ライフサイエンスコーパス: regimen

1 HCV genotype 3 infection are limited (2 DAA regimens).

2 observed with the manufacturers' recommended regimen.

3 negative breast cancer compared with the TC6 regimen.

4 re needed to define the optimal chemotherapy regimen.

5 e groups were each crossed over to the other regimen.

6 survival compared with the current standard regimen.

7 for six cycles (TC6) or to a standard TaxAC regimen.

8 There was no emergent resistance to either regimen.

9 rior to that of a 13-hour oral premedication regimen.

10 -label study regimen or continue the control regimen.

11 ith at least one platinum-based chemotherapy regimen.

12 s on the optimal high intensity conditioning regimen.

13 etastatic sites, and first-line chemotherapy regimen.

14 ule of 4mg SN-38/kg was the most efficacious regimen.

15 compromising the WHO-recommended first-line regimen.

16 -51322) to AGN 197727 in the systemic dosing regimen.

17 g a TDF- or tenofovir alafenamide-containing regimen.

18 rable between EVR-containing and TAC control regimens.

19 e cartilage formed under different induction regimens.

20 ifetime and often involves multidisciplinary regimens.

21 eive one of the widely-accepted chemotherapy regimens.

22 erm gestational ages and different treatment regimens.

23 ce in body mass index between both treatment regimens.

24 ne of the limitations of current therapeutic regimens.

25 rtant components of opioid-sparing analgesic regimens.

26 he manufacturers' currently recommended dose regimens.

27 d doses were found between the two predosing regimens.

28 immunologic activity of the different dosing regimens.

29 orbid conditions, and adherence to treatment regimens.

30 n of appropriate conditioning or maintenance regimens.

31 dicts outcome following rituximab-containing regimens.

32 lderly population following myelosuppressive regimens.

33 nroll in clinical trials investigating novel regimens.

34 ster, prompting consideration of alternative regimens.

35 TC) participants; rates did not differ among regimens.

36 erve as a guide for optimising CED treatment regimens.

37 rogrammes using WHO-recommended standardised regimens.

38 response to first- and later-line treatment regimens.

39 ilure during treatment with NNRTI-containing regimens.

40 ated in clinical trials with IMiD-containing regimens.

41 GLP-1 without invasive surgical or injection regimens.

42 otentially efficacious combinatorial therapy regimens.

43 chemic preconditioning, and postconditioning regimens.

44 on response prediction to existing treatment regimens.

45 th 300 mg SQ109, or a daily standard control regimen (10 mg/kg rifampicin, 5 mg/kg isoniazid, 25 mg/k

46 and 53% for those allotted the event-driven regimen (1161 of 2203 doses taken; p<0.0001).

47 d that the newest latent tuberculosis (LTBI) regimen, 12 weekly doses of directly observed isoniazid

48 with 65% for those assigned the time-driven regimen (2367 of 3616 doses taken; p=0.0028) and 53% for

49 from before washout) to one of six tenapanor regimens (3 or 30 mg once daily or 1, 3, 10, or 30 mg tw

50 ed 395 patients, in a 2:2:1:1 ratio, to four regimens: 5 mg of tofacitinib administered orally twice

51 -seven patients (median 5 [range 1-12] prior regimens; 83% refractory to previous lenalidomide therap

52 ed on tacrolimus/mycophenolate mofetil-based regimen along with steroid.

53 administered every 12 weeks is a suboptimal regimen; alternative dosing strategies are being investi

54 Radiation is a staple in therapeutic regimens, although cells surviving radiation can become

55 the safety and tolerability of the treatment regimen, analysed in the intention-to-treat population.

56 per 100 000 population with the short-course regimen and 4.3 (2.9-7.6) per 100 000 population with co

57 were collected continuously during the CSDS regimen and a 5 day recovery period.

58 related to the lymphodepleting chemotherapy regimen and included lymphopenia, neutropenia, and throm

59 w of perioperative antimicrobial prophylaxis regimen and manual review for the 30-day incidence of SS

60 all sample size of each VRC01 administration regimen and missing data from participants who were unab

61 rculosis much more rapidly than the standard regimen and reduce treatment time to relapse-free cure b

62 ic or bleeding events remained on an aspirin regimen and were randomized to continued thienopyridine

63 tion attempt, such as different conditioning regimens and I-BET151 doses, are factors that might have

64 ted with increased SVR rates for certain DAA regimens and patient groups.

