ライフサイエンスコーパス: regarding the role of

1 tive disorders, though many questions remain regarding the role of a single allele in three clinicall

2 eriments are likely to provide further clues regarding the role of A-myb and B-myb in tumorigenesis.

3 this review, we will discuss recent findings regarding the role of AAMPhis in the development of dise

4 phere exchange of H2 and raise new questions regarding the role of aboveground biomass as a source of

5 However, most information regarding the role of accessory molecules in immune resp

6 This Review summarizes recent data regarding the role of aging in beta cell regeneration an

7 However, little is understood regarding the role of AIPL1 in cone photoreceptors.

8 However, little information is available regarding the role of Akt itself in thymocyte developmen

9 zed and the studies are put into perspective regarding the role of allelic variants, genetic backgrou

10 this review, we will summarize what is known regarding the role of allogeneic SCT in older patients a

11 These results also provide new insights regarding the roles of allosteric effectors in regulatin

12 the isoforms may yield valuable information regarding the role of alpha-tubulin and its posttranslat

13 A key issue regarding the role of alpha6beta4 in cancer biology is t

14 Although various hypotheses exist regarding the roles of alphaSyn in health and disease, n

15 quences of obesity; however, little is known regarding the role of alternatively activated resident M

16 There has been controversy regarding the role of AMPK in cancer, some of which may

17 There are conflicting reports regarding the role of Angiomotin (Amot) in regulating th

18 Despite a wealth of knowledge regarding the role of ankyrin-B for cardiac function, li

19 atients requiring PRP and informs the debate regarding the role of anti-vascular endothelial growth f

20 ling, and help reconcile conflicting reports regarding the role of apoA-II in this remodeling.

21 These observations have implications regarding the role of apoE in the pathogenesis of smokin

22 In addition to providing information regarding the role of astrocyte-secreted apoE lipoprotei

23 id early diagnosis and provides new evidence regarding the role of autoimmunity in IBM.

24 nalization Hypothesis and resolves a dilemma regarding the role of auxin in cell growth.

25 central nervous system (CNS), in particular regarding the role of axon-growth inhibitors.

26 Although much is understood regarding the role of B7/CD28 family of costimulatory mo

27 nation of high risk DLB-CLs prompted studies regarding the role of BAL in B-cell migration.

28 r sensory neuropathy and provide new insight regarding the role of Bcl-w and of mitochondria in preve

29 Current data regarding the role of bevacizumab and other novel agents

30 Given unanticipated results regarding the role of BPD and study limitations, these f

31 However, the molecular mechanisms regarding the roles of BRCA1 in maintaining genome integ

32 nds, our results have important implications regarding the role of Btk in myeloid cell function.

33 They then responded to policy questions regarding the roles of business and government actors in

34 f the EGFR, limited information is available regarding the role of c-Cblin the trafficking and signal

35 nderstood, and there is conflicting evidence regarding the role of Ca(local) and Ca(res) in its gener

36 Our results challenge the prevailing view regarding the role of Ca(v)beta in RGK inhibition of hig

37 ells, there is little functional information regarding the role of CaD in migrating cells in vivo.

38 r conclusively refute the initial hypothesis regarding the role of CAPN10 in T2D risk.

39 The knowledge gained regarding the role of cardiac structure in the initiatio

40 review, we bring together current knowledge regarding the role of caspase-8 in cellular inflammation

41 three clinically relevant focused questions regarding the role of CBCT in the management of inflamma

42 paper addresses three current controversies regarding the role of CCK to control gastric function vi

43 disruption has yielded different conclusions regarding the role of CD28 in the development of Th1 and

44 However, the reports regarding the role of CDC73 in oral squamous cell carcin

45 ar carcinoma (HCC); however, little is known regarding the role of CDKN1C/P57 and its regulation in H

46 e to plants, provide mechanistic information regarding the role of cell wall pores in plant uptake of

47 ntrasting this evidence with recent findings regarding the role of central sensitization in pain chro

48 Little is known regarding the role of ceramide in the regulation of vasc

49 gs constitute biochemical support for models regarding the roles of checkpoint Rads as damage sensors

