ライフサイエンスコーパス: regenerative capacity

1 knockout mice demonstrate similar increased regenerative capacity.

2 ion was associated with impaired endothelial regenerative capacity.

3 cation and delivery of stem cells to promote regenerative capacity.

4 spinal cord regeneration because of its high regenerative capacity.

5 The liver has a strong regenerative capacity.

6 and provided a fundamental readout of their regenerative capacity.

7 otent cell population and compromising their regenerative capacity.

8 nal back to stem cells to maintain long-term regenerative capacity.

9 uminal epithelial progenitors with extensive regenerative capacity.

10 ly mechanical loading despite having minimal regenerative capacity.

11 hereas the aged rats were deficient in their regenerative capacity.

12 ily contributes to postnatal loss of cardiac regenerative capacity.

13 ns that tumor suppression is a trade-off for regenerative capacity.

14 aintaining the robustness of skeletal muscle regenerative capacity.

15 results from axonal degeneration and reduced regenerative capacity.

16 aintained beyond embryogenesis in limbs with regenerative capacity.

17 nce, satellite cell depletion and diminished regenerative capacity.

18 ics such as enhanced clonal growth and tumor regenerative capacity.

19 of the multipotent cell population and their regenerative capacity.

20 nhance resistance to cell death and increase regenerative capacity.

21 ittle is known about mechanisms that control regenerative capacity.

22 echanisms responsible for this difference in regenerative capacity.

23 have mild skeletal muscle defects and potent regenerative capacity.

24 Mature neurons have diminished intrinsic regenerative capacity.

25 ggest a role for neurogenesis in maintaining regenerative capacity.

26 rogenitor cells (EPCs), a marker of vascular regenerative capacity.

27 changes in ways that broadly inhibit tissue regenerative capacity.

28 ithin a tumor that provide it with unlimited regenerative capacity.

29 ll capabilities as well as with an extensive regenerative capacity.

30 the brain was thought to have essentially no regenerative capacity.

31 nt satellite cells and interferes with their regenerative capacity.

32 Adult bones have a notable regenerative capacity.

33 e a key adaptation that is crucial for adult regenerative capacity.

34 nic zones within the MRL brain show enhanced regenerative capacity.

35 inflammation in a sensitive organ with poor regenerative capacity.

36 ted with more and larger fibers and enhanced regenerative capacity.

37 and atrophy, suggesting defects in stem-cell regenerative capacity.

38 of progenitors responsible for its life-long regenerative capacity.

39 echanism for the age-dependent loss of liver regenerative capacity.

40 uctal epithelium and loss of epithelial cell regenerative capacity.

41 in cells with a high proliferation rate and regenerative capacity.

42 Mammalian organs vary widely in regenerative capacity.

43 volving multiple pathways was central to PNS regenerative capacity.

44 are mechanistically linked to loss of muscle regenerative capacity.

45 entual restoration of tissue homeostasis and regenerative capacity.

46 culating PC levels, which reflect endogenous regenerative capacity.

47 romised muscle regrowth, suggesting impaired regenerative capacity.

48 he adjacent satellite cells to enhance their regenerative capacity.

49 sis, chronic inflammation and reduced muscle regenerative capacity.

50 otherapy is often associated with diminished regenerative capacity.

51 s and underlying supporting cells, and lacks regenerative capacity.

52 trol of the adult nervous system's intrinsic regenerative capacity.

53 implicating the thymus as having functional regenerative capacity.

54 pressor repertoires could influence species' regenerative capacity.

55 -related pathologies, including a decline in regenerative capacity.

56 Articular cartilage has little regenerative capacity.

57 tworm, Macrostomum lignano has an impressive regenerative capacity.

58 al tract (CST) neurons, display a much lower regenerative capacity.

59 apid pigment cell renewal and maintenance of regenerative capacity.

60 abolic syndrome features increased cutaneous regenerative capacity.