65 sistance acquisition with dolutegravir-based regimens and reduced use of expensive second-line booste

66 Providing second-line regimens and shifting treatment providers to professiona

67 ver other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionat

68 ce of new and flexible context-specific dose regimens and vaccination strategies.

69 tient data on SAEs, assigned drug and dosing regimen, and baseline prognostic factors were requested

70 with uniform GVHD prophylaxis, conditioning regimen, and donor source, we explored the correlation o

71 3 (45%) of 29 patients given the once-weekly regimen, and eight (29%) of 28 patients given placebo.

72 dding were HIV disease stage, antiretroviral regimen, and genital ulcers or cervical tenderness.

73 analyses evaluating histology, chemotherapy regimen, and incremental COX-2 expression did not demons

74 optimal immunosuppressive and antiretroviral regimens, and elucidating the incidence of rejection in

75 Pediatrics, nontacrolimus/mycophenolate regimens, and nonrenal transplants were excluded.

76 atment; had received, at most, two induction regimens; and had achieved stable disease or better in t

77 The described regimen appears to be safe and effective for patients af

78 Purpose Bevacizumab regimens are approved for the treatment of recurrent gli

79 Interferon-based regimens are associated with a substantial survival bene

80 his is despite the fact that these drugs and regimens are associated with improved interim outcomes a

81 ch multiple chemotherapy and nonchemotherapy regimens are considered as standard.

82 Intermittent fasting regimens are hypothesized to influence metabolic regulat

83 Once daily regimens are preferred for HIV-1 treatment, to facilitat

84 d to assign patients to individual treatment regimens are urgently needed.

85 tansine (2.4 mg/kg weekly) or a taxane (same regimen as above).

86 tments with close monitoring while receiving regimens associated with HCV reactivation.

87 These individuals were on two ART regimens based on either Non-Nucleoside Reverse Transcri

88 ications of using different chemotherapeutic regimens based on estrogen receptor and human epidermal

89 responder given a checkpoint inhibitor-based regimen because of a mismatch repair gene anomaly are pr

90 in the placebo group discontinued the trial regimen because of adverse events.

91 nd were on the tenofovir disoproxil fumarate regimen before screening were included in primary effica

92 ng HIV-infected women who started 3-drug ART regimens before their last menstrual period and did not

93 n are a key component of effective treatment regimens, but the genetic heterogeneity of HCV has limit

94 e reducing nonadherence to the corresponding regimens by 50% reduced TB and RR TB mortality by 2% (95

95 sis that a fractionated anti-GPA33 DOTA-PRIT regimen calibrated to deliver a radiation absorbed dose

96 Esophageal Cancer Followed by Surgery Study-regimen can be regarded as a standard of care.

97 Here, we developed an immunotherapeutic regimen capable of eliminating large established mouse t

98 mission rates vs children who received other regimens (cephalosporin and macrolide vs neither drug cl

99 , age, historical plasma viral load, and ART regimen changes prior to interruption were associated wi

100 dence and mortality, we sought to prioritize regimen characteristics from a population-level perspect

101 By linking these regimen characteristics to a novel regimen's ability to

102 with either mFOLFOX6 or FOLFIRI chemotherapy regimen chosen by the treating physician and patient.

103 2 doses taken) for women allocated the daily regimen compared with 65% for those assigned the time-dr

104 afety, and tolerability of switching to this regimen compared with remaining on coformulated efaviren

105 for efficacy of weekly rifapentine-isoniazid regimens compared with no treatment (OR, 0.36 [CrI, 0.18

106 and provide a rationale for new combination regimens comprising CDK4/6 inhibitors and immunotherapie

107 The study regimen consisted of a fixed-dose tablet containing daru

108 cosal immune responses elicited by a vaccine regimen containing Env cross-linked to a CD4-mimetic min

109 ined virologic response after treatment with regimens containing direct-acting antiviral agents (DAAs

110 Treatment regimens cost 1.9 to 13.0x the median amount spent on sm

111 d use of longer therapy-ie, the short-course regimen could reduce incidence by 23% (10-38).