50 Little is known regarding the role of chemokines and early cellular immu

51 Molecular genetic analyses regarding the role of chlamydiae in induction of inflamm

52 s to multipotent stem cells, little is known regarding the role of chromatin states during developmen

53 subgroups of CRC and provided novel insight regarding the role of CIMP-specific DNA hypermethylation

54 e group representing a wide variety of views regarding the role of clinical research results in clini

55 pplemented national and regulatory messaging regarding the role of clopidogrel after DES implantation

56 remain many unexplored questions especially regarding the role of CNVs in the pathogenesis of comple

57 based on a critical review of the literature regarding the role of colonoscopy, flexible sigmoidoscop

58 Conflicting data have emerged regarding the role of complement activation in the patho

59 ence between cryoglobulinemia types I and II regarding the role of complement.

60 nts and physicians often have many questions regarding the role of complementary and alternative medi

61 erefore call for rigorous collection of data regarding the role of consciousness in decisions.

62 ined in light of the recent intense interest regarding the role of corrole ligands in stabilizing hig

63 These results clearly raise questions regarding the role of COX-2 and elevated prostaglandin l

64 *0201 was performed to provide further clues regarding the role of CTLs.

65 rowth in primary HC infection, less is known regarding the role of cytolytic mechanisms.

66 Further, issues regarding the role of debulking nephrectomy, timing of t

67 e on STO, there are still many uncertainties regarding the role of defects in the properties of STO,

68 dual-process lens, we provide a clear answer regarding the role of deliberation in cooperation based

69 udies have elucidated much basic information regarding the role of development gradients, and theoret

70 fat type and fat content, some clarification regarding the role of dietary fat in T2D incidence could

71 as isolated provides mechanistic information regarding the role of dimeric 2 in the Mukaiyama aldol r

72 l activities of Ku and explain controversies regarding the role of dimerization in DNA binding.

73 Here, we address a longstanding question regarding the role of DksA in DeltadnaKJ suppression.

74 However, there is limited information regarding the role of DNA-PK in adaptive immunity mediat

75 his review encompasses the recent literature regarding the role of DNA-PK in the protection of genomi

76 However, little is known regarding the role of DOR and protein kinases in the reg

77 Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitm

78 transcription machinery but little is known regarding the role of each Mediator subunits.

79 scribe important new findings in A. nidulans regarding the role of EBA, the master regulator of micro

80 er studies and may help frame new hypotheses regarding the role of EBV in SLE etiology.

81 vitro T-cell experiments have left questions regarding the role of EBV in the pathogenesis of EBV-pos

82 Much remains to be understood regarding the role of eIF4E in human cancer.

83 lastin knockout mice will likely yield clues regarding the role of elastin in arterial morphogenesis

84 Here, current models regarding the role of enhancers in the regulation of tra

85 In the 1970s, controversy erupted regarding the role of enucleation for PUM.

86 bile Dictyostelium cells have been uncovered regarding the roles of enzymes regulating phosphoinositi

87 These results extend recent observations regarding the role of Ephrin signaling in the establishm

88 There are conflicting data in the literature regarding the role of epidermal Langerhans cells (LC) in

89 e tests of a number of biological hypotheses regarding the role of epistasis in determining biologica

90 ver, there are several outstanding questions regarding the role of escape mutations in viral persiste

91 To summarize recent data regarding the role of estrogen receptor-alpha polymorphi

92 sion in fruit, there is conflicting evidence regarding the role of ethylene in mediating its expressi

93 In addition, there is controversy regarding the role of EUS fine-needle aspiration, the fi

94 This study provides important information regarding the role of family life environment and single

95 However, little is known regarding the role of Fas-mediated cytotoxicity by tumor

96 but also raise important research questions regarding the role of fat in cardiovascular disease and

97 These results provide new insights regarding the roles of FGFRs in diversification of NSC p

98 However, little is known regarding the roles of FGFs/FGFRs in cortical circuit fo

99 report explores the roots of the controversy regarding the role of gastric carditis in the developmen

100 models allow empirical testing of hypotheses regarding the role of genetic and environmental factors,

