ライフサイエンスコーパス: regioselectivity

1 that the nature of the ligand is key to the regioselectivity.

2 stereocenters with good yield and excellent regioselectivity.

3 oduct is formed in up to 74% yield and >20:1 regioselectivity.

4 eeds rapidly under mild conditions with high regioselectivity.

5 tal control lead to incorrect predictions of regioselectivity.

6 are transformed in high yield and very high regioselectivity.

7 ) have been correlated to the reactivity and regioselectivity.

8 d gamma-amino acids in good yields with high regioselectivity.

9 ive site residues contribute to the enzyme's regioselectivity.

10 hydrothiolation in up to 88% yield and >20:1 regioselectivity.

11 mode and shed light on the unusual arylation regioselectivity.

12 kyne partners to afford good yields and high regioselectivity.

13 nes in moderate-to-good yields and with good regioselectivity.

14 y observable recognition motif and exquisite regioselectivity.

15 ite residues and quaternary structure govern regioselectivity.

16 (i.e., NOBIN-type) are formed with complete regioselectivity.

17 actors that are responsible for the observed regioselectivity.

18 enes are converted with unprecedentedly high regioselectivity.

19 4j, 4k, 4m with complete levels of branched regioselectivity.

20 zed products with high stereoselectivity and regioselectivity.

21 e silylated in good yield and with excellent regioselectivity.

22 neate the theoretical basis of the reduction regioselectivity.

23 ane products in high yield with good to high regioselectivity.

24 as an efficient strategy to ensure promising regioselectivity.

25 opyranosyl sulfones in good yields with high regioselectivity.

26 alkynes can be coupled efficiently with high regioselectivity.

27 nism and support the experimentally observed regioselectivity.

28 roceeds in excellent yield and with complete regioselectivity.

29 friendly reaction conditions with excellent regioselectivity.

30 rted to the desired aryl fluorides with high regioselectivity.

31 es play a crucial role in the reactivity and regioselectivity.

32 tching orientation that translates into high regioselectivity.

33 remarkable chemoselectivity and predictable regioselectivity.

34 t and with high levels of sterically derived regioselectivity.

35 yclic compounds in moderate yields with high regioselectivity.

36 alkane products in high yields and excellent regioselectivity.

37 moderate to good yields with high chemo- and regioselectivity.

38 bstituted pyridines with very high levels of regioselectivity.

39 stem 1a/1a' without a change in the high gem regioselectivity.

40 nal groups can be oxidized in high yield and regioselectivity.

41 s of the halogenated products with excellent regioselectivity.

42 acid 2-aminoethyl ester (DPBA) as inducer of regioselectivity.

43 alkyl olefins with complete anti-Markovnikov regioselectivity.

44 tibility, low atom economy, and insufficient regioselectivity.

45 other in good yield and excellent chemo- and regioselectivity.

46 chlorides in excellent yields and with high regioselectivity.

47 te size determines the reaction products and regioselectivity.

48 ive treatment of the cycloaddition site- and regioselectivity.

49 oisomers with high enantio-, diastereo-, and regioselectivity.

50 ording acrylamides with excellent chemo- and regioselectivity.

51 amine derivatives in up to 94% yield and 99% regioselectivity.

52 mma-aryl allylboronates with good yields and regioselectivities.

53 es are obtained in good yields and excellent regioselectivities.

54 action model is used to explain the observed regioselectivities.

55 s were obtained in high yields with complete regioselectivities.

56 modes enabled the quantitative prediction of regioselectivities.

57 id (palmitic and linoleic, respectively) and regioselectivity (3 and 3', respectively).

58 s C5 isomer b is achieved in almost complete regioselectivity (46:1) and good yield.

