ライフサイエンスコーパス: refractoriness

1 stricted by a natural resistance phenomenon (refractoriness).

2 alities, because all spiking neurons exhibit refractoriness.

3 th a 10-ms decrement until AT termination or refractoriness.

4 ding assays are not associated with platelet refractoriness.

5 cer initiation, progression, and therapeutic refractoriness.

6 t ventricular extrastimuli were delivered to refractoriness.

7 regionally to result in large dispersion of refractoriness.

8 of them target the VEGF pathway and lead to refractoriness.

9 n responsiveness in a mouse model of insulin refractoriness.

10 sponse) and considerable post-repolarization refractoriness.

11 on potential amplitudes, latency and in axon refractoriness.

12 pment of atrial-specific post-repolarization refractoriness.

13 odel predicted maximal spatial dispersion of refractoriness.

14 y conduction by promoting postrepolarization refractoriness.

15 re initiated immediately after recovery from refractoriness.

16 onor platelets prevented alloimmune platelet refractoriness.

17 e myeloid cells is also sufficient to confer refractoriness.

18 between platelet transfusions, and platelet refractoriness.

19 echanism contribute to spark termination and refractoriness.

20 ) whose coupling interval just exceeded RSPV refractoriness.

21 suggest a common mechanism underlying G-CSF refractoriness.

22 ssociated with both elevated P2' and reduced refractoriness.

23 nistered for up to 8 weeks or until platelet refractoriness.

24 ts by delaying repolarization and prolonging refractoriness.

25 the period of illumination and does not show refractoriness.

26 rising from vesicle depletion or postrelease refractoriness.

27 node, atrial, and ventricular conduction and refractoriness.

28 Similar changes were observed in ventricular refractoriness.

29 ization as an indicator of the male's sexual refractoriness.

30 oltage-gated Ca2+ channels does not initiate refractoriness.

31 account for the immune mechanism in platelet refractoriness.

32 elated with improved callosal conduction and refractoriness.

33 hly immunogenic stimulus), or until platelet refractoriness.

34 ndothelial vulnerability contributes to GVHD refractoriness.

35 nt of the number of prior lines and level of refractoriness.

36 ts is closely associated with corticosteroid refractoriness.

37 trial voltage, conduction velocity (CV), and refractoriness (7 sites, 2 cycle lengths), vulnerability

38 osure to short winter day lengths results in refractoriness, a spontaneous reversion to long-day phys

39 A universal property of spiking neurons is refractoriness, a transient decrease in discharge probab

40 fixed heterogeneity; namely, the gradient of refractoriness across the ischemic border zone (BZ).

41 ing preferences and the cost and efficacy of refractoriness affects the long-term prevalence of malar

42 evels of HLA antibodies were associated with refractoriness among LCA(+) recipients.

43 els of HLA or HPA antibodies did not predict refractoriness among LCA(-) recipients, although higher

44 RA refractoriness and aberrant histone acetylation were att

45 etoclax or higher (>/=400 mg/d), fludarabine refractoriness and complex karyotype were associated wit

46 history of AF or risk factors for AF, atrial refractoriness and conduction were measured, followed by

47 er methods of preventing alloimmune platelet refractoriness and demonstrated that successful methods

48 causes accelerated conduction with prolonged refractoriness and electric instability.

49 unwanted immune responses, such as platelet refractoriness and graft-vs-host disease.

50 erimental observations we present, including refractoriness and increase of puff frequency during the

51 Nevertheless, HERG-G628S abbreviated refractoriness and increased beat-to-beat variability, l

52 his resulted in enhanced post-repolarization refractoriness and more effective Na-channel inhibition.

53 properties of cells such as restitutions of refractoriness and of conduction velocity are given via

54 Ca(2+) release and uptake, and the other on refractoriness and other properties of Ca(2+) sparks.

55 lated with some clinical characters, such as refractoriness and pleural effusion.

56 ed dynamically induced spatial dispersion of refractoriness and predisposed the heart to the developm

57 ugments the shortening that occurs in atrial refractoriness and predisposes to the reinduction of AF.