101 Little is known regarding the role of genetic variation surrounding T-be

102 These data should facilitate research regarding the role of geographic, ethnic, racial, and en

103 Because of discrepancies in previous reports regarding the role of glial cell line-derived neurotroph

104 finding resolves a long-standing controversy regarding the role of glial cells in regulating blood fl

105 have generated several conflicting proposals regarding the role of glycosylation in rhodopsin maturat

106 Here, current knowledge is reviewed regarding the role of HDL and its apolipoproteins in reg

107 vascular injury, there is little information regarding the role of high-density lipoprotein (HDL) oxi

108 ctures of Ung and Ung H187D provided insight regarding the role of His-187 in the catalytic mechanism

109 Conclusions regarding the role of His111 in the conduction of proton

110 Significant discoveries regarding the role of histone chaperones and specificall

111 There is a plethora of information regarding the roles of histone residues in transcription

112 yet there remains a relative paucity of data regarding the role of HIV-specific CD4(+) T cells in sha

113 ytochemistry and computerized image analysis regarding the roles of HIV-1 proteins and tumor necrosis

114 condary vascular outcomes, raising questions regarding the role of homocysteine as a mediator of card

115 to 60% of female migraineurs, but knowledge regarding the role of hormones, especially estrogen, app

116 irm predictions of disease ecological models regarding the role of host density in the spread of path

117 zes the research advances of the past decade regarding the role of human genetic differences in energ

118 lity in DRG neurons, however little is known regarding the role of Ih in supraspinal pain pathways.

119 studies have provided important information regarding the role of Ikaros in the mouse, little is kno

120 he Th1 type; however, there are limited data regarding the role of IL-18 in Helicobacter pylori-induc

121 re, we summarize data from many laboratories regarding the role of individual E-series of prostagland

122 However, there is no clinical evidence regarding the role of indoxyl sulfate in hemodialysis va

123 Questions regarding the role of induction chemotherapy (ICT) and a

124 Conflicting evidence exists regarding the role of infralimbic cortex (IL) in the env

125 mproved insulin sensitivity, there is debate regarding the role of insulin sensitivity in hypertensio

126 ed stimuli, these data lead to new questions regarding the role of interactions between corticosteron

127 This manuscript reviews the controversy regarding the role of intravascular brachytherapy in the

128 a quantitative theory that makes predictions regarding the role of intrinsic disorder in protein stru

129 Controversy remains regarding the role of invasive urodynamics and anticholi

130 Fur and iron regulons, and provides insight regarding the role of iron in C. jejuni colonization in

131 Yet, the evidence is uncertain regarding the role of iron in the development of gestati

132 rtant insights into and testable predictions regarding the role of key components and feedback loops

133 results help resolve a long-standing debate regarding the role of large-scale dendritic plasticity o

134 Limited information exists regarding the role of left ventricular function in predi

135 There has been controversy regarding the role of lipoprotein-associated phospholipa

136 ant new findings in Saccharomyces cerevisiae regarding the role of LIS1 (Pac1) in dynein-mediated nuc

137 Here, we will review recent literature regarding the role of lncRNAs in transcriptional control

138 t evidence from the peer-reviewed literature regarding the role of local anesthetics, NSAIDs, gabapen

139 This study provides new findings regarding the role of local mucosal epithelial cells in

140 Uncertainty remains regarding the role of locally produced inoculum in disea

141 However, questions remain regarding the role of loop motion in TCR binding, and cr

142 y patients, and also discusses controversies regarding the role of low molecular weight heparin and i

143 phatic vessels and evoke testable hypotheses regarding the role of lymphatic vessels in health and di

144 lications to clarify conflicting conclusions regarding the role of m(6)A in mRNA biogenesis and funct

145 years important new information has emerged regarding the role of magnetic resonance imaging in the

146 of MeCP2 that might reconcile previous data regarding the role of MeCP2 in cell growth and cytoskele

147 No data exist regarding the role of melatonin synthesized locally by c

148 Collectively, our data provide new insights regarding the role of Mfn2 in controlling cellular proli

149 ith the development of asthma; less is known regarding the role of microbiome alterations in food all