112 Quadruple Levofloxacin-containing regimens could be an option for first-line treatment, bu

113 These findings suggest that dosing regimens could be individualised and tailored for patien

114 e to the overweight and diet-induced obesity regimens, CR decreased body weight, adiposity, and serum

115 nd vision, vitreoretinal findings, treatment regimens, culture data, and final visual acuities.

116 tients with stage III FHWT were treated with Regimen DD4A and radiation therapy.

117 The low-dose chemotherapy conditioning regimen depleted blood lymphocytes and increased serum i

118 on of tolvaptan to a standardized furosemide regimen did not improve the number of responders at 24 h

119 t year after transplantation; however, these regimens do not have a durable effect on long-term graft

120 hen we are able to optimize the immunization regimen (dose, interval between doses, and drug partner)

121 erity, with no discontinuations of the trial regimen due to adverse events for tezacaftor-ivacaftor a

122 Prior endocrine regimens during which progression occurred included arom

123 Modern immunosuppression regimens effectively control acute rejection and decreas

124 melphalan is a comparatively safe and active regimen for ASCT in patients with refractory or relapsed

125 (<50 copies of HIV-1 RNA per mL) on a stable regimen for at least 6 months, CD4 count of more than 10

126 ts suggest that MART-10 could be a promising regimen for CCA treatment.

127 enal transplant and is a promising treatment regimen for eradicating HCV in this patient population.

128 udies are needed to identify the optimal DAA regimen for kidney transplant recipients, accounting for

129 to, the labour-intensive basal-bolus insulin regimen for the management of hyperglycaemia in patients

130 ic acid was noninferior to the every 4 weeks regimen for the proportion of patients experiencing 1 or

131 d aggressive focal therapies is an effective regimen for the treatment of advanced retinoblastoma and

132 Is remains the best standardised second-line regimen for use in programmes in resource-limited settin

133 omponent of primary and salvage chemotherapy regimens for acute myeloid leukemia (AML).

134 eveloping the most effective neoadjuvant CRT regimens for both adenocarcinomas and squamous cell carc

135 been engineered to evaluate novel immunogens/regimens for effectiveness in driving bnAb responses.

136 s prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied.

137 identifiable surrogate to evaluate potential regimens for mesenchymal TNBC.

138 e development of increased and serial dosing regimens for somatic gene editing in vivo.

139 The current drug regimens for treating tuberculosis are lengthy and onero

140 tment option that does not disrupt treatment regimens for underlying psychiatric illnesses.

141 ively for weeks and observe whether training regimens (FTM or LTM) can induce durable changes in the

142 been demonstrated after withdrawal from this regimen; furthermore, Ca(2+)-permeable AMPA receptors (C

143 =4 positive nodes), and trastuzumab adjuvant regimen (given sequentially vs concurrently with chemoth

144 -free, pangenotypic, direct-acting antiviral regimen, glecaprevir coformulated with pibrentasvir, has

145 inamide is central to tuberculosis treatment regimens, globally.

146 locomotor activity) persisted after the CSDS regimen had ended.

147 artial response to their last platinum-based regimen, had a cancer antigen 125 concentration of less

148 ast two previous platinum-based chemotherapy regimens, had achieved complete or partial response to t

149 tion modelling suggests that the triple-drug regimen has potential to accelerate the elimination of l

150 with high-risk neuroblastoma; however, which regimen has the greatest patient benefit has not been es

151 The use of these simplified regimens has the potential to increase access to treatme

152 Recently, regimens have become available that might improve HCW ac

153 Similar vaccination regimens have been used successfully to induce broad pro

154 itors (ICI), in single agent and combination regimens, have produced durable and long-lasting clinica

155 x regression analysis, treatment with either regimen (hazard ratio [HR], 0.43; 95% confidence interva

156 ed rituximab in addition to the chemotherapy regimen (hazard ratio, 3.3; 95% CI, 1.0-14.7; P = .06).

157 With the advent of the new IFN-free regimens, highly effective and safe even in those histor

158 ity compared with myeloablative conditioning regimens (HR 1.36, 1.10-1.68, p=0.0041), transplantation

159 Conclusion The TaxAC regimens improved IDFS in patients with high-risk human

160 al trial evaluating an alternating treatment regimen in an attempt to delay disease progression in cl

161 ior and clinically comparable with a monthly regimen in improving VA from baseline to the end of stud

162 We found that synbiotic therapy was the best regimen in reducing surgical site infection (SSI) (RR =

163 gin) of the study regimen versus the control regimen in the intention-to-treat population.