58 t and AP14145 significantly prolonged atrial refractoriness and reduced AF duration without affecting

59 tive incidence of failure (including primary refractoriness and relapse), event-free survival, and ov

60 light-induced response in that both exhibit refractoriness and repriming depends upon endothelium-de

61 lcholine delivery into the AVN increased AVN refractoriness and significantly decreased ventricular r

62 promoting cardiac substrates (e.g. prolonged refractoriness and spatiotemporal dispersion of action p

63 physiological has effects on the threshold, refractoriness and superexcitability of the shortest lat

64 ommon; Anonymous impulses thus lack the same refractoriness and tend to occur in bursts.

65 Whether refractoriness and the associated serial ballistic hypot

66 on of abbreviated ryanodine receptor channel refractoriness and the preceding synchronous stimulated

67 voltage changes; and the ability to control refractoriness and the shape of the cardiac action poten

68 ary to the development of postrepolarization refractoriness, and an increase in diastolic threshold o

69 reby accelerating repolarization, increasing refractoriness, and diminishing beat-to-beat action pote

70 conduction, lower activation threshold, less refractoriness, and improved response to high-frequency

71 ink mismatch, spatiotemporal distribution of refractoriness, and rate-sensitive electric instability,

72 with 3 basic properties (random activation, refractoriness, and recruitment) produces the classic ph

73 bbreviation of action potential duration and refractoriness, and reduce the affinity of the channels

74 allenged by insufficient efficacy, intrinsic refractoriness, and resistance.

75 with severe gout, allopurinol intolerance or refractoriness, and serum uric acid concentration of 8.0

76 achycardia cycle: when a PAC is timed to His refractoriness, any perturbation of the subsequent His i

77 period nor the link between excitability and refractoriness are properly understood.

78 human monocytes we detected two forms of TNF refractoriness, as follows: absolute tolerance was selec

79 ed effector CD8 T cells probably acquire TCR refractoriness at the time the patient is experiencing f

80 wn to cause both a rapid reduction in atrial refractoriness (atrial electrical remodeling) and a more

81 such as action potential duration gradients, refractoriness barriers, conduction velocity restitution

82 Dispersion of refractoriness between apex and base was markedly reduce

83 it prolonged ventricular repolarization and refractoriness by 7.5% to 15%, respectively (p < .05).

84 bbreviation of action potential duration and refractoriness by acetylcholine combine to produce rapid

85 Reducing spatial dispersion of refractoriness by modulating restitution parameters can

86 Verapamil decreased spatial dispersion of refractoriness by reducing action potential duration and

87 y, that the temporal correlations imposed by refractoriness can play a significant role in shaping sp

88 ation that I(Ks)-mediated postrepolarization refractoriness can promote wavebreak formation and fibri

89 of changing: C-signal strength, sensitivity/refractoriness, cell density, and noise upon the formati

90 days of sinus rhythm was just sufficient for refractoriness changes to reverse fully in all goats.

91 and high-risk features, such as fludarabine refractoriness, complex karyotype, or abnormalities of c

92 e click stimulation, suggesting that spindle refractoriness contributes to this protective mechanism.

93 and numerically how preexisting gradients in refractoriness control the vulnerable window for unidire

94 fection, and that NK cell responsiveness and refractoriness correlate to the antiviral effectiveness

95 The equivalent dispersion of refractoriness created dynamically in homogeneous tissue

96 Postrelease Ca(2+) signaling refractoriness critically influences the occurrence of D

97 Some will exhibit platelet transfusion refractoriness, defined as inappropriately low platelet

98 n either reduce or enhance the dispersion of refractoriness depending on its propagation direction wi

99 , number of prior therapies, and fludarabine refractoriness did not influence the response rate.

100 Shortened Ca(2+) signaling refractoriness due to RyR2 phosphorylation and oxidation

101 nistered acetylcholine on AVN conduction and refractoriness during sinus rhythm and AF.

102 maps were constructed to assess gradients of refractoriness during VF.

103 For ratios less than approximately 0.9, refractoriness enhanced entrainment and this enhancement

104 y and behaviorally relevant factors: spiking refractoriness, event-locked firing rate non-stationarit

105 in Anopheles gambiae mosquitoes that confer refractoriness (failure of oocyst development in mosquit

106 premature beat (APB) given during His bundle refractoriness followed by resetting of an antidromic ta

107 ent angiogenic programs that induce the drug refractoriness found in cancers resistant to anti-angiog

108 Fludarabine refractoriness (FR) represents an unsolved clinical prob

109 n-mediated dissociation of drive and disease refractoriness functions.