150 iew, we summarize a number of major findings regarding the role of microglia in brain development and

151 However, conflicting reports regarding the role of miR-200 in suppressing or promotin

152 eview, we highlight the most recent findings regarding the role of miRNAs in hepatocellular carcinoma

153 Relatively little is known regarding the role of mitochondrial metabolism in stem c

154 ted HIV disease, challenge current paradigms regarding the role of monocytes in HIV/AIDS and open new

155 aturity (ROP), but little information exists regarding the role of mosaic photography for ROP telemed

156 ive molecular motors, which raises questions regarding the role of motor cooperation in intracellular

157 Here we examine the current information regarding the role of mucosal immunity in prevention of

158 in the animals, raising important questions regarding the role of mutagenesis in carcinogenesis.

159 Evidence is presented regarding the role of mutator gene mutL(-) in the establ

160 We aim to provide the reader with an update regarding the role of MVECs in the pathogenesis of SSc a

161 and the ability to make stronger inferences regarding the role of natural selection in gene family e

162 ngs should contribute to answering questions regarding the role of neural activity in guiding the est

163 Here we review the most recent findings regarding the role of neutrophil extracellular traps (NE

164 This paper reviews recent observations regarding the role of nitric oxide in osteoarthritis and

165 s reports have differed in their conclusions regarding the role of NKT cells in clearance of P. aerug

166 Controversy exists regarding the role of nonphysicians performing laser sur

167 There is, however, debate regarding the role of Notch in the CD4 versus CD8 lineag

168 luding diabetic nephropathy, little is known regarding the role of Nox5 in this context.

169 A finding that provides new insight regarding the role of NRF-1 was that expression of MEF2A

170 Much of the existing literature regarding the role of O-GlcNAcylation in disease address

171 In addition, we discuss the data regarding the role of organ-specific and bone marrow-der

172 provides a framework to test new hypotheses regarding the role of organic molecules and metal specie

173 finding is discussed in light of recent data regarding the role of other glycosyl-phosphatidylinosito

174 a strong mutator phenotype, little is known regarding the role of other Pol3p domains in mutation av

175 To date, very little is known regarding the role of P. micros in periodontal disease.

176 However, little is understood regarding the role of p22phox in oxidative stress-relate

177 rt immunomodulatory effects, little is known regarding the role of PAF in these events.

178 his review, we discuss the current knowledge regarding the roles of Panx3 in skeletal formation and a

179 his review is to summarize the emerging data regarding the role of PAR-2 in neuroinflammation and isc

180 pled with their divergence, raises questions regarding the role of paralogs and potential functional

181 mouse bladder, and evoke testable hypotheses regarding the roles of PARs in bladder inflammation.

182 Three main conclusions regarding the roles of photoactive site residues in sign

183 Limited knowledge currently exists regarding the roles of plant genes and proteins in the A

184 and rheumatoid arthritis (RA), specifically regarding the role of Porphyromonas gingivalis (Pg).

185 there has been only circumstantial evidence regarding the role of potassium released by skeletal mus

186 ad pathway raises very interesting questions regarding the role of PP during bone and tooth developme

187 Some controversy remains regarding the role of preoperative motility assessments

188 udies provide previously unknown information regarding the role of presynaptic T-channels in nocicept

189 s in monkeys have provided conflicting views regarding the role of primary auditory cortex (A1) in pi

190 w of experimental and epidemiologic evidence regarding the role of protein in weight loss and cardiov

191 Nevertheless, little is known regarding the role of protein phosphatases in the signal

192 There has been a longstanding debate regarding the role of proteolysis in Huntington's diseas

193 There is little information regarding the role of proteolysis in Mycobacterium tuber

194 However, little is known regarding the role of PTHrP in regulating cementoblast-m

195 , and in particular, there is no information regarding the role of quorum sensing during the overexpr

196 There is insufficient information regarding the role of race and ethnicity on healthcare u

197 have led to considerable debate, especially regarding the role of radiation therapy.

