ライフサイエンスコーパス: regioselective

1 Zn as catalyst and is highly diastereo- and regioselective.

2 r, the methodology demonstrates to be highly regioselective.

3 talytic aerobic examples that are chemo- and regioselective.

4 addition (1-naphthyl, 2-N-methylpyrrolyl) to regioselective 1,2-addition (2-furyl, 2:1).

5 l, undergo exclusive or exceptionally highly regioselective 1,4-addition reactions to alpha,beta-gamm

6 The protocol involves a Pd(II)-catalyzed C-regioselective 1,4-addition to vinylketones, followed by

7 utorial review summarizes recently developed regioselective [1,3]-transpositions of allylic alcohols

8 le, easy to handle and facilitate direct and regioselective (18) F-labeling to prepare [(18) F]fluoro

9 rich spectator ligands allows efficient and regioselective [(18)F]fluorination of non-activated arom

10 d repeat units via a combination of uncommon regioselective 2,1-insertion and precision chain-walking

11 ly enantioselective, diastereoselective, and regioselective [2,3]-rearrangement of iodonium ylides ha

12 imple, high yielding and scalable method for regioselective 3-acylation of 2-substituted indoles unde

13 pfb)4 or Rh2 (esp)2 directs the reactants to regioselective [3+2]-cycloaddition generating cyclopenta

14 2-silyloxy-substituted butadienes by highly regioselective (4 + 3) cycloadditions.

15 The reaction proceeds via a Cu(I)-catalyzed regioselective 5-endo-trig radical cyclization of 2,2,2-

16 ults could be explained through a chemo- and regioselective 5-exo aminocyclization to the central all

17 titution at the alkene terminus, the initial regioselective 5-exo-trig cyclizations can be intercepte

18 functionalized 2-benzyl benzo[b]furans via a regioselective 5-exo-trig intramolecular oxidative cycli

19 Regioselective 5-O-deprotection was also successfully pe

20 An efficient method for complete regioselective 5-O-opening of conformationally restricte

21 d 3,6-dihydro-2H-pyrans through a chemo- and regioselective 6-endo cycloetherification.

22 this new methodology, which provides highly regioselective access to valuable 1,4-azaborinines in mo

23 Novozyme-435-catalyzed efficient regioselective acetylation of one of the two diastereoto

24 Regioselective activation of aromatic C-H bonds is a lon

25 ns into the substituent effects that lead to regioselective addition based on the recent discovery of

26 chlorobenzoate, which undergoes enantio- and regioselective addition of HBpin catalyzed by DTBM-SEGPH

27 A regioselective addition of isocyanates to fluoroalkylate

28 tion of 1,2-dihydropyrimidines involves 100% regioselective addition of the rhodium carbenoid to endo

29 A regioselective Ag(I)-promoted Pd-catalyzed C3-H activati

30 oute to the pentacyclic core relies on a new regioselective alkenylation of ketones and a tandem radi

31 The palladium-catalyzed regioselective alkoxycarbonylation of allenes with aliph

32 This regioselective alkyl radical addition reaction does not

33 le of the dinuclear active site in promoting regioselective alkyne coupling is discussed.

34 logs based on a pyrazole core through highly regioselective alkyne cycloaddition reactions of sydnone

35 Here we report a new catalytic method for regioselective alkyne hydroarylation with benzoic acid d

36 0 enzyme was employed to effect a chemo- and regioselective allylic C-H oxidation in the presence of

37 A unique chemo- and regioselective alpha- and gamma-arylation of palladium a

38 In addition to cyanomethylation with MeCN, regioselective alpha-cyanoalkylation was observed with v

39 This methodology is also applicable for the regioselective amination of indolizines.

40 We have discovered a highly regioselective aminofluorination of cyclopropanes.

41 his approach is a sequence composed of a (1) regioselective and -retentive preparation of allyloxycar

42 A completely regioselective and challenging gold(I)-catalyzed ring-op

43 tide sequences requires the development of a regioselective and chemoselective methodology.

44 We report the regioselective and direct functionalization of rationall

45 Here we report the enantioselective, regioselective and E/Z-selective allylic oxidation of un

46 or other epoxide activations, leading to the regioselective and enantioretentive formation of 1,2-bif

47 This includes the regioselective and enantioselective coupling and subsequ

48 We report the regioselective and enantioselective formal hydroaminatio

49 Regioselective and enantioselective silylation of unsymm

50 icient and practical protocol for completely regioselective and highly stereoselective synthesis of v

51 e SN2'-6-endo-trig fashion and is completely regioselective and highly stereoselective.

