ライフサイエンスコーパス: regenerative

1 The amazing regenerative abilities of the giant ciliate Stentor coer

2 were attracted to the system because of its regenerative abilities-if large portions of a cell are s

3 s suggest that the decline of intrinsic axon regenerative ability is associated with selective exclus

4 in-derived neurotrophic factor (BDNF) in the regenerative ability of adult brain, after stab wound te

5 ential niche-LSC interactions or improve the regenerative ability of the disease-associated hematopoi

6 rain injury models for the evaluation of the regenerative action of Gal-1.

7 d proresolving properties with potent tissue regenerative actions.

8 increased expression of several markers for regenerative activity in sensory neurons, including phos

9 Most of the adult CNS lacks regenerative activity in terms of both neuron birth and

10 n of phospho-STAT3 and GAP43, two markers of regenerative activity, in sensory neurons.

11 Emerging manufacturing processes to generate regenerative advanced therapies can involve extensive ge

12 s, and also demonstrating that both can show regenerative all-or-none behaviour.

13 which has been previously reported to induce regenerative and anti-senescence responses in a variety

14 By contrast, many salamanders are highly regenerative and can spontaneously replace lost limbs ev

15 approaches demonstrated a startling array of regenerative and morphogenetic processes in this single-

16 vered several injury-responsive genes across regenerative and nonregenerative time points.

17 es that will truly deliver on the promise of regenerative and precision medicine.

18 n improves recovery through neuroprotective, regenerative, and cell replacement mechanisms in a novel

19 cularization, the microcirculation formed by regenerative angiogenesis in skeletal muscle is profound

20 n must be recognized and overcome to advance regenerative approaches for ischemic disease.

21 main model to understand this extraordinary regenerative behavior.

22 Temporary modulation of regenerative bioelectric dynamics in amputated trunk fra

23 atile platform for applications ranging from regenerative biology to the ex vivo cultivation of meat.

24 Instead, the altered regenerative bodyplan is stored in seemingly normal plan

25 hat contribute to cell growth, survival, and regenerative capabilities of ANG.

26 nerate models for the uneven distribution of regenerative capacities among vertebrates.

27 venate aged/diseased cells and improve their regenerative capacities.

28 Depending on the tissue's regenerative capacity and the quality of the inflammator

29 Endogenous cardiomyocytes have regenerative capacity at birth but this capacity is lost

30 ggest that both biological aging and reduced regenerative capacity contribute to cardiovascular event

31 wever, the intestine is able to maintain the regenerative capacity even in spite of an ischemic injur

32 Reduced regenerative capacity has been proposed as a mechanism.

33 ith chemical modulators indicated autonomous regenerative capacity in both leader and follower cells,

34 nous stem cell therapies designed to improve regenerative capacity in HF, especially, in HF with pres

35 efining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a c

36 ncreased expression of stem cell markers and regenerative capacity in vivo.

37 egeneration of dorsal root (DR) axons, whose regenerative capacity is particularly weak.

38 However, evidence suggests that their regenerative capacity may be limited in conditions of se

39 hermore, Eed regulates the proliferative and regenerative capacity of adult urothelial progenitors an

40 ly challenging to substantially increase the regenerative capacity of damaged nerves without deleteri

41 ts highlight concerns on the homeostasis and regenerative capacity of muscles in these patients who o

42 tracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts.

43 reasingly necessary with age to preserve the regenerative capacity of old haematopoietic stem cells.

44 However, the repair capacity of SCs and the regenerative capacity of peripheral axons are limited.

45 ir, muscle function, histopathology, and the regenerative capacity of primary muscle cells.

46 The regenerative capacity of the liver is essential for reco

47 essing cells are essential for the efficient regenerative capacity of the testis, and also display fa

48 The current study investigated the regenerative capacity of this cell population by compari

49 HF patients in the attempts to augment their regenerative capacity prior to use in the clinical setti

50 The molecular events underlying this regenerative capacity remain elusive.

51 ransferase in hepatocytes exhibited impaired regenerative capacity that was completely rescued by adm

52 The improvements in I/R injury, regenerative capacity, and oncological outcomes await co

53 Endogenous regenerative capacity, assessed as circulating progenito

54 ugh shorter LTL is associated with decreased regenerative capacity, both LTL and circulating progenit

55 We demonstrate that in a vertebrate of high regenerative capacity, Wnt/beta-catenin signaling contro

56 Articular cartilage has little regenerative capacity.

57 aintained beyond embryogenesis in limbs with regenerative capacity.