59 Excellent yields (up to 95 %) and regioselectivities (5-exo vs. 6-endo) were achieved thro

60 water, alcohols, and HF proceeded with high regioselectivity, affording piperidinol products with ad

61 Full regioselectivity along with short reaction time (1-2 h)

62 ions has grown rapidly in recent years, poor regioselectivities and the need to use a large excess of

63 yalkylated products of vinylarenes with good regioselectivity and accomplishes with the principles of

64 use of directing group strategies to control regioselectivity and build structural patterns for synth

65 The origin of the regioselectivity and catalytic activity was elucidated b

66 odium catalyst proved to be crucial for high regioselectivity and conversion.

67 -amino alcohols were obtained with excellent regioselectivity and converted to oxazolidinones and dih

68 The mechanism and reasons for regioselectivity and diastereoselectivity were analyzed

69 ions of aliphatic internal alkenes with high regioselectivity and enantioselectivity.

70 ynthesized from an internal alkene with high regioselectivity and enantioselectivity.

71 liphatic esters were obtained with excellent regioselectivity and enantioselectivity.

72 have proceeded in high yields with complete regioselectivity and excellent geometric selectivity.

73 ally hindered alkenes experience a change in regioselectivity and form unconjugated carboxylic acids.

74 Both protocols demonstrate a good level of regioselectivity and functional group tolerance.

75 The sp(2) C-H functionalization showed high regioselectivity and good functional group compatibility

76 hols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98%

77 ctional group tolerance, often with complete regioselectivity and high yields, resulting in a highly

78 nd 3, respectively, indicated the reaction's regioselectivity and kinetic control.

79 ion proceeds with excellent anti-Markovnikov regioselectivity and provides exclusively (E)-alkenes.

80 ntate directing group is used to control the regioselectivity and stabilize the putative alkylpalladi

81 cyl chain provide a structural basis for the regioselectivity and stereospecificity of the desaturati

82 ubstituent effects on reactivity, chemo- and regioselectivity and the effects of oxidant in the inter

83 Strong points of the new protocol are its regioselectivity and thus the immediate access to pyrimi

84 olated in good to excellent yields with high regioselectivity and under mild reaction conditions (25-

85 This allows achieving superior degrees of regioselectivity and yields in the desaturation of alcoh

86 ible mechanism was proposed for the observed regioselectivity and Z-selective arylation of N-allylpic

87 ctional groups were obtained in high yields, regioselectivities, and diastereoselectivities.

88 xcellent functional group tolerance, yields, regioselectivities, and stereochemical fidelities are ob

89 an 99% carbonate linkages, 100% head-to-tail regioselectivity, and a glass-transition temperature (Tg

90 enables the binding of substrate, guides the regioselectivity, and expels product efficiently.

91 acetates, affording coumarins with excellent regioselectivity, and proceeds via C-H bond activation p

92 The observed chemoselectivity and regioselectivity are explained via an acid-catalyzed mec

93 The reasons for regioselectivity are interpreted through density functio

94 Good levels of regioselectivity are observed for a wide range of electr

95 Modest effects of the catalyst nature on regioselectivity are observed in the sorbyl alcohol and

96 computational studies support the origin of regioselectivity as being thiocarbonyl-directed lithiati

97 This process displays exceptional chemo- and regioselectivity as well as high diastereoselectivity, a

98 strategies developed to date lack chemo- and regioselectivity as well as result in non-native linkage

99 way for Mitsunobu sequence and supported the regioselectivity as well as the diastereoselectivity obs

100 Reverse Halex regioselectivity at the 4-position was predicted by comp

101 ine has been achieved, wherein the switch in regioselectivity between positions C3 and C7 is under co

102 sily prepared with high levels of chemo- and regioselectivities by hydrofluorination of readily avail

103 strate's channel, residue Phe87 controls the regioselectivity by causing the substrate's chain to cur

104 pairing to a SbF6(-) counterion changes the regioselectivity by up to a factor of 12 depending on th

105 y more demanding than at C2 due to issues of regioselectivity (C3 versus C2), and the requirement of

106 In the free-base case, this regioselectivity can be explained using resonance argume

107 substrate binding and specificity, oxidative regioselectivity, catalytic efficiency, and stability.

