ライフサイエンスコーパス: region-specific

1 ship was component, neurochemical, and brain region specific.

2 ass, but the effects of these variables were region specific.

3 hanisms responsible for seizure onset can be region specific.

4 conversion of tau into a prion exist and are region specific.

5 he observed increase in synchrony is cue and region specific.

6 on protein (FMRP) on these pathways is brain region specific.

7 suggesting that the regulation is not brain region-specific.

8 M, however, was generally more sensitive and region-specific.

9 This reduction reflected a combination of a region-specific 7%-16% decrease in tissue concentration

10 We tested two brain region-specific A2AR knockout lines with A2ARs selective

11 y (96.2%) blocked by competition with the C1 region-specific A32 Fab fragment.

12 Knowledge about the region-specific absorption profiles from the gastrointes

13 al and evolutionary processes, which promote region-specific accumulation of diversity through time o

14 unique modulatory role of Rgs4 in the brain region-specific actions of a wide range of antidepressan

15 egions that undergo gyrification, indicating region-specific actions of FGF2 on the VZ and subventric

16 1 are involved in neuronal activity-induced, region-specific, active DNA demethylation and subsequent

17 rst time, our study identifies the time- and region-specific activity of a perinatal progenitor domai

18 These results suggest that CCI induced a region-specific adaptation of mu-opioid receptor-mediate

19 c and hindbrain choroid plexi contributes to region-specific, age-dependent protein secretion in vitr

20 SCA3 knockin mice exhibit region-specific aggregate pathology marked by intranucle

21 d mortality differ among regions, suggesting region-specific air pollution control strategies.

22 increased immobility in the FST and induced region-specific alterations in Oprk1, Oprm1, and PDYN mR

23 The region-specific alterations of brain 5-HT1A gene express

24 Region-specific amyloid-beta(4)(2) accumulation might ac

25 The region-specific analysis determined that 81 bases and 10

26 lation of dendritic spine formation is brain-region specific and age-dependent is unknown.

27 We found the following: (1) region-specific and age-dependent synapse loss in aged W

28 These differences were frequency- and region-specific and implicated brain systems thought to

29 on their development of a strategy that uses region-specific and molecularly engineered astrocytes to

30 lso, the hydrolysis activity was found to be region-specific and sugar-specific for the Gal beta-1,3-

31 es of short bursts of synchrony occurring in region-specific and task-time-specific patterns.

32 ng acute and repeated THC administration was region-specific, and results suggest that multiple, over

33 ing proteins, e.g., protein A, protein G, Fc region specific antibodies or various recombinant protei

34 g strategy to eliminate undesirable constant region-specific antibodies and select for anti-idiotypic

35 ried by region, indicating the importance of region-specific approaches for quantifying N2O emissions

36 Interestingly, the synaptic difference is region specific as no differences were found in excitato

37 These impairments were age and region-specific as rats infused with TTX into the VH at

38 ly with Tc-hth and Tc-exd to specify several region-specific aspects of the adult body wall.

39 ide the first national, season-specific, and region-specific associations between mortality and PM2.5

40 There are some documented species and brain region-specific astrocyte specializations, but the exten

41 and important molecular atlas for exploring region-specific astroglial functions.

42 m high-resolution micro-computed tomography, region-specific atrial cell electrophysiology and the ef

43 e novo wiring is both condition specific and region specific because it does not occur in pseudocondi

44 these data provide crucial insight into the region-specific behavior of neuronal ensembles during co

45 SAG treatment, this lack of improvement in a region-specific behavioral assay supports the possibilit

46 different brain regions but with unexpected, region-specific behavioral outcomes.

47 about the molecular mechanisms that regulate region-specific behaviours and that maintain the coheren

48 and flaring and four times greater than our region-specific bottom up inventory-based estimate.

49 own measurements were directly compared with region-specific bottom-up inventories that utilized curr

50 rectly reported data but consistent with our region-specific bottom-up inventory-based estimate.