58 changes in ways that broadly inhibit tissue regenerative capacity.

59 uctal epithelium and loss of epithelial cell regenerative capacity.

60 in cells with a high proliferation rate and regenerative capacity.

61 s and underlying supporting cells, and lacks regenerative capacity.

62 In comparison to other regenerative chips, the new chip surface has much wider

63 hrons after birth, suggesting a low level of regenerative competence, the tubular epithelial cells of

64 postnatal life and adulthood, as well as in regenerative contexts.

65 vation as a potential approach to ameliorate regenerative defects in WNT10A patients.

66 y quiescent and only activate in response to regenerative demands, while embryonic stem cells continu

67 Since regenerative dendritic events can provide the depolariza

68 field firing was associated with widespread regenerative dendritic events, which decreased in preval

69 biomaterials have potential to enable novel regenerative dental therapies in the clinic by both rest

70 ally affects billions of patients, and while regenerative dentistry aims to heal dental tissue after

71 The regenerative-donor glycosidation strategy is promising a

72 , the hematopoietic system provides critical regenerative drive to the brain that can be modulated by

73 ve-guidance scaffold was used to explore the regenerative effect of reparative monocyte recruitment.

74 When added to PRF, HA increases the regenerative effects observed with PRF in the treatment

75 ll-transplant models-we demonstrate that the regenerative effects of IL-10 in postnatal wounds are de

76 ronic loss of hepatocytes is associated with regenerative efforts characterized by continual hepatocy

77 Regenerative electroless etching (ReEtching), described

78 Regenerative endodontic procedures (REPs) are a treatmen

79 face of the scaffold is able to induce a pro-regenerative environment at the site of a subcutaneous i

80 matory markers and by the induction of a pro-regenerative environment.

81 s a key regulator of SC loss during repeated regenerative episodes.

82 This transient increase in regenerative events was likely facilitated by a reductio

83 s as an anticoagulant, anti-inflammatory and regenerative factor.

84 ation of proinflammatory and upregulation of regenerative factors in cocultured EC and PO, indicating

85 eficial effects mainly through secretion (of regenerative factors) and membrane-based cell-cell inter

86 The mechanisms leading to this regenerative failure are largely unknown.

87 role for the interaction of KLF9 and JNK3 in regenerative failure in the optic nerve and suggest new

88 utes to axon growth suppression in vitro and regenerative failure in vivo These studies suggest poten

89 ation, resulting in depletion of SC pool and regenerative failure.

90 of the OFox imidates could be conducted in a regenerative fashion.

91 ator with an enhanced quality factor using a regenerative feedback loop operating at 1.4 GHz and an a

92 llite cells and an increase in the number of regenerative fibers, with a reduction in inflammatory in

93 useful for rechargeable metal-air batteries, regenerative fuel cells, and other important clean energ

94 These findings reveal a new regenerative function of Treg in the CNS, distinct from

95 l for long-term maintenance of SCs and their regenerative function.

96 cause blastema cells (BCs) and expression of regenerative genes, such as Msh homeobox (Msx) genes, ar

97 as significant for focal active colitis with regenerative glandular changes and neural hyperplasia.

98 egulate a fibroblast-specific formation of a regenerative, HA-rich wound extracellular matrix may lea

99 ve capacity of aged donor hepatocytes or the regenerative impairment of the recipient livers.

100 cquired disease and whether original states, regenerative in nature, can be restored with therapy.

101 study assesses the adjunctive use of PRF in regenerative management of intrabony defects in comparis

102 The spontaneous regenerative mechanism known as axonal fusion provides a

103 In the mammalian brain, the regenerative mechanisms are very limited and newly forme

104 se also guides the generation of healing and regenerative mediators after cardiac damage.

105 luding cell therapy, tissue engineering, and regenerative medicine and are frequently used in preclin

106 have become a standard platform not only for regenerative medicine and developmental biology but also

107 opment and for applying stem cell biology to regenerative medicine and disease modeling.

108 ently produce cardiovascular progenitors for regenerative medicine and drug discovery applications.

109 across stem cell and developmental biology, regenerative medicine and neuroscience.

110 investigation of the roles of stem cells in regenerative medicine and pathogenesis of various diseas

111 ted unprecedented potential for a variety of regenerative medicine applications including novel drug

112 In regenerative medicine applications, the differentiation

113 multi-component functional biomaterials for regenerative medicine applications.

114 rofiles is essential for wound treatment and regenerative medicine applications.

115 o control VEGF availability and signaling in regenerative medicine applications.