110 Introducing refractoriness genes in areas of the genome void of inve

111 ity (P1', P2', fecundity, remating rate, and refractoriness), genotyped at 70 polymorphic markers in

112 parasites and that the frequency of natural refractoriness genotypes may be higher in the basin regi

113 Here we investigated mechanisms of RA refractoriness in 14 lung cancer cell lines.

114 gy to overcome stromal-mediated chemotherapy refractoriness in aggressive MCL.

115 f excitation, and induced postrepolarization refractoriness in atria but not in ventricles.

116 rapy, and prognostication of time to hormone refractoriness in castrate disease and overall survival.

117 erebral endothelial cells displayed a marked refractoriness in chemokine production and secretion, wh

118 s are strong predictors of poor survival and refractoriness in chronic lymphocytic leukemia (CLL) and

119 the role of dispersion of repolarization and refractoriness in facilitating re-entry arrhythmias.

120 The relationship between repolarization and refractoriness in human atrium and the effect of prior a

121 dopted the double stimulus paradigm to study refractoriness in human neuromotor control.

122 ent (I(Ks)) contribute to postrepolarization refractoriness in isolated cardiomyocytes.

123 e whether low-level antibodies could predict refractoriness in longitudinal panels from 170 lymphocyt

124 ocardial (M) cells formed zones of increased refractoriness in LQT2, producing steep spatial gradient

125 acetylation consistently correlated with RA refractoriness in lung cancer cell lines.

126 beta-adrenergic regulation of Ca(2+) release refractoriness in mouse myocytes.

127 o beta-adrenergic regulation of Ca2+ release refractoriness in mouse myocytes.

128 Here we studied regulation of Ca(2+) spark refractoriness in mouse ventricular myocytes by examinin

129 Here we studied regulation of Ca2+ spark refractoriness in mouse ventricular myocytes by examinin

130 nt effects are attributed to the build-up of refractoriness in representations with shared neural cir

131 n velocity restitution promote dispersion of refractoriness in response to multiple extrasystoles, an

132 ndependent predictor of survival and disease refractoriness in several ALL patient cohorts.

133 analysis has been presented that quantifies refractoriness in sustained control tasks and discrimina

134 istant HER2(+) clones exhibiting stable drug refractoriness in vitro and in vivo Genomic comparisons

135 AD presence do not cause large dispersion of refractoriness in well-coupled tissue.

136 or conduction block is spatial dispersion of refractoriness, in this study we investigate how the fir

137 us and AGAP001476 failed to reverse the near refractoriness induced by the knockdown of cactus, sugge

138 latelets per L, aged at least 18 years, with refractoriness, ineligibility to receive treatment with

139 en 0 and 22 +/- 6 ms following recovery from refractoriness initiated arrhythmic activity specificall

140 In intact hearts, RyR refractoriness initiates SR Ca(2+) release alternans tha

141 sustained manual tracking involves repeated refractoriness (insensitivity to sensory information for

142 manual tracking incurs substantial, serial, refractoriness (insensitivity to sensory information of

143 ems and constraints, we propose that central refractoriness is an appropriate control mechanism for a

144 Inherent anti-VEGF refractoriness is associated with infiltration of the tu

145 Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accu

146 xtrasystole can create a large dispersion of refractoriness leading to conduction block of a subseque

147 duration, depolarization of E(K1) increased refractoriness, leading to a slowing of VF, which effect

148 hanced dispersion of repolarization (DR) and refractoriness may be a unifying mechanism central to ar

149 d, dose, and administration site, nociceptor refractoriness may last from minutes up to months, sugge

150 These forms of refractoriness may provide a cellular paradigm for resol

151 ate or which have prematurely recovered from refractoriness might release Ca(2+) later during the act

152 Finally, MDP stimulation induced refractoriness not only to MDP, but also to iE-DAP stimu

153 Refractoriness occurred at a repolarization level of 72

154 Refractoriness occurs locally and independently at each

155 The refractoriness of bacterial infections to antibiotic the

156 ned coupling intervals, suggesting a reduced refractoriness of Ca(2)(+) release events; (3) have a re

157 erogeneity of Ca(2+) cycling attributable to refractoriness of Ca(2+) release from corbular sarcoplas

158 hyperactivity of RyRs and thereby shortened refractoriness of Ca(2+) release in cardiomyocytes from

159 content and ICa-L, another factor, possibly refractoriness of Ca2+ release from the SR contributes.