108 insertion pathway, explaining the change in regioselectivity caused by steric effects and distinguis

109 f (S)-alpha- and (S)-beta-arylalanines, with regioselectivity correlating to the strength of electron

110 ortance of hydrogen bonding for this unusual regioselectivity could be confirmed by NMR studies and D

111 at tune the unique substrate specificity and regioselectivity could be identified.

112 Chemo- and regioselectivity depend on both linker elongation as wel

113 allenyl-type were employed, giving different regioselectivities, depending on its nature; the regiose

114 ified that allow alteration in the rate- and regioselectivity-determining step of nickel-catalyzed al

115 the result of exquisite catalyst controlled regioselectivity enabling use of electronically unbiased

116 acid selectivity (palmitic vs. linoleic) and regioselectivity (esterification at positions 3 vs. 3').

117 Observed regioselectivities for nucleophilic opening are rational

118 ne, well-defined precatalyst 3 provides high regioselectivities for the anti-Markovnikov product, eve

119 Very high regioselectivity for 3-substituted indoline products is

120 hydrophobic chain caused an increase in the regioselectivity for a secondary rather than tertiary su

121 ein, we demonstrate a reversal of the native regioselectivity for alkene halofunctionalization throug

122 usive cis-diastereoselectivity, and distinct regioselectivity for alkyne addition.

123 These factors do not distinguish the regioselectivity for attack on allyliridium complexes fr

124 yridine can play a key role in enabling high regioselectivity for difficult reactions.

125 Detailed studies on the origin of the regioselectivity for formation of branched products over

126 efforts to develop biocatalysts that confer regioselectivity for site-specific modification, thereby

127 roxypyridines was found to proceed with high regioselectivity for the 2-position.

128 he first catalytic system shown to give high regioselectivity for the branched product with iridium a

129 Evidence for electronic-controlled regioselectivity for the cyclopalladation step was obtai

130 High regioselectivity for the glycosylation on the equatorial

131 ts, which likely accounts for the unique 1,4-regioselectivity for the hydroboration of pyridine deriv

132 uch CYTOP 292 or P(p-anisyl)3 to enhance the regioselectivity for the linear isomers in the range of

133 idinyl-N-oxyl) displays excellent chemo- and regioselectivity for the oxidation of less hindered unsy

134 dynamics and completely shifts the enzyme's regioselectivity from the C4 to the C5 position of L-try

135 nocatalyst provokes a dramatic change in the regioselectivity, from the 1,5- to the 1,3-functionaliza

136 Excellent regioselectivity (>/=92:8) is realized for the Wacker ox

137 93% e.e.), diastereo- (up to 25:1 d.r.), and regioselectivity (>50:1) at low catalyst loadings and mi

138 e primary cross-metathesis product with high regioselectivity (>98%) along with a molybdenum metallac

139 rotocol for amide O-alkylation with complete regioselectivity has been designed, and its scope and ef

140 This regioselectivity has been long known but was never fully

141 A change in regioselectivity has been observed in the hydrogen atom

142 This acid-induced change in regioselectivity has been successfully applied for selec

143 luding vanillin production, although lack of regioselectivity has precluded its more widespread appli

144 4A/K132A or HemOin) and one that has altered regioselectivity (HemO N19K/K34A/F117Y/K132A or HemOalph

145 olved in this procedure, which features high regioselectivity, high efficiency, and environmental fri

146 The presented method features full regioselectivity, high isolated yields, and simplicity o

147 Cycloaddition regioselectivity, however, is the result of differences

148 problem and resulted in drastically improved regioselectivities in this palladium-catalyzed fluorinat

149 The decisive step in the determining regioselectivity in fluorine functionalization is fluori

150 enzobicycloheptanone products with excellent regioselectivity in high yields (up to 96%).

151 formation of stable boro-oxazines with high regioselectivity in most of the cases, in moderate to go

152 ns with a high degree of chemo-, stereo- and regioselectivity in most of the reactions.

153 s, as well as insight into the source of the regioselectivity in reactions of internal alkynes.