198 , 2011, and created this consensus statement regarding the roles of radiography, ultrasonography (US)

199 Here we discuss recent discoveries regarding the role of reprogramming factors in remodelli

200 lution to previously described discrepancies regarding the role of retinal waves in retinogeniculate

201 This review presents evidence regarding the role of rod and cone photoreceptors, as we

202 These results raise questions regarding the role of secondary structure propensities a

203 continue to demonstrate conflicting results regarding the role of several commonly used drugs as mel

204 hological changes and provide novel insights regarding the role of several genes in the mammalian agi

205 Because of recent insights regarding the role of several secreted molecules in tubu

206 Moreover, we describe recent findings regarding the roles of several signaling pathways in mod

207 discuss here the state of current knowledge regarding the roles of small RNAs and their targets in m

208 itate speech and raise interesting questions regarding the role of social interaction in learning and

209 However, until now, no data exist regarding the role of soluble receptor for advanced glyc

210 provided to support long-standing hypotheses regarding the role of solvent molecule as a base catalys

211 Apparently conflicting data regarding the role of SOS-inducible, error-prone DNA pol

212 on-independent and cultivation-based studies regarding the role of specific bacteria in coral disease

213 ith other proteins, conclusions can be drawn regarding the role of specific partner proteins in the r

214 Yet, community-based data regarding the role of sTNFRs are lacking.

215 ormation) and then asked about their beliefs regarding the roles of structural (e.g., being born weal

216 aradigm has provided fundamental information regarding the role of substrate oxidation in the develop

217 Uncertainty exists regarding the role of synergistic gentamicin for uncompl

218 There is a lack of information regarding the role of systemic surveillance in patients

219 liver of PBC patients would provide insight regarding the role of T cells in PBC.

220 Emerging consensus regarding the role of TAFs is that TFIID assumes a gene

221 These studies provide new information regarding the role of target tissue expression of CD40 i

222 ential functions is an attractive hypothesis regarding the role of TDP-43 in neurodegeneration.

223 nd little information is currently available regarding the role of TfR2 in cellular iron homeostasis.

224 acroparasites raises important new questions regarding the role of Th2 immunity and the mechanistic n

225 Less is known regarding the role of the acquired immune response.

226 or (AhR) signaling, but very little is known regarding the role of the AhRR in vivo.

227 f a viable knock-out animal, little is known regarding the role of the alpha2/delta1 subunit in EC co

228 dings are discussed with reference to models regarding the role of the amygdala in the development of

229 oss disciplines and raised serious questions regarding the role of the auditory cortex in encoding on

230 cuss the recent finding by Mizishima's group regarding the role of the autophagy-related conjugation

231 ocused attention on long-standing hypotheses regarding the role of the basal ganglia in causing tics

232 ed oxides, it has been a long-standing issue regarding the role of the chemical ordering of the dopan

233 These results hold theoretical implications regarding the role of the dominant hippocampus in determ

234 but some knowledge gaps remain, particularly regarding the role of the energy balance entering pregna

235 sociated with immune memory, little is known regarding the role of the epithelium in targeting dendri

236 ny dynamic neural processes, little is known regarding the role of the family member Katanin p60 subu

237 l (GI) motility, and awareness is increasing regarding the role of the gut microbiome in modulating G

238 however, conflicting data have been reported regarding the role of the HH pathway in adult hematopoie

239 review provides a neuroadaptive perspective regarding the role of the hormonal and brain stress syst

240 In summary, the exciting research regarding the role of the immune system in autism spectr

241 w, we discuss the current state of knowledge regarding the role of the intestinal microbiota in immun

242 In this chapter, current knowledge regarding the role of the JAK2V617F mutation on the path

243 pAT is expected to enhance our understanding regarding the role of the latter in cardiac physiology a

244 ber of conflicting claims have been advanced regarding the role of the left inferior frontal gyrus, i

245 The broader implications of this result regarding the role of the local environment ("solvation"

246 tional mechanisms; however, debate continues regarding the role of the medial septum in behavior (MS)

247 2017 is focused on what has been established regarding the role of the microbiome in patients with as

248 ave led to sometimes conflicting conclusions regarding the role of the minor capsid protein of papill

249 es the knowledge accumulated in recent years regarding the role of the Notch pathway in the different

250 of students, researchers, and administrators regarding the role of the NSRG.