160 Time-dependent refractoriness of calcium (Ca(2+)) release in cardiac my

161 Time-dependent refractoriness of calcium (Ca2+) release in cardiac myoc

162 Refractoriness of calcium release in heart cells is alte

163 We examined refractoriness of calcium release in mouse ventricular m

164 We found that refractoriness of calcium release is abbreviated by stim

165 ds also retained the ability to increase the refractoriness of cardiac tissue at both slow and fast p

166 nues to be associated both with presence and refractoriness of cutaneous lupus erythematosus to thera

167 equency at the network level by reducing the refractoriness of excitatory transmission.

168 servation may provide an explanation for the refractoriness of human beta-cells to proliferation.

169 pture depends critically upon the stochastic refractoriness of its 30,000 sampling units (microvilli)

170 nzoic acid) porphyrin (MnTBAP) decreased the refractoriness of LEW rat peritoneal cells to T. gondii

171 fatty acid-derived CyPGs and the well-known refractoriness of LSCs to currently used clinical agents

172 The intrinsic refractoriness of naive T cells for cytokine production

173 ells and whether it affects the response and refractoriness of NK cells to IFN-alpha-based therapy of

174 sychiatric neurosurgery, ensuring documented refractoriness of patients, proper consent procedures th

175 The refractoriness of PBMCs to DM was examined after precond

176 al motor thalamic nuclei nicely explains the refractoriness of PRS rats to haloperidol-induced catale

177 ostsynaptic currents: vesicle heterogeneity, refractoriness of release sites, and superpriming.

178 their association with Ca(2+) channels, and refractoriness of release sites, while accounting for da

179 Refractoriness of solid tumors, including colorectal can

180 arcoplasmic reticulum (SR) refilling whereas refractoriness of spark triggering depends on both refil

181 arcoplasmic reticulum (SR) refilling whereas refractoriness of spark triggering depends on both refil

182 ck interface) is unnecessary, we ask whether refractoriness of substantial duration (~200 ms) is evid

183 Ibutilide prolonged refractoriness of the atrioventricular node, His-Purkinj

184 ptor mechanism is required for the prolonged refractoriness of the MEK/ERK and phosphatidylinositol 3

185 Refractoriness of the memory T cells to TCR activation w

186 d cellular and molecular events that mediate refractoriness of tumors to anti-angiogenic therapy.

187 urthermore, for a set [Ca(2+)](SR) level the refractoriness of wave occurrence (Ca(2+) wave latency)

188 ise: "randomness" (of Ca spark activation), "refractoriness" (of a CRU after a Ca spark), and "recrui

189 stimulus and spike history dependence (e.g., refractoriness) of the spike trains.

190 the stimulus period predicted the impact of refractoriness on entrainment and synchronization.

191 us activity can be modeled as resulting from refractoriness operating on a non-Poisson stochastic poi

192 F duration without affecting the ventricular refractoriness or blood pressure in pigs subjected to 7

193 nts are deprived of treatment due to primary refractoriness or development of resistance during thera

194 Several patients, however, display treatment refractoriness or relapse soon after obtaining a respons

195 ent findings on the role of myeloid cells in refractoriness or/and acquired resistance to such therap

196 s or no EADs with a very small dispersion of refractoriness, or synchronize regionally to result in l

197 In the recovery cycle, refractoriness (P < 0.0002) and superexcitability (P < 0

198 ected for all phenotypes except male-induced refractoriness (P = 0.053).

199 Ryanodine receptor (RyR) refractoriness played a key role in the onset of SR Ca(2

200 delayed myocardial activation and dispersed refractoriness predispose to reentrant excitation that m

201 ntractility, left atrial dilation, fibrosis, refractoriness prolongation, and AF promotion occurred i

202 nd improved postinjury strength-duration and refractoriness properties only in N2 CAPs.