116 d use in a variety of tissue engineering and regenerative medicine applications.

117 hence, have been linked to reprogramming and regenerative medicine approaches.

118 lay a pivotal role in tissue engineering and regenerative medicine by functioning as biomimetic subst

119 folds have shown promise for applications in regenerative medicine by providing a natural extracellul

120 Advancements in arterial regenerative medicine could benefit from a detailed unde

121 of importance to the development of improved regenerative medicine for patients with white matter dis

122 Rapid advances in stem cell biology and regenerative medicine have opened new opportunities for

123 s) represent promising resource of cells for regenerative medicine in neurological disorders.

124 Their future outlook in regenerative medicine including the current clinical sig

125 Stem cell tracking in cellular therapy and regenerative medicine is an urgent need, superparamagnet

126 One of the ultimate goals of regenerative medicine is the generation of patient-speci

127 A major challenge in regenerative medicine is to improve therapeutic cells' d

128 otent stem cells (embryonic and induced) for regenerative medicine of incurable diseases, immunothera

129 d their potential therapeutic application in regenerative medicine or angiogenesis-related diseases i

130 atures have established NDs as an invaluable regenerative medicine platform, with a broad range of cl

131 Progress in regenerative medicine requires reverse-engineering cellu

132 ighlighting this significant advancement for regenerative medicine strategies in the lung.

133 , gene therapy, drug screening, and emerging regenerative medicine therapies are fundamentally relian

134 ssues and organs than do currently available regenerative medicine therapies.

135 tors differentiate into MSNs is critical for regenerative medicine to develop specific differentiatio

136 c stem/progenitor cells (hCPCs) may serve in regenerative medicine to repair the infarcted heart.

137 l applications including tissue engineering, regenerative medicine, and cell and therapeutic delivery

138 The combination of stem cell research, regenerative medicine, and tissue engineering seems a pr

139 e great potential as a human model system in regenerative medicine, disease modeling, and drug screen

140 s logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of

141 be used for various applications, including regenerative medicine, drug sensitivity testing, gene ex

142 broad applications in tissue engineering and regenerative medicine, followed by a summary and perspec

143 m adult tissues offer tangible potential for regenerative medicine, given their feasibility for autol

144 studies of human infectious disease, cancer, regenerative medicine, graft-versus-host disease, allerg

145 In regenerative medicine, natural protein-based polymers of

146 t agonists for translational applications in regenerative medicine.

147 esident progenitors with great potential for regenerative medicine.

148 used biomaterials for tissue engineering and regenerative medicine.

149 serves to advance developmental research and regenerative medicine.

150 ility in the areas of tissue engineering and regenerative medicine.

151 cipline to facilitate stem cell research and regenerative medicine.

152 y, immunology, and embryonic stem cell-based regenerative medicine.

153 o differentiation and future applications in regenerative medicine.

154 ventricular noncompaction cardiomyopathy and regenerative medicine.

155 could open new opportunities in the field of regenerative medicine.

156 region-restricted adult tissue stem cells in regenerative medicine.

157 for their widespread distribution and use in regenerative medicine.

158 or tissue engineering, disease modeling, and regenerative medicine.

159 in many areas, such as biomedical devices or regenerative medicine.

160 xt generation of researchers in the field of regenerative medicine.

161 the potential therapeutic role of hypoxia in regenerative medicine.

162 otent stem cells (hPSCs) is a major goal for regenerative medicine.

163 PSC-derived lineages in disease modeling and regenerative medicine.

164 l therapy represents a promising strategy in regenerative medicine.

165 egenerate should provide important clues for regenerative medicine.

166 l applications for both disease modeling and regenerative medicine.

167 ls for drug screening, disease modeling, and regenerative medicine.

168 proteins in the context of drug delivery and regenerative medicine.

169 ar biomaterials are promising candidates for regenerative medicine.

170 s remains a concern for disease modeling and regenerative medicine.

171 cessary prior to use in drug development and regenerative medicine.

172 ore find application in cancer treatment and regenerative medicine.

173 plinary studies, including organogenesis and regenerative medicine.

174 tem cells (iPSCs) holds enormous promise for regenerative medicine.

175 ardiac reprogramming holds great promise for regenerative medicine.

176 ed is also of great interest in the field of regenerative medicine.

177 e body makes them invaluable in the field of regenerative medicine.

178 o features are therefore highly desirable in regenerative medicine.

179 yocardium with new tissue is a major goal of regenerative medicine.

180 studying cardiac biology, drug discovery and regenerative medicine.