51 e effects of selective potentiation of M4 on region-specific brain activation, VU0152100 alone and in

52 ity in providing non-invasive stimulation of region-specific brain circuits for neuroscientific and t

53 Re-methylation is region-specific but random with respect to individual CG

54 ihha-dependent bone development is not only region specific, but also begins exactly at the onset of

55 Common region-specific causes of hospital admission included ma

56 ent that antibodies directed against several region-specific cell adhesion molecules, including neuro

57 Live imaging of KV cells revealed region-specific cell shape changes that mediate tight pa

58 Brain region-specific changes have been demonstrated with a va

59 These data indicate that region-specific changes in 5-HT(2A) receptor mRNA expres

60 Detailed analysis of primary cilia revealed region-specific changes in ciliary morphology accompanie

61 a position to be differentially affected by region-specific changes in dopamine signaling, the funct

62 ependent (linear and curvilinear), and brain region-specific changes in expression of genes encoding

63 Together with region-specific changes in glutamate acid decarboxylase

64 transcription by interaction with Sp1 and by region-specific changes in histone acetylation within th

65 We investigated region-specific changes in pro- and anti-inflammatory ma

66 However, region-specific changes in rhythms across multiple, inte

67 ent protein C3 in mediating aged-related and region-specific changes in synaptic function and plastic

68 eral nerve injury induced time-dependent and region-specific changes in the spinal YAP and TAZ expres

69 These results suggest region-specific changes of ERK1 and ERK2 mRNA expression

70 usion, Ang II promotes ascending AAs through region-specific changes that are independent of hypercho

71 of subjects with schizophrenia show complex, region-specific changes with consistently replicated and

72 demonstrated distinct biochemical profiles, region-specific changes, and distinct subcellular locali

73 den the use of embryonic chimeras, including region-specific chimeras, for basic developmental biolog

74 This study shows for the first time region-specific circadian oscillation of dCREB2/NF-kappa

75 in disorders affect I/E dynamics, leading to region-specific circuit dysfunction and behavioral impai

76 QTL signals produced well-defined modules of region-specific co-regulated genes, in contrast to stand

77 which is not regionally restricted, requires region-specific cofactors in the form of Hox proteins to

78 Using novel cell-type- and region-specific conditional knockouts of the GABAA recep

79 t loss of HDAC11 has age dependent and brain-region specific consequences.

80 dividual Bdnf transcripts make differential, region-specific contributions to total BDNF levels.

81 tion factor Gsx2 plays a crucial role in the region-specific control of adult NSCs in both persistent

82 n of the L2 protein, results that imply skin region-specific control of postentry aspects of the vira

83 at learning to produce AG sounds resulted in region-specific cortical reorganization within the infer

84 We also found that total and region-specific cortical thickness was significantly neg

85 patients), 495 received a letter describing region-specific CRC screening adherence rates (generic r

86 nd endoscopic scanning programs require new, region-specific criteria to diagnose UGI cancers in this

87 These region-specific CSNs terminate in different spinal level

88 We utilize region specific data and models to analyze the consumpti

89 Nation- and region-specific data were examined for (1) a composite o

90 the availability and quality of country- and region-specific data.

91 ss of cilia during development resulted in a region-specific decrease in neurogenesis, implicating HB

92 General or brain-region-specific decreases in spine number or morphology

93 rference-mediated DBIRD depletion results in region-specific decreases in transcript elongation, part

94 These findings suggest that region-specific degeneration of cortical interneurons is

95 Experiments with region-specific deletion of Fz3 using a variety of Cre l

96 (e.g., dose), topographic distribution, and region-specific delivery in small (rodent) and large (po

97 Accordingly, eFSE provoked region-specific dendritic loss in the hippocampus, and a

98 Brain region-specific deposition of extracellular amyloid plaq

99 signaling level, Pten(m3m4) mice show brain region-specific differences in Akt activation.