52 The reaction is stereospecific and alpha-regioselective and proceeds with exceptional functional

53 thetic transformations used to make multiple regioselective and stereoselective carbon-carbon bonds.

54 A new method for the regioselective and stereoselective iodoacyloxylation of

55 Reactions are regioselective and stereospecific and enable the rapid p

56 Azo coupling is completely regioselective and, according to DFT calculations, a kin

57 The hydrogenation was also found to be regioselective, and by controlling the reaction conditio

58 Non-oxidative, regioselective, and convergent access to densely functio

59 The reaction is simple, regioselective, and effective at moderate temperature wi

60 This method is highly regioselective, and produces good to moderate yields on

61 An efficient, highly regioselective, and scalable ruthenium-catalyzed o-aryl

62 LT2 inhibitors, featuring an underexploited, regioselective, and stereospecific palladium-catalyzed a

63 sponding alpha-halo aldehydes, which undergo regioselective annulation to form borylated thiazoles.

64 A regioselective anti-hydrochlorination of unactivated alk

65 A highly efficient and regioselective approach to new polycyclic embelin deriva

66 gy provides a straightforward, high-yielding regioselective approach toward the synthesis of an array

67 The 1,3-diarylpyrimidines exhibited regioselective aroylation of the 2-phenyl moiety irrespe

68 An efficient copper(I)-catalyzed direct regioselective arylamination of various heterocyclic N-o

69 ylation was studied, and conditions allowing regioselective arylation at position 3 were successfully

70 Additionally, several examples of the regioselective arylation of benzotrifluoride derivatives

71 A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyrid

72 A method for the regioselective arylboration of isoprene and its derivati

73 The reaction is both chemo- and regioselective, as only 4,6-disubstituted 2-aminopyridin

74 Alternatively, the regioselective assembly of 3-CF3-substituted pyrazoles c

75 A regioselective base-mediated cyclization of mono-N-acylp

76 Highly regioselective benzylic metalations in hydrocarbon solve

77 The first example of a regioselective beta-arylation of benzo[b]thiophenes and

78 lpha-d-Glcp-(1<-->1)-alpha-d-Glcp, through a regioselective beta-d-transfructosylation of trehalose (

79 A powerful strategy for the regioselective bidirectional synthesis of unsymmetricall

80 Regioselective bisaddition of M3N@Ih-C80 (M = Y, Gd) was

81 Subsequent regioselective bromination of phthalazin-1(2H)-ones 3 wi

82 livers ortho-arylated derivatives, and (2) a regioselective Buchwald-Hartwig amination procedure inst

83 CAL-A was not regioselective but rather fatty acid selective, showing

84 Regioselective C-5 arylations were also performed on 1,4

85 Regioselective C-alkylation in the presence of free amin

86 bisubstrate analogues 3-OPP and 4-OPP are a regioselective C-alkylation of the dianion of 3-methyl-3

87 This regioselective C-H activation was conducted without any

88 A highly regioselective C-H benzoxylation of tertiary benzamides

89 a 2-pyridyl directing group, which undergoes regioselective C-H bond activation, serving as a valuabl

90 -H bonds at different positions resulting in regioselective C-H bond activation; paradoxically, the s

91 Methods for the regioselective C-H borylation and subsequent cross-coupl

92 A successive metal-free TBHP-mediated regioselective C-H functionalization of coumarins toward

93 This highly regioselective C-H functionalization reaction with elect

94 hanistic studies suggest a pathway involving regioselective carbometalation and endocyclic beta-hydri

95 id](+)[Co(CO)4](-) catalyst for a late-stage regioselective carbonylation of an enantiomerically pure

96 The regioselective carbyne transfer methodology and the deta

97 This regioselective carbyne transfer strategy gives access to

98 Regioselective carbyne-transfer reagents derived from (3

99 The approach relies on a regioselective cascade reaction involving two equivalent

100 Their synthesis was enabled by exclusively regioselective catalytic arene-norbornene annulation (CA

101 cyclopentanone intermediates, which arise by regioselective, Cbz-directed insertion of Rh and CO into

