ライフサイエンスコーパス: refinement

1 en centroid algorithm was used for signature refinement.

2 areas of development including callosal axon refinement.

3 mitations of the ACA and potential areas for refinement.

4 e labeling and empirical potential structure refinement.

5 layer segmentation algorithms without manual refinement.

6 iole interactions is currently in a state of refinement.

7 facilitates model building and atomic model refinement.

8 annealing (global optimization) and Rietveld refinement.

9 comas, and available prognostic methods need refinement.

10 force fields for efficient protein structure refinement.

11 hich suggests an optimal condition for grain refinement.

12 ained conformational search with a full-atom refinement.

13 already been learned and not those still in refinement.

14 rning techniques were applied for prediction refinement.

15 e compared with those determined by Rietveld refinement.

16 e not ideal, with much potential for further refinement.

17 sequent synapse development, maturation, and refinement.

18 trations, current pesticide monitoring needs refinement.

19 models of proteins via successive rounds of refinement.

20 ccompanied by some notion of iterative model refinement.

21 ted segmentation only and scans using manual refinement.

22 contrast to >30 inputs before developmental refinement.

23 eneration in gap filling and metabolic model refinement.

24 m thinner, P < .001) when compared to manual refinement.

25 lular, and imaging parameters offers further refinement.

26 s; we identify challenges to their technical refinement.

27 the episodic Ca(2+) oscillations involved in refinement.

28 microstructure to a dislocation one by grain refinement.

29 akin to M2 rather than M1 based on structure refinements.

30 s of computation through iterative partition refinements.

31 cks of these methods as well as their latest refinements.

32 sual system may act on vestibular projection refinements.

33 a sets and establishes new evidence to guide refinements.

34 de opportunities for future disease-specific refinements.

35 ibitor-bound to agonist-bound binding pocket refinement, a key task for GPCR SBDD programs.

36 ensor imaging is sensitive to these cellular refinements affecting neuronal connectivity.

37 nverted to explicit all-atom coordinates for refinement against SAXS data using the Xplor-NIH program

38 direct solid-solid processes, and sequential refinement against the diffraction patterns obtained per

39 With further refinements aimed at reducing cost and increasing throug

40 Global genomic refinements along with systems-based comparative and co-

41 putational methods in large-scale structural refinement, along with current and future challenges, is

42 Iterative model refinement and behavior analysis, compared with biologic

43 We also need to improve model elaboration, refinement and coarse graining procedures to better unde

44 n states, solvation in explicit solvent, and refinement and filtering with molecular simulation to en

45 es were thought dedicate to respectively the refinement and growth enhancement.

46 tween enriched neonatal experience, synaptic refinement and induction of epigenetic processes within

47 lloy was investigated by analyzing the grain refinement and microstructural evolution resulting from

48 n OPUS-PSP, previously developed by us, with refinement and new features.

49 cs play instrumental roles in neural pattern refinement and progression, but the impact of cell behav

50 but could also lead to inappropriate circuit refinement and psychopathology in adverse situations.

51 characterization performed by x-ray Rietveld refinement and Radial Distribution Function (RDF) method

52 1.5 million compounds, followed by in silico refinement and screening for biological activity in vitr

53 g results used by CNS for final atomic model refinement and selection.

54 ABSTRACT: Synaptic refinement and strengthening are activity-dependent proc

55 Synaptic refinement and strengthening are activity-dependent proc

56 a(2+) oscillations are required for synaptic refinement and the response to the muscle-derived chemor

57 ty to monitor detector and crystal parameter refinement and to display the average spot shape in diff

58 Further refinement and validation of automated analysis techniqu

59 continued need for both thermodynamic model refinements and alternate RNA structure prediction metho

60 Further refinements and broad adoption of the Cpf1 genome editin

61 dramatically hampers structure solution and refinement, and has a strong impact on the quality of el

62 cytoskeletal networks in the establishment, refinement, and maintenance of E1 cells' PCP.

63 e proposed indicator domains require further refinement, and mark the beginning of an ongoing consult

64 could expedite the development, validation, refinement, and selection of risk models.

65 ultaneous simulation of mobile solutes; mesh refinement; and root growth plasticity.

66 In this study, we present a structural refinement approach that combines solid-state NMR experi

67 , we identify credible SNPs using a Bayesian refinement approach, with two loci harbouring only one p

68 e planar due to the limitation of local grid refinement approach.