203 sed intranodal fibrosis and heterogeneity of refractoriness, provides substrates for SAN reentry.

204 refractory period (ERP), post repolarization refractoriness (PRR), maximum rate of rise of the action

205 Identification of P. falciparum-refractoriness QTL in natural An. gambiae mosquitoes is

206 The only factors that reduced platelet refractoriness rates were increasing the dose of platele

207 py, chemotherapeutic resistance, and hormone refractoriness remains essential in the rational design

208 ical role in the timing of seasonal rhythms, refractoriness remains poorly understood.

209 f puff generation and the recovery rate from refractoriness, respectively.

210 In daylight, refractoriness sacrifices sensitivity to enhance intensi

211 the heart, markedly enhancing dispersion of refractoriness so that ectopic beats have a high probabi

212 terized by a high and rapid development of a refractoriness state and known for their poor prognosis.

213 al target tissue, rather than in a separate "refractoriness" substrate.

214 ical and laboratory measures predict steroid refractoriness (such as stool frequency 3-8/day and C-re

215 Currently, refractoriness, such as the Psychological Refractory Per

216 t-threshold relationship and recovery cycle (refractoriness, superexcitability and late subexcitabili

217 t-threshold relationship and recovery cycle (refractoriness, superexcitability and late subexcitabili

218 ggering an LCS also depends on recovery from refractoriness that appears after prior activation.

219 s functional substrates dependent on altered refractoriness that cause abnormalities in activation an

220 The uterine refractoriness that follows the receptive state at high

221 ne thrombocytopenia and platelet transfusion refractoriness) the causative idiotypic platelet-reactiv

222 rength of Ca(2+) release, ryanodine receptor refractoriness, the magnitude of initiating stimulus, or

223 c acid level, and allopurinol intolerance or refractoriness, the use of pegloticase 8 mg either every

224 Among those diagnosed with immune refractoriness, there is no standard method for identify

225 rld intensity changes that reduce microvilli refractoriness, these performance gains are submaximal a

226 ad mediate a decrease in ventricular APD and refractoriness through activation of the beta-adrenergic

227 apid spread of transgenes conferring disease refractoriness throughout wild populations.

228 ion induced heterogeneous changes in the SAN refractoriness; thus, competing atrial or SAN pacemaker

229 These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by t

230 y tumor or stromal cells is a determinant of refractoriness to anti-VEGF-A treatment.

231 d CD11b(+)Gr1(+) myeloid cells contribute to refractoriness to antiangiogenic therapy with an anti-VE

232 Tx PRA levels, percentage of re-Tx patients, refractoriness to antilymphocyte therapy, and outcome.

233 reates a negative feedback loop that induces refractoriness to chronic stimulation of the cAMP pathwa

234 nchyme contributes to disease chronicity and refractoriness to corticosteroids.

235 activated during this depolarization, caused refractoriness to CtVm-induced [Ca2+]i elevation, cells

236 This drug failed to prevent the onset of refractoriness to CtVm-induced [Ca2+]i elevation, provid

237 th advanced multi-drug resistant disease and refractoriness to currently available combination regime

238 myeloma (MM) cells in vitro irrespective of refractoriness to dexamethasone and chemotherapy.

239 kemia cells to proliferate and explain their refractoriness to differentiation-inducing agents.

240 ted to the weakened angiogenic response, and refractoriness to diminished endoglin signaling was acco

241 Refractoriness to DM was achieved by means of repeated e

242 s preconditioning of PBMCs with MSCs, caused refractoriness to DM.

243 bition by c-Myc shRNA established that their refractoriness to DNTCF was because of their independenc

244 Refractoriness to epinephrine could be corrected by nitr

245 lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin toler

246 ting switch in females, inducing a permanent refractoriness to further mating and triggering egg-layi

247 f its biosynthesis in males, oviposition and refractoriness to further mating in the female are stron

248 strong and sustained induction of SOCS1 and refractoriness to further stimulation with IFN-lambda3.

249 owed by recovery of activity and a period of refractoriness to further stimulation.

250 ed Shh activity is also required to maintain refractoriness to Gremlin expression in response to Bmp

251 nt features-such as sustained proliferation, refractoriness to growth suppressors, resistance to cell

252 ate nonlytic effector phenotypes from target refractoriness to immune lysis.