102 The transformation involves a stereo- and regioselective chloropalladation of an internal alkyne t

103 iety and the advantages of highly chemo- and regioselective click chemistry, such as mild reaction co

104 The regioselective condensation of hydrazines and ynone trif

105 Our ability to understand the high regioselective control that PT domains exert is hindered

106 The regioselective conversion of C-H bonds into C-Si bonds i

107 alpha-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinyls

108 A new chemo- and regioselective coupling protocol between 3-aryl-substitu

109 A copper-mediated picolinamide directed regioselective cross-coupling of naphthylamines with azo

110 A regioselective cross-dehydrogenative coupling between el

111 y subsequent stereoselective epoxidation and regioselective cyclization to afford the signature tetra

112 e phosphonite PPh(catechyl) and proceeds via regioselective cycloaddition with an in situ-generated p

113 (-) species comprises a sequence of multiple regioselective cyclodehydrofluorination and cyclodehydro

114 A regioselective dearomative aza-(3 + 2) cycloaddition rea

115 (-)-actinophyllic acid; and an unprecedented regioselective dehydroxylation.

116 The approach relies upon regioselective deprotection of per-O-trimethylsilyl-alph

117 ing in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hy

118 react with enals in a highly chemoselective, regioselective, diastereoselective and enantioselective

119 ure is described, in which the key step is a regioselective Diels-Alder reaction between a pyranobenz

120 zole uses a route centered upon a late-stage regioselective Diels-Alder reaction.

121 be also used as efficient catalysts for the regioselective dimerization of phenyl acetylene.

122 arenes as the electrophile partners for this regioselective direct arylation.

123 A new and highly regioselective direct C-H arylation polymerization (DARP

124 ersity to this methodology was achieved by a regioselective DoM rather than DreM reaction, affording

125 Therefore, regioselective double functionalization can be achieved

126 was synthesized from phosphatidylcholine via regioselective enzymatic hydrolysis and was reacted with

127 uring 1,2-addition, cyclic ketalization, and regioselective epoxidation.

128 c homoallylic epoxidation and elaborated via regioselective epoxide-ring opening and diastereoselecti

129 es late-stage conformation-controlled highly regioselective esterification of the glucose diol in the

130 The latter occurred in a regioselective fashion at the challenging C6-position of

131 ishet(aryl)-4-het(aroyl)imidazoles in highly regioselective fashion in most of the cases.

132 herification pathways in a highly chemo- and regioselective fashion to obtain skeletally and structur

133 s C-2 or C-8 functionalized derivatives in a regioselective fashion.

134 cyclopropanes and dihydrofurans in a highly regioselective fashion.

135 In addition, a regioselective fluorination reaction allows access to th

136 The reaction is promoted by KOtBu and is regioselective for C3 over N.

137 and convenient method was developed for the regioselective formation of 2-aryl- or 2,5-diarylselenop

138 d to unsaturated ketones, bringing about the regioselective formation of benzoyl-substituted indolizi

139 A regioselective formation of C-S bonds has been achieved

140 lation of the starting material explains the regioselective formation of densely functionalized heter

141 zed dihalogenation processes allowing highly regioselective formation of different carbon-halogen bon

142 ure in the presence of oxygen results in the regioselective formation of ethyl 5,7-difluoro-4-azaspir

143 lective insertion of the amido group and the regioselective formation of the 1,4-disubstituted triazo

144 an electrophilic halogen source and leads to regioselective formation of the halofunctionalized adduc

145 e 2H- and 4H-chromenol derivatives underwent regioselective Friedel-Crafts reactions with heteroarene

146 The reactivity and the regioselective functionalization of silyl-diene enol eth

147 heterogeneous, and recyclable catalysts for regioselective functionalization of sp(2) C-H bond.