181 Thus, our study advances the goals of liver regenerative medicine.

182 ationale of using appropriate stem cells for regenerative medicine.

183 herapy may be cardioprotective, and not just regenerative, merits further exploration before we aband

184 ersals of bioelectric state reset subsequent regenerative morphology back to wild-type.

185 ulation of satellite cell homeostasis during regenerative myogenesis.

186 y, which enables comparative analyses of the regenerative (neonatal) versus nonregenerative (adult) s

187 way for endogenous tissue repair by a highly regenerative neuroepithelium and introduce a system to s

188 orce the value of zebrafish for the study of regenerative neurogenesis.

189 However, regenerative NMDA conductances can be activated with str

190 o mechanisms of "rescue" have been proposed: regenerative or trophic.

191 neering approaches have tried to improve the regenerative outcome following an injury, through the co

192 ically applicable approach to potentiate the regenerative outcome in the injured CNS.

193 key regulators of inflammatory response and regenerative outcome.

194 s are needed to investigate how this impacts regenerative outcomes.

195 ular responses in relation to postextraction regenerative outcomes.

196 n variably proposed to stimulate overall fin regenerative outgrowth or promote ray branching.

197 The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiom

198 ells (ECs) to support metabolism and express regenerative paracrine factors is a strategy to treat va

199 ection, gene replacement and stem cell-based regenerative paradigms.

200 Alternative regenerative pathways become activated when normal regen

201 quely hepatic process encompass a variety of regenerative pathways that are specific to different typ

202 Gas-phase autoxidation-regenerative peroxy radical formation following intramol

203 adherin-mediated cell contact, followed by a regenerative phase, during which Wnt and Hippo signaling

204 During the regenerative phase, only axons that fuse to their distal

205 Interleukin-10-mediated regenerative postnatal tissue repair is dependent on reg

206 and is achieved through the balance between regenerative potential and level of degeneration.

207 feration is restricted to cells with limited regenerative potential found within the HSC compartment.

208 sence of resident progenitor cells and their regenerative potential in a rabbit model with lacrimal g

209 indings also provide evidence for detectable regenerative potential in the postnatal cochlea beyond 1

210 Their regenerative potential is important to develop new thera

211 upstream therapeutic strategy to promote the regenerative potential of CNS progenitors in diseases wi

212 n PDC "knockout" (KO) animals, the long-term regenerative potential of hepatocytes was unimpaired, an

213 The plasticity and regenerative potential of meningeal LVs should allow man

214 es upon optic nerve injury nor the increased regenerative potential of RGCs upon lens injury (LI).

215 riggers, selective markers, and the residual regenerative potential of scar-forming myofibroblasts ar

216 k identifies new mechanisms that control the regenerative potential of SCs and gives new insight into

217 age polarization is essential for the robust regenerative potential of skeletal muscle.

218 We explore the regenerative potential of these organoids in vivo and de

219 l of progenitors with extended viability and regenerative potential residing within osteoarthritic ca

220 athways downstream of it may re-activate CPC regenerative potential under ischemic conditions.

221 s, decreased satellite cell self-renewal and regenerative potential, and increased neuromuscular frag

222 , HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellul

223 nally differentiated cells that have limited regenerative potential.

224 divisional history, they progressively lose regenerative potential.

225 nt anatomic locations and showed a promising regenerative potential.

226 heart muscle, at least in mammals, has poor regenerative potential.

227 tion with short-term, and primarily myeloid, regenerative potential.

228 balance is challenged during periods of high regenerative pressure and is often compromised in aged a

229 al blood perfusion after postextraction bone regenerative procedures follows an ischemia-reperfusion

230 All three regenerative procedures predictably altered the disease-

231 y affecting the buccal plate, occurs despite regenerative procedures.

232 To further understand the regenerative process in the zebrafish, we compared the p

233 pable of spontaneous remyelination, but this regenerative process often fails.

234 omponent, it is not essential to the overall regenerative process.

235 The role of microglia in degenerative and regenerative processes after damage of the nervous syste

236 and invading macrophages in degenerative and regenerative processes after injury are still controvers

237 eems to generate a favorable environment for regenerative processes and therefore could be a treatmen

238 t podocytes are very stationary cells making regenerative processes by podocyte walking along the GBM

239 e search for new and more efficient cellular regenerative products, interesting cardioprotective, imm

240 increase their population size as part of a regenerative program and, if so, what the underlying mec

241 In both contexts, the regenerative program echoes molecular and cellular event

242 llectively, these data suggest that should a regenerative program exist in the newborn mammalian hear

243 andscape that could limit reinduction of the regenerative program in adult cardiomyocytes.