69 Both refinement approaches yielded ensembles of model structu

70 gies for computational real-space structural refinement are reviewed, and their specific applications

71 Refinements are also suggested for the diagnostic criter

72 Further refinements are needed for prediction of ARDS.

73 SEalpha for protein structure prediction and refinement as well as function prediction.

74 ch leads to in-situ toughening and sub-grain refinement at elevated temperatures.

75 consensus model rankings, followed by model refinement based on model combination (i.e. averaging).

76 high frequency of symptoms warrants further refinements before symptom-triggered diagnostic testing

77 Geometry refinement by density functional theory (DFT) calculatio

78 her show that new strategies for ultra grain refinement can be evoked by combining DT and DRX mechani

79 Rietveld refinement carried out on 2-dimensional diffraction patt

80 Manual refinement changed 298 of 3486 (8.5%) of scans to a diff

81 We present its refinement, CHARMM36m, with improved accuracy in generat

82 rasonics caused significant additional grain refinement compared to that provided by the master alloy

83 We have employed quantum refinement (crystallographic refinement enhanced with qu

84 hat defect density decreases with grain size refinement due to the increase in grain boundary surface

85 Application of sequential re-refinement enables MDFF to achieve a radius of convergen

86 mployed quantum refinement (crystallographic refinement enhanced with quantum-mechanical calculations

87 scattering and empirical potential structure refinement (EPSR).

88 We conclude that our technical refinement extends the utility of radiocarbon simulation

89 , and high resolution X-ray diffraction with refinement fitting.

90 of classification and subtomogram averaging refinement for cryo-ET data of purified hepatitis B caps

91 cus attention on which components might need refinement for policy applications.

92 er as a powerful tool for model building and refinement has revolutionized the field of structure det

93 Further refinement has yielded, in particular, a 36-residue Site

94 oth image classification and high-resolution refinement have been accelerated more than an order-of-m

95 However, refinements have recently been proposed by the consensus

96 The refinement highlights local conformational differences,

97 structed by the iterative threading assembly refinement (I-TASSER) simulations, where physics- and kn

98 a dramatic and ancient degree of ecological refinement in a major lineage of insect predators, for a

99 retardation protein (FMRP) sculpts synaptic refinement in an activity sensor mechanism based on sens

100 In agreement, mossy fiber refinement in CA3 was impaired in SynCAM 1 KO mice.

101 ing research landscape towards endophenotype refinement in clinical and preclinical settings.

102 ndritic growth in J-RGCs is accompanied by a refinement in dendritic self-crossing.

103 er CPN birth, with a progressive postmitotic refinement in expression, becoming restricted to CPN of

104 What has not evolved is any refinement in our evaluation of HLA relatedness between

105 critical functions in synapse formation and refinement in the developing brain, and there is growing

106 y activity-dependent circuit elaboration and refinement in the mammalian visual system.

107 cuits are thought to mature first and direct refinement in the thalamus, after which cortical circuit

108 retation and make recommendations on further refinement in these areas.

109 Further refinements in combination therapies such as algorithms

110 As further refinements in islet isolation and culture are made in p

111 We describe refinements in optogenetic methods for circuit mapping t

112 elaborate this hypothesis, in particular the refinements in our understanding of ventral and dorsal s

113 e graft and native liver along with multiple refinements in surgical technique have improved the outc

114 regulate one of the most crucial functional refinements in the mammalian cochlea, the disruption of

115 regulate one of the most crucial functional refinements in the mammalian cochlea, the disruption of

116 ds) and for providing a framework for future refinements in the modelling of leaf optical properties.

117 ults create further opportunities to develop refinements in the modification of CD163 with the goal o

118 Further refinements in these treatment options combined with enr

119 uitry in schizophrenia, 2) the developmental refinements in this circuitry that occur during the peri

120 limitations of the capture methods, further refinements in WES technologies have the potential to en

121 ostic regulators that were obscured prior to refinement, in particular NFY, and offer a detailed look

122 Structure refinements indicate that the consecutive phase transiti

123 Synaptic refinement is a critical step in nervous system maturati

124 y of circumstances, and demonstrate that the refinement is able to quantitatively improve registratio

125 lcohol, and marijuana use disorders, further refinement is needed before it can be recommended broadl

126 romise as a screening program, but algorithm refinement is needed to achieve better performance.

127 eous group of clinical subtypes, and further refinement is needed to improve treatment outcomes.