154 understanding of the factors that determine regioselectivity in reactions of these strained intermed

155 Regioselectivity in the aziridination of silyl-substitut

156 an ion pair-directed approach to controlling regioselectivity in the iridium-catalyzed borylation of

157 been achieved through switchable chemo- and regioselectivity in the metal-catalyzed heterocyclizatio

158 ance arguments, but the explanations for the regioselectivity in the metallochlorin reactions require

159 ta-unsaturated esters are obtained with high regioselectivity in the presence of PPh2Py as the ligand

160 ioselectivities, but also provides exclusive regioselectivity in the presence of two methylene groups

161 3,2,5-diazadiborinine (1), which showed high regioselectivity in the reactions with methyl trifluorom

162 The alpha-angelica lactone displays unusual regioselectivity in this reaction, acting as a nucleophi

163 mportant thermodynamic factor which controls regioselectivity in this system is the weak C2-Cl bond.

164 The regioselectivity in triazole substitution at the C-5 pos

165 ltaneous control of diastereoselectivity and regioselectivity in Zn-catalyzed allenylation reactions

166 echanistic study sheds light on the observed regioselectivity involving a Cu-vinylidene complex, and

167 The regioselectivity is achieved by controlling the reaction

168 The persistence of this regioselectivity is also observed during the liquid-phas

169 We hypothesize that the change in regioselectivity is an effect of diverging coordination

170 Notably, the observed regioselectivity is complementary to conventional radica

171 oselectivities, depending on its nature; the regioselectivity is complete with alkyl azides and pheny

172 The regioselectivity is directed by the substituent at the C

173 al calculations indicate that this startling regioselectivity is driven by dispersion interactions as

174 de range of functional groups, and excellent regioselectivity is found with unsymmetrical diynes.

175 Here, regioselectivity is governed for 10 of the 11 active sub

176 The strict regioselectivity is guided by the pyridyl substituent at

177 The regioselectivity is guided by the pyridyl substituent at

178 The regioselectivity is justified by the DFT calculations at

179 plings of 1-substituted-1,3-dienes, novel C2 regioselectivity is observed.

180 Regioselectivity is of fundamental importance in chemica

181 MeCN)3]PF6 (1) as the catalyst; however, the regioselectivity is often poor with unsymmetrical substr

182 The observed regioselectivity is strongly ring size dependent, with s

183 The reaction regioselectivity is supported by the data of quantum-che

184 eneration of organometallic reagents and the regioselectivity issues commonly associated with asymmet

185 y of the functional group incompatibilities, regioselectivity issues, and high-energy reagents genera

186 s dimerization points to a certain degree of regioselectivity, leading to a low sheet homogeneity (Hs

187 he substituents present on the chlorin, this regioselectivity may change, but ALIE calculations provi

188 internal vicinal fluoro carbamates with high regioselectivity (N vs F), many of which are difficult t

189 The regioselectivities observed computationally allowed the

190 ange of substrates investigated, the kinetic regioselectivity observed at low temperatures under nonc

191 noncatalytic conditions roughly predicts the regioselectivity observed for catalytic transformations

192 The high chemo- and regioselectivity observed for these reactions is attribu

193 The regioselectivity observed in alkyl azides and phenyldiaz

194 icyclic character and that the low levels of regioselectivity observed in the reactions are a consequ

195 The regioselectivity observed in these lactonization reactio

196 The regioselectivities of La2@C80 in thermal nucleophilic an

197 e effects of the organoboron catalyst on the regioselectivities of the epoxide ring-opening and acyla

198 arbon-carbon bond formation and controls the regioselectivities of the pair of subsequent aminal bond

199 ntate directing group is used to control the regioselectivity of aminopalladation and stabilize the r

200 The regioselectivity of anisole bromination changed with pH,

201 emovable directing group to both control the regioselectivity of carbopalladation and enable subseque

202 or ProcA3.3 these mutations also altered the regioselectivity of cyclization resulting in a new major

203 iterion for understanding and predicting the regioselectivity of different reactions such as Diels-Al

204 ence of steric and electronic factors in the regioselectivity of endoperoxide formation of tetracene

205 e of aryl sulfonates and shows excellent C-3 regioselectivity of imidazo[1,2-a]pyridine.