164 ter one previous platinum-based chemotherapy regimen in the metastatic setting.

165 se of these drugs and for the shorter MDR-TB regimen in the pediatric population.

166 hat imposing a time-restricted feeding (TRF) regimen in which all caloric intakes occur consistently

167 rated increased morbidity with liberal fluid regimens in abdominal surgery.

168 nvestigate the feasibility of non-daily PrEP regimens in adult women.

169 cy (ie, <80%) with clarithromycin-containing regimens in countries where the clarithromycin resistanc

170 ticenter trials of induction and maintenance regimens in first-line FL therapy published after 1990 a

171 hed patients, we found no difference between regimens in health care use overall or for chemotherapy-

172 bjective response compared with chemotherapy regimens in ipilimumab-refractory patients with advanced

173 , and the role of using "pediatric-inspired" regimens in older adults considered.

174 Current immunosuppression regimens in organ transplantation primarily inhibit T ce

175 ectiveness and safety of interferon-free DAA regimens in patients with advanced liver disease, includ

176 0.5 mg treat-and-extend (T&E) versus monthly regimens in patients with neovascular age-related macula

177 (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry), 4222 patients wh

178 ith progression on two or more HER2-directed regimens in the advanced setting.

179 ely used fludarabine, melphalan conditioning regimen, in hopes of reducing relapse and decreasing gra

180 urpose To evaluate a multimodal surveillance regimen including yearly full-field digital (FFD) mammog

181 impact of isoniazid resistance and treatment regimen, including use of a fluoroquinolone, on clinical

182 nes recommending tenofovir alafenamide-based regimens, including coformulation with rilpivirine and e

183 3) per 100,000 per year at the time of novel regimen introduction and RR TB incidence and mortality o

184 No once-daily single-tablet regimen is available for HIV-infected children under 12

185 and mycophenolate mofetil immunosuppressive regimen is efficacious, with a low incidence of PTDM and

186 with viral suppression for each long-acting regimen is not worse than the oral regimen proportion by

187 perly selected patients; greater use of this regimen is recommended.

188 Choosing the optimal chemotherapy regimen is still an unmet medical need for breast cancer

189 orin, fluorouracil, and irinotecan (FOLFIRI) regimen is superior as first-line therapy in advanced or

190 However, one dose of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole

191 The experimental regimens kill M. tuberculosis much more rapidly than the

192 servational studies have suggested that this regimen may lead to high failure rates in coinfected pat

193 fts, we conclude that targeted alpha-therapy regimens may stretch beyond the realm of micrometastatic

194 MVC-containing regimens may warrant further study for pre-exposure prop

195 ks following randomisation, both long-acting regimens met primary criteria for comparability in viral

196 olerability study was conducted, comparing 4 regimens: MVC alone, MVC plus emtricitabine (FTC), MVC p

197 For both vaccine regimens, natural killer (NK) cell signatures negatively

198 We used an intravenous fractionated regimen of alpha-radioimmunotherapy in a subcutaneous tu

199 nd tenofovir alafenamide versus continuing a regimen of boosted protease inhibitor, emtricitabine, an

200 All patients received the same chemotherapy regimen of bortezomib and dexamethasone.

201 s after a low-dose chemotherapy conditioning regimen of cyclophosphamide plus fludarabine.

202 y and safety of switching to a single-tablet regimen of darunavir, cobicistat, emtricitabine, and ten

203 gned (1:1) to receive either a single-tablet regimen of dolutegravir plus abacavir and lamivudine onc

204 amide (25 mg) or to continue a single-tablet regimen of efavirenz (600 mg), emtricitabine (200 mg), a

205 ical evidence for the fixed-dose combination regimen of elbasvir plus grazoprevir for 12 weeks and su

206 The doublet regimen of gemcitabine and capecitabine is preferred in

207 ivalent in magnitude to a standard multi-day regimen of granulocyte colony-stimulating factor (G-CSF)

208 reatment-naive NVAMD were managed with a TAE regimen of intravitreal aflibercept.