251 skeletal coupling, highlight recent findings regarding the role of the nucleus in cellular mechanotra

252 dings are discussed with reference to models regarding the role of the orbitofrontal cortex in the co

253 Two hypotheses regarding the role of the placenta are possible: one is

254 Recommendations are made regarding the role of the primary care physician and the

255 reconcile previous contradictory conclusions regarding the role of the protein and support a model wh

256 results substantiated our previous findings regarding the role of the specific residues in the viral

257 important to assess, as little is understood regarding the role of the stress induced by iron depleti

258 ning tasks, consistent with current theories regarding the role of the striatum.

259 th Tourette syndrome (TS), but less is known regarding the role of the thalamus in TS pathogenesis.

260 er of the trans-Golgi matrix and offer clues regarding the role of the trans-Golgi matrix in sorting

261 BACKGROUND & AIMS: There is controversy regarding the role of the type 2 immune response in the

262 iew highlights the current body of knowledge regarding the role of the vascular endothelial growth fa

263 on comparing the progress of recent research regarding the roles of the BMP signaling pathway in diff

264 ew is therefore to highlight recent advances regarding the roles of the cardiomyocyte circadian clock

265 orical perspective, along with new findings, regarding the roles of the IKK and NF-kappaB pathways in

266 However, once doped, little is understood regarding the role of their reduced Coulomb interaction

267 rall, these data have important implications regarding the role of thermal changes experienced during

268 ells of PBC raises interesting possibilities regarding the role of these autoantigens in the pathogen

269 s has been demonstrated, but functional data regarding the role of these cells in T1D have been lacki

270 gulatory cell generation, although questions regarding the role of these cells in vivo remain.

271 Less is known regarding the role of these interactions in the mechanis

272 The paucity of data regarding the role of these lymphocytes in human autoimm

273 e reviews clinical and experimental evidence regarding the role of these nutrients in modulating endo

274 ng disparity between physicians and patients regarding the role of these practices is large enough to

275 all, these studies provide novel information regarding the role of these residues in Fur function, an

276 aging modalities, there is still uncertainty regarding the role of these tests in clinical practice.

277 endent functions, providing further insights regarding the role of this adhesion molecule in the regu

278 There is skepticism regarding the role of this low-level network in more com

279 sis has been widely studied, little is known regarding the role of this process in chemotherapy resis

280 data presented permit tantalizing hypotheses regarding the role of this protein subunit shared by arc

281 stic perspective, important questions remain regarding the role of this single disease allele in 3 re

282 In contrast, information regarding the roles of this hormone in humans is limited

283 covery of TNF-alpha, and the insights gained regarding the roles of this molecule and its related fam

284 We also discuss new insights regarding the role of titin as a biomechanical sensor an

285 Little is known regarding the role of Toll-like receptors (TLRs) in regu

286 ge conversion has led to remarkable insights regarding the roles of transcription factors and chromat

287 However, very little is known regarding the role of TRIM11 in cancer biology.

288 ium raised a number of interesting questions regarding the role of TTX-resistant Na+ currents in infl

289 dvanced the field and discuss main questions regarding the role of tumor heterogeneity in predicting

290 rescue, we resolve an important controversy regarding the role of two phenylalanine residues in Ago2

291 pective of Newell & Shanks' (N&S's) concerns regarding the role of unconscious influences in theories

292 well & Shanks (N&S) do a service for debates regarding the role of unconscious influences on decision

293 While there are significant conflicting data regarding the role of urodynamics, particularly in the f

294 Moreover, direct evidence regarding the role of various proposed hubs in network f

295 ndings resolve seemingly discrepant findings regarding the roles of various caspases after NGF depriv

296 choroid, with the purpose of providing cues regarding the role of VEGF in development and stabilizat

297 mation in VAT, which supports prior evidence regarding the role of visceral adiposity and cancer.

298 that reconciles all currently available data regarding the role of VP24 in nucleocapsid assembly as w

299 There are many unresolved questions regarding the role of water in protein folding.

300 Finally, we review current findings regarding the roles of Wnt, bone morphogenic protein, Pt