206 bstrates are more challenging as they affect regioselectivity of iridium-hydride insertion.

207 parative study, revealing that the oxidative regioselectivity of LPMO9s (C1, C4, or both) correlates

208 f substituents demonstrates the efficacy and regioselectivity of metalation.

209 nic couplings plays an important role in the regioselectivity of nucleophilic cycloadditions.

210 the data in this study suggest that the high regioselectivity of product formation is governed by the

211 It was found that the regioselectivity of reaction depends dramatically on the

212 eactivity descriptors were used to study the regioselectivity of the addition steps.

213 In addition, the regioselectivity of the addition was probed using both D

214 , together with a solvent dependence for the regioselectivity of the addition.

215 ium, it is possible to carefully control the regioselectivity of the aerobic oxidation of amides cata

216 Products distribution shows that the regioselectivity of the anchimerically driven alkylation

217 Evidence obtained from the resulting regioselectivity of the annulation reactions and DFT stu

218 ts of conditions successfully controlled the regioselectivity of the arylation.

219 ocated hydrogen bond to transcend the normal regioselectivity of the C-F functionalization event.

220 rol the rate of the alkene insertion and the regioselectivity of the catalytic reactions of vinylaren

221 In certain cases, the regioselectivity of the CC coupling can be inverted by u

222 ate directing groups are used to control the regioselectivity of the chloropalladation step and stabi

223 studies, we provide insight into stereo- and regioselectivity of the chloropalladation step, as well

224 prior to reaction could greatly enhance the regioselectivity of the dehydrocyclization reaction and

225 The regioselectivity of the diamination is controlled by the

226 The regioselectivity of the dual C-H/C-X borylation is deter

227 Factors governing the regioselectivity of the final cyclization step are discu

228 nvestigate the effects of ion pairing on the regioselectivity of the hydroarylation of 3-substituted

229 nsition state theory incorrectly predict the regioselectivity of the hydroboration of propene with BH

230 The chemo- and regioselectivity of the initial attack in skipped oligoa

231 The complete shift of the regioselectivity of the intermediate enolate from a C-C

232 Intramolecular hydrogen bonding governed the regioselectivity of the key spiroketalization step, affo

233 otecting-group strategy that facilitated the regioselectivity of the key transformations, stereoselec

234 e enantioselectivity but also to reverse the regioselectivity of the noncatalyzed nitroso-Diels-Alder

235 the Wacker oxidation suggested that the high regioselectivity of the oxidation in these lactam alkene

236 ects have a strong influence on the rate and regioselectivity of the oxidation.

237 The regioselectivity of the palladium-catalyzed cyclization

238 The regioselectivity of the process and the factors controll

239 n as a major problem, the causes of the poor regioselectivity of the reaction are unknown.

240 ta-photocycloaddition, it was found that the regioselectivity of the reaction depends strongly on the

241 The regioselectivity of the reaction is controlled by the el

242 The chemo- and regioselectivity of the reaction may be tuned by changin

243 icated that the nitro group has influence on regioselectivity of the reaction.

244 at we expected to be crucial for guiding the regioselectivity of the reaction.

245 bridged intermediate lower both the rate and regioselectivity of the reaction.

246 The structures of the products and regioselectivity of the reactions were determined on the

247 uents via orbital crossings greatly enhances regioselectivity of the ring closure step in comparison

248 The regioselectivity of the second annulation reaction was r

249 substrate enabled the ligands to dictate the regioselectivity of the transformations.

250 The low regioselectivity of the wild-type enzyme was addressed v

251 nate esters and studies on the origin of the regioselectivity of these reactions are reported.

252 The regioselectivity of these reactions is often controlled

253 The observed regioselectivity of this reaction is governed by the nat

254 ty (>/=90:10 for 20 examples), and excellent regioselectivity (only one regioisomer formed).