209 f body weight after receiving a conditioning regimen of low-dose cyclophosphamide and fludarabine.

210 fter they were exposed to an escalating dose regimen of MA (or saline control).

211 public health use of a reduced, single-dose regimen of oral cholera vaccine, and show the details of

212 A regimen of protease inhibitor with NRTIs remains the bes

213 ly assigned (1:1) to receive a single-tablet regimen of rilpivirine (25 mg), emtricitabine (200 mg),

214 The every 12 weeks regimen of zoledronic acid was noninferior to the every

215 1 [CrI, 0.19 to 0.85]), rifampicin-isoniazid regimens of 3 to 4 months (OR, 0.53 [CrI, 0.36 to 0.78])

216 ously included studies showed that isoniazid regimens of 6 months (odds ratio [OR], 0.65 [95% credibl

217 would be of great value in tailoring dosing regimens of antibiotics so as to maximize the duration o

218 half of the pens later receiving three 5-day regimens of chlortetracycline from day 4 to day 20.

219 and other biological treatments, both dosing regimens of sirukumab were well tolerated and significan

220 no significant effect of either benralizumab regimen on the forced expiratory volume in 1 second (FEV

221 gned (2:1) to switch to the open-label study regimen or continue the control regimen.

222 in, fluorouracil, and oxaliplatin (mFOLFOX6) regimen or the combination of leucovorin, fluorouracil,

223 infants is not due to differences in vaccine regimen or vaccine dose between adults and infants.

224 ts may benefit from intensified chemotherapy regimens or, ideally, should enroll in clinical trials i

225 to 0.78]), rifampicin-isoniazid-pyrazinamide regimens (OR, 0.35 [CrI, 0.19 to 0.61]), and rifampicin-

226 , 0.50 [CrI, 0.41 to 0.62]), rifampicin-only regimens (OR, 0.41 [CrI, 0.19 to 0.85]), rifampicin-ison

227 0.19 to 0.61]), and rifampicin-pyrazinamide regimens (OR, 0.53 [CrI, 0.33 to 0.84]) were efficacious

228 ched after following a fixed dose-escalation regimen) or once-daily insulin glargine (starting dose 1

229 rade 3-4 adverse events did not differ among regimens (P = .37).

230 interval, .5%-3.3%], without differences by regimen; P = .32); 2 had undetectable drug concentration

231 l duration of treatment with interferon-free regimens, particularly in HIV-coinfected individuals, re

232 patients who failed previous DAA-containing regimens, particularly those with nonstructural protein

233 under the curve 5]) or the same chemotherapy regimen plus bevacizumab (15 mg/kg of bodyweight) every

234 It is unknown if antimicrobial regimens possessing in vitro MRSA activity provide impro

235 ta are available on the efficacy of RBV-free regimens posttransplant, particularly the use of sofosbu

236 s an active and well-tolerated first salvage regimen, potentially providing patients with R/R HL an a

237 This training regimen produced large, significant long-term changes in

238 The 2 riboflavin dosing regimens produced equivalent reduction in the maximum ke

239 ng-acting regimen is not worse than the oral regimen proportion by more than 10% (denoted comparable)

240 muscular dystrophy and determined that both regimens provided comparable benefits in terms of annexi

241 Results Average doses from 647 regimens published during 2010 to 2015 were 5.7 Gy for w

242 med of lung and heart doses in breast cancer regimens published during 2010 to 2015.

243 /=5 mg daily warfarin and those with an LMWH regimen (RAR: 0.9; 95% CI: 0.3 to 2.4).

244 An optimal RR TB regimen reduced RR TB incidence by an estimated 32% (95%

245 d to 2 different room temperature incubation regimens reflective of current corneal tissue handling p

246 Although most tolerance-inducing regimens rely on regulatory T cells, we found that induc

247 rbidity and mortality, and current treatment regimens rely on the use of drugs that have been in use

248 f 29 subjects) in the single-dose and 3-dose regimens, respectively (absolute difference, 13% [95% co

249 ART initiation and start DTG- or DRV/r-based regimens, respectively.

250 a heterologous DNA-viral vector prime-boost regimen, resulting in a high proportion of cross-reactiv

251 This mobilization regimen results in preferential trafficking of stem cell

252 ing these regimen characteristics to a novel regimen's ability to reduce TB incidence and mortality,

253 the new strategy, called PRES (Personalized REgimen Selection), may significantly increase response

254 of response and more effective preoperative regimens should be aggressively sought.