100 ytokines, and our results may partly explain region-specific differences in the clinical spectrum of

101 lopmental literature and suggest interesting region-specific differences in the prevalence and timing

102 es with restricted expression patterns, (ii) region-specific differences in the relative expression o

103 epithelial crypt-like structures expressing region-specific differentiation markers.

104 Further, the equiaxial load induced region-specific differentiation of ASCs within the inner

105 ntrolling adult epithelial proliferation and region-specific differentiation, and suggest downstream

106 osition and normal aging are associated with region-specific disruption of functional connectivity an

107 presentations in ASD or that there is an eye region-specific disruption to attentional processes enga

108 w V i statistic was proposed to estimate the region-specific divergence in CNVR for each group based

109 The analysis suggests region-specific dynamics including precontact land use d

110 ion in the brain hinders an understanding of region-specific ECM functions and the role of ECM in hea

111 re based on evidence-based clinical data and region-specific economic data acquired from direct field

112 ngs are (1) the changes at wdw have sex- and region-specific effects and could, therefore, be regulat

113 random-effects model was used to combine the region-specific effects and generate summary odds ratios

114 ain-penetrant TrkB antagonist leads to brain region-specific effects and may be a potential pharmacol

115 Interestingly, Scn2b deletion resulted in region-specific effects in the heart.

116 In addition, we found region-specific effects of each drug, suggesting both co

117 eduction of miR-185 also has milder age- and region-specific effects on the expression of some Golgi-

118 s modulated by PM reaction time, pointing to region-specific effects within medial BA10.

119 apical constriction when it is combined with region-specific elasticities in the membranes surroundin

120 Region-specific endocardial Notch activity regulates hea

121 Here, we report region-specific engagement of the DYN/KOR system and sub

122 ted novel molecular mechanisms that regulate region-specific enhancer activity in the developing brai

123 uation, University of Washington, to develop region-specific estimates of premature cardiovascular mo

124 These data reveal ongoing region-specific evolution of PfCRT that impacts drug sus

125 vulnerability to prenatal alcohol via brain region-specific expression of Dio3.

126 tic tools have enabled identification of the region-specific expression of peripheral metabolic hormo

127 This region-specific expression pattern of genes, such as syn

128 red pectoral fins identified many genes with region-specific expression, several of which encoded tra

129 well-known signaling pathways together with region-specific factors transform thickened ectodermal p

130 rm progenitors specifically contributed in a region-specific fashion to endodermal tissues.

131 ceptor alpha changes across development in a region-specific fashion.

132 logy in major depression with sex- and brain region-specific features.

133 We describe here a novel, region-specific focal seizure pattern that mimics seizur

134 terium exchange mass spectrometry to monitor region-specific folding of the canonical serpin human al

135 ling, hPSCs were differentiated to different region-specific forebrain neuron subtypes, including glu

136 e provided an optimized paradigm to generate region-specific forebrain neurons from hPSCs under a def

137 tion of FOXP2 biochemically and analyzed the region-specific function and sumoylation of FOXP2 in the

138 However, neither the region-specific function of FOXP2 in the brain, in parti

139 The global function of RNase H2 and the region-specific function of RNase H1 provide insight int

140 es proof-of-concept that a cell-specific and region-specific gene expression approach can provide pot

141 Many examples of region-specific gene expression in the adult intestine a

142 natal spinal cord astrocytes express several region-specific genes, and that ventral astrocyte-encode

143 iated with DNA rearrangements resulting from region-specific genome instability, that is, genome arch

144 , South Carolina and South Dakota using nine region specific genotypes.

145 uple for the first time, to our knowledge, a region-specific global health model based on dietary and

146 ology (illness burden) have implications for region specific health policy.

147 pathological type is important for targeted region-specific health-care planning for stroke and coul

148 We show how myocardial region-specific heterogeneity in cell function emerges d

149 Here, we take advantage of a region-specific heterogeneity in luminal progenitors to

150 areas during prolonged wakefulness lead to a region-specific homeostatic increase in theta activity (

151 Vibrio cholerae revealed infection-stage and region-specific host barriers to infection and showed un

152 Finally, there are region-specific hotspots of future changes in precipitat

153 scores from different regions and a range of region-specific HRM diversity assay cutoffs.