255 , these catalytic additives have changed the regioselectivity or diastereoselectivity.

256 h an increase in the ee, the reversal of the regioselectivity, or the complete suppression of one byp

257 ganometallic species and by an unprecedented regioselectivity pattern using simple alcohols as proton

258 bility to drug-like molecules, classified by regioselectivity patterns, and gives guidance on how to

259 ctions using fluoride salts, controlling the regioselectivity presented a challenge in developing a p

260 al conditions and proceeds with good to high regioselectivity, producing the corresponding 1,2-dihydr

261 Mechanistic studies suggest that the regioselectivity results from a selective allene formati

262 Studies on the origins of the observed regioselectivity show that borylation occurs distal to N

263 Achieving chemo- and regioselectivity simultaneously is challenging in organi

264 incorporating the Ampaphos ligand triggers a regioselectivity switch, allowing both linear and branch

265 -2-ones with very high levels of stereo- and regioselectivity, the 7-exo and 8-endo carbocyclization

266 he linear (E)-allylated arene with excellent regioselectivity; this reaction occurs with arenes that

267 zes can be obtained with generally excellent regioselectivities through either a chloro- or a bromocy

268 and with excellent enantio-, diastereo-, and regioselectivity through catalytic asymmetric fluoroenol

269 ese ring-opening reactions proceed with high regioselectivity through nucleophilic attack at the C-6

270 ine serves to promote reactivity and enforce regioselectivity through the formation of the favored me

271 enes with formaldimines with complete branch-regioselectivity, thus representing a new method for hyd

272 reaction conditions and leads with a perfect regioselectivity to a wide variety of diversely function

273 by DFT calculations, which show the observed regioselectivity to arise from steric effects in the B-C

274 cts with high selectivity, while a switch in regioselectivity to branched products is observed for ar

275 or cyclopropyl acid chlorides, with complete regioselectivity, to form 1,3-oxazin-4-ones in moderate

276 The regioselectivity toward C-alkylation is explained by the

277 ensures a unique reaction outcome with high regioselectivity toward the more valuable branched isome

278 The observed regioselectivity towards primary C(sp(3) )-H activation

279 ano anions, react with unexpected stereo- or regioselectivity under standard glycosylation conditions

280 quire exquisite control over both chemo- and regioselectivity, under ambient, aqueous conditions.

281 and -alkylated benzothiophenes with complete regioselectivity, under metal-free and mild conditions.

282 ivatives were efficiently obtained with high regioselectivity (up to >95:5) and high enantioselectivi

283 with formation of chiral acyloins with high regioselectivity (up to 99%) and enantioselectivity (up

284 High regioselectivity was achieved in the case of unsymmetric

285 This change in the regioselectivity was attributed to the electronic and, p

286 High regioselectivity was observed with 1-substituted and 1,2

287 Additionally, in all cases with high 3'-5' regioselectivity, Watson-Crick base pairing between the

288 Experimental Halex regioselectivities were consistent with kinetic control

289 Experimentally determined regioselectivities were consistent with predictions made

290 Although the intended regioselectivities were not observed, unusual organopall

291 Their specific activity and regioselectivity were studied in the synthesis of conjug

292 The reaction mechanism and regioselectivity were then systematically explored by qu

293 ons are distinguished by excellent levels of regioselectivity when unsymmetrical alkynes are used tha

294 ith air as the oxidant, this method has high regioselectivity, which provides a new route for constru

295 ty, high functional group compatibility, and regioselectivity while relying on FeCl3 as an environmen

296 The ligand identity is key to achieving high regioselectivity, while the mild reaction conditions min

297 ate's binding by Arg241 determines the alpha-regioselectivity, while the Pro242 residue locks the pro

298 s for heteroaromatic azadiene reactivity and regioselectivity with alkene dieneophiles.

299 This process presented high regioselectivity, with approximately 80mol% of concentra

300 st promotes alkyne transformations with high regioselectivity, with examples that include the differe