128 ake time improves sensitivity, but algorithm refinement is needed.

129 The extent of the refinement is significant when compared with typical hel

130 cture diversification, rather than structure refinement, is the driving force behind the creation of

131 rmance in enriching for the chemotype of the refinement ligand.

132 ecrystallization (DRX) is an important grain refinement mechanism to fabricate steels with high stren

133 Most genotype refinement methods are based on hidden Markov models, wh

134 t also incorporates recently developed model refinement methods that can consistently improve model q

135 This human-avian system offers a simple refinement model for animal research and a step towards

136 independent age constraint and a Monte Carlo refinement modeling of lead isotopes, we place the likel

137 assessing future tractography methodological refinements objectively.

138 We found that, in contrast to the refinement observed for excitatory maps, inhibitory sens

139 Rasch Measurement Theory analyses led to the refinement of 8 appearance scales with 66 total items.

140 This is important, as global refinement of a full chain model may not always be possi

141 Finally, we outline the selection and refinement of a highly selective recombinant antibody fo

142 important tool for the further analysis and refinement of ADCC-inducing HIV and other antiviral vacc

143 computation that mediates the emergence and refinement of an invariant neural representation of natu

144 modify the effects of climate on health, and refinement of analytic techniques for detection and attr

145 rable 3Rs benefits in terms of reduction and refinement of animal use.

146 Further refinement of artemether-lumefantrine dosing to improve

147 Future refinement of biomarkers will be necessary to subclassif

148 e widespread utilisation, interrogation, and refinement of candidate naive cells.

149 r further metabolomic and functional genomic refinement of characteristic biosynthesis pathways and w

150 ptic plasticity plays a critical role in the refinement of circuitry during postnatal development and

151 fluence of ultrasonic treatment on the grain refinement of commercial purity aluminium with a range o

152 d spin labels provide critical input for the refinement of computer models and the elucidation of the

153 factory system connectivity, a defect in the refinement of connections to second-order neurons in the

154 e NMDAR is thought to play a key role in the refinement of connectivity in developing neural circuits

155 ole in initiating and guiding the functional refinement of cortical circuits in critical period devel

156 Refinement of cre site composition via analysis of the c

157 re-objectively measurable phenotypes enables refinement of current animal models of PTSD, and it supp

158 other analyses, comprehensive validation and refinement of de novo genome assemblies.

159 Continued refinement of decision-making techniques is warranted to

160 The refinement of existing biomarkers and identification of

161 retinal wave loss during the development and refinement of eye-specific segregation.

162 health in US children, opportunities for the refinement of health metrics, improvement of health metr

163 y during learning prevents stabilization and refinement of hippocampal maps.

164 Our analyses speak to a possible refinement of how the hemody-namic process is parameteri

165 These findings indicate that further refinement of imaging to identify anatomic factors predi

166 Our successful refinement of initial server models combined with our bu

167 assessment and training, and prompt further refinement of international ROP guidelines.

168 ection of patient-centered outcome measures, refinement of intervention content and format, and langu

169 However, further refinement of methods of induction and maturation of neu

170 Refinement of microdeletion breakpoints identifies a sub

171 gs establish a time course for the onset and refinement of mPFC-BLA transmission and point to potenti

172 ed to a novel procedure for the simultaneous refinement of multiple parameters (DeltaG degrees , Delt

173 entury, progressing from the recognition and refinement of natural products with therapeutic benefit,

174 rain volume overgrowth and disruption of the refinement of neural circuit connections and is associat

175 Dendritic spine elimination is vital for the refinement of neural circuits during development and has

176 arning and memory, and it is crucial for the refinement of neuronal circuits during development.

177 sory pathways promote maturation of neurons, refinement of neuronal connections, and assembly of appr

178 quiring a carefully timed reorganization and refinement of neuronal connections.

179 learning rules, which underlie learning and refinement of neuronal connectivity, postulate input spe

180 ptive brain activity is concomitant with the refinement of noxious-evoked limb reflexes.

181 d Rosetta FlexPepDock for flexible full-atom refinement of PIPER docked models, we successfully addre

182 oplasmic streaming and are essential for the refinement of posterior determinants.

183 ell subpopulations, and ultimately provide a refinement of precision therapeutics for cancer treatmen

184 The refinement of prognosis for this molecular subtype of NS

185 hanced Raman scattering (SERS), requires the refinement of proper biological protocols for their effe

186 also serves as a model compound for test and refinement of quantum chemical calculations.