154 in order to predict disease-relevant, brain region-specific HTT interaction partners.

155 s, including genome-wide hypomethylation and region-specific hypermethylation, are frequently observe

156 s morphology may account for a differential, region-specific, impact of LC output on different cortic

157 To further investigate the region-specific importance of CREB in depression-related

158 a specific drop in nuclear Pten and exhibit region-specific increases in brain weight.

159 re than a decade ago explain the organizer's region-specific inductions (i.e., head and trunk) as the

160 These findings suggest region-specific influences of maternal care in shaping n

161 degradation (e.g. REDD+) require country- or region-specific information on temporal changes in fores

162 Using in vivo optogenetics, the brain region-specific inputs to the NAc that mediate these nuc

163 ered lipid synthesis patterns distinguishing region-specific intratumor subpopulations.

164 indicate that this non-canonical feedback is region specific: it is most prominent in lobules that re

165 nd that beta-catenin interacts directly with region-specific LEF/TCF factors, and with KLF4 in differ

166 We quantified brain region-specific levels of Oxtr messenger RNA and oxytoci

167 chnology in foreign economies, (2) utilizing region-specific life-cycle inventories (in a hybrid fram

168 potential of lipidomics and identifies novel region-specific lipid anomalies potentially linked to AD

169 oposed workflow has been used to investigate region-specific lipid signatures in colorectal cancer ti

170 sets of input and output neurons as well as region-specific local interneurons.

171 yed the expected increase in body weight and region-specific loss of leptin signaling in the hypothal

172 Region-specific manipulations indicate that CSNs from ca

173 roach, using genetic animal models and brain region-specific manipulations of oxytocin activity.

174 Using region-specific manipulations of the mouse oxytocin rece

175 obilization of adult NSCs is controlled in a region-specific manner and that distinct mechanisms oper

176 h as Pax6 regulate cortical progenitors in a region-specific manner are poorly understood.

177 nesis in two models of neurodevelopment in a region-specific manner has significant mechanistic impli

178 either MGE- or CGE-derived interneurons in a region-specific manner in mouse neonatal hippocampus in

179 tified several genes that are expressed in a region-specific manner in the developing human intestine

180 ults show that tau pathology is related in a region-specific manner to cognitive impairment in Alzhei

181 pe in IECs is preprogrammed by the host in a region-specific manner to permit responses to microbiota

182 n was upregulated in CASP4/APP/PS1 mice in a region-specific manner, including hippocampus and prefro

183 e show that the mPOA innervates the VTA in a region-specific manner, that lesions of the mPOA augment

184 leads to ciliary morphology disruptions in a region-specific manner, which may explain the complex mu

185 ffects transcriptome in the vasculature in a region-specific manner, which may help to identify genes

186 stress (CUS) paradigm on the rat brain in a region-specific manner.

187 for the treatment of FXS may vary in a brain-region-specific manner.

188 n "master clock," which is DNA methylated in region-specific manner.

189 tonin, and dopamine levels in the brain in a region-specific manner.

190 perconnectivity was related to symptoms in a region-specific manner.

191 tivation of pubertally born cells in a brain region-specific manner.

192 d Abeta (GAbeta) immunoreactivity in a brain region-specific manner.

193 ulation of embryonic RGCs, in a temporal and region-specific manner.

194 ved with high efficiency in a cell-type- and region-specific manner.

195 , was differentially affected by stroke in a region-specific manner.

196 that control dephosphorylation, we monitored region-specific mapping of phosphorylation sites in ASF/

197 etal gray matter volume, which both indicate region-specific maturation, were significantly correlate

198 gions of interests, of which whole-brain and region-specific means were compared by using a general l

199 during energy crisis, and triggers a marked region-specific metabolic response.