255 Such regimens should be used with initial treatment, rather t

256 after sex), pills needed or used to achieve regimen-specific adherence and coverage, and symptoms an

257 aseline prevalence (10-40%), the triple-drug regimen strikingly reduced the number of rounds of mass

258 ne setting compared with more widely adopted regimens such as chemotherapy and/or radiation therapy.

259 li burn and explored a novel neuroprotective regimen suitable for prompt administration in emergency

260 provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits

261 amine a DNA and adenovirus (Ad5) combination regimen targeting guanylyl cyclase C (GUCY2C), a recepto

262 Our study suggests that a combinatorial regimen targeting the vasculature, GSCs, and GECs, using

263 al History of Asthma: Outcomes and Treatment Regimens (TENOR I) study demonstrated high morbidity in

264 levodopa plus benserazide or carbidopa in a regimen that had been stable for 4 weeks or longer.

265 i, thus devising a new, low-dose, sequential regimen that imparts a robust anti-tumor effect for non-

266 Treatment regimens that are recommended for post-LT patients are n

267 that had progressed during one or more prior regimens that included a vascular endothelial growth fac

268 nsive second-line boosted protease inhibitor regimens, this policy option is also predicted to lead t

269 timized dosing, the use of customized dosing regimens through either evidence-based dosing nomograms

270 one could be employed as a novel therapeutic regimen to help improve MCC in smoking-related chronic b

271 , and a detailed safety substudy showed both regimens to be safe, deliverable, and tolerable.

272 Improved drug regimens to shorten and simplify treatment are urgently

273 ectly compare outcomes with belatacept-based regimens to tacrolimus.

274 Conclusion The hypofractionated RT regimen used in this trial was not inferior to conventio

275 ir planned cisplatin-containing chemotherapy regimen, using permuted blocks of four.

276 We developed a rapid stem cell mobilization regimen utilizing a unique CXCR2 agonist, GRObeta, and t

277 ted non-inferiority (4% margin) of the study regimen versus the control regimen in the intention-to-t

278 Adherence to the assigned regimen was 75% (7283 of 9652 doses taken) for women all

279 Importantly, this immunotherapeutic regimen was also curative for large established mouse Re

280 An evidence-based optimised dose regimen was constructed that would provide piperaquine e

281 zumab 0.5 mg administered according to a T&E regimen was statistically noninferior and clinically com

282 of ongoing viral replication on current ART regimens, we analyzed HIV populations in longitudinal sa

283 herapy with an anti-CD20 antibody-containing regimen were treated with 560 mg ibrutinib orally once d

284 travenous infusion every 8 h) for 7-14 days; regimens were adjusted for renal function.

285 ients treated with 12 different fibrinolytic regimens were assessed.

286 Compared with Tac + MPA, SRL regimens were associated with higher risks for patient d

287 s under loading dose and maintenance therapy regimens were nearly identical.

288 in routine practice (all currently approved regimens were registered).

289 Maraviroc-containing PrEP regimens were safe and well-tolerated compared with TDF-

290 agents (except pomalidomide) to the RD or VD regimens were superior to the double combinations in ter

291 response by 12 weeks after therapy, and DAA regimens were well tolerated.

292 for, and the design of, antibiotic treatment regimens, which hyper-emphasizes antibiotics as if they

293 World Health Organization-recommended 5-drug regimen while awaiting second-line drug-susceptibility t

294 However, activity of TC relative to AC regimens with a taxane (TaxAC) is unknown.

295 were generated with standard intense smoking regimens with careful consideration for dose by normaliz

296 Renal function did not worsen on LDV/SOF regimens with TDF.

297 n activity in AITL are paired with induction regimens with the hope of demonstrating long-term progre

298 -tuberculosis by Xpert initiate a suboptimal regimen, with information to adjust therapy available in

299 eceiving the T&E (8.7) versus monthly (11.1) regimen, with mean number of postbaseline visits of 8.9

300 The sofosbuvir-containing regimens without interferon for treatment of acute HCV i