148 For purines, the coupling is also regioselective, giving the N-9 nucleotide for adenine as

149 This synthetic approach also allowed a regioselective glycosylation of 6-OH of aspicilin with d

150 of donor and acceptor on the efficiency of a regioselective glycosylation reaction, a problem that wa

151 Organoboron-mediated regioselective glycosylations were employed as key steps

152 thetic strategy involves a highly chemo- and regioselective gold-catalyzed cycloisomerization reactio

153 Here we demonstrate that integration of regioselective halogenase enzymes with Pd-catalysed cros

154 Regioselective halogenation at the 3-position allows int

155 eliable, facile, and cleaner methods for the regioselective halogenation of organic compounds are the

156 ond method is divergent and achieved through regioselective halogenation reactions of 4,4'-bipyridine

157 The Au(I)-catalyzed regioselective hydration of gamma-acetoxy-alpha,beta-ace

158 The highly regioselective hydration, stereoselective reduction, and

159 t in this synthesis was the development of a regioselective hydroamination of a monoprotected proparg

160 Highly Markovnikov regioselective hydroboration of styrenes as well as exce

161 ch include a critical haloboration reaction, regioselective hydroboration, and controlled oxidation (

162 A mild and user-friendly Ni-catalyzed regioselective hydrocarboxylation of alkynes with CO2 (1

163 We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to fur

164 and 28-fold increase in mass activity in the regioselective hydrogenation of quinoline, compared with

165 We report the chemo- and regioselective hydrogenolysis of the C-O bonds in di-ort

166 catalysts, methanol engages in redox-neutral regioselective hydrohydroxymethylations.

167 An efficient, highly regioselective hydrolysis and transesterification of dim

168 the functionalization at C-7 by an efficient regioselective hydrostannylation of an allene precursor,

169 of the fatty acid substrate and its enantio/regioselective hydroxylation by the active species of th

170 [OTf]2 (5) with iodosobenzene results in the regioselective hydroxylation of a bridging pyrazolate li

171 tightly bound Cu(II) ion that catalyzes the regioselective hydroxylation of crystalline cellulose, l

172 ond formation using an alpha-chloro sulfide, regioselective hydrozirconation of an internal alkyne fo

173 n at an sp(2) carbon atom, allows the direct regioselective incorporation of mono-, di-, tri-, and te

174 he Ox group also facilitates the stereo- and regioselective incorporation of nucleophiles (Nu) and di

175 succinctly summarized, with emphasis on the (regioselective) incorporation of various types of cataly

176 s a unique CYP profile and was found to be a regioselective inhibitor of midazolam CYP3A metabolism.

177 Key steps include regioselective installation of a thiocarbonate using cat

178 developed a mild and general method for the regioselective installation of benzyl, allyl, para-metho

179 A chemo- and regioselective intermolecular sp(3) C-H and sp(2) C-H co

180 ective metal-halogen exchange and subsequent regioselective intramolecular 6-endo-tet cyclization.

181 a-trifluoroboratoamide with an aryl bromide, regioselective intramolecular carboalkoxylation, and a 1

182 ion of aryne into the C-O bond followed by a regioselective intramolecular conjugate addition.

183 , which upon treatment with Cs2CO3 underwent regioselective intramolecular cyclization furnishing tet

184 tives via a well-designed aldol condensation/regioselective intramolecular cyclization/conjugate addi

185 4 (5 mol %), and NaOAc (2 equiv) allowed the regioselective introduction of various alkynyl residues

186 An efficient regioselective iodination of the Fischer-Borsche ring ha

187 To this end, regioselective iodination protocols were developed for 7

188 A highly regioselective iodine-mediated cascade reaction for the

189 pment of the first enantio-, diastereo-, and regioselective iridium-catalyzed allylic alkylation reac

190 Herein, we report a novel, regioselective, iridium-catalyzed multicomponent synthes

191 trans-alkenes followed by a mild and highly regioselective isomerization to give the major ketone is

192 this protocol enables the chemoselective and regioselective late-stage silylation of small heterocycl

193 synthesize valuable substituted azoles in a regioselective manner by capping (e.g., acylation) of th

194 olo[3,4-b]pyridines 4 has been prepared in a regioselective manner by the microwave-assisted reaction

195 ienes into the methanol C-H bond occurs in a regioselective manner to form all-carbon quaternary cent

196 These triazoles are formed in a regioselective manner, and several pairs of regioisomeri

197 sor, yet the coupling reaction proceeds in a regioselective manner, with the position of attachment o

198 e, X = OMe) were successfully applied in the regioselective Markovnikov addition of carboxylic acids

199 d with different nucleophiles for performing regioselective metal-free C-O and C-N bond-cleaving to a

200 Here, we report a one-step, regioselective, metal-free (18)F-labeling method that us

201 imparting activity for Lewis acid catalysis (regioselective methanolysis ring-opening of styrene oxid