61 venate aged/diseased cells and improve their regenerative capacities.

62 es and inductive cues, and obtains different regenerative capacities.

63 re markedly different cellular functions and regenerative capacities.

64 ostnatal skeletal muscle growth and impaired regenerative capacity after cardiotoxin-induced injury.

65 The heart has little regenerative capacity after damage, leading to much inte

66 d responses prevent the premature decline of regenerative capacity after injury.

67 adult zebrafish hearts, which have a unique regenerative capacity after injury.

68 The liver has a remarkable regenerative capacity, allowing recovery following injur

69 nerate models for the uneven distribution of regenerative capacities among vertebrates.

70 Planarians are flatworms with robust regenerative capacities and utilize epidermal cilia for

71 reduction in cross-sectional area, impaired regenerative capacity and a significant decrease in forc

72 refore provide a basis for understanding the regenerative capacity and biology of the esophageal epit

73 ing, whereas neonatal hearts maintained full regenerative capacity and cardiomyocyte proliferation an

74 anization of the immune system, reducing its regenerative capacity and facilitating viral evolution t

75 dystrophy contributes substantially to lost regenerative capacity and increased fibrosis of dystroph

76 disease involving progressive loss of muscle regenerative capacity and increased fibrosis.

77 ngs identify a natural sex bias in appendage regenerative capacity and indicate an underlying regulat

78 wasting severity parallels a decline in MuSC regenerative capacity and is ameliorated histologically

79 The human heart has limited endogenous regenerative capacity and is thus an important target fo

80 rch, based on powerful genetics, high tissue regenerative capacity and low maintenance costs.

81 ntain preserved T lymphocyte populations and regenerative capacity and manifest far lower levels of a

82 nohistochemistry analyses revealed increased regenerative capacity and proliferation in IGF-1 transge

83 emonstrate that beta cells have a remarkable regenerative capacity and that normal beta cell mass can

84 Depending on the tissue's regenerative capacity and the quality of the inflammator

85 s with age may contribute to impaired muscle regenerative capacity and to increased muscle adiposity,

86 anipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug

87 The mammalian heart has a very limited regenerative capacity and, hence, heals by scar formatio

88 g, well-characterized development and a high regenerative capacity, and are thus an excellent model s

89 with that in P14 mice, which have lost their regenerative capacity, and identified a population of ma

90 The improvements in I/R injury, regenerative capacity, and oncological outcomes await co

91 ulating the balance among tumor suppression, regenerative capacity, and senescence.

92 as well as enhanced antioxidant defenses and regenerative capacities are also key to hypoxia survival

93 rogramming can be reversed and how intrinsic regenerative capacities are determined should facilitate

94 are the only modern tetrapods that retained regenerative capacities as well as preaxial polarity in

95 Endogenous regenerative capacity, assessed as circulating progenito

96 Endogenous cardiomyocytes have regenerative capacity at birth but this capacity is lost

97 Impaired regenerative capacity, attenuated ability to respond to

98 ugh shorter LTL is associated with decreased regenerative capacity, both LTL and circulating progenit

99 Most adult mammalian tissues have limited regenerative capacities, but in lower vertebrates, the m

100 the muscles were of normal size, despite low regenerative capacity, but did have increased fibrosis.

101 Bone has remarkable regenerative capacity, but this ability diminishes durin

102 own of CELF or MBNL factors lead to abnormal regenerative capacities by affecting self-renewal and di

103 ity of CNS axons to regenerate, an increased regenerative capacity can be elicited following conditio

104 termine whether this age-dependent change in regenerative capacity can develop in organotypic culture

105 in echinoderms, a group well known for their regenerative capacities, can give us an insight on the e

106 adult zebrafish is endowed with a remarkable regenerative capacity, capable of de novo cardiomyocyte

107 ggest that both biological aging and reduced regenerative capacity contribute to cardiovascular event

108 e peripheral nervous system has retained its regenerative capacity, enabling severed axons to reconne