200 les, microbial metabolites, medications, and region-specific metabolism of medications and placed it

201 entative database of visits to PAs and built region-specific models predicting visit rates from PA si

202 cis-proline-specific regulatory factors and region-specific modulation of the CTD code that may augm

203 rly and sclera posteriorly, are regulated by region-specific molecular mechanism remains unclear.

204 Using region-specific mouse reporter strains, we performed an

205 nses in each brain region as trajectories in region-specific multidimensional spaces, and models the

206 ral primary tumour specimens reveals various region-specific mutations.

207 ptibility, at least in part, originates from region-specific myoepithelial progenitors.

208 ecific enhancer as a tool to isolate a pure, region-specific NC subpopulation for transcriptional pro

209 Here we identify a brain-region-specific neural progenitor-based signaling pathwa

210 ental impairments may contribute not only to region-specific neurodegeneration, but also to non-neura

211 NCA-OVX mice thus provides insights into the region-specific neuronal disturbances preceding and acco

212 strating that they are orientation- and skin-region-specific, occur even when just one hand is adapte

213 ttle is known about the molecular control of region-specific oligodendrocyte development.

214 resource-constrained regions but may require region-specific optimization before widespread use.

215 Together, our brain-region-specific organoids and SpinOmega provide an acces

216 Finally, fusing region-specific organoids followed by live imaging enabl

217 When region-specific organoids were transplanted into immunoc

218 ably reflect the differential involvement of region-specific pathological or protective mechanisms, s

219 les and fast ripples show distinct time- and region-specific patterns during LVF and HYP seizures, th

220 ry genome of epidemic clones partly reflects region-specific patterns of antibiotic usage, which may

221 These region-specific patterns of entrainment evolved dynamica

222 evolved dynamically with the development of region-specific patterns of interneuron and MSN activity

223 Region-specific phenotypes of BG microglia emerged durin

224 s and visualization, opening new options for region-specific phenotypic screening of complex physiolo

225 formation was proportional to the amount of region-specific plaque deposition seen later in older AP

226 We show here that region-specific PMCA in part reproduces the specific bra

227 and CaMKII engage in a cell-type- and brain-region-specific positive feedforward loop as a key mecha

228 The Midwest had the lowest region-specific prevalence (1.14% [95% CI, 1.04%-1.30%])

229 The West census region had the highest region-specific prevalence (2.14% [95% CI, 1.96-2.48]);

230 oups and we observed striking enrichment for region-specific processes.

231 ain tissue sections revealed distinct, brain region-specific profiles in each transgenic line.

232 By enrichment for region-specific progenitors, we identify bipotent and mu

233 findings support developing both global and region-specific programmes to prevent stroke.

234 of the duct, and incorporates morphometrics, region-specific proliferation and apoptosis rates.

235 f the 55 regions (22%), the most significant region-specific, prostate-cancer associated variant repr

236 g dynamic regulation by FMRP and other brain region-specific proteins.

237 RP during early synaptogenesis in layer- and region-specific pyramidal neurons.

238 n the cortex was accompanied with layer- and region-specific reactive gliosis without cell loss.

239 In this study, we demonstrate that region-specific receptor fragmentation modifies channel

240 ctivity in the DPFC network bilaterally, and region-specific reductions in connectivity were related

241 These molecular changes were accompanied by region-specific reductions of dendritic spine density in

242 irm that series of large eruptions may cause region-specific regime shifts in the climate system and

243 g enzyme encoded by cyp24a1, contributing to region-specific regulation of bone metabolism.

244 ntrol of DA signaling, shedding new light on region-specific regulation of DA-mediated effects.

245 Furthermore, we uncovered region-specific regulation of neurexin transcription and

246 This region-specific removal likely underlies the two-step se

247 ovides the first in vivo evidence of genomic region-specific repair in mammals.

248 els are finely tuned to yield cell-type- and region-specific repression or activation outcomes.