202 A general and regioselective method for the chlorination of activated

203 The first regioselective, mild bromination of thieno[2,3-b]pyridin

204 MT are shown to provide highly versatile and regioselective modification of a diverse range of substr

205 base [(dioxane)0.5 NaFe(HMDS)3 ] (1) enables regioselective mono and di-ferration (via direct Fe-H ex

206 The most common method for achieving the regioselective monoalkylation of diols involves formatio

207 The Pd-catalyzed quinazolinone-directed regioselective monoarylation of aromatic rings by C-H bo

208 Alternatively, regioselective monotriflation at O2, O3, and O4 of l-rha

209 Regioselective N1-alkylation, -arylation, and -heteroary

210 A novel and efficient method for the regioselective nitration of a series of aliphatic and ar

211 Furthermore, a newly developed regioselective nitration procedure for perylene monoimid

212 he initial formation of thiourea followed by regioselective nucleophilic addition and intramolecular

213 to selective chemical modifications such as regioselective O- and N-sulfation and selective de-sulfa

214 a quite strong sterically nondemanding base, regioselective O-acylations should be possible at low te

215 Regioselective O-alkylation of an amide to form the corr

216 d elimination, aromatization, hydrogenation, regioselective O-exchange, Stork-Danheiser transposition

217 cyclization for the tricycle assembly and a regioselective OH-directed C-H activation are presented.

218 First, we describe a regioselective one-pot synthesis of CF3-, SCF3-, Ph2(O)P

219 available l-rhamnose and l-fucose via highly regioselective, one-pot double serial and double paralle

220 tial Zr-mediated oxidative diyne-cyclization/regioselective opening sequence for preparation of the u

221 n-rich or an electron-deficient unit, with a regioselective orientation of the respective Tz unit, ha

222 An efficient Cu-catalyzed chemo- and regioselective ortho-nitration of N,1-diaryl-5-aminotetr

223 on-coupled electron transfer (PCET) mediated regioselective ortho-specific nitration of aromatic C(sp

224 entafluorophenyl)chlorin is susceptible to a regioselective OsO4-mediated dihydroxylation, generating

225 yzed reaction, thus leading to complementary regioselective outcomes and addressing the limitations o

226 in reversibility of a key step allows highly regioselective outcomes that were not possible using pre

227 A late-stage TEMPO-mediated regioselective oxidation has been performed to achieve t

228 with just traces of oxygen is shown to yield regioselective oxidation, dehydrogenation, and fragmenta

229 A rhodium catalyzed direct regioselective oxidative annulation by double C-H activa

230 A palladium-catalyzed pyrazole-directed regioselective oxidative C(sp2)-H functionalization of t

231 A highly efficient iodine-catalyzed regioselective oxidative cross-coupling of an indole C-H

232 The acetamide group enables regioselective oxidative ortho-C-H activation reactions,

233 lylic amine with a vinyl cyclohexenone and a regioselective palladium catalyzed hydrogenation.

234 An efficient and regioselective palladium(II)-catalyzed primary acetamide

235 disclose a template-assisted method for the regioselective para silylation of toluene derivatives.

236 The pentachloro-BODIPY is shown to undergo regioselective Pd(0)-catalyzed Stille and Suzuki couplin

237 Ligand-controlled regioselective Pd-catalyzed carbonylation of styrenes wi

238 Deacetylation followed by regioselective phosphorylation gave isomeric (R,S)-(P)-4

239 emistry, mainly because it allows a valuable regioselective postfunctionalization of BODIPY chromopho

240 Their efficient regioselective preparation is often still a challenge de

241 S preparation OM-RML brings forth an optimal regioselective preparation of sn-1 mono and sn-1,3 diacy

242 However, to date, regioselective processes for this copolymerization have

243 A BF3.OEt2 mediated novel and regioselective protocol for the construction of a C-C bo

244 r the development of an efficient and highly regioselective protocol for the fluorination of vinyl tr

245 f the formation of 4-hydroxyacridine and the regioselective reaction of diepoxyacridine with nucleoph

246 studies suggest distinct mechanisms for the regioselective rearrangements.