109 wever, the intestine is able to maintain the regenerative capacity even in spite of an ischemic injur

110 ifferentiation, and apoptosis and by reduced regenerative capacity following methimazole-induced neur

111 The mammalian heart has a remarkable regenerative capacity for a short period of time after b

112 lanarian flatworms with apparently limitless regenerative capacity fueled by a population of highly p

113 This regenerative capacity has been linked to elevated matrix

114 Reduced regenerative capacity has been proposed as a mechanism.

115 enous muscle stem cells, and impaired muscle regenerative capacity has led to the hypothesis that the

116 The source of this regenerative capacity has long been a hotly debated topi

117 not uncommon in clinical practice and their regenerative capacity has long been questioned.

118 llular and molecular events controlling this regenerative capacity, however, are unknown.

119 This regenerative capacity, however, is diminished as early a

120 The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cu

121 Notably, we found that regenerative capacity in Acomys was extended to ear hole

122 ith chemical modulators indicated autonomous regenerative capacity in both leader and follower cells,

123 ession in SCs and potentiate skeletal muscle regenerative capacity in chronic diseases.

124 ifferentiation are hallmarks of tissue/organ regenerative capacity in diverse species.

125 as a potential mechanism underlying loss of regenerative capacity in dystrophic muscle.

126 nous stem cell therapies designed to improve regenerative capacity in HF, especially, in HF with pres

127 cardiac failure, can be reversed by natural regenerative capacity in lower vertebrates such as zebra

128 sful axon regeneration is the poor intrinsic regenerative capacity in mature neurons in the adult mam

129 -responsive enhancers can therefore restrict regenerative capacity in maturing organisms without comp

130 for myofiber regeneration results in loss of regenerative capacity in part due to proliferative senes

131 is involved in the onset of the loss of axon regenerative capacity in PCs.

132 ak in T(3) is involved in the loss of axonal regenerative capacity in Purkinje cells (PCs).

133 Retinoic acid (RA) has strong regenerative capacity in several organs, but its role in

134 boptimal Sox11 expression contributes to low regenerative capacity in the adult mammalian CNS.

135 neuronal populations that normally show poor regenerative capacity in the adult nervous system.

136 s neuronal growth, contribute to the limited regenerative capacity in the central nervous system foll

137 tion, mice lacking RIP140 exhibited improved regenerative capacity in the intestine, while mice overe

138 efining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a c

139 examine the effects of exercise on cutaneous regenerative capacity in the setting of metabolic syndro

140 Mammalian ageing is associated with reduced regenerative capacity in tissues that contain stem cells

141 as muscle stem cells (MuSCs), exhibit robust regenerative capacity in vivo that is rapidly lost in cu

142 sence of ECFCs modulates MSC engraftment and regenerative capacity in vivo.

143 ncreased expression of stem cell markers and regenerative capacity in vivo.

144 subclonal patterns, and vary in competitive regenerative capacity in vivo.

145 roperties of the stem cells, including their regenerative capacity in vivo.

146 Such regenerative capacities involve a robust ability to rest

147 disease, suggesting that impaired endogenous regenerative capacity is associated with increased morta

148 es such as Duchenne Muscular Dystrophy, this regenerative capacity is exhausted.

149 s from postnatal day (P) 6 gerbils, but this regenerative capacity is lost by P12.

150 without scarring following MI; however, this regenerative capacity is lost by P7.

151 However, this regenerative capacity is lost by postnatal day 7 and the

152 on during a short postnatal period, but this regenerative capacity is lost in the adult cochlea.

153 e during the neonatal stage, this endogenous regenerative capacity is lost with age.

154 egeneration of dorsal root (DR) axons, whose regenerative capacity is particularly weak.

155 newt and axolotl) species, but notably such regenerative capacity is rare in mammals.

156 However, this regenerative capacity is reduced in muscular dystrophies

157 How to make full use of the body's innate regenerative capacity is thus a key issue.

158 g after retinal damage may unlock the latent regenerative capacity long speculated to reside in mamma

159 However, evidence suggests that their regenerative capacity may be limited in conditions of se

160 A hostile environment and decreased regenerative capacity may contribute to the failure of a

161 PNS axons have a better regenerative capacity, mediated in part by integrins (ex

162 This loss of regenerative capacity might be part of the general progr

163 l survival and axon regeneration in the high regenerative capacity model, further supporting a key ro

164 However, the endogenous regenerative capacities of different tissues are difficu

165 Aging reduces the regenerative capacities of many tissues.

166 s mitophagy, and reduces the replicative and regenerative capacities of the CPCs.

167 tion of GSK3beta with age causes the loss of regenerative capacities of the liver.

168 n removal of doxycycline suggesting that the regenerative capacities of the mammary epithelial progen

169 liver resection, overburdening metabolic and regenerative capacities of the remnant organ.

170 We developed a mouse model to assess the regenerative capacity of a critically small liver remnan

171 mportant role of the microcirculation in the regenerative capacity of a muscle even when satellite ce

172 and interstitial fibrosis, and increased the regenerative capacity of actively cycling renal tubular

173 The low regenerative capacity of adult human hearts has thus far

174 hermore, Eed regulates the proliferative and regenerative capacity of adult urothelial progenitors an

175 d HSCs, and SIRT7 up-regulation improved the regenerative capacity of aged HSCs.

176 ppressor pathways that combine to reduce the regenerative capacity of aged HSCs.

177 remodelling factor brahma (Brm) inhibits the regenerative capacity of aged liver.

178 signalling as well as the proliferation and regenerative capacity of aged satellite cells.

179 Chronic infections strain the regenerative capacity of antiviral T lymphocyte populati

180 The regenerative capacity of beta-cells declines rapidly wit

181 Young rodents may not faithfully model the regenerative capacity of beta-cells in mature adult mice

182 d increase of p16INK4a expression limits the regenerative capacity of beta-cells with ageing.

183 cking IL-1 or IL-6 receptors may improve the regenerative capacity of BM cells after AMI.

184 Therefore, we analyzed the regenerative capacity of BM from CVB3-infected mice.

185 ted endothelial cells can influence the bone-regenerative capacity of bone marrow stromal cells.

186 icity, osteogenic potential and in vivo bone regenerative capacity of chemically modified ribonucleic

187 ed activities of different KLFs regulate the regenerative capacity of CNS neurons.

188 The regenerative capacity of CSCs in very young patients wit

189 s, it is possible that the lack of sustained regenerative capacity of cTEC progenitor cells underlies

190 kinesis provides mechanistic support for the regenerative capacity of cyclin A2.

191 ly challenging to substantially increase the regenerative capacity of damaged nerves without deleteri

192 Topical siKeap1 therapy resulted in improved regenerative capacity of diabetic wounds and accelerated

193 ut the mTOR-dependent proteins enhancing the regenerative capacity of DRG neurons remain unknown.

194 ression and differentiation can restrict the regenerative capacity of Drosophila tissues.

195 jured tissue is thus thought to restrict the regenerative capacity of endogenous neural stem/progenit

196 The regenerative capacity of Ercc1(-/Delta) liver after part

197 Full limb regenerative capacity of failed stumps was restored by r

198 ts into the genetic programs that govern the regenerative capacity of hair cells, we interrogated cus

199 The regenerative capacity of hCPCs in young patients with no

200 e constrain the proliferation, survival, and regenerative capacity of hCPCs.

201 in folding stress (PFS(mt)), and compromised regenerative capacity of hematopoietic stem cells (HSCs)

202 ere alterations were associated with reduced regenerative capacity of hematopoietic stem cells.