249 However, the temporal and region-specific requirements for alphaCaMKII have remain

250 The region-specific restoration might impose limitations in

251 Region-specific RICS analysis remains very challenging b

252 hese results provide evidence of a critical, region-specific role for ERK signaling in the dorsal str

253 r (AVPV) and arcuate (ARC) nuclei, while the region-specific role of progesterone receptors in these

254 s, suggesting that IFNAR signaling has brain region-specific roles in CNS immune responses.

255 s, making it difficult to delineate time- or region-specific roles of PIP2.

256 ro- and antioxidant systems that orchestrate region-specific ROS production and removal.

257 we address these shortcomings by developing region-specific SDRs for Europe at various scales (conti

258 rol comparisons in specific disorders, using region-specific seed-based analyses.

259 omeostatic functions but could also underlie region-specific sensitivities to microglial dysregulatio

260 These findings are consistent with region-specific sexual selection and/or random genetic d

261 We also demonstrated a region-specific shift in power of cortical oscillations

262 fferently in each brain region, resulting in region-specific "signature" pools of non-glycolytic subs

263 or genes that mechanistically regulate brain region-specific signatures associated with dependent and

264 Markers at 55 regions passed a region-specific significance threshold (P-value cutoff r

265 identified a strong association between one region-specific SNP (rs10509852), 400 kb upstream of SOR

266 These findings provide insights into region-specific specialization of neurovascular communic

267 This study demonstrates region-specific structural effects of chronic APD treatm

268 Site- and region-specific studies suggest that large trees, which

269 e existence of two synaptically distinct and region-specific subcellular domains.

270 nfer stress on all relevant brain cells, but region-specific susceptibility stems from metabolism of

271 pathology appeared to follow a hierarchy of region-specific susceptibility, independent of the clini

272 ications for establishing novel temporal and region-specific targeted therapies to ameliorate core am

273 to be transcriptionally silent, we detected region-specific temporal patterns of transcription in he

274 Laser capture microdissection (LCM)-enabled region-specific tissue analyses are critical to better u

275 rovides a tool for understanding the genomic regions specific to each individual species.

276 his allowed us to identify networks of brain regions specific to production and comprehension, as wel

277 ay upregulate neuronal excitability in brain regions specific to the limb, in this study the right ha

278 rovides a tool for understanding the genomic regions specific to the species and the Edwardsiella gen

279 any hereditary diseases are characterized by region-specific toxicity, despite the fact that disease-

280 d ventral poles, producing a cell-class- and region-specific transcriptional description for these po

281 Intersection of region-specific transcriptomes with expression changes i

282 Here, a cell-specific and region-specific transcriptomics approach was used to det

283 Here we demonstrate region-specific unidirectional airflow in the lungs of t

284 d over the same time period, demonstrating a region-specific uptake based on the progression of the i

285 To understand the molecular basis of this region-specific variability we analyzed gene expression

286 Here we show region-specific variation in MAT adipocyte development,

287 and function of heterochromatin and reveals region-specific variation of heterochromatin.

288 normalities in autism spectrum disorders are region-specific, vary with age, and may remain dynamic w

289 ll, our findings support the conclusion that region specific vascular and haemodynamic changes occur

290 After region-specific viral injections of AAV-GFP or AAV-CRE i

291 Linking our region-specific visit estimates to valuation studies ind

292 The underlying basis of the region-specific vulnerability remains enigmatic.

293 rons) or the hippocampus, suggesting a brain region-specific vulnerability to the G2019S mutation.

294 These results suggest substantial region-specific white matter alterations in survivors of

295 TRPC3c expression is brain region specific, with prevalence in the cerebellum and b

296 nockout mouse lines, that this regulation is region-specific, with the 5-HT4 receptor upregulated in

297 These data reveal that ER expression is region-specific within the neonatal amygdala.

298 nt network dysfunction is highly dynamic and region specific, yet with lasting effects on cognition a

299 At age 4, we calculated the age-, sex-, and region-specific z-scores for cholesterol, triglycerides

300 as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs.