 A reengineered regulatory system inserted into the embryo

88 are these events to other mutations, we have reengineered reporters that detect specific base substit

89 opy expression plasmids were introduced into reengineered S. Typhi strains previously tested in clini

90 and magnitude of subunit communication in a reengineered single-chain version of the homodimeric tra

91 nt studies by Park, Zarrinipar, and Lim with reengineered Ste5 scaffold proteins underscore the funda

92 The primary macrolide produced by the reengineered strain was 6-ethylErA.

93 Such insights will be critical in reengineering suboptimal immune systems in immunocomprom

94 ethod of codon harmonization was employed to reengineer the gene sequence for expression in Escherich

95 state of PAK1, we used molecular modeling to reengineer the isolated IS domain so that it was soluble

96 nowledge of in vivo fluxes can be applied to reengineer the metabolic, regulatory, and phenotypic cha

97 ork, we used a library screening approach to reengineer the multi-specific anti-apoptotic protein Bcl

98 p sequences, prompting us to computationally reengineer the Rep gene by using synonymous codon pair r

99 hat recognizes an orthogonal promoter and to reengineer the tryptophanyl tRNA-synthetase:suppressor t

100 Here, we reengineered the BG505 SOSIP.664 glycoprotein to engage

101 of bacterial and mitochondrial dynamins, we reengineered the classical dynamin by replacing its PHD

102 We reengineered the human A(2A) adenosine receptor by repla

103 odel for non-LTR retrotransposition, we have reengineered the Zorro3 retrotransposon, an L1 homolog f

104 discovery, research teams of the future, and reengineering the clinical research enterprise.

105 re, including network-based annotation; (ii) reengineering the database backend and supporting code r

106 strate specificity and provides guidance for reengineering the enzyme to further improve its utility

107 t linkage of the trimers to the liposomes by reengineering the polyhistidine tail to include a free c

108 uld alter the specificity of the reporter by reengineering the protease recognition sequence.

109 Reengineering the receptor footprints of adeno-associate

110 The result of reengineering the regulatory circuitry in this way was t

111 nding diversity within the superfamily or by reengineering the specificity of individual proteins.

112 experiments also highlight the potential of reengineering the sugar substituents on plant wall polys

113 The results suggest that reengineering the VH/VL interface could be useful in imp

114 roenvironment, but instead, they dynamically reengineer their surroundings.

115 entury efficiently, a drastic need exists to reengineer this system into a coordinated, safe, and mor

116 Reengineering this change back into the wild-type cowpox

117 Reengineering this knowledge back into molecular structu

118 tor proteins, and thus are a good target for reengineering through synthetic biology.

119 quality-of-care indicators from 1994 (before reengineering) through 2000 and compared the quality of

120 netic circuits and metabolic pathways can be reengineered to allow organisms to process signals and m

121 ies in rhesus monkeys, the humanized mAb was reengineered to bind to rhesus CD11a by changing four re

122 the 6-deoxyerythronolide B synthase has been reengineered to catalyze two successive rounds of chain

123 When the phage genome is further reengineered to contain like green fluorescent protein o

124 recognition principles, a homeodomain can be reengineered to create factors where its specificity is

125 In some cases, these enzymes have been reengineered to create novel products.

126 which the potent Ad5 vector was genetically reengineered to display the mucosal-targeting sigma1 pro

127 Clones were reengineered to express soluble Fab, and neutrophil bind

128 ow that both luciferase and luciferin can be reengineered to extend the scope of this light-emitting

129 blast, at the NCBI website has recently been reengineered to improve usability and performance.

130 Similar results were obtained when AOX1a was reengineered to target the plastid.

131 A) health care system initiated a systemwide reengineering to, among other things, improve its qualit

132 cians, systems for managing tests need to be reengineered using methods from reliability sciences.

133 These results suggest that reengineering using the PUF scaffold redirects and can e

134 The reengineering was accomplished through a series of chore