203 th progressive bone marrow loss and impaired regenerative capacity of HSCs in competitive bone marrow

204 The regenerative capacity of human ALDH(hi) cells was assess

205 cisor stem cell niches in the embryo and the regenerative capacity of incisors in the adult.

206 The regenerative capacity of many placode-derived epithelial

207 Seeking to understand the superior regenerative capacity of MDSCs compared with myoblasts i

208 lucidate an important cause for the superior regenerative capacity of MDSCs, and provide functional e

209 In mammals, the regenerative capacity of most of the adult nervous syste

210 t PTEN/mTOR are critical for controlling the regenerative capacity of mouse corticospinal neurons.

211 The reparative and regenerative capacity of multiple mammalian tissues depe

212 These cells enhanced the regenerative capacity of muscle in the transgenic animal

213 erized by muscle necrosis that overtakes the regenerative capacity of muscle.

214 ts highlight concerns on the homeostasis and regenerative capacity of muscles in these patients who o

215 Pax7 responds to NF-kappaB by impairing the regenerative capacity of myogenic cells in the muscle mi

216 tracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts.

217 This is due to the limited regenerative capacity of neurones in the central nervous

218 Since the regenerative capacity of normal haematopoietic stem cell

219 reasingly necessary with age to preserve the regenerative capacity of old haematopoietic stem cells.

220 However, the repair capacity of SCs and the regenerative capacity of peripheral axons are limited.

221 onent underlying inherent differences in the regenerative capacity of peripheral vs. central motoneur

222 Cellular plasticity contributes to the regenerative capacity of plants, invertebrates, teleost

223 ir, muscle function, histopathology, and the regenerative capacity of primary muscle cells.

224 cle environment has a profound effect on the regenerative capacity of resident and implanted cells.

225 Although much is known about the regenerative capacity of retinal ganglion cells, very si

226 sensory functions as a result of the limited regenerative capacity of sensory axons and the inhibitor

227 on of stem cell populations to highlight the regenerative capacity of skeletal muscle and emphasize t

228 The regenerative capacity of skeletal muscle declines with a

229 in stem cell function with age, and how the regenerative capacity of somatic stem cells can be enhan

230 e diseases by 'seeding' injured tissues, the regenerative capacity of stem cells is influenced by reg

231 t the molecular pathways responsible for the regenerative capacity of teleosts, amphibians, and repti

232 The stability of this complex influences the regenerative capacity of the active 3+ oxidation state o

233 nal circuitry, highlights the plasticity and regenerative capacity of the adult mammalian brain.

234 of structural plasticity and highlights the regenerative capacity of the adult mammalian brain.

235 The regenerative capacity of the adult mammalian heart is li

236 We examined the regenerative capacity of the adult zebrafish retina by i

237 contribute to an age-related decline in the regenerative capacity of the bladder.

238 Lymphocyte support of the regenerative capacity of the bone marrow was provided by

239 their differentiating descendants to ensure regenerative capacity of the flatworm via transposon sil

240 The limited regenerative capacity of the glomerular podocyte followi

241 have questioned the accepted dogma that the regenerative capacity of the heart following injury is l

242 The regenerative capacity of the heart is markedly diminishe

243 gin, most likely Kupffer cells, regulate the regenerative capacity of the hepatocyte through IL-6 exp

244 ar matrix proteins substantially dampens the regenerative capacity of the hepatocytes, resulting in p

245 Enhancing the intrinsic regenerative capacity of the host by altering its enviro

246 depletion does not initially compromise the regenerative capacity of the immune system because naive

247 The regenerative capacity of the injured CNS in adult mammal

248 hows that a single dose of T(3) enhances the regenerative capacity of the liver following PH.