244 ble mechanisms underlying the stimulation of regenerative programs and suggest a practical strategy f

245 e injury and allow for exploration of latent regenerative programs with potential applications to adu

246 otes partial de-differentiation to allow pro-regenerative proliferation of hepatocytes.

247 sed as vertebrate model, also possesses high regenerative properties after injury.

248 Here, we compared the regenerative properties of rod and green cone opsins wit

249 hese results demonstrate that the endogenous regenerative properties of the adult mammalian heart can

250 in the body and loss of its function or its regenerative properties results in debilitating musculos

251 and the potential of targeting ephrinB1 as a regenerative pulp therapy.

252 ssential role in coordinating the epimorphic regenerative response in mammals.

253 ffected the overlying epithelium, inducing a regenerative response marked by increased cell prolifera

254 content of muscle, but resulted in a delayed regenerative response to injury.Consistent with this, th

255 iliary Hh signaling by FAPs orchestrates the regenerative response to skeletal muscle injury.

256 on of myocardial infarction induces a robust regenerative response with decreased myocardial fibrosis

257 bility derived during the IL6-mediated liver regenerative response within a milieu of chronic inflamm

258 To identify orchestrators of this regenerative response, we performed quantitative large-s

259 e progression while promoting a hypertrophic regenerative response, without increasing apoptosis.

260 dependent manner, without modifying the peak regenerative response.

261 al role for inflammatory cells to regulate a regenerative response.

262 d others suggest that stimulating endogenous regenerative responses can emerge as a therapeutic strat

263 f inflammation and cell metabolism in tissue-regenerative responses, highlight emerging concepts that

264 Finally, activation of regenerative signaling is not neuroprotective in motor n

265 ously shown to affect vascular integrity and regenerative signaling, is here shown to regulate ligand

266 nflammation after injury initiates important regenerative signals in part through NF-kappaB-mediated

267 regulatory program underpinning the neonatal regenerative state and identify alterations in the chrom

268 he stimulatory effect of nerve injury on the regenerative state of the primary sensory neurons.

269 In response to regenerative stimuli, SCs in the intestinal epithelium o

270 c senescence arrest to counter the continued regenerative stimuli.

271 Regenerative strategies for both compartments therefore

272 Such regenerative strategies may ultimately enable the thymus

273 emyelination capacities will provide new pro-regenerative strategies.

274 In summary, the mouse testis has adopted a regenerative strategy to expand stem cell activity by in

275 However, regenerative studies in patients with late disease make

276 h previously reported results of periodontal regenerative surgery.

277 VMIS has not been reported with traditional regenerative surgery.

278 A multistep regenerative synthesis of oligosaccharides is also repor

279 lar mechanism underlying regenerative vs non-regenerative tendon healing.

280 mising tool for human developmental biology, regenerative therapies, disease modeling, and drug disco

281 c cell types for basic laboratory studies or regenerative therapies.

282 ces for improving stem cell fate in clinical regenerative therapies.

283 this ability may provide insights into human regenerative therapies.

284 nitely, making them an attractive source for regenerative therapies.

285 CAL-V achieved by regenerative therapy in IBDs may have retained stability

286 ogenitor cells (CPCs) is being evaluated for regenerative therapy in older patients with ischaemic he

287 Regenerative therapy resulted in significant attachment

288 promising approach to expand stem cells for regenerative therapy.

289 which progressed to a failure in regular and regenerative thymopoiesis and peripheral T-cell homeosta

290 To date, there is no regenerative treatment available.

291 All patients who had received regenerative treatment for at least one IBD between 2004

292 and, therefore, has the potential for use as regenerative treatment for periodontal defects.

293 h a buccal single flap approach (SFA) in the regenerative treatment of intraosseous defects is evalua

294 r treating skin burns and have potential for regenerative treatment of other types of epithelial inju

295 t (SFA group; n = 15) placement of a CTG and regenerative treatment were retrospectively derived at t

296 ment achieved in infrabony defects (IBDs) by regenerative treatment.

297 gulatory roles, this also captures emerging, regenerative Treg functions.

298 ncover a novel cellular mechanism underlying regenerative vs non-regenerative tendon healing.

299 importance of IL-10-induced HA synthesis for regenerative wound healing is demonstrated by inhibition

300 pericellular matrix, which mimics the fetal regenerative wound healing phenotype with reduced fibros