253 sorder, perhaps contributing to its relative refractoriness to immune-directed therapies previously r

254 bution of refractory periods, the ability of refractoriness to improve temporal coding is restricted

255 in seasonally breeding mammals by triggering refractoriness to inhibitory short photoperiods during m

256 ng to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion

257 nd 2 genes, PTGFR and MMP-1, were related to refractoriness to latanoprost.

258 Refractoriness to LEN, or resistance to both LEN and BOR

259 A unique feature of Pincher-Trk endosomes is refractoriness to lysosomal degradation, which ensures p

260 ize that new QTL may be involved in mosquito refractoriness to malaria parasites and that the frequen

261 The mid-winter development of refractoriness to melatonin (Mel) triggers recrudescence

262 The refractoriness to MMR of hypermutation in Hi tetranucleo

263 id carcinoma (ATC) characterized by complete refractoriness to multimodal therapeutic approaches.

264 onferring insecticide resistance or possibly refractoriness to parasites and (2) to reveal novel insi

265 which would provide cattle with a degree of refractoriness to perchlorate.

266 d be used to spread desirable genes, such as refractoriness to Plasmodium infection, through target p

267 on of Rh alloimmunization, and management of refractoriness to platelet transfusion ( www.asco.org/su

268 the diagnosis, prevention, and management of refractoriness to platelet transfusion.

269 Refractoriness to platelet transfusions developed in 27%

270 metinib (AZD6244, ARRY-142886) could reverse refractoriness to radioiodine in patients with metastati

271 Nevertheless, a high rate of refractoriness to recombinant human interleukin-12 occur

272 he overall response rate and to overcome the refractoriness to recombinant human interleukin-12 thera

273 0A with the male's influence on the female's refractoriness to remating (refractory), Esterase-6 with

274 as of the stones themselves, associated with refractoriness to shockwave lithotripsy are fairly well

275 e expression is associated with reproductive refractoriness to short day lengths.

276 Vernal refractoriness to short photoperiods reestablished summe

277 Successful mating induces lifetime refractoriness to subsequent insemination by other males

278 ure to LPS induces a transient state of cell refractoriness to subsequent LPS restimulation, known as

279 nary LPS exposure does not induce whole-body refractoriness to systemic LPS, because i.t. administrat

280 inhibitor colchicine, contrasted with their refractoriness to the anti-inflammatory effects of gluco

281 with the wAlbB strain of Wolbachia, inducing refractoriness to the human malaria parasite Plasmodium

282 mia (CML) whose disease manifests relapse or refractoriness to therapy.

283 s of naturally occurring alleles that confer refractoriness to transmission can reduce transmission b

284 eous cell populations demonstrate short-term refractoriness to up-front dose delivery, but "resensiti

285 Short PR/AH with increased refractoriness was additionally found in 3 patients with

286 This refractoriness was associated with decreased D1 receptor

287 Platelet refractoriness was associated with lymphocytotoxic antib

288 oreduction in preventing alloimmune platelet refractoriness was evaluated in a canine model.

289 s progesterone, which confirmed that uterine refractoriness was fully attributable to the underlying

290 In sustained control refractoriness was only found when the target reverses d

291 Ventricular refractoriness was prolonged, along with both QRS and QT

292 ng interval decremented by 20 to 30 ms until refractoriness was reached.

293 r, and ventricular conduction parameters and refractoriness were assessed in 22 MyBP-C(t/t), 10 MyBP-

294 d, but no increases in atrial or ventricular refractoriness were detected, despite achieving plasma c

295 % repolarization (MAPD(50) and MAPD(90)) and refractoriness were determined at low (9+/-3 mL) and hig

296 fibrillation shock must now not only prolong refractoriness when delivered during the action potentia

297 blocking was consistent with a collision or refractoriness when one motoneuron tried to excite the f

298 Spatial dispersion of refractoriness, which is amplified by genetic diseases,

299 Optical mapping revealed cardiac refractoriness with loss of 1:1 capture above 3 Hz, and

300 one demonstrated that prolongation of atrial refractoriness with MK-0448 was markedly attenuated in t

301 r dysfunction, exhibit normal conduction and refractoriness, yet are vulnerable to ventricular arrhyt