249 The regenerative capacity of the liver is essential for reco

250 K3beta)-cyclin D3 pathway in the loss of the regenerative capacity of the liver.

251 ty in the Western world owing to the limited regenerative capacity of the mammalian cardiovascular sy

252 ) has provided an explanation for the unique regenerative capacity of the mammary gland throughout ad

253 vide further insight into the plasticity and regenerative capacity of the mature central nervous syst

254 These findings demonstrate a striking regenerative capacity of the mature CNS to support long-

255 ytes after infarction overwhelms the limited regenerative capacity of the myocardium, resulting in th

256 ged skeletal-muscle tissue is limited by the regenerative capacity of the native tissue.

257 These findings demonstrate that the profound regenerative capacity of the neonatal mammalian heart re

258 The regenerative capacity of the peripheral nervous system d

259 ies have also provided new insights into the regenerative capacity of the respiratory system.

260 essing cells are essential for the efficient regenerative capacity of the testis, and also display fa

261 Moreover, the regenerative capacity of the Xenopus retina makes these

262 Here, we harnessed the endogenous regenerative capacity of the zebrafish retina to reconst

263 The current study investigated the regenerative capacity of this cell population by compari

264 The regenerative capacity of tissues to recover from injury

265 This indicates that the regenerative capacity of transected corticospinal tract

266 Taking advantage of the regenerative capacity of zebrafish retina, we show here

267 onishing plasticity may contribute to a high regenerative capacity on severe damage, but how plants c

268 state, accelerate regeneration, and maintain regenerative capacity over several injury-induced regene

269 HF patients in the attempts to augment their regenerative capacity prior to use in the clinical setti

270 This persistent regenerative capacity provides hope for neuronal replace

271 Despite a remarkable regenerative capacity, recovery of the mammalian olfacto

272 s, the ventricular epicardium has pronounced regenerative capacity, regulated by the neighbouring car

273 The molecular events underlying this regenerative capacity remain elusive.

274 echanisms that determine the tissue's cyclic regenerative capacity remain elusive.

275 reasons for this interspecies difference in regenerative capacity remain unclear.

276 ion programme that leads to the differential regenerative capacity remains elusive.

277 The stem cell population underlying this regenerative capacity remains elusive.

278 and whether they have stem cells and tissue-regenerative capacity remains largely unexplored.

279 ouse corticospinal neurons reactivates their regenerative capacity, resulting in significant regenera

280 The liver has enormous regenerative capacity such that, after partial hepatecto

281 long-lived animals with substantial somatic regenerative capacity, such as vertebrates, p53 is an im

282 The progressive loss of endogenous regenerative capacity that accompanies mammalian aging h

283 restore itself after injury yet has a modest regenerative capacity that could be enhanced by innovati

284 The liver has a high regenerative capacity that involves stem/progenitor cell

285 ransferase in hepatocytes exhibited impaired regenerative capacity that was completely rescued by adm

286 enting advanced age, infirmity, and impaired regenerative capacity, the use of Pim-1 modification sho

287 icoids impairs blastema formation and limits regenerative capacity through an acute inflammation-inde

288 on factor that can confer an elevated innate regenerative capacity to CNS neurons.

289 Furthermore, the robust regenerative capacity to respond to both acute and susta

290 MRL/MpJ mice, known to demonstrate enhanced regenerative capacity, to those from C57BL/6 (WT) mice.

291 lar disease and diabetes mellitus impair PAC regenerative capacities via molecular mechanisms that ar

292 ypic culture, we found that the loss of axon regenerative capacity was triggered prematurely by early

293 ral crest cells from other axial levels have regenerative capacity, we asked whether the cardiac neur

294 gnaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6

295 nce a progressive decline in homeostatic and regenerative capacities, which has been attributed to de

296 al muscle mass, skeletal muscle function and regenerative capacity, which can lead to sarcopenia and

297 We show here that this regenerative capacity, which has been attributed to a sm

298 The progressive loss of muscle regenerative capacity with age or disease results in par

299 We demonstrate that in a vertebrate of high regenerative capacity, Wnt/beta-catenin signaling contro

300 gans, such as the heart and brain, with poor regenerative capacity, yet the role of TLR9 in such noni