187 of the circadian clock and light-independent refinement of retinogeniculate projections.

188 elucidate the genetic basis may lead to the refinement of risk stratification for affected patients

189 porin for empirical therapy in high-risk FN, refinement of risk stratification to define patients wit

190 te that the enhanced nucleation leads to the refinement of secondary phases such as eutectic silicon

191 Despite the development and refinement of several techniques designed to locate an o

192 During the preterm period, refinement of spinal cord excitability is also observed:

193 During this time, reorganization and refinement of spinal sensorimotor circuits occurs as sup

194 ked network activity, followed by subsequent refinement of temporal dynamics, which was related to a

195 icantly with increasing gNa, indicating that refinement of temporal information by BCs is degraded by

196 By a spatially resolved refinement of the anomalous scattering contributions of

197 0 ChIP-Seq motifs allowing for expansion and refinement of the ARE.

198 Here, we report the refinement of the Bax agonist SMBA1 to generate CYD-2-11

199 driven cell autonomy among HSCs implies that refinement of the concepts of stem cell plasticity and o

200 l entropy or "entropy meter" also allows for refinement of the contributions of solvent entropy and t

201 e chemotactic axes could be explored for the refinement of the cutaneous homing of the therapeutic st

202 hair cells (IHCs), which is crucial for the refinement of the developing auditory circuitry.

203 hair cells (IHCs), which is crucial for the refinement of the developing auditory circuitry.

204 ervations, underscoring the need for further refinement of the halogen emissions and chemistry scheme

205 This leads to a refinement of the hypothesis linking directional lateral

206 , which may play a role in the developmental refinement of the MNTB-LSO pathway.

207 Future refinement of the model and the characterization of spec

208 Future refinement of the model presented here will allow for an

209 Refinement of the PFL-AE crystal structure reveals Na(+)

210 In this study, through a refinement of the phenotype spectrum of AN, we present a

211 Based on the PELDOR distance data, structure refinement of the POTRA domains was performed taking two

212 ectively indicate the growth enhancement and refinement of the primary Al2Cu phase in the magnetic fi

213 which appear to result in a modification and refinement of the relationship between motor cortical ac

214 from cortex to thalamus critically regulates refinement of the retinogeniculate projection during a d

215 Refinement of the sentinel-lymph-node biopsy technique m

216 Further refinement of the signal acquisition and analysis algori

217 The new anatomical data facilitate a refinement of the species diagnosis and allowed us to re

218 ns as rigid bodies; and 2) using an all-atom refinement of the structure.

219 g circuits, followed by experience-dependent refinement of their functional connectivity.

220 model in which to study the development and refinement of these pathways.

221 Further refinement of this approach may lead to new tools for me

222 portant implications for the development and refinement of this auditory circuit and may play a role

223 Refinement of this chemotype for establishing structure-

224 s, a recent and very promising technological refinement of this class of transformations.

225 Refinement of this T-cell therapy is crucial to improve

226 Further biological refinement of this tool will permit the rapid developmen

227 GUTS appears to be a promising refinement of traditional survival curve analysis and do

228 of CAR technology is a clinically applicable refinement of Treg therapy for organ transplantation.

229 We conclude that further refinement of type 2 therapies to specific type 2 phenot

230 Some of those methods are refinements of classic biochemical tools, whereas most o

231 been systematically characterized, hindering refinements of future epidemic predictions and explorati

232 Refinements of the animal model have also improved its u

233 However, full Rietveld refinements of the in situ neutron diffraction data indi

234 tion extractors without expert annotation or refinement, opening an unprecedented opportunity of usin

235 as a potential role in the establishment and refinement/plasticity of precerebellar circuits during p

236 The refinement procedure is discussed for the multiple bindi

237 t errors, and the object, using an iterative refinement procedure.

238 xternal boundaries, followed by an efficient refinement process guided by key biological structures w

239 anglion cells (ipRGCs) are critical for this refinement process.

240 The joint refinement protocol offers unique opportunities to detec

241 The 3Drefine refinement protocol utilizes iterative optimization of h

242 sms mediating their emergence and subsequent refinement remain poorly understood in general.