247 yclooctadiene) as a more robust catalyst for regioselective reductive coupling of ynoates and aldehyd

248 cetamido-beta-D-glucopyranoside, obtained by regioselective reductive opening of the acetal ring in t

249 We report that a regioselective reductive transposition of primary allyli

250 This family of directing groups enables regioselective remote hydrocarbofunctionalization of sev

251 partial charge models demonstrated that the regioselective removal of halogens is governed by the le

252 otocycloaddition reactions followed by fully regioselective ring opening/Hofmann rearrangement/nitrog

253 Diastereoselective epoxidation and regioselective ring-opening methods were developed for t

254 egy for the syntheses of 2-alkyl indoles via regioselective ring-opening of 2-(2-haloaryl)-3-alkyl-N-

255 A convenient low-cost method for regioselective ring-opening of donor-acceptor cyclopropa

256 econdary alcohol with diethylsilane, undergo regioselective silylation at a secondary C-H bond gamma

257 The results show quantitative and regioselective SPRi images correlating to MALDI IMS imag

258 ,5,8-trichloro-BODIPY that readily undergoes regioselective Stille coupling at the 8-position, or hom

259 A novel, mild, and versatile approach for regioselective syn-addition of both the CN and OTf group

260 A palladium(II)-catalyzed regioselective syn-hydroarylation reaction of homopropar

261 potential for the development of stereo- and regioselective syntheses of structurally defined bioacti

262 We also report the regioselective synthesis and spectroscopic characterizat

263 lkyl) hydrazines was performed, aimed to the regioselective synthesis of 3- or 5-trifluoromethylated

264 Regioselective synthesis of 3-bromoquinoline derivatives

265 A regioselective synthesis of 6-alkyl- and 6-aryluracils w

266 A general, efficient, and regioselective synthesis of a series of hydroxylated 1-m

267 t metal and protection-free approach for the regioselective synthesis of C-3-functionalized quinoline

268 The regioselective synthesis of easily isolable pure bismeth

269 We report the regioselective synthesis of eight pi-expanded diarenoind

270 A microwave-assisted approach for the regioselective synthesis of functionalized 6-(aryldiazen

271 Regioselective synthesis of functionalized dihydropyran

272 nals with azides, which allows the efficient regioselective synthesis of highly fused furo[3,4-d][1,2

273 This method allows regioselective synthesis of hydroxyl-functionalized aryl

274 A regioselective synthesis of multisubstituted furan deriv

275 eta-nitrostyrenes has been developed for the regioselective synthesis of multisubstituted furan deriv

276 An atom-economical regioselective synthesis of N-substituted prolinamides o

277 A regioselective synthesis of naphtho[2,1,8-def]coumarins

278 ced ipso-desilylation tactics applied to the regioselective synthesis of phenanthrenes ( Scheme 2 ).

279 A simple and regioselective synthesis of phenoxy esters and phenylthi

280 elective conventional cross-coupling for the regioselective synthesis of potential pharmacophores.

281 An efficient regioselective synthesis of substituted 4-alkylamino and

282 A one-pot three-component reaction for the regioselective synthesis of thioarylated imidazoheterocy

283 s been developed, enabling highly chemo- and regioselective synthesis of unsymmetrical dialkyl ketone

284 A new, regioselective synthesis of V-shaped 2,9-bis(6-(4-haloph

285 An alternative highly regioselective synthetic method for the preparation of 3

286 Described is a reactant-directed regioselective synthetic method, which was found to be h

287 e report the development of a highly active, regioselective system for the copolymerization of a vari

288 ddition reactions were highly diastereo- and regioselective to yield, in most of the cases, a very ma

289 Significantly, the unusual regioselective transformation occurs only when an Fe-dec

290 mation of ynamine to thiophene and the first regioselective transformation of a longer polyynes to bu

291 Regioselective transformations of the newly formed unsym

292 A regioselective transition metal-catalyzed cycloisomeriza

293 A diverse range of novel regioselective triazolyl glycoconjugates 6a-u have been

294 The reaction is highly regioselective under the directing group influence of py

295 de C, the short synthesis of Sch-725674, and regioselective Wacker oxidation of internal olefin are t

296 notable features of our synthesis comprised regioselective Wacker oxidation, Sharpless asymmetric di

297 developed method is simple, mild, and highly regioselective with a broad range of substrate scope.

298 optimized method is simple, mild, and highly regioselective with a broad substrate scope.

299 We demonstrate that the ALD is regioselective, with preferential deposition of oxy-Zn(I

300 A practical, straightforward, and highly regioselective Zn(OAc)2-mediated method toward propargyl