243 Spike-timing-dependent synaptic refinement represents one possible mechanism for the cha

244 Automated segmentation without manual refinement resulted in reduced global RNFL thickness and

245 The joint X-ray and NMR refinement reveals that-despite the poor quality of the

246 ReFOLD is a novel hybrid refinement server with integrated high performance globa

247 utomatically detected and corrected, and the refinement shows a large radius of convergence.

248 serine as an endogenous modulator of circuit refinement.SIGNIFICANCE STATEMENT Activation of NMDARs i

249 hods such as mutual information benefit from refinements such as shuffling, while being highly effici

250 ts also include glial regulators of synaptic refinement, such as Sparc Finally, the transcripts conta

251 ce do not demonstrate a defect in glomerular refinement, suggesting that distinct genes or sets of ge

252 An hp-refinement technique is applied to decrease the Degrees-

253 Previously, we adapted classical post-refinement techniques to XFEL diffraction data to produc

254 g electric current a powerful microstructure refinement technology.

255 a(2+)-dependent signaling network underlying refinement that involves the phosphatases calcineurin an

256 With further refinement, the methodology reported herein could lead t

257 With further refinement, the methodology reported herein could lead t

258 ased grain/phase boundaries due to the grain refinement, the more homogeneous distribution of the sec

259 Under high pressure, GaSb undergoes grain refinement, the number of interfaces increases, and carr

260 ay powder diffraction combined with Rietveld refinement, the slight but significant alteration in sca

261 nal workflow were 'rescued' by the Warpgroup refinement, thereby resulting in greater analyte coverag

262 With replication and significant refinement, this technique has potential in the future a

263 rver allows for convenient protein structure refinement through a text or file input submission, emai

264 s low-priority stimuli, but it requires some refinement to account for physiological fluctuations in

265 h linkage-disequilibrium (LD)-based genotype refinement to accurately and cost-effectively infer geno

266 presentative' abundances require substantial refinement to be extrapolated to regional or global scal

267 Here we present an essential methodological refinement to correct [CO3(2-)]spec absorbance data for

268 s of sgRNAs are two likely areas for further refinement to enhance efficiency while limiting unfavora

269 ill open the door to achieving optimal grain refinement to nanoscale in a variety of steels requiring

270 them through various stages of modeling and refinement to produce simulation-ready structures.

271 n intervention and also incorporates angular refinement to reduce the tilt angle error.

272 The LEnS concept is a practical refinement to the exposome that accounts for total expos

273 Continued refinement to the model to reflect diverse biological sy

274 The CL/K/D switching, which represents a refinement to the previously described CL/K pathway, fin

275 nisms to highlight shared features and novel refinements to the basic alternating-access model.

276 ur method, which indicate a need for further refinements to the metabolic model.

277 pments such as OCT microscope guidance added refinements to the surgical technique.

278 We suggest some conceptual refinements to their "appropriate-response" perspective,

279 ition, we exported the results after "manual refinement" to correct errors in the automated segmentat

280 ignificant toughness, through a simple grain-refinement treatment, which refines the grain size to 4

281 The MDFF refinements uniquely offer map-model validation and B-fa

282 Rietveld refinement using geometric restraints were then performe

283 diffraction data, and allows for a structure refinement using rigid carbonate groups.

284 utions quickly as initial inputs for further refinement using the MD/SA method.

285 jury severity, these thresholds need further refinements using histopathology, immunohistochemistry a

286 Real-space refinement was used to generate closed and open conforma

287 ovel approach of multistep and, with further refinement, we believe, multiple micro-organism biotrans

288 To provide a template for further refinement, we propose a new working model for ESCRT-med

289 ical way that could be used during structure refinement, we tested translation-libration-screw (TLS),

290 These refinements, we suggest, overcome older criticisms, just

291 rotron X-ray powder diffraction and Rietveld refinement were then used to elucidate the structures of

292 Powder X-ray Diffraction (XRD) and refinement were used to analyze the crystal structure.

293 current status of APOLT for NCMLD, technical refinements which have improved outcomes and novel indic

294 in the molecular pathway underlying network refinement, which includes oscillatory calcium signals v

295 he first pediatric guidelines, re-review and refinement will be necessary as studies further detail,

296 n neuro-oncology trials, although additional refinements will be needed.

297 computationally efficient protein structure refinement with the capability to perform web-based stat

298 ling pathway contributes to ongoing synaptic refinement within the dentate circuit.

299 We aimed to determine whether such a refinement would be cost effective.

300 Rietveld refinement yielded a monoclinic structural model for a w